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kdm5b (54) 54
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Oncotarget, ISSN 1949-2553, 09/2018, Volume 9, Issue 76, pp. 34320 - 34335
Hepatocellular carcinoma (HCC) has high potential for recurrence, even in curative operative cases. Although several molecular-targeting drugs have been... 
Epigenetics | Histone demethylase | KDM5B/JARID1B | Hepatocellular carcinoma (HCC)
Journal Article
European Journal of Cancer, ISSN 0959-8049, 03/2019, Volume 109, pp. 137 - 153
Introduction: Treatment of patients with metastatic melanoma is hampered by drug-resistance and often requires combination with radiotherapy as last-resort... 
Resistance | Repopulation | Targeted therapy | Cross-resistance | Melanoma | Therapy sequencing | Slow-cycling cells | Radiotherapy | JARID1B/KDM5B
Journal Article
by McRae, Jeremy F and Clayton, Stephen and Fitzgerald, Tomas W and Kaplanis, Joanna and Prigmore, Elena and Rajan, Diana and Sifrim, Alejandro and Aitken, Stuart and Akawi, Nadia and Alvi, Mohsan and Ambridge, Kirsty and Barrett, Daniel M and Bayzetinova, Tanya and Jones, Philip and Jones, Wendy D and King, Daniel and Krishnappa, Netravathi and Mason, Laura E and Singh, Tarjinder and Tivey, Adrian R and Ahmed, Munaza and Anjum, Uruj and Archer, Hayley and Armstrong, Ruth and Awada, Jana and Balasubramanian, Meena and Banka, Siddharth and Baralle, Diana and Barnicoat, Angela and Batstone, Paul and Baty, David and Bennett, Chris and Berg, Jonathan and Bernhard, Birgitta and Bevan, A. Paul and Bitner-Glindzicz, Maria and Blair, Edward and Blyth, Moira and Bohanna, David and Bourdon, Louise and Bourn, David and Bradley, Lisa and Brady, Angela and Brent, Simon and Brewer, Carole and Brunstrom, Kate and Bunyan, David J and Burn, John and Canham, Natalie and Castle, Bruce and Chandler, Kate and Chatzimichali, Elena and Cilliers, Deirdre and Clarke, Angus and Clasper, Susan and Clayton-Smith, Jill and Clowes, Virginia and Coates, Andrea and Cole, Trevor and Colgiu, Irina and Collins, Amanda and Collinson, Morag N and Connell, Fiona and Cooper, Nicola and Cox, Helen and Cresswell, Lara and Cross, Gareth and Crow, Yanick and D'Alessandro, Mariella and Dabir, Tabib and Davidson, Rosemarie and Davies, Sally and De Vries, Dylan and Dean, John and Deshpande, Charu and Devlin, Gemma and Dixit, Abhijit and Dobbie, Angus and Donaldson, Alan and Donnai, Dian and Donnelly, Deirdre and Donnelly, Carina and Douglas, Angela and Douzgou, Sofia and Duncan, Alexis and Eason, Jacqueline and Ellard, Sian and Ellis, Ian and Elmslie, Frances and Evans, Karenza and Everest, Sarah and Fendick, Tina and Fisher, Richard and Flinter, Frances and Foulds, Nicola and Fry, Andrew and Fryer, Alan and Gardiner, Carol and Gaunt, Lorraine and Ghali, Neeti and ... and Deciphering Developmental Disorders Study
Nature, ISSN 0028-0836, 02/2017, Volume 542, Issue 7642, pp. 433 - 438
The genomes of individuals with severe, undiagnosed developmental disorders are enriched in damaging de novo mutations (DNMs) in developmentally important... 
