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Journal of neurochemistry, ISSN 0022-3042, 2016, Volume 139, Issue S1, pp. 156 - 178
... challenging activity is created and modulated by the orchestrated function of different ion channels and dopamine D2‐autoreceptors... 
D2‐autoreceptor‐coupled GIRK2 channels | Cav1.3 L‐type/Cav3.1 T‐type calcium channels | neuronal calcium sensor NCS‐1 | ambroxol | A‐type Kv4.3/KChip3 potassium channels | Kir6.2/SUR1 potassium channels | Cav1.3 L-type/Cav3.1 T-type calcium channels | neuronal calcium sensor NCS-1 | A-type Kv4.3/KChip3 potassium channels | D2-autoreceptor-coupled GIRK2 channels | SENSITIVE POTASSIUM CHANNELS | OXIDANT STRESS | CA2+ CHANNELS | GLUCOCEREBROSIDASE MUTATIONS | KChip3 potassium channels | D2-AUTORECEPTOR RESPONSES | SUR1 potassium channels | 1 T-type calcium channels | Kir6 | Cav3 | Cav1 | K-ATP CHANNELS | BIOCHEMISTRY & MOLECULAR BIOLOGY | A-type Kv4 | NEUROSCIENCES | 3L-type | 2 | 3 | ALPHA-SYNUCLEIN FORM | LOCUS-COERULEUS | MPTP MOUSE MODEL | MITOCHONDRIAL-DNA DELETIONS | Stress, Physiological - physiology | Parkinson Disease - pathology | Animals | Calcium - physiology | Substantia Nigra - pathology | Dopaminergic Neurons - pathology | Dopaminergic Neurons - metabolism | Humans | Ion Channels - physiology | Parkinson Disease - metabolism | Substantia Nigra - metabolism | Health Status | Calcium channels | Stress (Physiology) | Parkinson's disease | Potassium channels | Neurons | Dopamine | Calcium | Animal behavior | Rodents | Bandwidths | Parkinsons disease | Homeostasis | Physiology | Metabolism | Kir6.2 | Cav3.1 T‐type calcium channels | Cav1.3 L‐type | Jörg B. Schulz and John Hardy | Review | Parkinson Disease. Guest Editors | A‐type Kv4.3
Journal Article
Biochemical journal, ISSN 0264-6021, 01/2005, Volume 385, Issue 1, pp. 95 - 104
.... OSK1 and several structural analogues were produced by solid-phase chemical synthesis, and were tested for lethality in mice and for their efficacy in blocking a series of 14 voltage-gated and Ca2+-activated K+ channels in vitro... 
channel | Peptide synthesis | Scorpion toxin | Voltage-gated K | activated K | OSK1 | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | KV1.3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | BLOCK | voltage-gated K+ channel | MAUROTOXIN | scorpion toxin | 3-DIMENSIONAL STRUCTURE | PANDINUS-IMPERATOR | CHARYBDOTOXIN | Ca(2+)activated K+ channel | PURIFICATION | CHEMICAL-SYNTHESIS | INHIBITOR | peptide synthesis | Humans | Injections, Intraventricular | Molecular Sequence Data | Potassium Channels - metabolism | Scorpion Venoms - toxicity | Inhibitory Concentration 50 | Nuclear Magnetic Resonance, Biomolecular | Potassium Channel Blockers - toxicity | Potassium Channel Blockers - pharmacology | Toxins, Biological - pharmacology | Toxins, Biological - chemical synthesis | Amino Acid Sequence | Toxins, Biological - toxicity | Mice, Inbred C57BL | Scorpions - chemistry | Lethal Dose 50 | Potassium Channel Blockers - chemical synthesis | Scorpion Venoms - pharmacology | Scorpion Venoms - chemical synthesis | Animals | Scorpion Venoms - chemistry | Cell Line, Tumor | Mice | Toxins, Biological - chemistry | Potassium Channel Blockers - chemistry | Biochemistry, Molecular Biology | Potassium Channels | Toxins, Biological | Life Sciences | Scorpion Venoms | Scorpions | Potassium Channel Blockers | GFP, green fluorescent protein | [Ca2+]i, internal Ca2+ concentration | KCa3.1 channel, type 1 intermediate-conductance Ca2+-activated K+ channel (IK1) | OSK1, toxin 1 from the scorpion Orthochirus scrobiculosus (α-KTx3.7) | Ca2+-activated K+ channel | Kv channel, mammalian voltage-gated K+ channel | NOE, nuclear Overhauser effect | LD50, 50% lethal dose | 3D, three-dimensional | Kv11.x channel, human ether-a-go-go-related K+ channel (HERG) | FCS, foetal calf serum | KTx1, kaliotoxin 1 | AgTx, agitoxin | KCa1.1 channel, large-conductance Ca2+-activated K+ channel (BK or Sloα) | t-Bu, t-butyl | Fmoc, Nα-fluoren-9-ylmethyloxycarbonyl | KCa2.1, KCa2.2 and KCa2.3 channels, type 1, 2 and 3 small-conductance Ca2+-activated K+ channels (SK1, SK2 and SK3 respectively) | MALDI–TOF, matrix-assisted laser-desorption ionization–time-of-flight | TFA, trifluoroacetic acid
Journal Article
Circulation research, ISSN 1524-4571, 2015, Volume 116, Issue 12, pp. 1971 - 1988
The movement of ions across specific channels embedded on the membrane of individual cardiomyocytes is crucial for the generation and propagation of the cardiac electric impulse... 
