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science & technology (261) 261
life sciences & biomedicine (227) 227
animals (221) 221
humans (207) 207
kcnq3 potassium channel - metabolism (121) 121
neurosciences & neurology (118) 118
kcnq2 potassium channel - metabolism (104) 104
kcnq3 potassium channel - genetics (103) 103
potassium channels (103) 103
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epilepsy (98) 98
neurosciences (96) 96
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kcnq2 potassium channel - genetics (89) 89
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kcnq3 potassium channel (84) 84
kcnq2 potassium channel (75) 75
female (71) 71
potassium channels, voltage-gated (70) 70
mice (60) 60
patch-clamp techniques (57) 57
potassium (56) 56
biological and medical sciences (55) 55
potassium channels - genetics (54) 54
cho cells (53) 53
neurons (49) 49
cricetinae (48) 48
kcnq3 (47) 47
neurology (47) 47
medical sciences (46) 46
nervous system (46) 46
neurons - metabolism (45) 45
carbamates - pharmacology (44) 44
phenylenediamines - pharmacology (44) 44
kcnq3 protein (43) 43
rats, sprague-dawley (43) 43
clinical neurology (41) 41
epilepsy, benign neonatal - genetics (41) 41
biochemistry & molecular biology (40) 40
cells, cultured (39) 39
kcnq2 (39) 39
kcnq2 protein (38) 38
potassium channel blockers - pharmacology (38) 38
physiology (37) 37
potassium channels - metabolism (36) 36
multidisciplinary sciences (35) 35
pharmacology & pharmacy (35) 35
proteins (35) 35
science & technology - other topics (35) 35
transfection (35) 35
m-current (34) 34
cricetulus (33) 33
electrophysiology (32) 32
genetic aspects (31) 31
molecular sequence data (31) 31
seizures (31) 31
amino acid sequence (30) 30
kcnq3 potassium channel - physiology (30) 30
excitability (29) 29
kcnq3 potassium channel - chemistry (29) 29
neurons - drug effects (29) 29
kcnq (28) 28
kcnq2 potassium channel - physiology (28) 28
potassium channel (28) 28
cell line (27) 27
epilepsy - genetics (27) 27
anticonvulsants - pharmacology (26) 26
kcnq potassium channels - metabolism (26) 26
anthracenes - pharmacology (25) 25
gene expression (25) 25
hek293 cells (25) 25
neurons - physiology (25) 25
xenopus laevis (25) 25
headache. facial pains. syncopes. epilepsia. intracranial hypertension. brain oedema. cerebral palsy (24) 24
membrane potentials - drug effects (24) 24
phosphatidylinositol 4,5-diphosphate - metabolism (24) 24
analysis (23) 23
dose-response relationship, drug (23) 23
infant, newborn (23) 23
kcnq potassium channels - genetics (23) 23
mice, inbred c57bl (23) 23
ion channels (22) 22
neuroscience (22) 22
potassium channels - physiology (22) 22
pyridines - pharmacology (22) 22
rodents (22) 22
cell biology (21) 21
cell membrane - metabolism (21) 21
genes (21) 21
mutation - genetics (21) 21
kcnq potassium channels (20) 20
kcnq3 potassium channel - antagonists & inhibitors (20) 20
membrane potentials - physiology (20) 20
nerve tissue proteins - genetics (20) 20
potassium - metabolism (20) 20
binding sites (19) 19
kcnq2 potassium channel - chemistry (19) 19
indoles - pharmacology (18) 18
m current (18) 18
neonates (18) 18
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1. Full Text Epilepsy-associated mutations in the voltage sensor of KCNQ3 affect voltage dependence of channel opening
by Barro-Soria, Rene and Barro-Soria, Rene
The Journal of general physiology, ISSN 0022-1295, 02/2019, Volume 151, Issue 2, pp. 247 - 257
Life Sciences & Biomedicine | Physiology | Science & Technology | Xenopus | Animals | Membrane Potentials | KCNQ3 Potassium Channel - metabolism | Humans | KCNQ3 Potassium Channel - chemistry | Epilepsy - genetics | KCNQ3 Potassium Channel - genetics | Mutation | Ion Channel Gating | Channel opening | Epilepsy | Excitability | Ions | Fluorometry | Potassium channels | KCNQ3 protein | Molecular modelling | Arginine | Potassium channels (voltage-gated) | Potassium | KCNQ2 protein | Index Medicus | 501
