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Neuron, ISSN 0896-6273, 03/2013, Volume 77, Issue 5, pp. 899 - 914
Molecular determinants of threshold sensitivity of mammalian mechanoreceptors are unknown. Here, we identify a mechanosensitive (MS) K current (I ) that... 
IN-VITRO | ROOT GANGLION NEURONS | GATED POTASSIUM CHANNELS | MECHANOSENSITIVE CURRENTS | RECEPTORS | EXPRESSION | NEUROSCIENCES | SENSORY NEURONS | K+ CHANNELS | MOLECULAR-MECHANISMS | MECHANOTRANSDUCTION | Immunohistochemistry | Pain Threshold - physiology | Mechanoreceptors - physiology | Nociceptors - physiology | Kv1.1 Potassium Channel - physiology | Nerve Fibers - physiology | Sensory Receptor Cells - physiology | Ether-A-Go-Go Potassium Channels - physiology | Kv1.1 Potassium Channel - genetics | Physical Stimulation | Data Interpretation, Statistical | Potassium Channels, Calcium-Activated - physiology | Mice, Inbred C57BL | Membrane Potentials - physiology | Mice, Inbred C3H | Hyperalgesia - physiopathology | Patch-Clamp Techniques | Animals | Sensory Thresholds - physiology | Pain - physiopathology | Signal Transduction - physiology | KCNQ Potassium Channels - physiology | Mice | Mice, Inbred BALB C | Touch - physiology | Genetic engineering | Skin | Mammals | Laboratory animals | Neurons | Rodents | Touch | Potassium Channels, Calcium-Activated | KCNQ Potassium Channels | Hyperalgesia | Life Sciences | Pain | Biomolecules | Mechanoreceptors | Signal Transduction | Sensory Thresholds | Biochemistry, Molecular Biology | Ether-A-Go-Go Potassium Channels | Sensory Receptor Cells | Membrane Potentials | Nociceptors | Pain Threshold | Nerve Fibers | Kv1.1 Potassium Channel | Neurologi | Klinisk medicin | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Fysiologi
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 04/2009, Volume 156, Issue 8, pp. 1185 - 1195
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 04/2013, Volume 20, Issue 10, pp. 1241 - 1285
Ion channel targeted drugs have always been related with either the central nervous system (CNS), the peripheral nervous system, or the cardiovascular system.... 
ASIC | TRP | Central nervous system | P2X | KCNQ | NMDA | CNS | Ion channels | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | GATED SODIUM-CHANNELS | SUBTYPE-SELECTIVE AGONIST | D-ASPARTATE RECEPTOR | ion channels | ACID-SENSING ION-CHANNEL-1 | central nervous system | GLYCINE ANTAGONIST GV150526 | TARANTULA TOXIN PSALMOTOXIN-1 | TRAUMATIC BRAIN-INJURY | ISCHEMIC CELL-DEATH | PHARMACOLOGY & PHARMACY | PERIPHERAL NEUROPATHIC PAIN | TRANSGENIC MOUSE MODEL | Ligand-Gated Ion Channels - antagonists & inhibitors | Transient Receptor Potential Channels - antagonists & inhibitors | Calcium Channels - metabolism | Humans | Calcium Channel Blockers - therapeutic use | Potassium Channel Blockers - therapeutic use | Sodium Channel Blockers - pharmacology | Calcium Channel Blockers - pharmacology | Ion Channels - antagonists & inhibitors | Potassium Channels - metabolism | Animals | Ion Channels - metabolism | Sodium Channels - chemistry | Calcium Channels - chemistry | Central Nervous System Diseases - drug therapy | Sodium Channels - metabolism | Calcium Channel Blockers - chemistry | Sodium Channel Blockers - therapeutic use | Potassium Channels - chemistry | Sodium Channel Blockers - chemistry | Transient Receptor Potential Channels - metabolism | Ligand-Gated Ion Channels - metabolism | Potassium Channel Blockers - chemistry | Potassium Channel Blockers - pharmacology
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 10/2015, Volume 764, pp. 633 - 642
M/Kv7 K channels, Ca -activated Cl channels (CaCCs) and voltage gated Na channels expressed in dorsal root ganglia (DRG) play an important role in nociception.... 
