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Genes and Development, ISSN 0890-9369, 03/2000, Volume 14, Issue 6, pp. 655 - 665
The ordered progression through the cell cycle depends on regulating the abundance of several proteins through ubiquitin-mediated proteolysis. Degradation is... 
Ubiquitin | Specificity | KEN box | APC | Cdh1 | Proteolysis | ANAPHASE-PROMOTING COMPLEX | XENOPUS EGG EXTRACTS | PROTEIN | DEVELOPMENTAL BIOLOGY | SACCHAROMYCES-CEREVISIAE | ubiquitin | CELL BIOLOGY | YEAST | GENETICS & HEREDITY | specificity | S-PHASE | DEGRADATION | CELL-CYCLE | INHIBITOR | proteolysis | Proteins | Ligases | Denaturation | Cell cycle | Physiological aspects | Research | Cytochemistry
Journal Article
NATURE, ISSN 0028-0836, 02/2011, Volume 470, Issue 7333, pp. 274 - 274
The ubiquitylation of cell-cycle regulatory proteins by the large multimeric anaphase-promoting complex (APC/C) controls sister chromatid segregation and the... 
YEAST | ANAPHASE-PROMOTING COMPLEX | KEN BOX | RECOGNITION | CRYSTAL-STRUCTURE | CYCLIN-B | MULTIDISCIPLINARY SCIENCES | DESTRUCTION BOX | BINDING | SUBUNIT | COMPLEX/CYCLOSOME
Journal Article
Molecular Cell, ISSN 1097-2765, 2005, Volume 18, Issue 5, pp. 543 - 553
Journal Article
Genes and Development, ISSN 0890-9369, 09/2002, Volume 16, Issue 17, pp. 2274 - 2285
Journal Article
NATURE CELL BIOLOGY, ISSN 1465-7392, 06/2006, Volume 8, Issue 6, pp. 607 - 614
The temporal control of mitotic protein degradation remains incompletely understood. In particular, it is unclear why the mitotic checkpoint prevents the... 
CDC20 | ANAPHASE-PROMOTING COMPLEX | KEN BOX | CDH1 | PROTEIN-KINASE | DESTRUCTION BOX | CELL-CYCLE | CHECKPOINT | PROTEOLYSIS | SUBSTRATE RECOGNITION | CELL BIOLOGY
Journal Article
Nature, ISSN 0028-0836, 04/2012, Volume 484, Issue 7393, pp. 208 - 213
In mitosis, the spindle assembly checkpoint (SAC) ensures genome stability by delaying chromosome segregation until all sister chromatids have achieved bipolar... 
ANAPHASE-PROMOTING COMPLEX | FISSION YEAST | KEN BOX | BUDDING YEAST | PROTEIN BUBR1 | MULTIDISCIPLINARY SCIENCES | PSEUDOSUBSTRATE INHIBITION | DESTRUCTION BOX | SACCHAROMYCES-CEREVISIAE | MAD2 ACTIVATION | SPINDLE-ASSEMBLY CHECKPOINT | Anaphase-Promoting Complex-Cyclosome | Schizosaccharomyces pombe Proteins - chemistry | M Phase Cell Cycle Checkpoints | Schizosaccharomyces - chemistry | Humans | Ubiquitin-Protein Ligase Complexes - antagonists & inhibitors | Substrate Specificity | Crystallography, X-Ray | Structure-Activity Relationship | Spindle Apparatus | Cell Cycle Proteins - chemistry | Multiprotein Complexes - metabolism | Cdh1 Proteins | Protein Structure, Quaternary | Schizosaccharomyces pombe Proteins - metabolism | Conserved Sequence | Mad2 Proteins | Cdc20 Proteins | Protein Structure, Tertiary | Cell Cycle Proteins - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Saccharomyces cerevisiae Proteins - genetics | Nuclear Proteins - chemistry | Ubiquitin-Protein Ligase Complexes - chemistry | Amino Acid Motifs | Multiprotein Complexes - chemistry | Ubiquitin-Protein Ligase Complexes - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Ubiquitin-Protein Ligase Complexes - ultrastructure | Proteins | Kinases | Binding sites | Crystal structure
Journal Article
GENES & DEVELOPMENT, ISSN 0890-9369, 03/2007, Volume 21, Issue 6, pp. 655 - 667
Inappropriate attachment/tension between chromosomal kinetochores and the kinetochore microtubules activates the spindle assembly checkpoint, which delays... 
budding yeast | FISSION YEAST | SHUTTLE VECTORS | cell cycle | PROTEIN BUBR1 | DESTRUCTION BOX | DEVELOPMENTAL BIOLOGY | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | anaphase-promoting complex | KEN BOX | GENETICS & HEREDITY | MITOTIC REGULATOR | SISTER-CHROMATID SEPARATION | Cdc20
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 08/2019, Volume 10, Issue 1, pp. 3863 - 16
The anaphase-promoting complex/cyclosome (APC/C) orchestrates cell cycle progression by controlling the temporal degradation of specific cell cycle regulators.... 
KEN-BOX | DEPENDENT PROTEOLYSIS | ANAPHASE-PROMOTING COMPLEX | ACTIVATION | MECHANISM | SUBSTRATE | MULTIDISCIPLINARY SCIENCES | DEGRON RECOGNITION | CRYO-EM | DESTRUCTION BOX | CELL-CYCLE | Degradation | Binding | Regulators | Ubiquitination | Cell cycle | Anaphase-promoting complex | Anaphase | Assembly | Substrates | Ubiquitin-protein ligase | Cyclin B1
Journal Article