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2. Full Text Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model
by Zheng, Qin and Fang, Dong and Liu, Min and Cai, Jie and Wan, You and Han, Ji-Sheng and Xing, Guo-Gang
Pain (Amsterdam), ISSN 0304-3959, 03/2013, Volume 154, Issue 3, pp. 434 - 448
KCNQ channel | M current | Retigabine | Hyperexcitability | Dorsal root ganglion | Bone cancer pain | XE-991 | Neurosciences | Clinical Neurology | Anesthesiology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Biological and medical sciences | Medical sciences | Diseases of the osteoarticular system | Tumors of striated muscle and skeleton | Neoplasm Transplantation | Phenylenediamines - therapeutic use | Nociception - physiology | Bone Neoplasms - secondary | Stress, Mechanical | Ganglia, Spinal - physiopathology | KCNQ3 Potassium Channel - physiology | Bone Neoplasms - pathology | KCNQ2 Potassium Channel - antagonists & inhibitors | Synaptic Transmission | Tibia - pathology | Sensory Receptor Cells - physiology | Bone Neoplasms - physiopathology | Mammary Neoplasms, Experimental - pathology | Pain - etiology | Female | KCNQ2 Potassium Channel - physiology | Sensory Receptor Cells - metabolism | Carcinoma - pathology | Potassium Channel Blockers - pharmacology | Carbamates - pharmacology | Carcinoma - secondary | KCNQ3 Potassium Channel - antagonists & inhibitors | Hot Temperature - adverse effects | Down-Regulation | Rats | KCNQ3 Potassium Channel - genetics | KCNQ2 Potassium Channel - biosynthesis | Rats, Sprague-Dawley | Anthracenes - pharmacology | Carcinoma - physiopathology | Hyperalgesia - physiopathology | KCNQ3 Potassium Channel - biosynthesis | Patch-Clamp Techniques | Animals | KCNQ2 Potassium Channel - genetics | Hyperalgesia - etiology | Phenylenediamines - pharmacology | Carbamates - therapeutic use | Cancer pain | Bone cancer | Potassium channels | Ganglion | Neurons | Index Medicus
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3. Full Text Role of Kv7.2/Kv7.3 and M-1 muscarinic receptors in the regulation of neuronal excitability in hiPSC-derived neurons
by Kreir, Mohamed and De Bondt, An and Van den Wyngaert, Ilse and Teuns, Greet and Lu, Hua Rong and Gallacher, David J
European journal of pharmacology, ISSN 0014-2999, 09/2019, Volume 858, p. 172474
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | KCNQ3 Potassium Channel - antagonists & inhibitors | KCNQ3 Potassium Channel - metabolism | Humans | Rats | Neurons - cytology | Receptor, Muscarinic M1 - antagonists & inhibitors | KCNQ3 Potassium Channel - genetics | KCNQ2 Potassium Channel - antagonists & inhibitors | KCNQ2 Potassium Channel - agonists | Gene Expression Regulation - drug effects | Receptor, Muscarinic M1 - agonists | Animals | KCNQ2 Potassium Channel - metabolism | Muscarinic Antagonists - pharmacology | KCNQ2 Potassium Channel - genetics | Neurons - metabolism | KCNQ3 Potassium Channel - agonists | Induced Pluripotent Stem Cells - cytology | Neurons - drug effects | Potassium Channel Blockers - pharmacology | Receptor, Muscarinic M1 - metabolism | Electrophysiological Phenomena - drug effects
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4. Full Text Direct neurotransmitter activation of voltage-gated potassium channels
by Manville, Rían W and Papanikolaou, Maria and Abbott, Geoffrey W
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1847 - 13
