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index medicus (139) 139
humans (120) 120
kcnj5 mutations (96) 96
somatic mutations (87) 87
hypertension (85) 85
endocrinology & metabolism (84) 84
kcnj5 (73) 73
hyperaldosteronism - genetics (67) 67
g protein-coupled inwardly-rectifying potassium channels - genetics (63) 63
aldosterone (58) 58
primary aldosteronism (58) 58
female (56) 56
male (56) 56
mutation (53) 53
prevalence (50) 50
expression (48) 48
adenomas (46) 46
middle aged (46) 46
hyperaldosteronism (43) 43
diagnosis (42) 42
familial hyperaldosteronism (41) 41
adult (40) 40
aldosterone - metabolism (37) 37
hyperaldosteronism - metabolism (35) 35
peripheral vascular disease (35) 35
channel mutations (33) 33
adrenocortical adenoma - genetics (31) 31
aldosterone-producing adenoma (31) 31
potassium channel (31) 31
adrenal cortex neoplasms - genetics (29) 29
adenoma - genetics (27) 27
k+ channel mutations (27) 27
atp1a1 (26) 26
corticosteroids (26) 26
aldosterone-producing adenomas (24) 24
genetic aspects (24) 24
zona glomerulosa (24) 24
cells (22) 22
primary hyperaldosteronism (22) 22
sodium-potassium-exchanging atpase - genetics (22) 22
abridged index medicus (21) 21
adrenal cortex neoplasms - metabolism (21) 21
aged (21) 21
aldosterone - biosynthesis (21) 21
animals (21) 21
article (21) 21
potassium channels (21) 21
adrenocortical adenoma - metabolism (20) 20
aldosterone - secretion (20) 20
hyperaldosteronism - pathology (20) 20
adrenalectomy (19) 19
calcium channels, l-type - genetics (18) 18
hyperaldosteronism type-ii (17) 17
plasma membrane calcium-transporting atpases - genetics (17) 17
hyperaldosteronism - etiology (16) 16
secretion (16) 16
tumors (16) 16
g protein-coupled inwardly-rectifying potassium channels - metabolism (15) 15
genetic predisposition to disease (15) 15
hyperaldosteronism - complications (15) 15
hypertension - etiology (15) 15
mutation - genetics (15) 15
adenoma (14) 14
adrenal (14) 14
angiotensin-ii (14) 14
blood-pressure (14) 14
glucocorticoid-remediable aldosteronism (14) 14
hyperplasia (14) 14
remediable aldosteronism (14) 14
adenoma - metabolism (13) 13
adrenal-cortex (13) 13
adrenal-hyperplasia (13) 13
atp2b3 (13) 13
calcium channels (13) 13
cytochrome p-450 cyp11b2 - genetics (13) 13
gene mutations (13) 13
genetics (13) 13
hyperaldosteronism - diagnosis (13) 13
mutations (13) 13
adrenal glands - pathology (12) 12
hypertensive patients (12) 12
research (12) 12
steroids (12) 12
adrenal cortex neoplasms - secretion (11) 11
adrenal gland neoplasms - genetics (11) 11
dna mutational analysis (11) 11
immunohistochemistry (11) 11
phenotype (11) 11
retrospective studies (11) 11
risk factors (11) 11
adrenal cortex neoplasms - complications (10) 10
adrenal cortex neoplasms - pathology (10) 10
adrenal glands (10) 10
adrenocortical adenoma - complications (10) 10
aldosterone - blood (10) 10
analysis (10) 10
biochemistry & molecular biology (10) 10
cacna1d (10) 10
cyp11b2 (10) 10
gene-expression (10) 10
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1. Full Text Somatic ATP1A1, ATP2B3, and KCNJ5 Mutations in Aldosterone-Producing Adenomas
by Williams, Tracy Ann and Monticone, Silvia and Schack, Vivien R and Stindl, Julia and Burrello, Jacopo and Buffolo, Fabrizio and Annaratone, Laura and Castellano, Isabella and Beuschlein, Felix and Reincke, Martin and Lucatello, Barbara and Ronconi, Vanessa and Fallo, Francesco and Bernini, Giampaolo and Maccario, Mauro and Giacchetti, Gilberta and Veglio, Franco and Warth, Richard and Vilsen, Bente and Mulatero, Paolo
Hypertension, ISSN 0194-911X, 01/2014, Volume 63, Issue 1, pp. 188 - 195
Aldosterone-producing adenomas (APAs) cause a sporadic form of primary aldosteronism and somatic mutations in the KCNJ5 gene, which encodes the... 
