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Journal Article
Clinical & Experimental Immunology, ISSN 0009-9104, 07/2006, Volume 145, Issue 1, pp. 162 - 172
The Th2 cytokines interleukin (IL)‐4 and IL‐13 and chemokine monocyte chemoattractant protein‐1 (MCP‐1) are significantly involved in bronchial hyperreactivity... 
chemokines/monokines | allergy | epithelial cells | cytokines/interleukins | signalling/signal transduction | Allergy | Cytokines/interleukins | Epithelial cells | Chemokines/monokines | Signalling/signal transduction | ALLERGIC INFLAMMATION | CYTOKINES | CHEMOKINES | KAPPA-B | RELEASE | IMMUNOLOGY | HUMAN EOSINOPHILS | EOTAXIN-2 | ASTHMA PATHOGENESIS | ALVEOLAR MACROPHAGES | AIRWAY HYPERRESPONSIVENESS | Up-Regulation | Epithelial Cells - metabolism | Gene Expression - drug effects | Protein-Tyrosine Kinases - metabolism | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases - metabolism | Interleukins - metabolism | MAP Kinase Signaling System | Dose-Response Relationship, Drug | Janus Kinase 2 | Bronchi - metabolism | Chemokine CCL2 - metabolism | Flavonoids - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Proto-Oncogene Proteins - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Interleukin-4 - metabolism | Imidazoles - pharmacology | Tyrphostins - pharmacology | Interleukin-13 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mitogen-Activated Protein Kinase 3 - metabolism | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Pyridines - pharmacology | Enzyme Activation | Cell Line, Transformed | Protein-Tyrosine Kinases - antagonists & inhibitors | Proteins | Mutual fund industry | Protein kinases | Index Medicus | signal transduction | monokines | cytokines | Basic Immunology | chemokines | signalling | interleukins
Journal Article
Nature, ISSN 0028-0836, 09/2012, Volume 489, Issue 7414, pp. 155 - 159
The identification of somatic activating mutations in JAK2 (refs 1-4) and in the thrombopoietin receptor gene (MPL)(5) in most patients with myeloproliferative... 
MYELOFIBROSIS | LUNG-CANCER | POLYCYTHEMIA-VERA | GEFITINIB | MYELOPROLIFERATIVE DISORDERS | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | BCR-ABL | MUTATION | RESISTANCE | CHRONIC MYELOID-LEUKEMIA | Myeloproliferative Disorders - enzymology | Phosphorylation | Protein Biosynthesis | Humans | Protein Multimerization | STAT Transcription Factors - metabolism | TYK2 Kinase - metabolism | Janus Kinase 1 - deficiency | TYK2 Kinase - deficiency | Myeloproliferative Disorders - pathology | Janus Kinase 1 - biosynthesis | Gene Knockdown Techniques | Janus Kinase 2 - deficiency | Janus Kinase 1 - metabolism | Granulocytes - drug effects | RNA Interference | Janus Kinase 1 - genetics | Janus Kinase 2 - metabolism | Myeloproliferative Disorders - metabolism | Granulocytes - metabolism | Janus Kinase 2 - antagonists & inhibitors | Disease Models, Animal | Cell Line | Janus Kinase 2 - genetics | Myeloproliferative Disorders - drug therapy | Enzyme Activation - drug effects | TYK2 Kinase - biosynthesis | Granulocytes - enzymology | Animals | Signal Transduction - drug effects | HSP90 Heat-Shock Proteins - antagonists & inhibitors | HSP90 Heat-Shock Proteins - metabolism | Mice | TYK2 Kinase - genetics | Drug Resistance, Neoplasm - drug effects | Enzyme inhibitors | Gene mutations | Cancer cells | Dosage and administration | Genetic aspects | Cellular signal transduction | Identification and classification | Physiological aspects | Care and treatment | Research | Myeloproliferative disorders | Cancer | Index Medicus | tyrosine kinase inhibitors | persistence | MPN | JAK2 | resistance
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 05/2006, Volume 97, Issue 4, pp. 957 - 967
Rho family GTPases promote the survival of certain neuronal populations. However, pro‐survival and pro‐death signaling pathways regulated downstream of Rho... 