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cricetulus | gamma-Aminobutyric Acid - metabolism | Male | Ganglia, Spinal - cytology | KCNQ3 Potassium Channel - physiology | Phylogeny | PC12 Cells | Tryptophan - metabolism | Oocytes | Binding Sites - physiology | Neurons - physiology | CHO Cells | Xenopus laevis | Neurotransmitter Agents - metabolism | Anticonvulsants - metabolism | Rats | KCNQ Potassium Channels - chemistry | Patch-Clamp Techniques | Sequence Alignment | Animals | KCNQ3 Potassium Channel - chemistry | KCNQ Potassium Channels - physiology | Mice | Molecular Docking Simulation | Primary Cell Culture | Protein Binding - physiology | Binding | Electric potential | Channel gating | Tryptophan | Electrophysiology | Excitability | Activation | Electrostatic properties | KCNQ5 protein | γ-Aminobutyric acid | Neurotransmitters | Anticonvulsants | KCNQ3 protein | Metabolites | Acids | Docking | Ion channels | Potassium channels (voltage-gated) | Potassium | KCNQ2 protein | Index Medicus
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5. Full Text Phosphatidylinositol 4,5-bisphosphate (PIP 2 ) regulates KCNQ3 K channels by interacting with four cytoplasmic channel domains
by Choveau, Frank S and De la Rosa, Victor and Bierbower, Sonya M and Hernandez, Ciria C and Shapiro, Mark S
The Journal of biological chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 50, pp. 19411 - 19428
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Protein Conformation, alpha-Helical | Cricetulus | KCNQ3 Potassium Channel - metabolism | Humans | Models, Molecular | Cytoplasm - metabolism | KCNQ3 Potassium Channel - genetics | Phosphatidylinositol 4,5-Diphosphate - metabolism | Animals | KCNQ3 Potassium Channel - chemistry | Protein Binding | Protein Domains | Mutation | CHO Cells | Index Medicus | M current | Molecular Biophysics | signal transduction | neuroscience | structure-function | KCNQ | potassium channel | ion channel modulation | phospholipid | ion channel gating | lipid signaling | PIP2
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6. Full Text Autism and developmental disability caused by KCNQ3 gain‐of‐function variants
by Sands, Tristan T and Miceli, Francesco and Lesca, Gaetan and Beck, Anita E and Sadleir, Lynette G and Arrington, Daniel K and Schönewolf‐Greulich, Bitten and Moutton, Sébastien and Lauritano, Anna and Nappi, Piera and Soldovieri, Maria Virginia and Scheffer, Ingrid E and Mefford, Heather C and Stong, Nicholas and Heinzen, Erin L and Goldstein, David B and Perez, Ana Grijalvo and Kossoff, Eric H and Stocco, Amber and Sullivan, Jennifer A and Shashi, Vandana and Gerard, Benedicte and Francannet, Christine and Bisgaard, Anne‐Marie and Tümer, Zeynep and Willems, Marjolaine and Rivier, François and Vitobello, Antonio and Thakkar, Kavita and Rajan, Deepa S and Barkovich, A. James and Weckhuysen, Sarah and Cooper, Edward C and Taglialatela, Maurizio and Cilio, M. Roberta
Annals of neurology, ISSN 0364-5134, 08/2019, Volume 86, Issue 2, pp. 181 - 192
Neurosciences | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Autistic Disorder - genetics | Amino Acid Sequence | Protein Structure, Secondary | Humans | Child, Preschool | Gain of Function Mutation - genetics | Male | Developmental Disabilities - genetics | KCNQ3 Potassium Channel - genetics | Young Adult | KCNQ3 Potassium Channel - chemistry | Genetic Variation - genetics | Autistic Disorder - diagnosis | Child | Developmental Disabilities - diagnosis | Neonates | Phenotypes | Firing pattern | Identification methods | Epilepsy | EEG | Electroencephalography | Spikes | Autism | Convulsions & seizures | KCNQ3 protein | Sleep | Molecular modelling | International cooperation | Potassium channels (voltage-gated) | Recording | KCNQ2 protein | Seizures | Index Medicus | Life Sciences
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7. Full Text Atomic basis for therapeutic activation of neuronal potassium channels
