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Molecular and Cellular Endocrinology, ISSN 0303-7207, 04/2019, Volume 485, pp. 9 - 19
Journal Article
Journal Article
Analytical and Bioanalytical Chemistry, ISSN 1618-2642, 2/2016, Volume 408, Issue 4, pp. 1191 - 1204
The accurate analytical measurement of binding affinities of polyclonal antibody in sera to heroin, 6-acetylmorphine (6-AM), and morphine has been a... 
Biochemistry, general | Food Science | Apparent dissociation constant ( K d ) | UPLC/MS/MS | Laboratory Medicine | Chemistry | Analytical Chemistry | Competition ELISA | Antibody affinity | Characterization and Evaluation of Materials | Heroin hapten | Environmental Monitoring/Analysis | Equilibrium dialysis | Apparent dissociation constant (K | Apparent dissociation constant (K-d) | CHEMISTRY, ANALYTICAL | MINIMAL CROSS-REACTIVITY | SPECIFICITY | MORPHINE | DIACETYLMORPHINE HEROIN | VACCINE | BIOCHEMICAL RESEARCH METHODS | LINKED IMMUNOSORBENT ASSAY | MASS-SPECTROMETRY | RADIOIMMUNOASSAY | Heroinhapten | MONOCLONAL-ANTIBODIES | SIMPLE CHEMICAL-COMPOUNDS | Deuterium | Enzyme-Linked Immunosorbent Assay - methods | Substance Abuse Detection - methods | Chemistry Techniques, Synthetic | Chromatography, High Pressure Liquid - methods | Antibodies - metabolism | Antibodies - chemistry | Drug Stability | Antibody Affinity | Haptens - immunology | Morphine - blood | Haptens - chemistry | Tandem Mass Spectrometry | Morphine - immunology | Animals | Morphine Derivatives - immunology | Mice | Morphine Derivatives - blood | Viral antibodies | Analysis | Antibodies | Illegal drugs | Liquid chromatography | Chemical properties | Mass spectrometry | Enzyme-linked immunosorbent assay | Competition | Binding | Drug abuse | Narcotics | Morphine | Affinity | Assaying | UPLC | Apparent dissociation constant (Kd) | Research Paper
Journal Article
Analytical Biochemistry, ISSN 0003-2697, 05/2016, Volume 501, pp. 35 - 43
Journal Article
Angewandte Chemie (International ed. in English), ISSN 1433-7851, 3/2016, Volume 55, Issue 12, pp. 4007 - 4010
There is great demand for high-throughput methods to characterize ligand affinity. By combining mRNA display with next-generation sequencing, we determined the... 
High-throughput screening | Kinetic on- and off-rates | Dissociation Constant (Kd) | Affinity Measurement | Protein-protein interactions
Journal Article
TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, ISSN 0915-7352, 01/2018, Volume 31, Issue 172, pp. SE137 - SE153
Journal Article
mAbs, ISSN 1942-0862, 01/2015, Volume 7, Issue 3, pp. 584 - 604
To harness the potent tumor-killing capacity of T cells for the treatment of CD19(+) malignancies, we constructed AFM11, a humanized tetravalent bispecific... 