signal transducer and activator of transcription‐1 | apoptosis | Janus kinase | Rac1 | toxin B | Clostridium difficile | Signal transducer and activator of transcription-1 | Clostridium difficile toxin B | Apoptosis | CEREBELLAR GRANULE NEURONS | INDUCED APOPTOSIS | LETHAL TOXIN | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROSCIENCES | CELL-DEATH | CLOSTRIDIUM-SORDELLII | ACTIN STRESS FIBERS | RAC | PATHWAY | GROWTH | signal transducer and activator of transcription-1 | MAP Kinase Signaling System - physiology | rho GTP-Binding Proteins - antagonists & inhibitors | Apoptosis - drug effects | Protein-Tyrosine Kinases - metabolism | STAT Transcription Factors - metabolism | Male | Neurons - cytology | Extracellular Signal-Regulated MAP Kinases - metabolism | STAT1 Transcription Factor - metabolism | Female | Cerebellar Cortex - enzymology | Neurons - drug effects | Cell Survival - physiology | Repressor Proteins - metabolism | Animals, Newborn | Cell Survival - drug effects | Cerebellar Cortex - cytology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Rats, Sprague-Dawley | Proto-Oncogene Proteins c-raf - metabolism | Janus Kinase 1 | Bacterial Proteins - pharmacology | Animals | MAP Kinase Signaling System - drug effects | Bacterial Toxins - pharmacology | Neurons - enzymology | rho GTP-Binding Proteins - metabolism | Apoptosis - physiology | rac1 GTP-Binding Protein - metabolism | Proteins | Mutual fund industry | Gene expression | Neurons | Protein kinases | Gram-positive bacteria | Enzymes | Signal transduction | Index Medicus
Journal Article
Immunology, ISSN 0019-2805, 04/2015, Volume 144, Issue 4, pp. 561 - 573
Tumour progression is associated with immune‐suppressive conditions that facilitate the escape of tumour cells from the regimen of immune cells, subsequently... 
regulatory T cells | breast cancer | janus kinase/signal transducer and activator of transcription | mitogen‐activated protein kinase kinase/extracellular signal‐regulated kinase | nano‐curcumin | transforming growth factor | Mitogen-activated protein kinase kinase/extracellular signal-regulated kinase | Breast cancer | Regulatory T cells | Janus kinase/signal transducer and activator of transcription | Nano-curcumin | Transforming growth factor-β | FOXP3 EXPRESSION | extracellular signal-regulated kinase | TOLEROGENIC DENDRITIC CELLS | ACTIVATION | TGF-BETA | MECHANISM | janus kinase | CURCUMIN | KAPPA-B | IMMUNOLOGY | signal transducer and activator of transcription | CANCER-THERAPY | MEK/ERK SIGNALING PATHWAY | IN-VIVO | nano-curcumin | mitogen-activated protein kinase kinase | Tumor Escape - drug effects | T-Lymphocytes, Regulatory - metabolism | Breast Neoplasms - immunology | Coculture Techniques | Humans | STAT Transcription Factors - metabolism | Tumor Microenvironment | Case-Control Studies | T-Lymphocytes, Regulatory - immunology | Dose-Response Relationship, Drug | Nanoparticles | Breast Neoplasms - enzymology | Time Factors | Forkhead Transcription Factors - metabolism | Female | Tumor Cells, Cultured | MAP Kinase Kinase Kinases - antagonists & inhibitors | MAP Kinase Kinase Kinases - genetics | Curcumin - pharmacology | MAP Kinase Kinase Kinases - metabolism | Breast Neoplasms - drug therapy | Chemistry, Pharmaceutical | T-Lymphocytes, Regulatory - drug effects | Animals | Breast Neoplasms - genetics | Transforming Growth Factor beta - genetics | Interleukin-2 Receptor alpha Subunit - metabolism | Signal Transduction - drug effects | Breast Neoplasms - pathology | Paracrine Communication - drug effects | Mice, Inbred BALB C | Protein Kinase Inhibitors - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Smad Proteins - metabolism | Transforming Growth Factor beta - metabolism | Index Medicus | transforming growth factor-β | Original
Journal Article
Journal of Clinical Immunology, ISSN 0271-9142, 6/2011, Volume 31, Issue 3, pp. 472 - 478
Leptin, one of the adipokines, functions as a hormone and a cytokine. In this investigation, we show for the first time that leptin, in a... 
