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PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 1, p. e0147758
A critical and understudied property of endothelial cells is their ability to form lumens and tube networks. Although considerable information has been... 
COLLAGEN MATRIX | 3-DIMENSIONAL EXTRACELLULAR MATRICES | VASCULAR LUMEN FORMATION | IN-VITRO | CELL MORPHOGENESIS | ANGIOGENESIS | ACTIVATING PROTEIN | MULTIDISCIPLINARY SCIENCES | CAPILLARY LUMEN | BLOOD-VESSEL FORMATION | MOLECULAR-MECHANISMS | rap GTP-Binding Proteins - antagonists & inhibitors | ras Proteins - genetics | p120 GTPase Activating Protein - metabolism | Humans | rac GTP-Binding Proteins - metabolism | ras Proteins - metabolism | Male | cdc42 GTP-Binding Protein - metabolism | Phosphoproteins - antagonists & inhibitors | GTPase-Activating Proteins - metabolism | p120 GTPase Activating Protein - genetics | Phosphoproteins - metabolism | rac GTP-Binding Proteins - antagonists & inhibitors | Tubulin - metabolism | RNA Interference | rac GTP-Binding Proteins - genetics | cdc42 GTP-Binding Protein - antagonists & inhibitors | rap GTP-Binding Proteins - genetics | Phorbol Esters - pharmacology | Female | Cell Line | Endothelial Cells - metabolism | GTPase-Activating Proteins - antagonists & inhibitors | ras Proteins - antagonists & inhibitors | Phosphoproteins - genetics | p120 GTPase Activating Protein - antagonists & inhibitors | Animals | Signal Transduction - drug effects | Endothelial Cells - cytology | cdc42 GTP-Binding Protein - genetics | Cytoskeleton - metabolism | Vacuoles - metabolism | Mice | GTPase-Activating Proteins - genetics | rap GTP-Binding Proteins - metabolism | Microscopy, Fluorescence | Endothelial Cells - drug effects | Physiological aspects | Genetic aspects | Cellular signal transduction | Research | Guanosine triphosphatase | Endothelium | Cdc42 protein | Polarization | Membranes | Raf protein | K-Ras protein | Morphogenesis | Proteins | Lumens | Tubulin | Actin | IQGAP1 protein | Tubes | Physiology | Growth factors | Skewed distributions | RhoA protein | Rac1 protein | Pharmacology | siRNA | Rac2 protein | Endothelial cells | Effectors | Cytoskeleton | Membrane trafficking | Regulation | Molecular biology | Vacuoles | Guanosinetriphosphatase | Integrins
Journal Article
PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 12, p. e0167145
.... Here, structure-function relationships in the interaction between different RAS proteins and various effectors were investigated in detail by combining our in vitro data with in silico data... 
R-RAS | SIGNAL-TRANSDUCTION | H-RAS | PHOSPHOINOSITIDE 3-OH KINASE | K-RAS | N-RAS | BCL-XL | GTPASE-ACTIVATING PROTEINS | MULTIDISCIPLINARY SCIENCES | SWITCH I-REGION | RAF-1 | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Phosphatidylinositol 3-Kinases - metabolism | GTP Phosphohydrolases - chemistry | ral Guanine Nucleotide Exchange Factor - chemistry | Proto-Oncogene Proteins p21(ras) - chemistry | Protein Domains | Carrier Proteins - chemistry | Membrane Proteins - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Binding, Competitive | Amino Acid Sequence | Protein Structure, Secondary | Signal Transduction | Membrane Proteins - genetics | Phosphatidylinositol 3-Kinases - chemistry | Models, Molecular | Binding Sites - genetics | Monomeric GTP-Binding Proteins - genetics | ral Guanine Nucleotide Exchange Factor - genetics | Phosphatidylinositol 3-Kinases - genetics | Sequence Homology, Amino Acid | Carrier Proteins - genetics | Carrier Proteins - metabolism | Class I Phosphatidylinositol 3-Kinases | GTP Phosphohydrolases - metabolism | Membrane Proteins - chemistry | Monomeric GTP-Binding Proteins - metabolism | GTP Phosphohydrolases - genetics | Monomeric GTP-Binding Proteins - chemistry | Protein Binding | Kinetics | ral Guanine Nucleotide Exchange Factor - metabolism | Structure | Analysis | Crystals | Protein binding | GTP | Fluorescence | Amino acids | Biochemistry | Kinases | K-Ras protein | Proteins | Signal transduction | Cell growth | Next-generation sequencing | Cell cycle | Dissociation | Crystal structure | Binding | Fluorescence polarization | Hot spots | Gene expression | Studies | Signaling | Isoforms | Effectors | Mutation | Molecular biology | Cancer | Structure-function relationships
Journal Article
Cancer research (Chicago, Ill.), ISSN 1538-7445, 2017, Volume 77, Issue 8, pp. 1997 - 2007
.... Through proteomics and informatic analyses of PEAK1-depleted PDAC cells, we defined protein translation, cytoskeleton organization, and cell-cycle regulatory pathways as major pathways controlled by PEAK1... 