Hypertension | Potassium channels | Sodium-potassium-exchanging ATPase | Adrenal glands | Conn adenoma | Aldosterone | CELLS | APOPTOSIS | DIAGNOSIS | sodium-potassium-exchanging ATPase | K+-ATPASE | TRANSMEMBRANE SEGMENT M1 | aldosterone | NA,K-ATPASE | adrenal glands | potassium channels | GLOMERULOSA | PERIPHERAL VASCULAR DISEASE | SECRETION | hypertension | EXPRESSION | Adrenal Cortex Neoplasms - complications | Gene Expression | Sodium-Potassium-Exchanging ATPase - genetics | Plasma Membrane Calcium-Transporting ATPases - genetics | Aldosterone - biosynthesis | Humans | Middle Aged | Hyperaldosteronism - genetics | Male | Hyperaldosteronism - metabolism | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Hypertension - etiology | Hypertension - metabolism | Adrenal Cortex Neoplasms - genetics | Aldosterone - genetics | Hyperaldosteronism - etiology | Adrenocortical Adenoma - genetics | Adult | Female | Hypertension - genetics | Mutation | Adrenocortical Adenoma - complications | Cytochrome P-450 CYP11B2 - genetics
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2. Full Text Primary Aldosteronism: Mutations, Mechanisms, Prevalence, and Public Health
by Funder, John W
Hypertension, ISSN 0194-911X, 09/2019, Volume 74, Issue 3, pp. 458 - 466
ENDOGENOUS OUABAIN | RENIN HYPERTENSION | HYPERALDOSTERONISM TYPE-II | GENE | K+ CHANNEL MUTATIONS | KCNJ5 MUTATIONS | PERIPHERAL VASCULAR DISEASE | CACNA1D | FAMILIAL HYPERALDOSTERONISM | SOMATIC MUTATIONS | ADENOMAS
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3. Full Text Genetic Spectrum and Clinical Correlates of Somatic Mutations in Aldosterone-Producing Adenoma
by Fernandes-Rosa, Fabio Luiz and Williams, Tracy Ann and Riester, Anna and Steichen, Olivier and Beuschlein, Felix and Boulkroun, Sheerazed and Strom, Tim M and Monticone, Silvia and Amar, Laurence and Meatchi, Tchao and Mantero, Franco and Cicala, Maria-Verena and Quinkler, Marcus and Fallo, Francesco and Allolio, Bruno and Bernini, Giampaolo and Maccario, Mauro and Giacchetti, Gilberta and Jeunemaitre, Xavier and Mulatero, Paolo and Reincke, Martin and Zennaro, Maria-Christina
Hypertension, ISSN 0194-911X, 08/2014, Volume 64, Issue 2, pp. 354 - 361
Primary aldosteronism is the most common form of secondary hypertension. Somatic mutations in KCNJ5, ATP1A1, ATP2B3, and CACNA1D have been described in... 