Medical Microbiology | Biomedicine | Immunology | Internal Medicine | Infectious Diseases | activation markers | cytokines | B cells | PROTEIN-KINASE | TRANSDUCER | RECEPTOR | PROLIFERATION | IMMUNOLOGY | BLOOD MONONUCLEAR-CELLS | DEFICIENCY | PI3K/AKT | IMMUNE-RESPONSES | T-CELLS | Autoimmunity | Interleukin-6 - analysis | Janus Kinase 2 - biosynthesis | Mitogen-Activated Protein Kinase 3 - analysis | Humans | p38 Mitogen-Activated Protein Kinases - biosynthesis | p38 Mitogen-Activated Protein Kinases - analysis | Dose-Response Relationship, Drug | Signal Transduction - immunology | Inflammation - metabolism | Mitogen-Activated Protein Kinases - analysis | Mitogen-Activated Protein Kinase 3 - biosynthesis | Mitogen-Activated Protein Kinase 6 - analysis | Leptin - pharmacology | Phosphorylation - drug effects | Interleukin-10 - analysis | B-Lymphocytes - metabolism | Janus Kinase 2 - analysis | Enzyme-Linked Immunosorbent Assay | Lymphocyte Activation | Cells, Cultured | Mitogen-Activated Protein Kinases - biosynthesis | Receptors, Leptin - immunology | STAT3 Transcription Factor - analysis | Inflammation - immunology | Tumor Necrosis Factor-alpha - analysis | STAT3 Transcription Factor - biosynthesis | B-Lymphocytes - drug effects | B-Lymphocytes - immunology | Mitogen-Activated Protein Kinase 6 - biosynthesis | Interleukin-6 - biosynthesis | Interleukin-10 - biosynthesis | Receptors, Leptin - metabolism | Tumor Necrosis Factor-alpha - biosynthesis | Index Medicus
Journal Article
Cellular Signalling, ISSN 0898-6568, 11/2012, Volume 24, Issue 11, pp. 2024 - 2034
The constitutively activated mutation (V617F) of tyrosine kinase Janus kinase 2 (JAK2) is found in the majority of patients with myeloproliferative neoplasms... 
Myeloproliferative neoplasms (MPNs) | Fullerene | c-Jun N-terminal kinase (JNK) | Apoptosis signal-regulating kinase 1 (ASK1) | JAK2 V617F mutation | Apoptosis | C-Jun N-terminal kinase (JNK) | POLYCYTHEMIA-VERA | FERM DOMAIN | ACTIVATION | TYROSINE KINASE | ASK1 | PSEUDOKINASE DOMAIN | CELL BIOLOGY | SIGNAL-TRANSDUCTION | EXPRESSION | MYELOID METAPLASIA | Apoptosis - drug effects | JNK Mitogen-Activated Protein Kinases - metabolism | Fullerenes - pharmacology | Transcription Factor AP-1 - metabolism | MAP Kinase Kinase 7 - metabolism | MAP Kinase Kinase 4 - metabolism | RNA Interference | Janus Kinase 2 - metabolism | Fullerenes - chemistry | MAP Kinase Kinase Kinase 5 - metabolism | MAP Kinase Kinase Kinase 5 - antagonists & inhibitors | Cell Line | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | MAP Kinase Kinase Kinase 5 - genetics | Janus Kinase 2 - genetics | MAP Kinase Kinase Kinases - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Anthracenes - pharmacology | Animals | Signal Transduction - drug effects | Mice, Nude | Mice | Cell Transformation, Neoplastic - drug effects | Amino Acid Substitution | RNA, Small Interfering - metabolism | Prevention | Enzyme inhibitors | Dimethyl sulfoxide | Tumors | Index Medicus | Proteins | Cellular | Inhibitors | Pathways | Fullerenes | Derivatives | Kinases
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2016, Volume 126, Issue 6, pp. 2064 - 2076
Journal Article
Nature chemical biology, ISSN 1552-4450, 12/2014, Volume 10, Issue 12, pp. 1066 - 1072
Chemical probes that form a covalent bond with a protein target often show enhanced selectivity, potency and utility for biological studies. Despite these... 
RHEUMATOID-ARTHRITIS | DESIGN | LIGANDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | REACTIVITY | KINASE INHIBITORS | GENERATION | OPTIMIZATION | ELECTROPHILES | PREDICTION | TOOL | Small Molecule Libraries - pharmacology | Humans | Bacterial Proteins - chemistry | Molecular Probes - pharmacology | Janus Kinase 3 - antagonists & inhibitors | Protein Kinase Inhibitors - chemistry | beta-Lactamases - genetics | Janus Kinase 3 - chemistry | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Cysteine - metabolism | Bacterial Proteins - antagonists & inhibitors | Bacterial Proteins - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Cysteine - chemistry | beta-Lactamase Inhibitors - pharmacology | Ribosomal Protein S6 Kinases, 90-kDa - chemistry | Serine - chemistry | Drug Discovery | Serine - metabolism | Gram-Negative Bacteria - enzymology | Gram-Negative Bacteria - drug effects | Small Molecule Libraries - chemistry | beta-Lactamases - chemistry | Molecular Probes - chemistry | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Gram-Negative Bacteria - growth & development | Janus Kinase 3 - genetics | Hydrophobic and Hydrophilic Interactions | Protein Binding | Ligands | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | COS Cells | beta-Lactamase Inhibitors - chemistry | Proteins | Chemical bonds | Biochemistry | Crystal structure | Index Medicus | boronic acid | covalent virtual screening | JAK3 kinase | covalent fragments | covalent inhibition | beta-lactamase | RSK2 kinase | cyanoacrylamide | reversible covalent | covalent electrophile | MSK1 kinase
Journal Article
Neoplasia, ISSN 1476-5586, 2015, Volume 17, Issue 3, pp. 256 - 264
Journal Article