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Journal of Rheumatology, ISSN 0315-162X, 12/2008, Volume 35, Issue 12, pp. 2306 - 2312
Osteoarthritis (OA) is a major disabling disease and is ranked as a major cause of chronic pain in adults. The pathology of the illness is characterized by a... 
MATRIX METALLOPROTEINASES | TUMOR-NECROSIS-FACTOR | NITRIC-OXIDE SYNTHASE | GENE-EXPRESSION | DOUBLE-BLIND | PAINFUL KNEE OSTEOARTHRITIS | KAPPA-B-ALPHA | HUMAN ARTICULAR CHONDROCYTES | PLACEBO-CONTROLLED TRIAL | RHEUMATOLOGY | RECEPTOR ANTAGONIST
Journal Article
NATURE, ISSN 0028-0836, 04/2002, Volume 416, Issue 6882, pp. 703 - 709
SCF complexes are the largest family of E3 ubiquitin-protein ligases and mediate the ubiquitination of diverse regulatory and signalling proteins. Here we... 
ANAPHASE-PROMOTING COMPLEX | PROTEIN | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | KAPPA-B-ALPHA | CELL-CYCLE | F-BOX | IDENTIFICATION | P27(KIP1) | SUBUNIT | FAMILY
Journal Article
Nature, ISSN 0028-0836, 04/2009, Volume 458, Issue 7239, pp. 732 - 736
Journal Article
NATURE STRUCTURAL & MOLECULAR BIOLOGY, ISSN 1545-9993, 04/2014, Volume 21, Issue 4, pp. 308 - 316
Ubiquitin and ubiquitin-like modifications are central to virtually all cellular signaling pathways. They occur primarily on lysine residues of target proteins... 
BINDING DOMAINS | HISTONE H2A | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | KAPPA-B-ALPHA | PCNA RECRUITS | CELL BIOLOGY | BIOPHYSICS | STRUCTURAL BASIS | RING DOMAIN | SUMO E3 LIGASE | MOLECULAR-BASIS | INTERACTING MOTIF
Journal Article
Molecular Cell, ISSN 1097-2765, 2003, Volume 11, Issue 6, pp. 1445 - 1456
The SCF ubiquitin ligases catalyze protein ubiquitination in diverse cellular processes. SCFs bind substrates through the interchangeable F box protein... 
SYSTEM | ACTIVATION | HYDROXYPROLINE | RECOGNITION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SCF | RESOLUTION | F-BOX PROTEINS | KAPPA-B-ALPHA | BETA-CATENIN | CELL BIOLOGY
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 12/2018, Volume 27, Issue 24, pp. 4249 - 4262
Abstract Over 200 million people suffer from osteoporosis worldwide, one third of which will develop osteoporotic bone fractures. Unfortunately, no effective... 
RESORPTION | SPINAL MUSCULAR-ATROPHY | ACTIN | T-PLASTIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | PLS3 | KAPPA-B-ALPHA | TERMINAL DIFFERENTIATION | SEX-DIFFERENCES | OSTEOPOROSIS | GENETIC-REGULATION | Index Medicus
Journal Article
Nature Cell Biology, ISSN 1465-7392, 2010, Volume 12, Issue 10, pp. 973 - 981
The SCFFbw7 ubiquitin ligase mediates growth-factor-regulated turnover of the Myc oncoprotein. Here we show that SCF beta-TrCP binds to Myc by means of a... 
IN-VITRO | COMPLEX | PROTEIN STABILITY | C-MYC | KAPPA-B-ALPHA | CELL-CYCLE | PROLIFERATION | UBIQUITIN-LIGASE | DNA-REPLICATION | DEPENDENT DEGRADATION | CELL BIOLOGY
Journal Article
by Du, XH and Meng, F and Peng, D and Wang, ZN and Ouyang, W and Hang, Y and Gu, YY and Fan, LB and Wu, F and Jiang, XD and Xu, F and Qin, FXF
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 08/2019, Volume 203, Issue 4, pp. 1012 - 1020
The evolutionarily conserved F-box family of proteins are well known for their role as the key component of SKP1-Cullin1-F-box (SCF) E3 ligase in controlling... 
RECRUITMENT | RECOGNITION | UBIQUITIN LIGASE | NEGATIVE REGULATION | TRANSACTIVATION | DEGRADATION | COMMON | KAPPA-B-ALPHA | IMMUNOLOGY | BOX PROTEINS | I INTERFERON | Index Medicus | Abridged Index Medicus
Journal Article
Toxicology Letters, ISSN 0378-4274, 09/2019, Volume 312, pp. 65 - 71
Shikimic acid (SA), a widely-known hydroaromatic compound enriched in and (also known as Chinese star anise), increases the risk of gastric and esophageal... 
ER-positive breast cancer | NF-κB | IκBα | IN-VITRO | NF-kappa B | METASTASIS | I kappa B alpha | MIR-300 | ALPHA | TOXICOLOGY | CARCINOMA | Index Medicus
Journal Article
Arthritis research & therapy, ISSN 1478-6354, 08/2019, Volume 21, Issue 1, pp. 193 - 193
Gouty arthritis is characterized by the deposition of monosodium urate (MSU) within synovial joints and tissues due to increased urate concentrations. In this... 
MURINE MODEL | CELLS | ACTIVATION | NF-kappa B | I kappa B alpha | Gout | Curcumin | NLRP3 INFLAMMASOME | RHEUMATOLOGY | MSU | Index Medicus | NF-κB | IκBα
Journal Article
Journal Article
Proteins: Structure, Function and Bioinformatics, ISSN 0887-3585, 2010, Volume 78, Issue 2, pp. 365 - 380
Journal Article
JOURNAL OF MOLECULAR MEDICINE-JMM, ISSN 0946-2716, 05/2019, Volume 97, Issue 5, pp. 675 - 690
The antigen-mediated triggering of B cell receptor (BCR) activates the transcription factor NF-kappa B that regulates the expression of genes involved in B... 
TRANSFORMATION | MEDICINE, RESEARCH & EXPERIMENTAL | IBTK | NF-kappa B | MECHANISM | I kappa B-alpha tyrosine phosphorylation | GENETICS & HEREDITY | BTK | CHRONIC LYMPHOCYTIC-LEUKEMIA | B-cell receptor | INHIBITOR
Journal Article
Journal Article
by Zheng, L and Jia, J and Dai, HF and Wan, L and Liu, J and Hu, L and Zhou, M and Qiu, M and Chen, XF and Chang, LF and Kim, JY and Reckamp, K and Raz, DJ and Xia, ZP and Shen, BH
MOLECULAR AND CELLULAR BIOLOGY, ISSN 0270-7306, 08/2017, Volume 37, Issue 15
Chronic inflammation plays important roles in cancer initiation and progression. Resolving chronic inflammation or blocking inflammatory signal transduction... 
ACTIVATION | PROTEIN | DAMAGE-INDUCED PHOSPHORYLATION | UBIQUITIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | triptolide | CHEMOPREVENTION | p53 | CELL BIOLOGY | LUNG-CANCER | NF-kappa B | INHIBITION | I kappa B alpha | inflammation | GENE-EXPRESSION | aspirin | DEGRADATION | cancer | TUMORIGENESIS
Journal Article