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Journal of Hypertension, ISSN 0263-6352, 09/2010, Volume 28, Issue 9, pp. 1875 - 1882
Journal Article
Nature, ISSN 0028-0836, 08/2011, Volume 476, Issue 7359, pp. 210 - 213
Many of the cognitive deficits of normal ageing (forgetfulness, distractibility, inflexibility and impaired executive functions) involve prefrontal cortex... 
EXECUTIVE FUNCTION | COGNITIVE DECLINE | NETWORK | RHESUS-MONKEY | MACAQUE | MULTIDISCIPLINARY SCIENCES | MONKEY PREFRONTAL-CORTEX | DYSFUNCTION | IMPAIRMENT | Macaca mulatta - physiology | Neural Pathways - drug effects | Humans | Prefrontal Cortex - physiopathology | Aging - drug effects | Receptors, Adrenergic, alpha-2 - metabolism | Male | Memory, Short-Term - physiology | Adrenergic alpha-2 Receptor Agonists - pharmacology | Biomedical Enhancement | KCNQ Potassium Channels - antagonists & inhibitors | Prefrontal Cortex - pathology | Potassium Channels - metabolism | Time Factors | Cyclic AMP - metabolism | Action Potentials - drug effects | Cyclic Nucleotide-Gated Cation Channels - metabolism | Potassium Channel Blockers - pharmacology | Cues | Cyclic Nucleotide-Gated Cation Channels - antagonists & inhibitors | Guanfacine - pharmacology | Memory, Short-Term - drug effects | Prefrontal Cortex - cytology | Aging - pathology | Cyclic AMP - antagonists & inhibitors | Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels | Animals | Aging - physiology | Signal Transduction - drug effects | KCNQ Potassium Channels - metabolism | Models, Neurological | Prefrontal Cortex - physiology | Psychological aspects | Neurons | Short-term memory | Physiological aspects | Aging | Memory, Disorders of | Health aspects | Neurosciences | Memory | Cognitive ability | Regression analysis | Kinases | Monkeys & apes | Animal cognition | Camps
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 12/2016, Volume 36, Issue 12, pp. 2404 - 2411
OBJECTIVE—To establish the role of Kv7 channels in EPAC (exchange protein directly activated by cAMP)-dependent relaxations of the rat vasculature and to... 
K channel | signaling pathways | vascular smooth muscle | isoproterenol | cyclic nucleotide | SENSITIVE POTASSIUM CHANNELS | PROTEIN-KINASE | DOWN-REGULATION | K(V)7 CHANNELS | ADRENOCEPTOR-MEDIATED VASORELAXATION | ISOLATED MESENTERIC-ARTERY | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | HYPERTENSIVE-RATS | K+ CHANNELS | CAMP | Rats, Wistar | Humans | Male | Mesenteric Arteries - drug effects | KCNQ Potassium Channels - antagonists & inhibitors | Dose-Response Relationship, Drug | Transfection | Guanine Nucleotide Exchange Factors - metabolism | HEK293 Cells | Renal Artery - metabolism | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | A Kinase Anchor Proteins - metabolism | Potassium Channel Blockers - pharmacology | Cyclic AMP-Dependent Protein Kinases - metabolism | rap1 GTP-Binding Proteins - metabolism | Vasodilator Agents - pharmacology | Signal Transduction | KCNQ Potassium Channels - agonists | Adrenergic beta-Agonists - pharmacology | Mesenteric Arteries - metabolism | Guanine Nucleotide Exchange Factors - agonists | Animals | Guanine Nucleotide Exchange Factors - antagonists & inhibitors | Membrane Potentials | KCNQ Potassium Channels - metabolism | Protein Kinase Inhibitors - pharmacology | Renal Artery - drug effects | Vasodilation - drug effects | In Vitro Techniques | KCNQ Potassium Channels - genetics | Cell Signalling | Vascular Smooth Muscle | Ion Channels | Cyclic Nucleotide | Signalling Pathways | Vascular Biology | Membrane Transport | K Channel | Isoproterenol
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2008, Volume 105, Issue 22, pp. 7869 - 7874
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 09/2016, Volume 165, pp. 14 - 25
Smooth muscle cells provide crucial contractile functions in visceral, vascular, and lung tissues. The contractile state of smooth muscle is largely determined... 