aldosteronism | mutation | adrenal cortex | mineralocorticoids | aldosterone | potassium channels | DIAGNOSIS | ADRENAL-CORTEX | ATP2B3 | ATP1A1 | PREVALENCE | SURGICALLY CORRECTABLE FORMS | KCNJ5 MUTATIONS | PERIPHERAL VASCULAR DISEASE | CHANNEL MUTATIONS | HYPERTENSION | EXPRESSION | Adrenal Cortex Neoplasms - complications | Genetic Predisposition to Disease | Sodium-Potassium-Exchanging ATPase - genetics | Age Factors | Genetic Association Studies | Plasma Membrane Calcium-Transporting ATPases - genetics | Humans | Middle Aged | Hyperaldosteronism - genetics | Male | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Adrenocortical Adenoma - metabolism | Adrenal Cortex Neoplasms - genetics | Aldosterone - metabolism | Calcium Channels, L-Type - genetics | Hyperaldosteronism - etiology | Sex Factors | Adrenocortical Adenoma - genetics | Adult | Female | Potassium - blood | Mutation | Adrenocortical Adenoma - complications | Adrenal Cortex Neoplasms - metabolism
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4. Full Text Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism
by Scholl, Ute I and Goh, Gerald and Stölting, Gabriel and De Oliveira, Regina Campos and Choi, Murim and Overton, John D and Fonseca, Annabelle L and Korah, Reju and Starker, Lee F and Kunstman, John W and Prasad, Manju L and Hartung, Erum A and Mauras, Nelly and Benson, Matthew R and Brady, Tammy and Shapiro, Jay R and Loring, Erin and Nelson-Williams, Carol and Libutti, Steven K and Mane, Shrikant and Hellman, Per and Westin, Gunnar and Åkerström, Göran and Björklund, Peyman and Carling, Tobias and Fahlke, Christoph and Hidalgo, Patricia and Lifton, Richard P and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Institutionen för kirurgiska vetenskaper
Nature Genetics, ISSN 1061-4036, 09/2013, Volume 45, Issue 9, pp. 1050 - 1054
Adrenal aldosterone-producing adenomas (APAs) constitutively produce the salt-retaining hormone aldosterone and are a common cause of severe hypertension.... 
CELLS | KCNJ5 | LACKING | GENE | CA2+ CHANNELS | GENETICS & HEREDITY | CONGENITAL DEAFNESS | HYPERTENSION | FAMILIAL HEMIPLEGIC MIGRAINE | SUBUNIT | REVEALS | Amino Acid Sequence | Cell Line | Aldosterone - biosynthesis | Humans | Hyperaldosteronism - genetics | Child, Preschool | Molecular Sequence Data | Male | Hyperaldosteronism - metabolism | Adrenocortical Adenoma - metabolism | Adrenal Cortex Neoplasms - genetics | Sequence Alignment | Calcium Channels, L-Type - genetics | Pedigree | Adrenocortical Adenoma - genetics | Germ-Line Mutation | Female | Protein Conformation | Calcium Channels, L-Type - metabolism | Mutation | Child | Adrenal Cortex Neoplasms - metabolism | Calcium Channels, L-Type - chemistry | Calcium channels | Gene mutations | Hyperaldosteronism | Genetic aspects | Research | Health aspects | Risk factors | Hypertension | Rodents | Deoxyribonucleic acid--DNA | Medical and Health Sciences | Medicin och hälsovetenskap
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5. Full Text Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension
by Beuschlein, Felix and Boulkroun, Sheerazed and Osswald, Andrea and Wieland, Thomas and Nielsen, Hang N and Lichtenauer, Urs D and Penton, David and Schack, Vivien R and Amar, Laurence and Fischer, Evelyn and Walther, Anett and Tauber, Philipp and Schwarzmayr, Thomas and Diener, Susanne and Graf, Elisabeth and Allolio, Bruno and Samson-Couterie, Benoit and Benecke, Arndt and Quinkler, Marcus and Fallo, Francesco and Plouin, Pierre-Francois and Mantero, Franco and Meitinger, Thomas and Mulatero, Paolo and Jeunemaitre, Xavier and Warth, Richard and Vilsen, Bente and Zennaro, Maria-Christina and Strom, Tim M and Reincke, Martin
Nature Genetics, ISSN 1061-4036, 04/2013, Volume 45, Issue 4, pp. 440 - 444
Primary aldosteronism is the most prevalent form of secondary hypertension. To explore molecular mechanisms of autonomous aldosterone secretion, we performed... 
