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JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/1997, Volume 40, Issue 11, pp. 1749 - 1754
The syntheses of a centrally active nonpeptide CRF1 receptor antagonist 2,... 
CHEMISTRY, MEDICINAL | SECRETION | K DX CHEMISTRY, MEDICINAL
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 01/1997, Volume 86, Issue 1, pp. 1 - 12
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 1997, Volume 7, Issue 2, pp. 187 - 192
Due to its relatively clear etiology, Chronic myelogenous leukemia (CML) represents an ideal disease target for a therapy using a selective inhibitor of the... 
SIGNAL-TRANSDUCTION | K EE CHEMISTRY, ORGANIC | CHEMISTRY, MEDICINAL | TYROSINE | CHEMISTRY, ORGANIC | LEUKEMIA | K DX CHEMISTRY, MEDICINAL
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 08/1997, Volume 40, Issue 17, pp. 2762 - 2769
The syntheses of a series of substituted 2-(indol-1-yl)-1-methylethylamines and 2-(indeno[1,2-b]pyrrol-1-yl)-1-methylethylamines are reported. The binding... 
CHEMISTRY, MEDICINAL | RATS | K DX CHEMISTRY, MEDICINAL
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 08/1997, Volume 86, Issue 8, pp. 885 - 890
Replacement of traditional solvents with “environmentally benign” carbon dioxide is receiving increased attention in pharmaceutical processing. Among the... 
SOLUBILIZATION | CHEMISTRY, MEDICINAL | PARTICLES | K DX CHEMISTRY, MEDICINAL | FLUID ANTISOLVENT | POWDERS | RAPID EXPANSION | PRECIPITATION | POLYMERIC MICROSPHERES | POLY(L-LACTIC ACID) | MICRONIZATION | PHARMACOLOGY & PHARMACY | K TU PHARMACOLOGY & PHARMACY | MORPHOLOGY | Solvents | Carbon Dioxide - chemistry | Models, Chemical | Chemistry, Pharmaceutical | Crystallization
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 06/1997, Volume 86, Issue 6, pp. 690 - 700
The objectives of this work were to apply several profile comparison approaches to dissolution data of four different but bioequiva‐lent metoprolol tartrate... 
PHARMACOLOGY & PHARMACY | CHEMISTRY, MEDICINAL | K TU PHARMACOLOGY & PHARMACY | K DX CHEMISTRY, MEDICINAL | Kinetics | Metoprolol - chemistry | Analysis of Variance | Models, Chemical | Tablets | Solubility
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 05/1997, Volume 86, Issue 5, pp. 517 - 525
Formation of insulin fibrils is a physical process by which partially unfolded insulin molecules interact with each other to form linear aggregates. Shielding... 
ANTIBODIES | STORAGE | AQUEOUS-SOLUTIONS | CONTACT | CHEMISTRY, MEDICINAL | PUMPS | STABILIZATION | DENATURATION | K DX CHEMISTRY, MEDICINAL | PRECIPITATION | THERAPY | PHARMACOLOGY & PHARMACY | K TU PHARMACOLOGY & PHARMACY | AGGREGATION | Rabbits | Protein Conformation | Insulin - metabolism | Structure-Activity Relationship | Animals | Insulin - chemistry
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 1997, Volume 40, Issue 17, pp. 2755 - 2761
Cyclodextrins (CyDs) are known to be fermented to small saccharides by colonic microflora, whereas they are only slightly hydrolyzable and thus are not easily... 
GUEST | CHEMISTRY, MEDICINAL | K DX CHEMISTRY, MEDICINAL | DRUGS | MOLECULES
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/1997, Volume 40, Issue 10, pp. 1407 - 1416
Raloxifene, [2-(4-hydroxyphenyl)-6-hydroxybenzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride (2), is representative of a class of... 
LY156758 | GROWTH-FACTOR-BETA | CHEMISTRY, MEDICINAL | ANTIESTROGENS | ANTI-ESTROGEN | TAMOXIFEN | RATS | BREAST-CANCER-CELLS | K DX CHEMISTRY, MEDICINAL
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 01/1997, Volume 40, Issue 3, pp. 261 - 266
A new bisintercalating anthracycline antibiotic, WP631, has been designed and synthesized. The rational design of the new compound was based upon the geometry... 
NETROPSIN | DAUNOMYCIN | CHEMISTRY, MEDICINAL | DNA INTERACTION | AGENTS | BINDING | ASSOCIATION | K DX CHEMISTRY, MEDICINAL
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/1997, Volume 40, Issue 7, pp. 1149 - 1164
Recently, cyclooctylpyranone derivatives with m-carboxamide substituents (e.g. 2c) were identified as potent, nonpeptidic HIV protease inhibitors, but these... 
4-HYDROXY-2-PYRONES | AIDS | CHEMISTRY, MEDICINAL | 4-HYDROXYCOUMARINS | K DX CHEMISTRY, MEDICINAL
Journal Article