BREAST-CANCER | OCT4 | CARCINOGENESIS | ONCOLOGY | DUCTAL ADENOCARCINOMA | SELF-RENEWAL | YAP | KRAS | TAZ | TRANSLATION FACTOR EIF5A | NANOG EXPRESSION | RNA-Binding Proteins - genetics | Pancreatic Neoplasms - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Carcinoma, Pancreatic Ductal - metabolism | Octamer Transcription Factor-3 - biosynthesis | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Peptide Initiation Factors - biosynthesis | Carcinoma, Pancreatic Ductal - genetics | Octamer Transcription Factor-3 - genetics | RNA-Binding Proteins - biosynthesis | Protein-Tyrosine Kinases - genetics | Neoplastic Stem Cells - metabolism | Neoplastic Stem Cells - pathology | Protein-Tyrosine Kinases - biosynthesis | Phosphoproteins - biosynthesis | Signal Transduction | Pancreatic Neoplasms - pathology | RNA, Messenger - genetics | Pancreatic Neoplasms - genetics | Transcription Factors - biosynthesis | Phosphoproteins - genetics | Transcription Factors - genetics | Carcinoma, Pancreatic Ductal - pathology | Peptide Initiation Factors - metabolism | Transcription Factors - metabolism | Peptide Initiation Factors - genetics | Adaptor Proteins, Signal Transducing - genetics | Cell Cycle - physiology | Cell Line, Tumor | Cytoskeleton - metabolism | Adaptor Proteins, Signal Transducing - biosynthesis | Adaptor Proteins, Signal Transducing - metabolism | RNA-Binding Proteins - metabolism | Adenocarcinoma | Translation | Transcription factors | Oct-4 protein | c-Myc protein | Translation initiation | Tumorigenicity | Myc protein | Kinases | Adhesion | K-Ras protein | Proteins | Yes-associated protein | Signal transduction | Signaling | Pathways | Pancreatic cancer | Proteomics | Interrogation | Stem cells | Cytoskeleton | Protein expression | Focal adhesion kinase | Cancer | YAP1 | PEAK1 | pancreatic ductal adenocarcinoma | eIF5A
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 5, p. e62589
...Author(s): Yutaka Hashimoto, Yoshimitsu Akiyama, Yasuhito Yuasa * Introduction MicroRNAs (miRNAs), a class of small non-protein-coding RNAs... 
CELLS | SCIRRHOUS CARCINOMA | METHYLATION | CARCINOGENESIS | COLORECTAL-CANCER | MULTIDISCIPLINARY SCIENCES | PROLIFERATION | DIFFERENTIATION | INHIBITORS | ESTABLISHMENT | EXPRESSION | Proto-Oncogene Proteins - metabolism | Stomach Neoplasms - genetics | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Cell Proliferation | Humans | Carcinogenesis - genetics | Intercellular Signaling Peptides and Proteins - genetics | Methyl-CpG-Binding Protein 2 - metabolism | ras Proteins - metabolism | Azacitidine - analogs & derivatives | Proto-Oncogene Proteins - genetics | Nerve Tissue Proteins - genetics | Promoter Regions, Genetic - genetics | Methyl-CpG-Binding Protein 2 - genetics | Nerve Tissue Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | DNA Methylation | Transfection | Cell Line, Tumor | MicroRNAs - genetics | Gene Expression Regulation, Neoplastic - genetics | MicroRNA | Analysis | Genes | Genetic aspects | Genetic transcription | Stomach cancer | Cancer | Cell proliferation | Regulators | Transcription | Colorectal cancer | Oncology | Carcinogenesis | Data bases | K-Ras protein | Proteins | Carcinogens | Cell growth | Databases | Methyl-CpG binding protein | DNA methylation | miRNA | Gastric cancer | Gene expression | Overexpression | MeCP2 protein | MicroRNAs | Epigenetics | 5-aza-2'-deoxycytidine
Journal Article
Nature (London), ISSN 1476-4687, 2011, Volume 475, Issue 7354, pp. 106 - 109
... (also known as Nfe212) and its repressor protein Keap1 (refs 2-5). In contrast to the acute physiological regulation of Nrf2, in neoplasia there is evidence for increased basal activation of Nrf2... 