arrhythmias, cardiac | death, sudden, cardiac | multiprotein complexes | ion channels | LATE SODIUM CURRENT | CARDIAC & CARDIOVASCULAR SYSTEMS | FUNCTIONAL INTERACTION | death | K-ATP CHANNELS | BETA-SUBUNITS | LONG-QT SYNDROME | BRUGADA-SYNDROME | TRANSIENT OUTWARD CURRENT | arrhythmias | ANCHORING PROTEIN SAP97 | sudden | PERIPHERAL VASCULAR DISEASE | RECTIFYING POTASSIUM CHANNEL | HEMATOLOGY | MOLECULAR-BASIS | cardiac | Protein Subunits | KATP Channels - physiology | Channelopathies - complications | Channelopathies - physiopathology | Humans | Ion Channels - drug effects | Death, Sudden, Cardiac - etiology | Ion Channels - physiology | Potassium Channels, Inwardly Rectifying - chemistry | Arrhythmias, Cardiac - physiopathology | Cell Compartmentation | Ion Channel Gating - physiology | Macromolecular Substances - chemistry | Membrane Proteins - physiology | KATP Channels - chemistry | Ion Channels - chemistry | Arrhythmias, Cardiac - genetics | Calcium Channels, L-Type - chemistry | Disease Models, Animal | Calcium Channels, L-Type - physiology | Arrhythmias, Cardiac - etiology | NAV1.5 Voltage-Gated Sodium Channel - physiology | Protein Interaction Mapping | Channelopathies - genetics | Animals | Heart Conduction System - physiopathology | Potassium Channels, Inwardly Rectifying - physiology | Mice | NAV1.5 Voltage-Gated Sodium Channel - chemistry | Ion Channel Gating - drug effects | Ion channels | genetics | sudden cardiac death
Journal Article
Journal Article
FEBS letters, ISSN 0014-5793, 2012, Volume 586, Issue 22, pp. 3996 - 4001
► ShK is a potent blocker of potassium channels. ► A new ShK analogue with a C-terminal Lys residue and amide was designed... 
Electrophysiology | Potential of mean force | Potassium channel | Umbrella sampling | C-terminal amide | ShK | ShK with a C-terminal Lys and amide | effector memory T-cells | ShK-K-amide | PMF | voltage-gated K+ channel | molecular dynamics | potential of mean force | K+ channel toxin from Stichodactyla helianthus | ShK-amide | TEM | C-terminally amidated ShK | MOLECULAR-DYNAMICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEA-ANEMONE TOXIN | PEPTIDE | CELL BIOLOGY | BIOPHYSICS | AUTOIMMUNE-DISEASES | STICHODACTYLA-HELIANTHUS | RAT-BRAIN | INHIBITOR | MEMORY T-CELLS | FREE-ENERGY | K+ CHANNELS | Kv1.1 Potassium Channel - metabolism | Humans | Cnidarian Venoms - metabolism | Kv1.3 Potassium Channel - genetics | Cnidarian Venoms - pharmacology | Potassium Channel Blockers - metabolism | Kv1.1 Potassium Channel - physiology | Dose-Response Relationship, Drug | Ion Channel Gating - physiology | T-Lymphocytes - drug effects | Kv1.3 Potassium Channel - metabolism | Binding Sites | Potassium Channel Blockers - pharmacology | Binding, Competitive | Kv1.1 Potassium Channel - genetics | Protein Structure, Tertiary | Cells, Cultured | Models, Molecular | Kv1.3 Potassium Channel - physiology | Molecular Dynamics Simulation | Cnidarian Venoms - chemistry | Patch-Clamp Techniques | Algorithms | Animals | Ion Channel Gating - genetics | T-Lymphocytes - cytology | Amides - chemistry | Cell Line, Tumor | Protein Binding | Cell Proliferation - drug effects | Mice | Potassium Channel Blockers - chemistry | Ion Channel Gating - drug effects | Potassium channels | Peptides | T cells | Analysis | potassium channel | umbrella sampling | electrophysiology
Journal Article