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Oncogene, ISSN 0950-9232, 02/2019, Volume 38, Issue 22, pp. 4426 - 4426
Additionally, a further error has been corrected on page five in the sentence: Subsequent improvements to the chemistry of these lead compounds have resulted... 
Dimerization | K-Ras protein
Journal Article
Oncogene, ISSN 0950-9232, 05/2002, Volume 21, Issue 23, pp. 3792 - 3795
Human cancer is characterized by genetic and epigenetic alterations. In this study we provide evidence for the interruption of Ras signaling in sporadic... 
K-Ras | Methylation | Silencing | RASSF1A
Journal Article
PloS one, ISSN 1932-6203, 2017, Volume 12, Issue 4, p. e0176578
[This corrects the article DOI: 10.1371/journal.pone.0149099.]. 
Medical research | Cancer | K-Ras protein | Tumors
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 10/2019, Volume 25, Issue 59, pp. 13447 - 13447
Hook to a hole: A cell‐permeable bivalent inhibitor of protein prenyltransferases binds to the active pocket and delivers a small module compound onto an... 
protein–protein interactions | prenylation | bivalent inhibitors | K-Ras | c-Raf
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 04/2016, Volume 7
The prenyl-binding protein PDEd is crucial for the plasma membrane localization of prenylated Ras. Recently, we have reported that the small-molecule... 
TRANSPORT | K-RAS | DELTA | MULTIDISCIPLINARY SCIENCES | ARL2-GTP | PLASMA-MEMBRANE | RAS ONCOGENES | ASSOCIATION | CANCER-THERAPY | REVEALS
Journal Article
Cellular Signalling, ISSN 0898-6568, 01/2020, Volume 65, p. 109423
LRP-1 was identified as a specific receptor of MK in chondrocytes and mediated the endocytosis of MK. The MK-LRP-1-nucleolin signalling pathway regulates the... 
Proliferation | LRP1 | K-Ras | Midkine | Nucleolin | Chondrocytes
Journal Article
ChemBioChem, ISSN 1439-4227, 12/2019, Volume 20, Issue 23, pp. 2916 - 2920
Photocontrol of protein activity is an emerging field in biomedicine. For optical control of a mutant small GTPase K‐Ras(G12C), we developed small‐molecule... 
covalent inhibitors | photoswitches | azobenzenes | K-Ras(G12C) | allosterism
Journal Article
CANCER CELL, ISSN 1535-6108, 05/2005, Volume 7, Issue 5, pp. 469 - 483
To define the genetic requirements for pancreatic ductal adenocarcinoma (PDA), we have targeted concomitant endogenous expression of Trp53(R172H) and... 
MAMMALIAN TELOMERES | P53 GENE | K-RAS | ONCOLOGY | GERMLINE MUTATIONS | LI-FRAUMENI | CANCER | CARCINOMA | CELLULAR-TRANSFORMATION | MOUSE MODELS | TUMOR-ANTIGEN
Journal Article
Annals of oncology, ISSN 0923-7534, 2016, Volume 27, Issue 8, pp. 1386 - 1422
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 09/2010, Volume 70, Issue 18, pp. 7114 - 7124
KRAS mutations are found in similar to 90% of human pancreatic ductal adenocarcinomas (PDAC). However, mice genetically engineered to express Kras(G12D) from... 
ONCOGENIC K-RAS | CELLS | ONCOLOGY | DUCTAL ADENOCARCINOMA | SIGNALING PATHWAY | PROSTATE-CANCER | MOUSE | EXPRESSION | TUMORS | BREAST | BETA
Journal Article
Pancreatology, ISSN 1424-3903, 09/2017, Volume 17, Issue 5, pp. S19 - S19
Results: Extensive PDAC and few high grade precursor lesions were prominent in all 20-week old KPC;Z+/+ mice, whereas only low-grade precursor lesions were... 
Pancreatic cancer | Mutation | K-Ras protein
Journal Article
Free Radical Research, ISSN 1071-5762, 06/2018, Volume 52, Issue 6, pp. 661 - 671
K-ras is one of the most common oncogenes in human cancers, and its aberrant activation may lead to malignant transformation associated with oxidative stress... 
drug sensitivity | Anticancer agents | K-ras | Nrf2 | ROS
Journal Article
Nature Cell Biology, ISSN 1465-7392, 02/2012, Volume 14, Issue 2, pp. 148 - 158
We identify a role for the GDI-like solubilizing factor (GSF) PDE delta in modulating signalling through Ras family G proteins by sustaining their dynamic... 
LOCALIZATION | H-RAS | RAP2 PROTEINS | K-RAS | PANCREATIC-CANCER | PHOSPHODIESTERASE | FLUORESCENT PROTEIN | PLASMA-MEMBRANE | SURFACE-CHARGE | SUBUNIT | CELL BIOLOGY
Journal Article
Asian Pacific Journal of Cancer Prevention, ISSN 1513-7368, 2016, Volume 17, Issue 2, pp. 743 - 748
Journal Article
CARCINOGENESIS, ISSN 0143-3334, 09/2019, Volume 40, Issue 9, pp. 1142 - 1152
Cancers arising from the biliary tract are refractory to conventional therapies, requiring the development of novel therapeutics. However, only a limited... 
CELLS | INTRAHEPATIC CHOLANGIOCARCINOMA | ACTIVATION | K-RAS | GENE | EPITHELIUM | ONCOLOGY | GALLBLADDER CARCINOMA | PTEN | MUTATIONS | EXPRESSION
Journal Article
Cancer Research, ISSN 0008-5472, 05/2012, Volume 72, Issue 10, pp. 2457 - 2467
Journal Article