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11/2013
The mechanisms that regulate the activity of the neuron specific K+Cl- cotransporter (KCC2) remain poorly understood, despite the critical importance of this... 
KCC2 | chloride regulation | 0317
Dissertation
Biochemical Journal, ISSN 0264-6021, 03/2014, Volume 458, Issue 3, pp. 559 - 573
Precise homoeostasis of the intracellular concentration of Cl- is achieved via the co-ordinated activities of the Cl- influx and efflux. We demonstrate that... 
co-transporter (NCC) | Cl | Blood pressure/hypertension | K | Ion homoeostasis | Signal transduction | Na | co-transporter 1 (NKCC1) | Protein kinase | γ-aminobutyric acid (GABA) | 2Cl | co-transporter 2 (KCC2) | co-transporter 3 (KCC3) | SALT TRANSPORT | CELL-VOLUME | signal transduction | CATION-CHLORIDE COTRANSPORTERS | ION-TRANSPORT | BIOCHEMISTRY & MOLECULAR BIOLOGY | blood pressure/hypertension | ion homoeostasis | HYPOKALEMIC ALKALOSIS | K+-Cl- co-transporter 3 (KCC3) | Na+-K+-2Cl(-) co-transporter 1 (NKCC1) | K+-Cl- co-transporter 2 (KCC2) | protein kinase | BLOOD-PRESSURE | PROTEIN-KINASES | BARTTERS-SYNDROME | Na+-Cl- co-transporter (NCC) | ALANINE-RICH KINASE | MOLECULAR PHYSIOLOGY | gamma-aminobutyric acid (GABA) | Potassium - metabolism | Amino Acid Sequence | Cell Line | Phosphorylation | Signal Transduction | Humans | Molecular Sequence Data | Sodium-Potassium-Chloride Symporters - metabolism | Symporters - metabolism | Transcription Factors - metabolism | Protein Isoforms - metabolism | Chlorides - metabolism | Symporters - antagonists & inhibitors | Phosphopeptides - metabolism | Protein Isoforms - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism | Index Medicus | N[K]CC, Na+–K+ ion co-transporter | HEK, human embryonic kidney | TTBS, Tris-buffered saline containing Tween 20 | HRP, horseradish peroxidase | ES, embryonic stem | Na+–Cl− co-transporter (NCC) | CCT, conserved C-terminal | NCC, Na+–Cl− co-transporter | Na+–K+–2Cl− co-transporter 1 (NKCC1) | OSR1, oxidative stress-responsive kinase 1 | CCC, cation–Cl− co-transporter | K+–Cl− co-transporter 3 (KCC3) | KCC, K+–Cl− co-transporter | blood pressure | ERK1, extracellular-signal-regulated kinase 1 | SLC12, solute carrier family 12 | LDS, lithium dodecyl sulfate | NKCC, Na+–K+–2Cl− co-transporter | SPAK, SPS1-related proline | NTD, N-terminal cytoplasmic domain | WNK, WNK lysine-deficient protein kinase | CTD, C-terminal cytoplasmic domain | hypertension | XIC, extracted ion chromatogram | K+–Cl− co-transporter 2 (KCC2) | alanine-rich kinase
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2019, Volume 42, Issue 3, pp. 501 - 506
The mechanism underlying the increased pharmacological effects of phenobarbital in rats with glycerol-induced acute renal failure (ARF) was examined. In the... 
Journal Article
EPILEPSIA, ISSN 0013-9580, 09/2011, Volume 52, Issue 9, pp. 1570 - 1578
Purpose: gamma-Aminobutyric acid (GABA)ergic transmission plays an important role in the initiation of epileptic activity and the generation of ictal... 
