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Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 1997, Volume 39, Issue 5, pp. 603 - 608
The frequency of small colony variants of staphylococci associated with persistent, antibiotic resistant and relapsing infections is probably underestimated.... 
K QU MICROBIOLOGY | INFECTIONS | BACTERIA | PERSISTENT | GROWTH-RATE | MICROBIOLOGY | MODEL | EMERGENCE | GENTAMICIN | MUTANTS | THERAPY | PHARMACOLOGY & PHARMACY | K TU PHARMACOLOGY & PHARMACY | ENDOCARDITIS | Fibronectins | Microbial Sensitivity Tests | Anti-Bacterial Agents - pharmacology | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development
Journal Article
Drug Discovery Today, ISSN 1359-6446, 1997, Volume 2, Issue 10, pp. 436 - 444
The transformation of drug discovery in the past decade will result in an expanding array of novel development candidates that will outstrip the development... 
PHARMACOLOGY & PHARMACY | K TU PHARMACOLOGY & PHARMACY
Journal Article
Drug Discovery Today, ISSN 1359-6446, 1997, Volume 2, Issue 9, pp. 382 - 384
An important component of the successful highthroughput screening (HTS) strategy in drug discovery is the ability to assess HTS structure-activity data, and to... 
PHARMACOLOGY & PHARMACY | K TU PHARMACOLOGY & PHARMACY
Journal Article
by Yee, SY
PHARMACEUTICAL RESEARCH, ISSN 0724-8741, 06/1997, Volume 14, Issue 6, pp. 763 - 766
Purpose. To evaluate and optimize the use of Caco-2 cell monolayers to predict the in vivo absorption of a broad range of compounds in man. Methods. Caco-2... 
P-glycoprotein | MECHANISM | Caco-2 | absorption | prediction | PHARMACOLOGY & PHARMACY | K TU PHARMACOLOGY & PHARMACY | transport | MODEL | DRUG ABSORPTION | human | CARRIER
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 1997, Volume 48, Issue 2, pp. 195 - 201
Micelles of poly(ethylene oxide)-block-poly(β-benzyl-L-aspartate) (PEO-PBLA) were loaded with doxorubicin (DOX) and were characterized in relation to their use... 
Doxorubicin | Drug delivery | Copolymer micelles | ADRIAMYCIN | PHARMACOLOGY & PHARMACY | K TU PHARMACOLOGY & PHARMACY | doxorubicin | drug delivery | copolymer micelles
Journal Article
Journal of Pharmacy and Pharmacology, ISSN 0022-3573, 01/1997, Volume 49, Issue 1, pp. 105 - 107
Because curcumin, a compound with anti‐inflammatory and anticancer activity, inhibits induction of nitric oxide synthase in activated macrophages and has been... 
PHARMACOLOGY & PHARMACY | GENERATION | K TU PHARMACOLOGY & PHARMACY | PHARMACOLOGY | MACROPHAGES | BILOBA EXTRACT EGB-761 | Dose-Response Relationship, Drug | Free Radical Scavengers - pharmacology | Nitroprusside - metabolism | Antioxidants - pharmacology | Nitric Oxide - metabolism | Curcumin - pharmacology
Journal Article
Psychopharmacology, ISSN 0033-3158, 7/1997, Volume 132, Issue 2, pp. 107 - 124
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 1997, Volume 46, Issue 3, pp. 223 - 231
The development of long-circulating carriers capable of continuously delivering drugs intravenously provides a potential approach to achieve targeting of drugs... 
NANOPARTICLES | POLYMERS | PHARMACOLOGY & PHARMACY | K TU PHARMACOLOGY & PHARMACY | STEALTH | LIPOSOMES
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 1997, Volume 148, Issue 2, pp. 231 - 240
Chitosan is the N-deacetylated product of chitin, a naturally occurring polymer which has been used extensively to prepare microspheres for oral and... 
Microspheres | Biocompatibility | Drug targeting | Chitosan | drug targeting | chitosan | PHARMACOLOGY & PHARMACY | K TU PHARMACOLOGY & PHARMACY | biocompatibility | microspheres
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 10/1997, Volume 283, Issue 1, pp. 46 - 58
We describe a comprehensive retrospective analysis in which the abilities of several methods by which human pharmacokinetic parameters are predicted from... 
UNITED-STATES | ANIMALS | RAT | INVITRO | HEPATOCYTE DATA | DRUG DEVELOPMENT | PHARMACOLOGY & PHARMACY | K TU PHARMACOLOGY & PHARMACY | PLASMA-CLEARANCE | IN-VIVO DISPOSITION | ENDOTHELIN RECEPTOR ANTAGONIST | BOSENTAN | Animals | Humans | Half-Life | Biological Availability | Metabolic Clearance Rate | Retrospective Studies | Pharmacokinetics
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 1997, Volume 48, Issue 2, pp. 223 - 236
Drug carrier systems based on lipid nanosuspensions prepared by melt emulsification present a number of severe stability problems such as a high gelation... 
NMR | Molecular mobility | Solid lipid nanoparticles | Nanoparticles of supercooled melts | Loading capacity | molecular mobility | solid lipid nanoparticles | nanoparticles of supercooled melts | X-RAY-DIFFRACTION | PHARMACOLOGY & PHARMACY | K TU PHARMACOLOGY & PHARMACY | loading capacity | EMULSIONS
Journal Article