Kv7 channel | Visceral smooth muscle | KCNQ | Vascular smooth muscle | Voltage-gated potassium channel | Airway smooth muscle | DRUG-THERAPY | KCNE-BETA-SUBUNITS | CHROMANOL 293B | DOWN-REGULATION | K(V)7 CHANNELS | FUNCTIONAL-CHARACTERIZATION | I-KS | RETIGABINE EZOGABINE | RECTIFIER K+ CURRENT | PHARMACOLOGY & PHARMACY | CEREBRAL VASOSPASM | Bronchodilator Agents - therapeutic use | Muscle, Smooth, Vascular - metabolism | Humans | Potassium Channel Blockers - therapeutic use | Molecular Targeted Therapy | Bronchoconstrictor Agents - therapeutic use | Muscle, Smooth, Vascular - physiopathology | Potassium Channel Blockers - adverse effects | KCNQ Potassium Channels - antagonists & inhibitors | Muscle, Smooth - drug effects | Bronchoconstriction - drug effects | Drug Design | Viscera - physiopathology | Muscle, Smooth, Vascular - drug effects | Vasoconstrictor Agents - pharmacology | Viscera - metabolism | Vasodilator Agents - pharmacology | KCNQ Potassium Channels - agonists | Viscera - drug effects | Muscle, Smooth - metabolism | Vasoconstriction - drug effects | Animals | Signal Transduction - drug effects | KCNQ Potassium Channels - metabolism | Respiratory System - metabolism | Muscle, Smooth - physiopathology | Respiratory System - drug effects | Respiratory System - physiopathology | Vasodilation - drug effects | Smooth muscle | Potassium channels
Journal Article
Pain, ISSN 0304-3959, 03/2013, Volume 154, Issue 3, pp. 434 - 448
Suppression of KCNQ/M channels in dorsal root ganglia neurons is associated with neuronal hyperexcitability and cancer-induced bone pain in rats. Bone cancer... 
KCNQ channel | M current | Retigabine | Hyperexcitability | Dorsal root ganglion | Bone cancer pain | XE-991 | SRC TYROSINE KINASE | M-CURRENT MODULATORS | SYMPATHETIC NEURONS | NERVE INJURY | NEUROSCIENCES | MEMBRANE-POTENTIAL OSCILLATIONS | SENSORY NEURONS | CLINICAL NEUROLOGY | NEUROPATHIC PAIN | NR2B-CONTAINING NMDA RECEPTORS | ANESTHESIOLOGY | MEDIATED INHIBITION | K+ CHANNELS | Neoplasm Transplantation | Phenylenediamines - therapeutic use | Nociception - physiology | Bone Neoplasms - secondary | Stress, Mechanical | Ganglia, Spinal - physiopathology | KCNQ3 Potassium Channel - physiology | Bone Neoplasms - pathology | KCNQ2 Potassium Channel - antagonists & inhibitors | Synaptic Transmission | Tibia - pathology | Sensory Receptor Cells - physiology | Bone Neoplasms - physiopathology | Mammary Neoplasms, Experimental - pathology | Pain - etiology | Female | KCNQ2 Potassium Channel - physiology | Sensory Receptor Cells - metabolism | Carcinoma - pathology | Potassium Channel Blockers - pharmacology | Carbamates - pharmacology | Carcinoma - secondary | KCNQ3 Potassium Channel - antagonists & inhibitors | Hot Temperature - adverse effects | Down-Regulation | Rats | KCNQ3 Potassium Channel - genetics | KCNQ2 Potassium Channel - biosynthesis | Rats, Sprague-Dawley | Anthracenes - pharmacology | Carcinoma - physiopathology | Hyperalgesia - physiopathology | KCNQ3 Potassium Channel - biosynthesis | Patch-Clamp Techniques | Animals | KCNQ2 Potassium Channel - genetics | Hyperalgesia - etiology | Phenylenediamines - pharmacology | Carbamates - therapeutic use | Cancer pain | Bone cancer | Neurosciences | Potassium channels | Ganglion | Neurons
Journal Article
Journal Article