PATHWAYS | CELLS | ZONA GLOMERULOSA | ATPASE | NA,K-ATPASE | GENETICS & HEREDITY | KCNJ5 MUTATIONS | MICE | PREVALENCE | PUMP | Potassium - metabolism | Sodium-Potassium-Exchanging ATPase - genetics | Plasma Membrane Calcium-Transporting ATPases - genetics | Calcium - metabolism | Humans | Cells, Cultured | Electrophysiology | Sodium - metabolism | Adrenocortical Adenoma - etiology | Mutation - genetics | Immunoenzyme Techniques | Hypertension - etiology | Aldosterone - metabolism | Adrenal Cortex Neoplasms - etiology | Hypertension | Gene mutations | Hyperaldosteronism | Genetic aspects | Diagnosis | Research | Identification and classification | Health aspects | Risk factors | Proteins | Heart attacks | Rodents | Amino acids | Mutation | Tumors | Life Sciences | Neurons and Cognition
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6. Full Text KCNJ5 Mutations in European Families With Nonglucocorticoid Remediable Familial Hyperaldosteronism
by Mulatero, Paolo and Tauber, Philipp and Zennaro, Maria-Christina and Monticone, Silvia and Lang, Katharina and Beuschlein, Felix and Fischer, Evelyn and Tizzani, Davide and Pallauf, Anna and Viola, Andrea and Amar, Laurence and Williams, Tracy Ann and Strom, Tim M and Graf, Elisabeth and Bandulik, Sascha and Penton, David and Plouin, Pierre-François and Warth, Richard and Allolio, Bruno and Jeunemaitre, Xavier and Veglio, Franco and Reincke, Martin
Hypertension, ISSN 0194-911X, 02/2012, Volume 59, Issue 2, pp. 235 - 240
Primary aldosteronism is the most frequent cause of endocrine hypertension. Three forms of familial hyperaldosteronism (FH) have been described, named FH-I to... 
KCNJ5 | Familial hyperaldosteronism | Primary aldosteronism | Aldosterone | Endocrine hypertension | CRITERIA | endocrine hypertension | DIFFERENTIAL-DIAGNOSIS | CHROMOSOME 7P22 | FORM | familial hyperaldosteronism | aldosterone | primary aldosteronism | PERIPHERAL VASCULAR DISEASE | CORTISOL | European Continental Ancestry Group - genetics | Glucocorticoids - therapeutic use | Europe | Humans | Middle Aged | Hyperaldosteronism - genetics | Male | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Mutation - genetics | Hyperaldosteronism - classification | Hyperaldosteronism - drug therapy | Phenotype | Pedigree | Treatment Failure | Adult | Female
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7. Full Text Different somatic mutations in multinodular adrenals with aldosterone-producing adenoma
by Fernandes-Rosa, Fabio Luiz and Giscos-Douriez, Isabelle and Amar, Laurence and Gomez-Sanchez, Celso E and Meatchi, Tchao and Boulkroun, Sheerazed and Zennaro, Maria-Christina
Hypertension, ISSN 0194-911X, 11/2015, Volume 66, Issue 5, pp. 1014 - 1022
Primary aldosteronism is the most common form of secondary hypertension. Somatic mutations in KCNJ5, ATP1A1, ATP2B3, and CACNA1D are found in... 
hyperaldosteronism | mutation | adrenal cortex | mineralocorticoids | aldosterone | potassium channels | KCNJ5 | DIAGNOSIS | PREVALENCE | HYPERPLASIA | CORTEX | PERIPHERAL VASCULAR DISEASE | CHANNEL MUTATIONS | HYPERTENSION | EXPRESSION | Adrenal Glands - pathology | Sodium-Potassium-Exchanging ATPase - genetics | Plasma Membrane Calcium-Transporting ATPases - genetics | Humans | Hyperaldosteronism - pathology | Middle Aged | Adrenal Cortex - metabolism | Male | Hyperaldosteronism - metabolism | Adrenal Cortex - pathology | Aldosterone - metabolism | Adrenocortical Adenoma - genetics | Adult | Female | Retrospective Studies | Adrenal Cortex Neoplasms - metabolism | Genotype | Adrenal Cortex Neoplasms - pathology | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Mutation - genetics | Adrenocortical Adenoma - pathology | Adrenocortical Adenoma - metabolism | Adrenal Cortex Neoplasms - genetics | Calcium Channels, L-Type - genetics | Adrenal Glands - metabolism | Alleles | Cohort Studies | Adrenal Cortex | Potassium Channels | Primary Aldosteronism | Aldosterone producing adenoma | Endocrine Hypertension | Mineralocorticoids | Mutation | Aldosterone
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8. Full Text Aldosterone-stimulating somatic gene mutations are common in normal adrenal glands
by Koshiro Nishimoto and Scott A. Tomlins and Rork Kuick and Andi K. Cani and Thomas J. Giordano and Daniel H. Hovelson and Chia-Jen Liu and Aalok R. Sanjanwala and Michael A. Edwards and Celso E. Gomez-Sanchez and Kazutaka Nanba and William E. Rainey
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2015, Volume 112, Issue 33, pp. E4591 - E4599
Primary aldosteronism (PA) represents the most common cause of secondary hypertension, but little is known regarding its adrenal cellular origins. Recently,... 
