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index medicus (36) 36
kappa-conotoxin pviia (35) 35
animals (34) 34
amino acid sequence (21) 21
biochemistry & molecular biology (21) 21
molecular sequence data (20) 20
protein conformation (15) 15
models, molecular (13) 13
3-dimensional structure (12) 12
peptides (11) 11
pharmacology & pharmacy (11) 11
potassium channels (10) 10
biophysics (9) 9
humans (9) 9
peptides - chemistry (8) 8
potassium (8) 8
potassium channels - chemistry (8) 8
snails (8) 8
toxins (8) 8
charybdotoxin (7) 7
conotoxins - chemistry (7) 7
kappa-conotoxin-pviia (7) 7
shaker k+ channel (7) 7
ion channel gating - drug effects (6) 6
peptides - pharmacology (6) 6
potassium channel (6) 6
potassium channel blockers - chemistry (6) 6
potassium channels - drug effects (6) 6
potassium channels - physiology (6) 6
scorpion toxin (6) 6
toxicology (6) 6
toxins, biological - chemistry (6) 6
toxins, biological - pharmacology (6) 6
venom (6) 6
xenopus laevis (6) 6
amino-acid-sequence (5) 5
binding sites (5) 5
channels (5) 5
conotoxins - pharmacology (5) 5
dose-response relationship, drug (5) 5
female (5) 5
ion channels (5) 5
pore (5) 5
potassium channel blockers - pharmacology (5) 5
potassium channels - metabolism (5) 5
protein binding (5) 5
protein folding (5) 5
scorpion toxins (5) 5
shaker k+ channels (5) 5
shaker superfamily of potassium channels (5) 5
spider venoms - chemistry (5) 5
analysis (4) 4
animal toxins (4) 4
article (4) 4
cardioprotection (4) 4
conotoxin (4) 4
convergent evolution (4) 4
gating modifier toxins (4) 4
ligands (4) 4
membrane potentials - drug effects (4) 4
mollusks (4) 4
oocytes - physiology (4) 4
peptide (4) 4
peptides - isolation & purification (4) 4
peptides - therapeutic use (4) 4
potassium channel blockers (4) 4
potassium channels, voltage-gated (4) 4
potassium channels, voltage-gated - metabolism (4) 4
protein structure, secondary (4) 4
protein structures (4) 4
proteins (4) 4
residues (4) 4
sequence alignment (4) 4
sequence homology, amino acid (4) 4
sodium-channel (4) 4
structure-activity relationship (4) 4
brownian dynamics simulations (3) 3
calcium-channel blocker (3) 3
cells, cultured (3) 3
charybdotoxin - chemistry (3) 3
chemical-synthesis (3) 3
chromatography, high pressure liquid (3) 3
computer simulation (3) 3
conopeptides (3) 3
conotoxins (3) 3
conotoxins - isolation & purification (3) 3
conus (3) 3
cysteine (3) 3
cystine (3) 3
dependent k+ channel (3) 3
disulfides - chemistry (3) 3
drug design (3) 3
evolution (3) 3
human t-lymphocytes (3) 3
inhibitor (3) 3
ion channel gating - physiology (3) 3
k+ channels (3) 3
life sciences (3) 3
magnetic resonance spectroscopy (3) 3
marine snail (3) 3
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 05/2005, Volume 127, Issue 18, pp. 6836 - 6849
Brownian dynamics (BID) and molecular dynamics (MD) simulations and electrostatic calculations were performed to study the binding process of κ-PVIIA to the... 
PROTEIN-PROTEIN ASSOCIATION | MUTANT CYCLES | CRYSTAL-STRUCTURE | X-RAY-STRUCTURE | NICOTINIC ACETYLCHOLINE-RECEPTOR | PARTICLE-MESH EWALD | MOLECULAR-DYNAMICS SIMULATIONS | ION CONDUCTION | CHEMISTRY, MULTIDISCIPLINARY | KAPPA-CONOTOXIN-PVIIA | SCORPION TOXINS
Journal Article
Biotechnology and Bioengineering, ISSN 0006-3592, 10/2016, Volume 113, Issue 10, pp. 2202 - 2212
The bacterial enzyme sortase A was used to cyclize a disulfide‐rich conotoxin containing a cystine knot that was previously intractable to cyclization using... 