Gramicidin perforated patch-clamp | KCC2 | TEMPORAL-LOBE EPILEPSY | EXCITABILITY | CORTEX | Epilepsy | GABA | NEURONS | NKCC1 | CL-COTRANSPORTER KCC2 | CLINICAL NEUROLOGY
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 2018
GABA is the most abundant neurotransmitter in the circadian pacemaker circuits of mammals and insects. In the Madeira cockroach the accessory medulla (AME) in... 
insect circadian rhythms | NKCC1 | KCC2 | GABA receptors | chloride cotransporters
Journal Article
Nature Medicine, ISSN 1078-8956, 11/2013, Volume 19, Issue 11, pp. 1524 - 1528
Journal Article
Cerebral Cortex, ISSN 1047-3211, 11/2018, Volume 28, Issue 11, pp. 4049 - 4062
Abstract KCC2 is the major chloride extruder in neurons. The spatiotemporal regulation of KCC2 expression orchestrates the developmental shift towards... 
development | brain-derived neurotrophic factor | KCC2 | dendritic spines | synapse formation | CRITICAL PERIOD | CL-COTRANSPORTER KCC2 | FEBRILE SEIZURES | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | INHIBITORY NEUROTRANSMISSION | CORTICAL-NEURONS | VISUAL-CORTEX | IN-VIVO | RAT HIPPOCAMPUS | COFILIN PHOSPHORYLATION | Original
Journal Article
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, ISSN 0363-6119, 11/2018, Volume 315, Issue 5, pp. R972 - R982
Journal Article
Brain Research, ISSN 0006-8993, 06/2012, Volume 1463, pp. 1 - 20
α4βδ GABA receptors (GABARs) have low CNS expression, but their expression is increased by 48 h exposure to the neurosteroid THP (3α-OH-5α[β]-pregnan-20-one).... 
GABA | receptor | β-alanine | KCC2 | Pregnanolone | Trafficking
Journal Article
The journal of pain : official journal of the American Pain Society, ISSN 1526-5900, 05/2019
Our preliminary experiment indicated the activation of with-nolysine kinases 1 (WNK1) in bone cancer pain (BCP) rats. This study aimed to investigate the... 
Journal Article
Journal Article
EPILEPSIA, ISSN 0013-9580, 12/2012, Volume 53, pp. 79 - 88
Benzodiazepines have been used for decades as first-line treatment for status epilepticus (SE). For reasons that are not fully understood, the efficacy of... 
KCC2 | TEMPORAL-LOBE EPILEPSY | CATION-CHLORIDE COTRANSPORTERS | REFRACTORY STATUS EPILEPTICUS | INHIBITORY SYNAPSES | Trafficking | DENTATE GRANULE | CL-COTRANSPORTER KCC2 | CLINICAL NEUROLOGY | Refractory | Receptors | INDUCED-STATUS-EPILEPTICUS | GAMMA-AMINOBUTYRIC-ACID | ANTIEPILEPTIC DRUGS | ALTERED EXPRESSION | Diazepam | Seizures
Journal Article
Neuroscience, ISSN 0306-4522, 09/2018, Volume 387, pp. 48 - 57
Downregulation of the potassium chloride cotransporter type 2 (KCC2) after a spinal cord injury (SCI) disinhibits motoneurons and dorsal horn interneurons... 
spinal cord injury | neuropathic pain | KCC2 | spared nerve injury | TCB-2 | 5-HT2A | PROTEIN-KINASE-C | GABAERGIC INHIBITION | DOWN-REGULATION | CL-COTRANSPORTER KCC2 | NEUROLOGICAL DISORDERS | NEUROSCIENCES | DORSAL-HORN | PERIPHERAL-NERVE INJURY | EXPRESSION PATTERNS | SYNAPTIC INHIBITION | CATION-CHLORIDE-COTRANSPORTERS | Index Medicus
Journal Article
Journal Article
Cell Reports, ISSN 2211-1247, 07/2019, Volume 28, Issue 1, pp. 91 - 103.e7
KCC2 regulates neuronal transmembrane chloride gradients and thereby controls GABA signaling in the brain. KCC2 downregulation is observed in numerous... 
epilepsy | dentate gyrus | KCC2 | hippocampus | leak channels | transporter | GABA | K2P | chloride | synaptic transmission | HOMEOSTASIS | INHIBITION | CATION-CHLORIDE COTRANSPORTERS | DOWN-REGULATION | CL-COTRANSPORTER KCC2 | GAMMA-AMINOBUTYRIC-ACID | DENTATE GYRUS | GYRUS GRANULE CELLS | EXPRESSION | CONTRIBUTES | CELL BIOLOGY
Journal Article
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