Tannic acid | CaCCs | M/Kv7 K+ currents | Pain | Voltage-gated Na+ currents | Bradykinin | M/Kv7 K + currents | Voltage-gated Na + currents | Tannicacid | KCNQ POTASSIUM CHANNELS | ACTIVATION | PAIN PATHWAYS | TRP CHANNELS | CURRENTS | GATED CALCIUM-CHANNELS | INHIBITION | CA2+-ACTIVATED CL-CHANNELS | PHARMACOLOGY & PHARMACY | MOLECULAR-BASIS | K+ CHANNELS | Analgesics - pharmacology | Anoctamin-1 | Voltage-Gated Sodium Channels - drug effects | Humans | Ganglia, Spinal - physiopathology | Nociceptive Pain - chemically induced | Chloride Channels - genetics | Nociceptive Pain - drug therapy | KCNQ2 Potassium Channel - agonists | Dose-Response Relationship, Drug | Nociceptive Pain - metabolism | Transfection | KCNQ2 Potassium Channel - metabolism | HEK293 Cells | Nociception - drug effects | Behavior, Animal - drug effects | Sensory Receptor Cells - metabolism | Disease Models, Animal | Chloride Channels - antagonists & inhibitors | KCNQ3 Potassium Channel - metabolism | KCNQ Potassium Channels - agonists | Rats, Sprague-Dawley | Chloride Channels - metabolism | Animals | Nociceptive Pain - physiopathology | Sensory Receptor Cells - drug effects | Membrane Potentials | Tannins - pharmacology | KCNQ Potassium Channels - metabolism | Voltage-Gated Sodium Channel Blockers - pharmacology | Nociceptive Pain - psychology | KCNQ3 Potassium Channel - agonists | Ganglia, Spinal - drug effects | Voltage-Gated Sodium Channels - metabolism | Ganglia, Spinal - metabolism | KCNQ Potassium Channels - genetics | Analgesics | Neurons | Osteoarthritis | Health aspects | Analysis
Journal Article
Experimental Dermatology, ISSN 0906-6705, 05/2011, Volume 20, Issue 5, pp. 401 - 407
:  Touch is detected through receptors located in the skin and the activation of channels in sensory nerve fibres. Epidermal keratinocytes themselves, however,... 
touch | calcium signalling | mechanotransduction | purinergic signalling | human keratinocyte | Calcium signalling | Mechanotransduction | Human keratinocyte | Touch | Purinergic signalling | EXTRACELLULAR ATP | AORTIC ENDOTHELIAL-CELLS | CHLORIDE CHANNELS | MOBILIZES INTRACELLULAR CALCIUM | MAXI-ANION CHANNEL | DERMATOLOGY | CA2+ WAVES | EPITHELIAL-CELLS | PURINERGIC RECEPTORS | HUMAN EPIDERMAL-KERATINOCYTES | TERMINAL DIFFERENTIATION | Gadolinium - pharmacology | Calcium Channels - metabolism | Mechanotransduction, Cellular - drug effects | Calcium Signaling - physiology | Humans | Adenosine Triphosphate - secretion | Type C Phospholipases - metabolism | Mechanotransduction, Cellular - physiology | Type C Phospholipases - antagonists & inhibitors | Adenosine Triphosphate - pharmacology | Adenosine Triphosphate - metabolism | Egtazic Acid - analogs & derivatives | Transient Receptor Potential Channels - metabolism | Osmotic Pressure - physiology | Physical Stimulation | Purinergic P2Y Receptor Antagonists - pharmacology | Cells, Cultured | Receptors, Purinergic P2Y - metabolism | Chelating Agents - pharmacology | Transient Receptor Potential Channels - agonists | Adenosine Triphosphate - analogs & derivatives | Ion Channels - antagonists & inhibitors | Adenosine Triphosphatases - antagonists & inhibitors | Egtazic Acid - pharmacology | Ion Channels - metabolism | Keratinocytes - drug effects | Thapsigargin - pharmacology | Keratinocytes - physiology | Shock | Muscle proteins | Adenosine triphosphate | Osmotic Pressure | Ion Channels | Repressor Proteins | Gadolinium | Transient Receptor Potential Channels | Adenosine Triphosphate | KCNQ Potassium Channels | Life Sciences | Thapsigargin | Pain | Biomolecules | Calcium Signaling | Calcium Channels | Biochemistry, Molecular Biology | Keratinocytes | Receptors, Purinergic P2Y | Mechanotransduction, Cellular | Egtazic Acid | Animals | Adenosine Triphosphatases | Purinergic P2Y Receptor Antagonists | Type C Phospholipases | Chelating Agents
Journal Article
Journal Article