sortase A | κ‐PVIIA | cyclization | inhibitory cystine knot | Sortase A | κ-PVIIA | Cyclization | Inhibitory cystine knot | SHAKER K+ CHANNEL | STRUCTURAL MOTIF | BACKBONE CYCLIZATION | KALATA B1 | kappa-PVIIA | SODIUM-CHANNEL | CYCLIC-PEPTIDES | KAPPA-CONOTOXIN PVIIA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | FORCE-FIELD | GATED POTASSIUM CHANNEL | RAT-BRAIN | Cysteine Endopeptidases - chemistry | Aminoacyltransferases - chemistry | Aminoacyltransferases - ultrastructure | Models, Chemical | Peptides - chemistry | Bacterial Proteins - chemistry | Models, Molecular | Protein Folding | Conotoxins - chemistry | Cystine - chemistry | Animals | Disulfides - chemistry | Protein Binding | Conus Snail - metabolism | Potassium Channels - chemistry | Potassium Channels - ultrastructure | Protein Conformation | Bacterial Proteins - ultrastructure | Cysteine Endopeptidases - ultrastructure | Enzyme Activation | Binding Sites | Cysteine | Peptides | Hydrogen | Analysis | Cystine | Bioengineering | Enzymes | Pharmacology | Backbone | Amino acids | Channels | Engineering | Receptors | Functional anatomy | Hydrogen bonds | Chemical bonds | Bacteria | Ion channels | Potassium channels (voltage-gated) | Mathematical models | Protein engineering | Disulfide bonds | Forming | Electrostatic properties | Dynamic tests | Molecular modelling | Inhibitors | Snails | N-Terminus | Potassium | Sortase | Index Medicus | Shakers | Networks | Knots
Journal Article
亚太热带医药杂志:英文版, ISSN 1995-7645, 2015, Volume 8, Issue 5, pp. 337 - 351
The evolutionarily unique and ecologically diverse family Conidae presents fundamental opportunities for marine pharmacology research and drug discovery.The... 
Toxicology | Pharmacology | Conus | Conotoxin | Peptide | Distribution | CALCIUM-CHANNEL BLOCKER | RECEPTOR ANTAGONISTS | MILKED VENOM | TROPICAL MEDICINE | MARINE SNAIL | 3-DIMENSIONAL STRUCTURE | SUPERFAMILY CONOTOXINS | KAPPA-CONOTOXIN PVIIA | OMEGA-CONOTOXIN | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | ALPHA-CONOTOXIN | INTRATHECAL ZICONOTIDE
Journal Article
Journal Article
IDRUGS, ISSN 1369-7056, 03/2009, Volume 12, Issue 2, pp. 231 - 239
The peptides in the venoms of predatory marine snails belonging to the genus Conus ('cone snails') have well-established therapeutic applications for the... 
CALCIUM-CHANNEL BLOCKER | CONE SNAIL VENOM | N-TYPE | conopeptide | FOCAL CEREBRAL-ISCHEMIA | NMDA-RECEPTOR ANTAGONIST | KAPPA-CONOTOXIN PVIIA | conotoxin | Analgesic | TRAUMATIC BRAIN-INJURY | neuroprotection | cardioprotection | PHARMACOLOGY & PHARMACY | SHAKER K+ CHANNELS | RESISTANT SODIUM-CHANNELS | METHYL-D-ASPARTATE
Journal Article
Journal Article
STRUCTURE, ISSN 0969-2126, 11/2003, Volume 11, Issue 11, pp. 1381 - 1392
We have determined the binding site on agitoxin2 (AgTx2) to the KcsA K+ channel by a transferred cross-saturation (TCS) experiment. The residues significantly... 
CONVERGENT EVOLUTION | MUTANT CYCLES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | KAPPA-CONOTOXIN PVIIA | AMINO-ACID-SEQUENCE | BIOPHYSICS | ANEMONE BUNODOSOMA-GRANULIFERA | SEA-ANEMONE | BIOLOGICAL-ACTIVITY | INHIBITOR | POTASSIUM-CHANNEL | MOLECULAR-BASIS
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 2000, Volume 297, Issue 3, pp. 771 - 780
Journal Article