TRANSFORMATION | OXIDATIVE STRESS | ACTIVATION | INHIBITION | K-RAS | PATHWAY | MULTIDISCIPLINARY SCIENCES | PANCREATIC-CANCER | HEME OXYGENASE-1 | MUTATIONS | EXPRESSION | NIH 3T3 Cells | Cell Proliferation | Pancreatic Neoplasms - metabolism | Reactive Oxygen Species - metabolism | Cytoskeletal Proteins - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Antioxidants - metabolism | Humans | JNK Mitogen-Activated Protein Kinases - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | MAP Kinase Signaling System | Mitogen-Activated Protein Kinase Kinases - metabolism | Cell Transformation, Neoplastic - genetics | Cytoskeletal Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Intracellular Signaling Peptides and Proteins - genetics | Kelch-Like ECH-Associated Protein 1 | Proto-Oncogene Proteins B-raf - metabolism | Fibroblasts - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Oncogenes - genetics | Oxidation-Reduction | Pancreatic Neoplasms - pathology | Cells, Cultured | Pancreatic Neoplasms - genetics | NF-E2-Related Factor 2 - deficiency | Cell Transformation, Neoplastic - metabolism | Animals | Proto-Oncogene Proteins B-raf - genetics | Genes, myc - genetics | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Alleles | Cell Line, Tumor | Mice | Adaptor Proteins, Signal Transducing - metabolism | Cell Transformation, Neoplastic - pathology | Polymerase chain reaction | Usage | Reactive oxygen species | Physiological aspects | Research | Gene expression | Oncogenes | Studies | Mass spectrometry | Rodents | Evacuations & rescues | Cancer
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2016, Volume 113, Issue 44, pp. E6766 - E6775
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, p. e62667
.... We recently demonstrated that the Ras/mitogen-activated protein kinase (MAPK) signaling cascade regulates protein stability of Scavenger Receptor BI (SR-BI... 
ABCA1 | SIGNAL-TRANSDUCTION PATHWAYS | PPAR-ALPHA | B TYPE-I | SCAVENGER RECEPTOR | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | CHOLESTEROL EFFLUX | GENE-EXPRESSION | X-RECEPTOR-ALPHA | PEST SEQUENCE | Cricetinae | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Cricetulus | Humans | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | ras Proteins - metabolism | ATP Binding Cassette Transporter 1 - chemistry | Cholesterol - metabolism | ATP Binding Cassette Transporter 1 - metabolism | Gene Expression Regulation - drug effects | Proteolysis - drug effects | ATP-Binding Cassette Transporters - chemistry | Animals | MAP Kinase Signaling System - drug effects | ATP-Binding Cassette Transporters - genetics | Protein Stability - drug effects | ATP-Binding Cassette Transporters - metabolism | Biological Transport - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | ATP Binding Cassette Transporter 1 - genetics | CHO Cells | Proteolysis | DNA polymerases | Cellular signal transduction | Blood lipids | Macrophages | Mitogens | Protein kinases | Cholesterol | Protein binding | Phosphorylation | H-Ras protein | RNA-directed DNA polymerase | Transcription | Syngeneic grafts | Liver | Gene regulation | Kinases | Cell surface | Protein turnover | K-Ras protein | Degradation | ABCA1 protein | Proteins | Signal transduction | Pathways | Rodents | Atherosclerosis | Cell cycle | Inhibition | Lipoproteins (high density) | Efflux | Liver X receptors | Extracellular signal-regulated kinase | MAP kinase | Gene expression | Apolipoproteins | Polymerase chain reaction | Signaling | Lipoproteins | Inhibitors | Protein kinase | Pharmacy | Cell lines | ATP-binding protein | Transduction | ATP | Transporter | ABC transporter | Kidney transplantation | Reacció en cadena de la polimerasa | Colesterol | Proteïnes quinases
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 12, p. e115383
Background: Cholangiocarcinoma (CCA) is clinically heterogeneous; intra and extrahepatic CCA have diverse clinical presentations. Next generation sequencing... 
MORTALITY | INTRAHEPATIC CHOLANGIOCARCINOMA | MULTIDISCIPLINARY SCIENCES | ERBB2 | GALLBLADDER CANCER | FREQUENT MUTATION | IDENTIFICATION | EXPRESSION | TRENDS | BAP1 | EPIDEMIOLOGY | Multivariate Analysis | Demography | Prognosis | Humans | Middle Aged | Male | Molecular Targeted Therapy | Tumor Suppressor Protein p53 - genetics | Young Adult | DNA Mutational Analysis | Receptors, Fibroblast Growth Factor - genetics | Aged, 80 and over | Adult | Female | Genes, Neoplasm - genetics | Bile Ducts, Intrahepatic - pathology | Cholangiocarcinoma - therapy | Treatment Outcome | Signal Transduction - genetics | Mutation - genetics | Genome, Human - genetics | Disease-Free Survival | Regression Analysis | Cholangiocarcinoma - pathology | Oncogene Proteins, Fusion - genetics | Cholangiocarcinoma - genetics | Aged | Genetic aspects | Tumor proteins | Health aspects | Cancer | TOR protein | Chromatin | Dehydrogenases | Profiling | Identification methods | Exons | p53 Protein | Genes | Lung cancer | Clinical trials | Medical records | Raf protein | Cancer therapies | DNA repair | Smad4 protein | Subgroups | Cdc4 protein | K-Ras protein | Metastases | Gene sequencing | Liver cancer | Gallbladder | Cholangiocarcinoma | Deoxyribonucleic acid--DNA | Medical research | Epidermal growth factor receptors | Review boards | Introns | MEK inhibitors | MAP kinase | Patients | ErbB-2 protein | Mcl-1 protein | Gene amplification | Chemotherapy | Medical prognosis | Mutation | Aberration | Fibroblast growth factor receptors | Deoxyribonucleic acid | DNA
Journal Article