Aldosterone-producing cell cluster | Adrenal|somatic mutations | Primary aldosteronism | Aldosterone | DIAGNOSIS | VARIANTS | aldosterone | HEREDITARY HYPERTENSION | MULTIDISCIPLINARY SCIENCES | PREVALENCE | HYPERPLASIA | somatic mutations | adrenal | ZONA GLOMERULOSA | primary aldosteronism | aldosterone-producing cell cluster | KCNJ5 MUTATIONS | CHANNEL MUTATIONS | EXPRESSION | ADENOMAS | Oligonucleotide Array Sequence Analysis | Aldosterone - biosynthesis | Humans | Adrenal Cortex - metabolism | Gene Expression Regulation | Transcriptome | Homeostasis | Sequence Analysis, DNA | DNA - chemistry | Hyperaldosteronism - etiology | Sequence Analysis, RNA | Adrenal Glands - metabolism | Zona Glomerulosa | High-Throughput Nucleotide Sequencing | Mutation | Principal Component Analysis | Cytochrome P-450 CYP11B2 - metabolism | Genetic aspects | Gene mutations | Adrenal glands | Observations | Health aspects | Biological Sciences | PNAS Plus
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9. Somatic and inherited mutations in primary aldosteronism
by Fernandes-Rosa, Fabio Luiz and Boulkroun, Sheerazed and Zennaro, Maria-Christina
Journal of Molecular Endocrinology, ISSN 0952-5041, 07/2017, Volume 59, Issue 1, pp. R47 - R63
Primary aldosteronism (PA), the most common form of secondary hypertension, is caused in the majority of cases by unilateral aldosterone-producing adenoma... 
Calcium channels | Familial hyperaldosteronism | Primary aldosteronism | Somatic mutations | Aldosterone-producing adenoma | ATPase | Germline mutations | Potassium channels | Wnt/β-catenin pathway | aldosterone-producing adenoma | HYPERALDOSTERONISM TYPE-II | MEMBRANE CA2+ ATPASE | familial hyperaldosteronism | calcium channels | Wnt/beta-catenin pathway | germline mutations | PCR-SSCP ANALYSIS | somatic mutations | MOUSE ADRENAL-CORTEX | GLUCOCORTICOID-REMEDIABLE ALDOSTERONISM | potassium channels | K+ CHANNEL MUTATIONS | primary aldosteronism | ENDOCRINOLOGY & METABOLISM | CLINICAL-PRACTICE GUIDELINE | KCNJ5 MUTATIONS | POTASSIUM CHANNEL | Adrenal Glands - pathology | Sodium-Potassium-Exchanging ATPase - genetics | Plasma Membrane Calcium-Transporting ATPases - genetics | Adenoma - genetics | Humans | Hyperaldosteronism - pathology | Hyperaldosteronism - metabolism | Adrenal Hyperplasia, Congenital - genetics | Adenoma - metabolism | Plasma Membrane Calcium-Transporting ATPases - metabolism | Hyperaldosteronism - diagnosis | Adrenal Hyperplasia, Congenital - diagnosis | Hypokalemia - metabolism | Adrenal Hyperplasia, Congenital - pathology | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Hypertension - genetics | Hypertension - diagnosis | Hypokalemia - pathology | Adenoma - diagnosis | Gene Expression | Genetic Predisposition to Disease | Adrenal