INTELLECTUAL DISABILITY | METAANALYSIS | VARIANTS | GENETICS | HEART-DEFECTS | MULTIDISCIPLINARY SCIENCES | GENES | SEQUENCE | FRAMEWORK | DISCOVERY | GENOME | Prevalence | Humans | Middle Aged | Parents | Male | Mi-2 Nucleosome Remodeling and Deacetylase Complex - genetics | Developmental Disabilities - genetics | Casein Kinase II - genetics | Autoantigens - genetics | Young Adult | ras GTPase-Activating Proteins - genetics | Adult | Female | Child | CDC2 Protein Kinase - genetics | Histone-Lysine N-Methyltransferase - genetics | Repressor Proteins - genetics | Sex Characteristics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Nerve Tissue Proteins - genetics | Sequence Analysis, DNA | Homeodomain Proteins - genetics | DEAD-box RNA Helicases - genetics | Exome - genetics | Phenotype | Myeloid-Lymphoid Leukemia Protein - genetics | Adolescent | Heredity - genetics | Protein Phosphatase 2C - genetics | Cohort Studies | Child development deviations | Genetic aspects | Genetic disorders | Developmental disabilities | Distribution | Genes | Families & family life | Births | Genomes | Mutation | Causality | Estimates | Age | TRIO | MYT1L | EHMT1 | HNRNPU | SUV420H1 | COL4A3BP | SYNGAP1 | PPP2R1A | POGZ | EP300 | KCNH1 | SCN1A | MEF2C | CDKL5 | CSNK2A1 | DYRK1A | CASK | ALG13 | FOXP1 | KAT6B | TBL1XR1 | KAT6A | SCN8A | KCNQ2 | EEF1A2 | KCNQ3 | ADNP | PhenIcons | SET | KMT2A | ANKRD11 | STXBP1 | FOXG1 | ZC4H2 | ITPR1 | De novo mutation | Seizures | ZBTB18 | CREBBP | SMAD4 | PDHA1 | IQSEC2 | AUTS2 | BCL11A | BRAF | SMARCA2 | GRIN2B | MED13L | GNAO1 | CNOT3 | TCF4 | SCN2A | CDK13 | GABRB3 | SETD5 | KDM5B | Developmental Disease | DDX3X | CHD8 | PTEN | CHD4 | TCF20 | CTCF | CHD2 | WDR45 | SLC6A1 | MECP2 | CHAMP1 | KIF1A | Average Faces | MSL3 | PPP2R5D | SMC1A | ARID1B | DNM1 | CNKSR2 | PACS1 | WAC | ZMYND11 | AHDC1 | NFIX | SATB2 | HDAC8 | PPM1D | GNAI1 | PURA | PUF60 | NSD1 | Intellectual Disability | SLC35A2 | DYNC1H1 | NAA10 | USP9X | PTPN11 | GATAD2B | ASXL1 | KANSL1 | ASXL3 | CTNNB1 | QRICH1
Journal Article
Biology of Reproduction, ISSN 0006-3363, 2015, Volume 92, Issue 3
ABSTRACT KDM5B (JARID1B/PLU1) is a H3K4me2/3 histone demethylase that is implicated in cancer development and proliferation and is also indispensable for... 
KDM5B | histone demethylase | embryonic development | H3K4me3 | pig
Journal Article
Journal of Cancer, ISSN 1837-9664, 2018, Volume 9, Issue 1, pp. 198 - 204
Purpose: Lysine demethylase (KDM) 5B, as a member of the histone lysine demethylase family, is overexpressed and functions abnormally in various human cancers.... 
KDM5B | Head and neck cancer | Squamous cell carcinoma | Prognosis | Metastasis | SURVIVAL | PROLIFERATION | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER CELLS | HEPATOCELLULAR-CARCINOMA | ONCOLOGY | HISTONE DEMETHYLASE KDM5B | H3K4 METHYLATION | JARID1B | EXPRESSION
Journal Article
Biomedical Research (India), ISSN 0970-938X, 2017, Volume 28, Issue 20, pp. 8875 - 8881
Journal Article
EXPERIMENTAL CELL RESEARCH, ISSN 0014-4827, 06/2019, Volume 379, Issue 2, pp. 182 - 190
Lysine demethylase 5B (KDM5B) is up-regulated in many cancers, including breast cancer. However, the underlying metabolic mechanisms of KDM5B on breast cancer... 
