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Postępy Higieny i Medycyny Doświadczalnej, ISSN 0032-5449, 01/2019, Volume 73, pp. 1 - 14
The endothelium plays a crucial role in modulating vascular tone by synthesizing and releasing endothelium-derived relaxing factors, including nitric oxide... 
arterial hypertension | inhibitors of KCa2.3/KCa3.1 | activators of KCa2.3/KCa3.1 | KCa3.1 | KCa2.3 | EDH-type relaxation
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 12/2019, Volume 132, p. 104588
Neuroinflammation may induce a phenotype switch to reactive astrogliosis in neurodegenerative disorders. The calcium-activated potassium channel (KCa3.1) is... 
Orai1 | Tau | KCa3.1 | Astrocytes | Insulin
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 08/2009, Volume 157, Issue 8, pp. 1330 - 1339
Asthma affects 10% of the UK population and is an important cause of morbidity and mortality at all ages. Current treatments are either ineffective or carry... 
asthma | Kv1.3 | KCa3.1 | ion channel | Ion channel | Asthma | Reviews
Journal Article
Glia, ISSN 0894-1491, 10/2016, Volume 64, Issue 10, pp. 1733 - 1741
Over the past decade, glial cells have attracted attention for harboring unexploited targets for drug discovery. Several glial targets have attracted de novo... 
NCATS | drug repurposing | KCa3.1 | microglia | drug target | Pharmaceutical industry | Rodents
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 11/2017, Volume 37, Issue 46, pp. 11255 - 11270
Ca V 1 L-type calcium channels are key to regulating neuronal excitability, with the range of functional roles enhanced by interactions with calmodulin,... 
Facilitation | CDF | 1.2 | KCa3.1 | 1.3 | Densin | facilitation | densin | CaV1.3 | CaV1.2
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2010, Volume 160, Issue 4, pp. 836 - 843
Journal Article
Glia, ISSN 0894-1491, 01/2017, Volume 65, Issue 1, pp. 106 - 121
Microglia are highly plastic cells that can assume different phenotypes in response to microenvironmental signals. Lipopolysaccharide (LPS) and interferon‐γ... 
KCa3.1 | Kir2.1 | potassium channel | PAP‐1 | Kv1.3 | microglia | TRAM‐34 | TRAM-34 | PAP-1
Journal Article
GLIA, ISSN 0894-1491, 12/2016, Volume 64, Issue 12, pp. 2065 - 2078
The K(Ca)3.1 channel (KCNN4) is an important modulator of microglia responses in rodents, but no information exists on functional expression on microglia from... 
BK channel | CONDUCTANCE | patch clamp | IK channel | KCNN4/KCA3.1 | NEUROTOXICITY | NEUROSCIENCES | RAT MODEL | BLOCKERS | KCA3.1 CURRENT | glial cell | neuroinflammation | T-CELL-ACTIVATION | potassium channel | ACTIVATED POTASSIUM CHANNEL | KCNN4 | CONTRIBUTES
Journal Article
Brain Behavior and Immunity, ISSN 0889-1591, 10/2018, Volume 73, pp. 584 - 595
Recent studies described a critical role for microglia in amyotrophic lateral sclerosis (ALS), where these CNS-resident immune cells participate in the... 
Motor neurons | SOD1G93A | Spinal cord | KCa3.1 channels | Neurodegeneration | ALS | Mouse model | Neuromuscolare junction | Microglia
Journal Article
International Journal of Molecular Sciences, ISSN 1422-0067, 08/2019, Volume 20, Issue 17, p. 4118
The aim of this study was to investigate the hemodynamic effects of SKA-31, an activator of the small (KCa2.x) and intermediate (KCa3.1) conductance... 
Na+/K+-ATP-ase | SKA-31 | SHR | KCa3.1/KCa2.3-EDH–dilator system | KIR | hypertension
Journal Article
Neuropharmacology, ISSN 0028-3908, 10/2017, Volume 125, pp. 386 - 395
Intermediate conductance calcium-activated potassium channels (K 3.1) have been recently implicated in pain processing. However, the functional role and... 
Pain | TRAM-34 | KCa3.1 | Potassium channel | SK4 | Satellite glial cells
Journal Article