Hyperplasia, Congenital - metabolism | Hyperaldosteronism - genetics | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | beta Catenin - metabolism | Hypertension - pathology | beta Catenin - genetics | Hypertension - metabolism | Hypokalemia - diagnosis | Sodium-Potassium-Exchanging ATPase - metabolism | Calcium Channels, L-Type - genetics | Adrenal Glands - metabolism | Adenoma - pathology | Calcium Channels, L-Type - metabolism | Mutation | Hypokalemia - genetics
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10. Full Text Clinical characteristics of somatic mutations in Chinese patients with aldosterone-producing adenoma
by Zheng, Fang-Fang and Zhu, Li-Min and Nie, Ai-Fang and Li, Xiao-Ying and Lin, Jing-Rong and Zhang, Ke and Chen, Jing and Zhou, Wen-Long and Shen, Zhou-Jun and Zhu, Yi-Chun and Wang, Ji-Guang and Zhu, Ding-Liang and Gao, Ping-Jin
Hypertension, ISSN 0194-911X, 03/2015, Volume 65, Issue 3, pp. 622 - 628
Recent studies have shown that somatic mutations in the KCNJ5, ATP1A1, ATP2B3, and CACNA1D genes are associated with the pathogenesis of aldosterone-producing... 
KCNJ5 | potassium channel | somatic mutation | hypertension | aldosterone | DIAGNOSIS | HYPERALDOSTERONISM | ATP1A1 | SELECTIVITY FILTER | LEFT-VENTRICULAR HYPERTROPHY | KCNJ5 MUTATIONS | PERIPHERAL VASCULAR DISEASE | CHANNEL MUTATIONS | POTASSIUM | EXPRESSION | Sodium-Potassium-Exchanging ATPase - genetics | Prevalence | Plasma Membrane Calcium-Transporting ATPases - genetics | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | Molecular Sequence Data | Male | Tumor Burden | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Mutation - genetics | Adrenocortical Adenoma - metabolism | Adrenal Cortex Neoplasms - genetics | Aldosterone - metabolism | Phenotype | Calcium Channels, L-Type - genetics | Base Sequence | Sex Factors | Adrenocortical Adenoma - genetics | Adult | Female | Potassium - blood | Retrospective Studies | Adrenal Cortex Neoplasms - metabolism
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11. Full Text Novel somatic mutations in primary hyperaldosteronism are related to the clinical, radiological and pathological phenotype
by Scholl, Ute I and Healy, James M and Thiel, Anne and Fonseca, Annabelle L and Brown, Taylor C and Kunstman, John W and Horne, Matthew J and Dietrich, Dimo and Riemer, Jasmin and Kücükköylü, Seher and Reimer, Esther N and Reis, Anna‐Carinna and Goh, Gerald and Kristiansen, Glen and Mahajan, Amit and Korah, Reju and Lifton, Richard P and Prasad, Manju L and Carling, Tobias
Clinical Endocrinology, ISSN 0300-0664, 12/2015, Volume 83, Issue 6, pp. 779 - 789
Summary Aldosterone‐producing adenomas (APAs) and bilateral adrenal hyperplasia are important causes of secondary hypertension. Somatic mutations in KCNJ5,... 