KDM5B | ONCOLOGY | GLUCOSE | GROWTH | AMPK | Breast cancer | Lipid metabolism | MESENCHYMAL TRANSITION | EXPRESSION | CELL BIOLOGY | Synthesis | Analysis | Stem cells | Development and progression | Metastasis | Fatty acids | Protein kinases
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY, ISSN 0968-0896, 03/2019, Volume 27, Issue 6, pp. 1119 - 1129
Histone lysine demethylases (KDMs) have drawn much attention as targets of therapeutic agents. KDM5 proteins, which are Fe(II)/alpha-ketoglutarate-dependent... 
KDM5B | CELLS | DESIGN | CHEMISTRY, MEDICINAL | Inhibitor design | JHDM | Histone methylation | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | DISCOVERY | HISTONE DEMETHYLASE | POTENT | REPRESSION | KDM | PROSTATE-CANCER | LSD1 | Epigenetics
Journal Article
Gene, ISSN 0378-1119, 12/2018, Volume 679, pp. 305 - 313
Histone lysine methylation influences processes such as gene expression and DNA repair. Thirty Jumonji C (JmjC) domain-containing proteins have been identified... 
KDM5B | Histone demethylase | Splice variant | Intellectual disability | DEMETHYLASE | GENETICS & HEREDITY | DIFFERENTIATION | MUTATIONS | Proteins | Autism | Care and treatment | RNA | Cardiac patients | Methylation | Gene expression
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 11/2014, Volume 454, Issue 1, pp. 221 - 227
Epigenetic alterations such as aberrant expression of histone-modifying enzymes have been implicated in tumorigenesis. Upregulation of lysine (K)-specific... 
Glioma | KDM5B | Proliferation | CHROMATIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | INVOLVEMENT | P53 | EPITHELIAL-MESENCHYMAL TRANSITION | CUL4A | BIOPHYSICS | GASTRIC-CANCER | MYC | HISTONE DEMETHYLASE KDM5B | EXPRESSION | Up-Regulation | Cell Proliferation | Epigenesis, Genetic | Humans | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | Brain Neoplasms - metabolism | Case-Control Studies | Repressor Proteins - antagonists & inhibitors | Gene Knockdown Techniques | Glioma - metabolism | Brain - metabolism | Glioma - genetics | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Heterografts | Glioma - pathology | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Biomarkers, Tumor - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Nuclear Proteins - genetics | Oncogenes | Repressor Proteins - metabolism | Tumor Stem Cell Assay | Down-Regulation | Brain Neoplasms - genetics | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Jumonji Domain-Containing Histone Demethylases - genetics | Disease Progression | Animals | Mice, Nude | Nuclear Proteins - antagonists & inhibitors | Brain - pathology | Cell Line, Tumor | Biomarkers, Tumor - genetics | Mice | Jumonji Domain-Containing Histone Demethylases - metabolism | Gliomas | Development and progression | Enzymes | Medical colleges | Growth | Lysine | Analysis | Brain tumors | Brain damage | GLIOMAS | ONCOGENES | PATIENTS | LYSINE | CELL PROLIFERATION | ANIMAL TISSUES | TUMOR CELLS | IN VIVO | COMPARATIVE EVALUATIONS | 60 APPLIED LIFE SCIENCES | INHIBITION | SURVIVAL TIME | ENZYMES | IN VITRO | BRAIN
Journal Article
Cell Stem Cell, ISSN 1934-5909, 07/2017, Volume 21, Issue 1, pp. 135 - 143.e6
Vertebrate eggs can induce the nuclear reprogramming of somatic cells to enable production of cloned animals. Nuclear reprogramming is relatively inefficient,... 
reprogramming | endoderm | H3K4me3 | cell-fate stability | nuclear transfer | epigenetic memory | Kdm5b | PLURIPOTENT STEM-CELLS | GENE-EXPRESSION DATA | XENOPUS-LAEVIS | EPIGENETIC MEMORY | TRANSCRIPTION | DIFFERENTIATION | EFFICIENCY | TRICHOSTATIN | FEATURES | CYCLE | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Short
Journal Article
European Journal of Medical Genetics, ISSN 1769-7212, 09/2019, Volume 62, Issue 9, p. 103558
Microduplications involving 1q32.1 chromosomal region have been rarely reported in literature. Patients with these microduplications suffer from intellectual... 
