X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (14) 14
humans (10) 10
kdac (10) 10
epigenetics (7) 7
histone deacetylase inhibitors - pharmacology (7) 7
histone deacetylases - metabolism (7) 7
chemistry, medicinal (6) 6
animals (5) 5
histone deacetylase (5) 5
lysine (5) 5
lysine - metabolism (5) 5
proteins (5) 5
acetylation (4) 4
basic medicine (4) 4
biological sciences (4) 4
biologiska vetenskaper (4) 4
cancer (4) 4
cells (4) 4
chemical sciences (4) 4
computer and information sciences (4) 4
data- och informationsvetenskap (4) 4
gene expression (4) 4
hdac inhibitors (4) 4
histone deacetylase inhibitors (4) 4
histone deacetylase inhibitors - chemistry (4) 4
histone deacetylases - chemistry (4) 4
kemi (4) 4
läkemedelskemi (4) 4
medical and health sciences (4) 4
medicin och hälsovetenskap (4) 4
medicinal chemistry (4) 4
medicinska och farmaceutiska grundvetenskaper (4) 4
molecular docking simulation (4) 4
natural sciences (4) 4
naturvetenskap (4) 4
nf-kappa-b (4) 4
sirtuins (4) 4
analysis (3) 3
antitumor-activity (3) 3
biochemistry & molecular biology (3) 3
cell biology (3) 3
chromatin (3) 3
epigenetic inheritance (3) 3
genetics & heredity (3) 3
hdac (3) 3
kat (3) 3
kdac inhibitors (3) 3
lysine acetylation (3) 3
lysine deacetylase (3) 3
physiological aspects (3) 3
structure-activity relationship (3) 3
benzodiazepines (2) 2
biochemistry (2) 2
biology (2) 2
biophysics (2) 2
biotechnology & applied microbiology (2) 2
cell cycle (2) 2
drug design (2) 2
enzymes (2) 2
expression (2) 2
force-field (2) 2
gene regulation (2) 2
gene-expression (2) 2
genes (2) 2
genetics (2) 2
genomics (2) 2
histone deacetylase inhibitors - chemical synthesis (2) 2
histone deacetylase inhibitors - metabolism (2) 2
histone deacetylases (2) 2
histone deacetylases - genetics (2) 2
histones (2) 2
il-1 (2) 2
in-vivo (2) 2
inflammation (2) 2
isoenzymes - antagonists & inhibitors (2) 2
isoenzymes - chemistry (2) 2
isoenzymes - metabolism (2) 2
lysine acetyltransferases - metabolism (2) 2
lysine deacetylases (2) 2
medical colleges (2) 2
metabolism (2) 2
methylation (2) 2
micrornas - genetics (2) 2
micrornas - metabolism (2) 2
molecular biology (2) 2
molecular structure (2) 2
nitric-oxide synthase (2) 2
pharmacology & pharmacy (2) 2
posttranslational modifications (2) 2
protein (2) 2
protein conformation (2) 2
resveratrol (2) 2
saccharomyces cerevisiae - genetics (2) 2
signal transduction (2) 2
sirtuin (2) 2
small-molecule activators (2) 2
structure-based drug design (2) 2
3d qsar ; structure based drug design; molecular docking; combiner; clusterizer; dockaccessor; docking accuracy; hdac; kdac (1) 1
acetylome (1) 1
actin (1) 1
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Biogerontology, ISSN 1389-5729, 6/2019, Volume 20, Issue 3, pp. 303 - 319
Cell senescence, a state of cell cycle arrest and altered metabolism with enhanced pro-inflammatory secretion, underlies at least some aspects of organismal... 
Life Sciences | Tenovin-6 | Senescence | Geriatrics/Gerontology | Ageing | Longevity | Developmental Biology | Sirtuin | SASP | p21 | HDAC/KDAC | Cell Biology | Physiological aspects | Chromatin | Muscle proteins | Cells | Resveratrol | Sirtuins | Cell proliferation | Secretion | DNA damage | Genotoxicity | Mitochondrial DNA | Inflammation | SIRT1 protein | Interleukin 6 | Antitumor agents | Deacetylation | Actin | Transformed cells | Cell cycle | Fibroblasts | Aging | Cancer | KDAC | HDAC
Journal Article
Journal of visualized experiments : JoVE, ISSN 1940-087X, 01/2019, Issue 143
Regulated metabolic activity is essential for the normal functioning of living cells. Indeed, altered metabolic activity is causally linked with the... 
LIFE-SPAN | Drosophila | MULTIDISCIPLINARY SCIENCES | Oxygen consumption | Biochemistry | HISTONE ACETYLATION | epigenetics | whole head measurement | DISEASES | METABOLISM | Issue 143 | KDAC inhibitors | energy metabolism
Journal Article
ACS Synthetic Biology, ISSN 2161-5063, 10/2018, Volume 7, Issue 10, pp. 2348 - 2354
Lysine deacetylases (KDACs) are enzymes that catalyze the hydrolysis of acyl groups from acyl-lysine residues. The recent identification of thousands of... 
