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Molecular Medicine Reports, ISSN 1791-2997, 09/2017, Volume 16, Issue 3, pp. 3573 - 3580
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2018, Volume 61, Issue 7, pp. 3193 - 3208
Isomers of chiral drugs can exhibit marked differences in biological activities. We studied the binding and inhibitory activities of 12 compounds against... 
KDM5A | DOMAIN | CHEMISTRY, MEDICINAL | RBP2 | GASTRIC-CANCER | RESISTANCE | JARID1B | PROLIFERATION | ONCOMETABOLITE 2-HYDROXYGLUTARATE | BINDING | FAMILY
Journal Article
American Journal of Translational Research, ISSN 1943-8141, 2012, Volume 4, Issue 3, pp. 247 - 256
Lysine-specific demethylase 5A (KDM5A), an enzyme that removes activating H3K4 di- and trimethylation marks, plays critical roles in controlling transcription... 
KDM5A | Gene amplification | Histone demethylases | Drug-resistance | AMPLICON | ONCOGENES | MEDICINE, RESEARCH & EXPERIMENTAL | METHYLATION | histone demethylases | CELL-LINES | IDENTIFICATION | REARRANGEMENTS | RBP2 | GENE | ONCOLOGY | drug-resistance | DIFFERENTIATION | BINDING-PROTEIN 2 | gene amplification
Journal Article
Leukemia Research, ISSN 0145-2126, 05/2018, Volume 68, pp. 105 - 111
Journal Article
Cell Cycle, ISSN 1538-4101, 11/2015, Volume 14, Issue 21, pp. 3418 - 3429
Notwithstanding current multimodal treatment, including surgery, radiotherapy and chemotherapy with temozolomide (TMZ), median survival of glioblastoma (GBM)... 
temozolomide | KDM5A | glioblastoma | epigenetic | DNA methylation | cancer stem cells | histone demethylase | Glioblastoma | Histone demethylase | Epigenetic | Temozolomide | Cancer stem cells | METHYLATION ANALYSIS | STEM-CELLS | MGMT | DRUG-RESISTANCE | CANCER | TUMOR-INITIATING CELLS | CELL BIOLOGY | INHIBITION | GENE | MULTIDRUG-RESISTANCE | EXPRESSION | Glioblastoma - enzymology | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Humans | Brain Neoplasms - pathology | Antineoplastic Agents, Alkylating - pharmacology | Retinoblastoma-Binding Protein 2 - antagonists & inhibitors | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Retinoblastoma-Binding Protein 2 - metabolism | Retinoblastoma-Binding Protein 2 - genetics | Transfection | Glioblastoma - genetics | RNA Interference | Time Factors | Dacarbazine - pharmacology | Dacarbazine - analogs & derivatives | Neoplastic Stem Cells - pathology | Epigenesis, Genetic - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Brain Neoplasms - enzymology | Brain Neoplasms - genetics | Genotype | Brain Neoplasms - drug therapy | Cell Shape - drug effects | Drug Synergism | Drug Resistance, Neoplasm - genetics | Phenotype | Cell Differentiation - drug effects | Glioblastoma - pathology | Cell Line, Tumor | Histone Deacetylase Inhibitors - pharmacology | Cell Cycle - drug effects | Glioblastoma - drug therapy | DNA Methylation - drug effects | Neoplastic Stem Cells - enzymology
Journal Article
Journal Article
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, ISSN 1940-5901, 2017, Volume 10, Issue 7, pp. 10297 - 10305
Lysine demethylase 6A (KDM6A) plays a crucial function in several cancers. However, there is little known about the function of KDM6A in gastric cancer. Here,... 
MEDICINE, RESEARCH & EXPERIMENTAL | DOMAIN | proliferation | metastasis | HISTONE DEMETHYLASE KDM5A | RESISTANCE | apoptosis | p16(ink14) | KDM6A
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 05/2016, Volume 26, Issue 9, pp. 2284 - 2288
Journal Article
CANCERS, ISSN 2072-6694, 01/2019, Volume 11, Issue 1, p. 92
Breast cancer is the one of the most frequent causes of female cancer mortality. KDM5A, a histone demethylase, can increase the proliferation, metastasis, and... 
KDM5A | Jumonji domain | DOMAIN | virtual screening | MECHANISM | ANALOGS | DOCKING | RHODIUM(III) COMPLEX | breast cancer | cell cycle arrest | IN-VITRO | POTENT | histone demethylation | ONCOLOGY | protein-protein interaction | HISTONE DEMETHYLASE RBP2 | OPTIMIZATION | DERIVATIVES | cell senescence
Journal Article
Genetics, ISSN 0016-6731, 10/2017, Volume 207, Issue 2, pp. 559 - 569
Eukaryotic chromosome segregation requires a protein complex known as the kinetochore that mediates attachment between mitotic spindle microtubules and... 
Msc1 | CCAN | Kinetochore | Mis17 | Centromere | RBP2 | Mis15 | PLU-1 | Lysine demethylase KDM5 | Mis16/Mis18 | Mis6 | CENP-A | MIS18 | centromere | FISSION YEAST | COMPLEX | PROTEIN | MICROTUBULE DYNAMICS | lysine demethylase KDM5 | DEMETHYLASE KDM5A | GENETICS & HEREDITY | kinetochore | CELL-CYCLE | CHROMOSOME SEGREGATION | BINDING | Chromatin - metabolism | Schizosaccharomyces pombe Proteins - chemistry | Chromosome Segregation | Schizosaccharomyces pombe Proteins - genetics | Chromosomal Proteins, Non-Histone - metabolism | Kinetochores - metabolism | Cell Cycle Proteins - metabolism | Chromatin Assembly and Disassembly | Centromere - metabolism | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Chromosomal Proteins, Non-Histone - genetics | DNA-Binding Proteins - metabolism | Schizosaccharomyces - genetics | Carrier Proteins - genetics | Carrier Proteins - metabolism | Centromere - genetics | Schizosaccharomyces pombe Proteins - metabolism | Cell Cycle Proteins - genetics | Protein Domains | Chromatin - genetics | Eukaryotes | Research | Kinetochores | DNA | Histone deacetylase | Chromatin | Yeast | Mitosis | Homology | Chromosome deletion | Fission | Mutants | Chromatin remodeling | Critical components | Proteins | Clonal deletion | Microtubules | Cell cycle | DNA methylation | Deletion | Nucleosomes | Mutation | Localization | Chromosomes | Deoxyribonucleic acid--DNA | Investigations | Mis18 | Mis16
Journal Article