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SYNTHESIS-STUTTGART, ISSN 0039-7881, 11/2018, Volume 50, Issue 21, pp. 4263 - 4269
A novel retro-ene reaction via a [4.4.3]propellane intermediate containing a quaternary ammonium linkage was developed. The feature of this acetic anhydride... 
CHRONIC SPINAL DOG | CHEMISTRY, ORGANIC | acetic anhydride | MORPHINE-LIKE | 3]propellane | morphinan | retro-ene | reaction mechanism | NALTREXONE | LIGANDS | KAPPA-RECEPTOR AGONIST | OPIOID RECEPTORS | NALORPHINE-LIKE DRUGS | (-)-MORPHINE | DERIVATIVES | rearrangement
Journal Article
AMERICAN JOURNAL OF NEPHROLOGY, ISSN 0250-8095, 2012, Volume 36, Issue 2, pp. 175 - 183
Background: Our previous placebo-controlled, prospective, double-blind study demonstrated that a new opioid K-receptor agonist, nalfurafine hydrochloride,... 
Long-term efficacy and safety | SYSTEM | MULTICENTER | Hemodialysis | OPIOID RECEPTOR AGONIST | MU | Pruritus | Nalfurafine hydrochloride | ITCH | kappa-Receptor agonist | HEMODIALYSIS-PATIENTS | DOUBLE-BLIND | UROLOGY & NEPHROLOGY | UREMIC PRURITUS | TRK-820 | MICE
Journal Article
Journal Article
Psychopharmacology, ISSN 0033-3158, 5/2013, Volume 227, Issue 2, pp. 263 - 272
The use and misuse of prescription opiates in adolescent populations, and in particular, adolescent female populations, has increased dramatically in the past... 
Opiate | Quinpirole | Drug abuse | Neurosciences | Biomedicine | Dopamine | Kappa receptor | Epigenetics | Sensitization | Transgenerational | Pharmacology/Toxicology | Psychiatry | ENDOGENOUS OPIOIDS | CORTICOSTERONE | MESSENGER-RNA EXPRESSION | PSYCHIATRY | BEHAVIORAL SENSITIZATION | COCAINE | AGONIST QUINPIROLE | NEUROSCIENCES | NUCLEUS-ACCUMBENS | POSTSYNAPTIC MECHANISMS | FEMALE RATS | PHARMACOLOGY & PHARMACY | LOCOMOTOR SENSITIZATION | Dopamine Agonists - pharmacology | Age Factors | Morphine - pharmacology | Epigenesis, Genetic | Nucleus Accumbens - metabolism | Analgesics, Opioid - pharmacology | Motor Activity - drug effects | Rats | Male | Receptors, Dopamine D2 - metabolism | Quinpirole - administration & dosage | Rats, Sprague-Dawley | Receptors, Dopamine D2 - genetics | Gene Expression Regulation - drug effects | Animals | Analgesics, Opioid - administration & dosage | Dopamine Agonists - administration & dosage | Behavior, Animal - drug effects | Female | Quinpirole - pharmacology | Nucleus Accumbens - drug effects | Morphine - administration & dosage | Genetic aspects | Research | Gene expression | Health aspects | Mental illness | Risk factors | Dopamine receptors | Narcotics | Rodents | Females | Age | Addiction | kappa receptor | drug abuse | transgenerational | sensitization | dopamine | epigenetics | quinpirole
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2011, Volume 108, Issue 49, pp. 19778 - 19783
Pain remains a pervasive problem throughout medicine, transcending all specialty boundaries. Despite the extraordinary insights into pain and its mechanisms... 
Analgesia | Receptors | Opioid receptors | Analgesics | Exons | Morphine | Opiates | Pharmacology | Dosage | Opioid analgesics | Opiate receptor | Rewarding behavior | receptor | Kappa | NALOXONE BENZOYLHYDRAZONE | kappa receptor | opiate receptor | TOLERANCE | MULTIDISCIPLINARY SCIENCES | HETERODIMERIZATION | KNOCKOUT MICE | OPIATE | KAPPA | rewarding behavior | TISSUE DISTRIBUTION | GENE FAMILY | MOLECULAR-CLONING | MORPHINE-INDUCED ANALGESIA | Naltrexone - analogs & derivatives | Alternative Splicing | Receptors, G-Protein-Coupled - metabolism | Protein Multimerization | Analgesics, Opioid - pharmacology | Gastrointestinal Motility - drug effects | Naltrexone - chemistry | Male | Dose-Response Relationship, Drug | Naltrexone - pharmacology | Protein Isoforms - metabolism | Time Factors | Protein Isoforms - chemistry | Analgesics, Opioid - chemistry | Molecular Structure | Naltrexone - metabolism | Binding, Competitive | Receptors, Opioid, mu - chemistry | Pain - prevention & control | Receptors, Opioid, mu - metabolism | Mice, Inbred C57BL | Mice, Knockout | Pain Measurement - methods | Animals | Mice | Receptors, G-Protein-Coupled - genetics | Analgesics, Opioid - metabolism | Receptors, Opioid, mu - genetics | Receptors, G-Protein-Coupled - chemistry | Protein Isoforms - genetics | Genetic variation | Opioids | Drug targeting | G proteins | Research | Properties | Identification and classification | Biological Sciences | kappa3 receptor
Journal Article
Pharmacology, Biochemistry and Behavior, ISSN 0091-3057, 09/2016, Volume 148, pp. 69 - 75
Journal Article
Journal Article