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Biochemical journal, ISSN 0264-6021, 01/2005, Volume 385, Issue 1, pp. 95 - 104
.... OSK1 and several structural analogues were produced by solid-phase chemical synthesis, and were tested for lethality in mice and for their efficacy in blocking a series of 14 voltage-gated and Ca2+-activated K+ channels in vitro... 
channel | Peptide synthesis | Scorpion toxin | Voltage-gated K | activated K | OSK1 | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Humans | Injections, Intraventricular | Molecular Sequence Data | Potassium Channels - metabolism | Scorpion Venoms - toxicity | Inhibitory Concentration 50 | Nuclear Magnetic Resonance, Biomolecular | Potassium Channel Blockers - toxicity | Potassium Channel Blockers - pharmacology | Toxins, Biological - pharmacology | Toxins, Biological - chemical synthesis | Amino Acid Sequence | Toxins, Biological - toxicity | Mice, Inbred C57BL | Scorpions - chemistry | Lethal Dose 50 | Potassium Channel Blockers - chemical synthesis | Scorpion Venoms - pharmacology | Scorpion Venoms - chemical synthesis | Animals | Scorpion Venoms - chemistry | Cell Line, Tumor | Mice | Toxins, Biological - chemistry | Potassium Channel Blockers - chemistry | Index Medicus | Biochemistry, Molecular Biology | Potassium Channels | Toxins, Biological | Life Sciences | Scorpion Venoms | Scorpions | Potassium Channel Blockers | GFP, green fluorescent protein | [Ca2+]i, internal Ca2+ concentration | KCa3.1 channel, type 1 intermediate-conductance Ca2+-activated K+ channel (IK1) | OSK1, toxin 1 from the scorpion Orthochirus scrobiculosus (α-KTx3.7) | Ca2+-activated K+ channel | voltage-gated K+ channel | scorpion toxin | Kv channel, mammalian voltage-gated K+ channel | NOE, nuclear Overhauser effect | LD50, 50% lethal dose | 3D, three-dimensional | Kv11.x channel, human ether-a-go-go-related K+ channel (HERG) | FCS, foetal calf serum | KTx1, kaliotoxin 1 | AgTx, agitoxin | KCa1.1 channel, large-conductance Ca2+-activated K+ channel (BK or Sloα) | t-Bu, t-butyl | Fmoc, Nα-fluoren-9-ylmethyloxycarbonyl | KCa2.1, KCa2.2 and KCa2.3 channels, type 1, 2 and 3 small-conductance Ca2+-activated K+ channels (SK1, SK2 and SK3 respectively) | peptide synthesis | MALDI–TOF, matrix-assisted laser-desorption ionization–time-of-flight | TFA, trifluoroacetic acid
Journal Article
Journal Article
Journal Article
Journal Article
Journal Article
FEBS letters, ISSN 0014-5793, 05/2010, Volume 584, Issue 10, pp. 2033 - 2042
...+‐activated K+ channel (BKCa) has been implicated in several of these steps including, (1) channel closure causing membrane depolarization, and (2... 
Calcium | MLC | Arteriole | Ca2+ spark | PLC | regulator of conductance for K | iberiotoxin | small conductance, Ca2+-activated K+ channel | Smooth muscle | CICR | RyR | voltage sensor domain | sarcoplasmic reticulum | STRess axis regulated EXon | Ca2+-induced Ca2+ release | myosin light chain | STOC | reactive oxygen species | BKCa | spontaneous transient outward current | ryanodine receptor | voltage-gated Ca2+ channel | vascular smooth muscle | endothelial cell | VSD | IP3 | Phospholipase C | VSM | intermediate conductance, Ca2+-activated K+ channel | inositol triphosphate | Myogenic | large conductance, Ca2+-activated K+ channel | membrane potential | phosphatidylinositol 4,5-bisphosphate | ROS | VGCC | RCK | STREX | PIP2 | IBTX | Large conductance, Ca | spark | channel | activated K | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Arterioles - physiology | Blood Pressure | Large-Conductance Calcium-Activated Potassium Channels - chemistry | Large-Conductance Calcium-Activated Potassium Channels - metabolism | Animals | Arterioles - metabolism | Signal Transduction | Humans | Electrophysiological Phenomena | Arterioles - cytology | Index Medicus | myogenic | calcium | Ca2+ sparks | smooth muscle | large conductance | arterioles | Ca2+ - activated K+ channel
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Journal Article