1q32.1 region | Mosaicism | Histone demethylase | KDM5B gene | Monochorionic-diamniotic twins | Microduplication | INTELLECTUAL DISABILITY | GENETICS & HEREDITY | MUTATIONS | REVEALS
Journal Article
Seminars in Cancer Biology, ISSN 1044-579X, 08/2019, Volume 57, pp. 79 - 85
Epigenetic regulation of chromatin plays a critical role in controlling stem cell function and tumorigenesis. The histone lysine demethylase, KDM5B, which... 
KDM5B | Chromatin | H3K4me3 | Epigenetics | Pluripotent | Histone demethylase | Embryonic stem cells | Gene expression | Differentiation | Cancer | DOMAIN | PENETRANT INHIBITORS | TRANSCRIPTIONAL REPRESSION | PROLIFERATION | IDENTIFICATION | POTENT | ONCOLOGY | JARID1B | H3K4 TRIMETHYLATION | MAMMARY-GLAND | Epigenetic inheritance | Medical colleges | Lysine | Genes | Methylation | Cell differentiation
Journal Article
by Faundes, Víctor and Newman, William G and Bernardini, Laura and Canham, Natalie and Clayton-Smith, Jill and Dallapiccola, Bruno and Davies, Sally J and Davies, Sally and Demos, Michelle K and Goldman, Amy and Gill, Harinder and Horton, Rachel and Kerr, Bronwyn and Kumar, Dhavendra and Kumar, V.K. Ajith and Lehman, Anna and McKee, Shane and Morton, Jenny and Parker, Michael and Parker, Michael J and Rankin, Julia and Robertson, Lisa and Temple, I. Karen and Adam, Shelin and du Souich, Christèle and Elliott, Alison M and Mwenifumbo, Jill and Nelson, Tanya N and van Karnebeek, Clara and Friedman, Jan M and McRae, Jeremy F and Clayton, Stephen and Fitzgerald, Tomas W and Kaplanis, Joanna and Prigmore, Elena and Rajan, Diana and Sifrim, Alejandro and Aitken, Stuart and Akawi, Nadia and Alvi, Mohsan and Ambridge, Kirsty and Barrett, Jeffrey C and Barrett, Daniel M and Bayzetinova, Tanya and Jones, Wendy D and Jones, Philip and Jones, Elizabeth and King, Daniel and Krishnappa, Netravathi and Mason, Laura E and Singh, Tarjinder and Tivey, Adrian R and Ahmed, Munaza and Anjum, Uruj and Archer, Hayley and Armstrong, Ruth and Awada, Jana and Balasubramanian, Meena and Banka, Siddharth and Baralle, Diana and Barnicoat, Angela and Batstone, Paul and Baty, David and Bennett, Chris and Berg, Jonathan and Bernhard, Birgitta and Bevan, A. Paul and Bitner-Glindzicz, Maria and Blair, Edward and Blyth, Moira and Bohanna, David and Bourdon, Louise and Bourn, David and Bradley, Lisa and Brady, Angela and Brent, Simon and Brewer, Carole and Brunstrom, Kate and Bunyan, David J and Burn, John and Castle, Bruce and Chandler, Kate and Chatzimichali, Elena and Cilliers, Deirdre and Clarke, Angus and Clasper, Susan and Clowes, Virginia and Coates, Andrea and Cole, Trevor and Colgiu, Irina and Collins, Amanda and Collinson, Morag N and Connell, Fiona and Cooper, Nicola and Cox, Helen and Cresswell, Lara and Cross, Gareth and Crow, Yanick and D’Alessandro, Mariella and Dabir, Tabib and ... and Clin Assessment Utility Sequencin and Deciphering Dev Disorders DD and Clinical Assessment of the Utility of Sequencing and Evaluation as a Service (CAUSES) Study and Deciphering Developmental Disorders (DDD) Study
The American Journal of Human Genetics, ISSN 0002-9297, 01/2018, Volume 102, Issue 1, pp. 175 - 187
Journal Article