Non-Hodgkin lymphoma | ALL | CD3 | T cells | Bispecific antibodies | NHL, non-Hodgkin lymphoma | CHO, Chinese hamster ovary | ACTIVATION | MWCO, molecular weight cut-off | FC-RECEPTORS | MONOCLONAL-ANTIBODY | PROLIFERATION | BBB, blood-brain barrier | WBA, whole body autoradiography | KD, dissociation constant | ECL, electrochemiluminescence | FACS, fluorescence-activated cell sorting | LYMPHOMA | CCS, cell culture supernatant | SDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis | ANALYSIS TOOL | i.v., intravenous | ORR, overall response rate | PI, propidium iodide | TNF, tumor necrosis factor | VH, variable heavy | Vss, volume of distribution at steady state | PBS, phosphate buffered saline | FcRn, neonatal Fc receptor | Fab, fragment antigen-binding | ctrl., control | t(1/2), terminal elimination half-life | BITE ANTIBODY BLINATUMOMAB | IgG, immunoglobulin G | B-ALL, B-precursor acute lymphoblastic leukemia | NK, natural killer | E:T, effector:target | CLL, chronic lymphocytic leukemia | IL, interleukin | MALIGNANCIES | s.c., subcutaneous | His, histidine | FR, framework region | EC50, half maximal effective concentration | FCS, fetal calf serum | MEDICINE, RESEARCH & EXPERIMENTAL | CONSTRUCT | kd, dissociation rate constant | w/o, without | Fc, fragment crystallizable | LMF, low molecular weight forms | VL, variable light | HMF, high molecular weight forms | FcgR, Fc gamma receptor | F, fluorescence | SABC, standardized antibody binding capacity | SE-HPLC, size exclusion high-pressure liquid chromatography | CD, cluster of differentiation | CL, clearance | ACUTE LYMPHOBLASTIC-LEUKEMIA | SD, standard deviation | SEC, size exclusion chromatography | PBMC, peripheral blood mononuclear cell | scFv, single-chain variable fragment | IFN, interferon | MSD, MesoScale Discovery | BiTE, bispecific T cell engager | PHA, phytohemagglutinin | Fv, variable fragment | CAR, chimeric antigen receptor | HSA, human serum albumin | AUCtot, total area under the curve | PES, polyethersulfone | CNS, central nervous system | TandAb, tandem diabody | CDR, complementarity determining region | ka, association rate constant | DMSO, dimethyl sulfoxide | SPR, surface plasmon resonance | NOD/scid, nonobese diabetic/severe combined immunodeficiency | Cmax, maximal concentration | Cricetulus | Humans | Male | Neoplasms, Experimental - pathology | Antibodies, Neoplasm - pharmacology | Neoplasms, Experimental - immunology | HEK293 Cells | Antigens, CD19 - immunology | CHO Cells | Antibodies, Neoplasm - immunology | Cricetinae | Single-Chain Antibodies - pharmacology | Antibodies, Bispecific - pharmacology | Jurkat Cells | Mice, SCID | Antibodies, Bispecific - immunology | Xenograft Model Antitumor Assays | Animals | CD3 Complex - immunology | Antibodies, Bispecific - chemistry | Mice, Inbred NOD | Antibodies, Neoplasm - chemistry | Mice | Neoplasms, Experimental - drug therapy | Single-Chain Antibodies - chemistry | Single-Chain Antibodies - immunology
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2015, Volume 1278, pp. 529 - 544
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 06/2015, Volume 65, Issue 22, pp. 2404 - 2415
Journal Article
Protein Science, ISSN 0961-8368, 11/2004, Volume 13, Issue 11, pp. 3017 - 3027
Despite the widespread use of sonication in medicine, industry, and research, the effects of sonication on proteins remain poorly characterized. We report that... 
β‐structure | GSH, reduced glutathione | BSA, bovine serum albumin | ultrasound radiation | Abbreviations: ThT, thioflavin T | protein conformational disorder | TEM, transmission electron microscopy | DLS, dynamic light scattering | CR, Congo red | SDS‐PAGE, sodium dodecyl sulfate polyacrylamide electrophoresis | Kd, apparent dissociation constant | amyloid | protein aggregation | protein misfolding | PMCA, protein misfolding cyclic amplification | sonication | fibrils | CD, circular dichroism | SOD, human cytosolic Cu/Zn superoxide dismutase | Sonication | Protein aggregation | Protein conformational disorder | Protein misfolding | Fibrils | Ultrasound radiation | β-structure | Amyloid | FIBRIL FORMATION | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein conforniational disorder | ELECTRON-MICROSCOPY | GLOBULAR PROTEIN | INFRARED-SPECTROSCOPY | CIRCULAR-DICHROISM SPECTRA | IN-VITRO | beta-structure | CYCLIC AMPLIFICATION | SECONDARY STRUCTURE | BOVINE SERUM-ALBUMIN | Microscopy, Electron, Transmission | Animals | Humans | Protein Denaturation | Amyloidosis - etiology | Amyloid - chemistry | Proteins - chemistry | Spectrum Analysis | Dimerization | Fluorescent Dyes | Proteins - ultrastructure | SDS-PAGE, sodium dodecyl sulfate polyacrylamide electrophoresis | SOD, human cytosolic Cu | Zn superoxide dismutase
Journal Article