by Kim, Robin Y and Yau, Michael C and Galpin, Jason D and Seebohm, Guiscard and Ahern, Christopher A and Pless, Stephan A and Kurata, Harley T
Nature communications, ISSN 2041-1723, 09/2015, Volume 6, Issue 1, pp. 8116 - 8116
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Humans | KCNQ3 Potassium Channel - drug effects | KCNQ2 Potassium Channel - drug effects | Anticonvulsants - pharmacology | Phenylenediamines - metabolism | Tryptophan - metabolism | Carbamates - metabolism | Fluorine - metabolism | KCNQ2 Potassium Channel - metabolism | Oocytes - drug effects | Neurons - metabolism | Neurons - drug effects | Carbamates - pharmacology | Mutagenesis, Site-Directed | KCNQ3 Potassium Channel - metabolism | Oocytes - metabolism | Xenopus laevis | Anticonvulsants - metabolism | KCNQ3 Potassium Channel - genetics | KCNQ Potassium Channels - drug effects | Patch-Clamp Techniques | Animals | Hydrogen Bonding | KCNQ Potassium Channels - metabolism | KCNQ2 Potassium Channel - genetics | Phenylenediamines - pharmacology | Molecular Docking Simulation | KCNQ Potassium Channels - genetics | Index Medicus
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8. Full Text Conditional deletions of epilepsy-associated KCNQ2 and KCNQ3 channels from cerebral cortex cause differential effects on neuronal excitability
by Soh, Heun and Pant, Rima and LoTurco, Joseph J and Tzingounis, Anastasios V
The Journal of neuroscience, ISSN 0270-6474, 2014, Volume 34, Issue 15, pp. 5311 - 5321
M current | KCNQ3 | BFNC | Epilepsy | KCNQ2 | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Pyramidal Cells - metabolism | KCNQ3 Potassium Channel - metabolism | Mice, Inbred C57BL | Epilepsy - metabolism | Epilepsy - physiopathology | KCNQ3 Potassium Channel - genetics | Nerve Tissue Proteins - genetics | Action Potentials | Nerve Tissue Proteins - metabolism | Animals | KCNQ2 Potassium Channel - metabolism | Gene Deletion | Pyramidal Cells - physiology | KCNQ2 Potassium Channel - genetics | Epilepsy - genetics | Mice | Index Medicus | epilepsy
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9. Full Text Engram-specific transcriptome profiling of contextual memory consolidation
by Rao-Ruiz, Priyanka and Couey, J.J and Marcelo, IM and Bouwkamp, Christian and Zee, Ruurd and Matos, M.R and van der Loo, RJ and Martins, G.J and Hout, Marcel and IJcken, Wilfred and Costa, Rui and van den Oever, M.C and Kushner, Steven
Nature communications, ISSN 2041-1723, 05/2019, Volume 10, Issue 1, pp. 2232 - 2232
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Conditioning, Psychological - physiology | Enkephalins - metabolism | Male | Fear - physiology | Enkephalins - genetics | Cytoskeletal Proteins - metabolism | Models, Animal | Neurons - metabolism | Activating Transcription Factor 3 - genetics | Protein Precursors - genetics | KCNQ3 Potassium Channel - metabolism | Mice, Inbred C57BL | Gene Expression Regulation - physiology | Gene Expression Profiling - methods | Mice, Transgenic | KCNQ3 Potassium Channel - genetics | Activating Transcription Factor 3 - metabolism | Memory Consolidation - physiology | Protein Precursors - metabolism | Stereotaxic Techniques | Nerve Tissue Proteins - metabolism | Dentate Gyrus - cytology | Animals | Sequence Analysis, RNA | Dentate Gyrus - physiology | Cyclic AMP Response Element-Binding Protein - metabolism | Mice | Profiling | Transcription | Neurons | Activating transcription factor 3 | Animal memory | Ribonucleic acid--RNA | Gene expression | Cyclic AMP response element-binding protein | Gene sequencing | Fear conditioning | Fear | Dentate gyrus | KCNQ3 protein | Molecular modelling | Consolidation | Long term memory | Potassium channels (voltage-gated) | Index Medicus
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