KDAC | genetic code expansion | sirtuin | lysine acetylation | histone deacetylase | CELLS | ACTIVATION | PROTEIN | ASSAY | BIOCHEMICAL RESEARCH METHODS | SIRTUINS | HUMAN SIRT1 | GENE-EXPRESSION | HISTONE DEACETYLASE INHIBITORS | NF-KAPPA-B | Letter
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-4934, 2010, Volume 14, Issue 6, pp. 1225 - 1240
•  Introduction •  Epigenetics explained ‐  Epigenetic alterations are reversible •  Atherosclerosis •  Epigenetics and association with atherosclerosis • ... 
atherosclerosis | inflammation | CAD | histone modifications | chromatin | KDAC inhibitors | epigenetics | Chromatin | Atherosclerosis | Epigenetics | Histone modifications | Inflammation | MEDICINE, RESEARCH & EXPERIMENTAL | NITRIC-OXIDE SYNTHASE | HUMAN-ENDOTHELIAL CELLS | CELL BIOLOGY | RECEPTOR-DEFICIENT MICE | TUMOR-NECROSIS-FACTOR | SERUM RESPONSE FACTOR | SMOOTH-MUSCLE-CELLS | HISTONE DEACETYLASE INHIBITORS | NF-KAPPA-B | CORONARY-ARTERY-DISEASE | MHC CLASS-II | Inflammation - pathology | Atherosclerosis - pathology | Atherosclerosis - genetics | Epigenesis, Genetic | Humans | Atherosclerosis - complications | MicroRNAs - metabolism | Chemokines - genetics | Inflammation - complications | Animals | Inflammation - genetics | MicroRNAs - genetics | Receptors, Chemokine - genetics | Regulations | Transcription factors | Pathogenesis | Gene regulation | Smooth muscle | Cardiovascular disease | Lymphocytes T | Eotaxin | Modulators | Proteins | Receptors | Lymphocytes | DNA methylation | Histones | Lesions | Deoxyribonucleic acid--DNA | Enzymes | CCR5 protein | Immunoregulation | Immunomodulation | Therapeutic applications | MiRNA | Muscles | Cell division | Gene expression | CIITA protein | Nitric-oxide synthase | Endothelial cells | Monocytes | Major histocompatibility complex | Arteriosclerosis | Genetic engineering | Cyclooxygenase-2 | Methylation | Binding sites | Chemokines | Regulatory proteins | Reviews
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2016, Volume 59, Issue 4, pp. 1613 - 1633
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2017, Volume 127, pp. 531 - 553
A comprehensive investigation was performed to identify new benzodiazepine (BZD) derivatives as potent and selective human lysine deacetylase inhibitors... 
Histone deacetylase (HDAC) | Epigenetics | Structure-based drug design (SBDD) | Benzodiazepine (BZD) | Lysine deacetylase (KDAC) | HDAC INHIBITORS | CHEMISTRY, MEDICINAL | ROMIDEPSIN | ANTITUMOR-ACTIVITY | CANCER | BELINOSTAT | PHASE-II TRIAL | HISTONE-DEACETYLASE | IN-VIVO | BIOLOGICAL EVALUATION | EXPRESSION | Benzodiazepines - pharmacology | Chemistry Techniques, Synthetic | Benzodiazepines - chemical synthesis | Humans | Histone Deacetylases - chemistry | Histone Deacetylases - metabolism | Isoenzymes - chemistry | Structure-Activity Relationship | Histone Deacetylase Inhibitors - chemistry | Molecular Dynamics Simulation | Histone Deacetylase Inhibitors - chemical synthesis | Isoenzymes - metabolism | Drug Design | Benzodiazepines - chemistry | Histone Deacetylase Inhibitors - pharmacology | Protein Conformation | Molecular Docking Simulation | Histone Deacetylase Inhibitors - metabolism | Benzodiazepines - metabolism | Isoenzymes - antagonists & inhibitors | Molecular dynamics | Molecular biology | Lysine | Analysis | Benzodiazepines | Medical colleges | Derivatives (Financial instruments) | Basic Medicine | Biological Sciences | Data- och informationsvetenskap | Medical and Health Sciences | Medicin och hälsovetenskap | Computer and Information Sciences | Läkemedelskemi | Chemical Sciences | Medicinal Chemistry | Naturvetenskap | Kemi | Biologiska vetenskaper | Medicinska och farmaceutiska grundvetenskaper | Natural Sciences
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 04/2017, Volume 25, Issue 7, pp. 2105 - 2132