ALDOSTERONE-PRODUCING ADENOMAS | K+ CHANNEL MUTATIONS | ENDOCRINOLOGY & METABOLISM | KCNJ5 MUTATIONS | ATP2B3 | PREVALENCE | ATP1A1 | HYPERTENSION | EXPRESSION | ADRENAL-HYPERPLASIA | Sodium-Potassium-Exchanging ATPase - genetics | Plasma Membrane Calcium-Transporting ATPases - genetics | Humans | Hyperaldosteronism - pathology | Middle Aged | Hyperaldosteronism - genetics | Male | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Mutation - genetics | beta Catenin - genetics | Calcium Channels, L-Type - genetics | Hyperaldosteronism - etiology | Hyperaldosteronism - diagnostic imaging | Adult | Female | Retrospective Studies | Hypertension | Genetic aspects | computed tomography | KCNJ5 | CACNA1D | ATPase | primary aldosteronism
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12. Full Text Pathogenesis of Adrenal Aldosterone-Producing Adenomas Carrying Mutations of the Na+/K+-ATPase
by Stindl, J and Tauber, P and Sterner, C and Tegtmeier, I and Warth, R and Bandulik, S
Endocrinology, ISSN 0013-7227, 12/2015, Volume 156, Issue 12, pp. 4582 - 4591
Aldosterone-producing adenoma (APA) is a major cause of primary aldosteronism, leading to secondary hypertension. Somatic mutations in the gene for the α1... 
NA/K-ATPASE | SEVERE HYPERALDOSTERONISM | ENDOCRINOLOGY & METABOLISM | NCI-H295 CELLS | ADRENOCORTICAL CELL-LINE | KCNJ5 MUTATIONS | ANGIOTENSIN-II | K+ CHANNEL | SOMATIC MUTATIONS | ZONA GLOMERULOSA CELLS | POTASSIUM CHANNEL | Sodium-Potassium-Exchanging ATPase - genetics | Adrenal Cortex Neoplasms - secretion | Adrenocortical Carcinoma - genetics | Calcium - metabolism | Humans | Adrenal Cortex - metabolism | Aldosterone - secretion | Adrenocortical Adenoma - secretion | Reverse Transcriptase Polymerase Chain Reaction | Adrenal Cortex - cytology | Cytosol - chemistry | Sodium-Hydrogen Exchangers - metabolism | Adrenal Cortex Neoplasms - genetics | Sodium-Potassium-Exchanging ATPase - metabolism | Patch-Clamp Techniques | Adrenocortical Carcinoma - metabolism | Adrenocortical Adenoma - genetics | Cell Line, Tumor | Mutation | Hydrogen-Ion Concentration
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13. Full Text Aldosterone-Producing Adenomas: Histopathology–Genotype Correlation and Identification of a Novel CACNA1D Mutation
by Tan, Geok Chin and Negro, Giulia and Pinggera, Alexandra and Tizen Laim, Nur Maya Sabrina and Mohamed Rose, Isa and Ceral, Jiri and Ryska, Ales and Chin, Long Kha and Kamaruddin, Nor Azmi and Mohd Mokhtar, Norfilza and A. Jamal, A Rahman and Sukor, Norlela and Solar, Miroslav and Striessnig, Joerg and Brown, Morris Jonathan and Azizan, Elena Aisha
Hypertension, ISSN 0194-911X, 07/2017, Volume 70, Issue 1, pp. 129 - 136
Mutations in KCNJ5, ATP1A1, ATP2B3, CACNA1D, and CTNNB1 are thought to cause the excessive autonomous aldosterone secretion of aldosterone-producing adenomas... 
primary hyperaldosteronism | adrenal | zona glomerulosa | aldosterone | zona fasciculata | APOPTOSIS | MARKER | CA2+ CHANNELS | CA(V)1.3 | SOMATIC MUTATIONS | K+ CHANNEL MUTATIONS | KCNJ5 MUTATIONS | COMMON | PERIPHERAL VASCULAR DISEASE | HYPERTENSION | EXPRESSION | Adrenal Glands - pathology | Genetic Predisposition to Disease | Sodium-Potassium-Exchanging ATPase - genetics | Adenoma - genetics | Humans | Hyperaldosteronism - pathology | Middle Aged | Hyperaldosteronism - genetics | Male | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Aldosterone - metabolism | Calcium Channels, L-Type - genetics | Adenoma - pathology | Adult | Female | Adrenal Gland Neoplasms - genetics | Adrenal Gland Neoplasms - pathology | Index Medicus
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14. Full Text Novel somatic mutations and distinct molecular signature in aldosterone-producing adenomas
by Akerström, Tobias and Willenberg, Holger Sven and Cupisti, Kenko and Ip, Julian and Backman, Samuel and Moser, Ana and Maharjan, Rajani and Robinson, Bruce and Iwen, K. Alexander and Dralle, Henning and Volpe, Cristina D and Bäckdahl, Martin and Botling, Johan and Stalberg, Peter and Westin, Gunnar and Walz, Martin K and Lehnert, Hendrik and Sidhu, Stan and Zedenius, Jan and Björklund, Peyman and Hellman, Per and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för immunologi, genetik och patologi and Experimentell kirurgi and Uppsala universitet and Endokrinkirurgi and Institutionen för kirurgiska vetenskaper
Endocrine-Related Cancer, ISSN 1351-0088, 10/2015, Volume 22, Issue 5, pp. 735 - 744
Aldosterone-producing adenomas (APAs) are found in 1.5-3.0% of hypertensive patients in primary care and can be cured by surgery. Elucidation of genetic events... 
KCNJ5 | CACNA1D | ATP1A1 | Primary aldosteronism | Aldosterone-producing adenoma | aldosterone-producing adenoma | CA2+ CHANNELS | PREVALENCE | HYPERTENSIVE PATIENTS | CALCIUM-CHANNELS | ONCOLOGY | ZONA GLOMERULOSA | primary aldosteronism | ENDOCRINOLOGY & METABOLISM | KCNJ5 MUTATIONS | CHANNEL MUTATIONS | ADRENAL GLOMERULOSA | EXPRESSION | Sodium-Potassium-Exchanging ATPase - genetics | Prognosis | Follow-Up Studies | Plasma Membrane Calcium-Transporting ATPases - genetics | Humans | Hyperaldosteronism - pathology | Middle Aged | Male | Gene Expression Profiling | Hyperaldosteronism - metabolism | Immunoenzyme Techniques | Aldosterone - metabolism | Polymerase Chain Reaction | Adrenocortical Adenoma - genetics | Aged, 80 and over | Adult | Female | Adrenal Cortex Neoplasms - metabolism | Hyperaldosteronism - genetics | Adrenal Cortex Neoplasms - pathology | Adrenocortical Adenoma - pathology | Adrenocortical Adenoma - metabolism | Adrenal Cortex Neoplasms - genetics | Phenotype | Calcium Channels, L-Type - genetics | Aged | Biomarkers, Tumor - genetics | Mutation | Neoplasm Staging | Medical and Health Sciences | Medicin och hälsovetenskap | ATP1A1; CACNA1D; KCNJ5; primary aldosteronism; aldosterone-producing adenoma
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15. Full Text Adrenal Nodularity and Somatic Mutations in Primary Aldosteronism: One Node Is the Culprit?
by Dekkers, T and ter Meer, M and Lenders, J. W. M and Hermus, A. R. M and Schultze Kool, L and Langenhuijsen, J. F and Nishimoto, K and Ogishima, T and Mukai, K and Azizan, E. A. B and Tops, B and Deinum, J and Küsters, B
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 07/2014, Volume 99, Issue 7, pp. E1341 - E1351
Context: Somatic mutations in genes that influence cell entry of calcium have been identified in aldosterone-producing adenomas (APAs) of adrenal cortex in... 
PRIMARY HYPERALDOSTERONISM | SCREENING-TEST | MESSENGER-RNA | ZONA GLOMERULOSA | ENDOCRINOLOGY & METABOLISM | KCNJ5 MUTATIONS | UNILATERAL ADRENALECTOMY | HYPERPLASIA | HYPERTENSION | EXPRESSION | ADENOMAS | Adrenal Glands - pathology | Adrenal Cortex Neoplasms - secretion | Humans | Hyperaldosteronism - pathology | Middle Aged | Hyperaldosteronism - complications | Hyperaldosteronism - genetics | Aldosterone - secretion | Adrenocortical Adenoma - secretion | Male | Adrenal Cortex Neoplasms - pathology | Tumor Burden | Adrenocortical Adenoma - pathology | Adrenal Cortex Neoplasms - genetics | Young Adult | Hyperplasia - genetics | DNA Mutational Analysis | Adrenocortical Adenoma - genetics | Adult | Female | Aged | Mutation | Hyperplasia - complications
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