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Journal Article
Cancer discovery, ISSN 2159-8274, 10/2015, Volume 5, Issue 10, pp. 1049 - 1057
Oncogenic TRK fusions induce cancer cell proliferation and engage critical cancer-related downstream signaling pathways. These TRK fusions occur rarely, but in... 
NTRK1 | lung cancer | TrkA | NTRK3 | Phase I–III trials | oncogenes | kinase and phosphatase inhibitors | sarcomas | leukemias and lymphomas | soft tissue malignancies
Journal Article
The Lancet Oncology, ISSN 1470-2045, 05/2018, Volume 19, Issue 5, pp. 705 - 714
Gene fusions involving , or (TRK fusions) are found in a broad range of paediatric and adult malignancies. Larotrectinib, a highly selective small-molecule... 
ONCOLOGY | INFANTILE FIBROSARCOMA | MOLECULAR-DETECTION | RESPONSE ASSESSMENT | ACQUIRED-RESISTANCE | CONGENITAL FIBROSARCOMA | QUALITY-OF-LIFE | KINASE INHIBITOR LOXO-101 | TROPOMYOSIN | SOFT-TISSUE SARCOMA | MESOBLASTIC NEPHROMA | Age Factors | Discoidin Domain Receptor 2 - antagonists & inhibitors | United States | Humans | Receptor, trkA - antagonists & inhibitors | Child, Preschool | Infant | Male | Receptor, trkB - genetics | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Young Adult | Membrane Glycoproteins - antagonists & inhibitors | Neoplasms - genetics | Time Factors | Antineoplastic Agents - adverse effects | Receptor, trkB - antagonists & inhibitors | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Biomarkers, Tumor - antagonists & inhibitors | Child | Discoidin Domain Receptor 2 - genetics | Pyrazoles - adverse effects | Drug Administration Schedule | Administration, Oral | Pyrimidines - administration & dosage | Gene Fusion | Treatment Outcome | Membrane Glycoproteins - genetics | Neoplasms - drug therapy | Protein Kinase Inhibitors - administration & dosage | Pyrazoles - administration & dosage | Receptor Protein-Tyrosine Kinases - genetics | Adolescent | Pyrimidines - adverse effects | Receptor, trkA - genetics | Biomarkers, Tumor - genetics | Neoplasms - pathology | Genetic research | Pediatrics | Analysis
Journal Article
DRUGS OF THE FUTURE, ISSN 0377-8282, 05/2017, Volume 42, Issue 5, pp. 275 - 280
Larotrectinib (LOXO-101) is a small-molecule ATP-competitive oral inhibitor of the tropomyosin-related kinase (Trk) family of receptor kinases, including... 
LOXO-101 | Larotrectinib | FUSION | Tropomyosin-related kinase (Trk) inhibitor | PHARMACOLOGY & PHARMACY | KINASE INHIBITOR LOXO-101 | CANCER
Journal Article
Pediatrics Week, ISSN 1944-2637, 09/2016, p. 279
  According to the news reporters, the research concluded: "The patient experienced a rapid, radiographic response, demonstrating the potential for LOXO-101 to... 
Pediatrics | Genes | Oncology | Kinases | Cancer
Newspaper Article
EXPERT OPINION ON THERAPEUTIC PATENTS, ISSN 1354-3776, 2017, Volume 27, Issue 7, pp. 831 - 849
Journal Article
Cancer discovery, ISSN 2159-8274, 01/2016, Volume 6, Issue 1, pp. OF4 - OF4
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 05/2017, Volume 173, pp. 58 - 66
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 10/2017, Volume 16, Issue 10, pp. 2130 - 2143
Journal Article
Expert Opinion on Investigational Drugs, ISSN 1354-3784, 04/2016, Volume 25, Issue 4, pp. 385 - 392
Journal Article
European Journal of Cancer, ISSN 0959-8049, 12/2016, Volume 69, p. S144
Background: Oncogenic NTRK gene fusions occur at low frequency, but in a wide spectrum of tumor types in patients. Early clinical trials of LOXO-101, a... 
Bone grafts | Medical research | Immunoglobulins | Identification methods | Clinical trials | Pharmacology | Selectivity | Bioavailability | Kinases | Patients | Inhibitors | Vitamin B | TrkA protein | In vivo methods and tests | Mutation | Pharmacokinetics | Tumors
Journal Article
Laboratory Investigation, ISSN 0023-6837, 11/2017, Volume 97, Issue 11, pp. 1268 - 1270
Neurotrophic tyrosine kinase genes encode for the Trk-family proteins TrkA, TrkB, and TrkC, which have an important role in the development of the nervous... 
MEDICINE, RESEARCH & EXPERIMENTAL | ADVANCED SOLID TUMORS | ENTRECTINIB | ORAL PAN-TRK | RELEVANT MOLECULAR ALTERATIONS | PATHOLOGY | ALK INHIBITOR | ROS1 | EXPRESSION | Lung Neoplasms - drug therapy | Oncogene Proteins, Fusion - metabolism | Membrane Glycoproteins - metabolism | Humans | Lung Neoplasms - metabolism | Receptor, trkA - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Receptor, trkB - genetics | Membrane Glycoproteins - antagonists & inhibitors | Receptor, trkC - genetics | Antineoplastic Agents - adverse effects | Neoplasms, Squamous Cell - drug therapy | Receptor, trkB - antagonists & inhibitors | Lung Neoplasms - genetics | Molecular Targeted Therapy - adverse effects | Receptor, trkC - antagonists & inhibitors | Membrane Glycoproteins - genetics | Animals | Neoplasms, Squamous Cell - genetics | Receptor Protein-Tyrosine Kinases - genetics | Receptor, trkA - metabolism | Oncogene Proteins, Fusion - genetics | Receptor, trkA - genetics | Oncogene Proteins, Fusion - antagonists & inhibitors | Receptor, trkB - metabolism | Receptor, trkC - metabolism | Neoplasms, Squamous Cell - metabolism | Toxicity | Lung cancer | Clinical trials | Fluorescence | Nervous system | Kinases | Proteins | Fluorescence in situ hybridization | TrkA protein | TrkA receptors | Protein-tyrosine kinase | Tyrosine | Medical research | Squamous cell carcinoma | Invasiveness | Feasibility studies | Lung carcinoma | Patients | Brain-derived neurotrophic factor | Inhibitors | TrkB receptors | Solid tumors | Tumors | Cancer | Plastic foam | Index Medicus
Journal Article
Benzinga Newswires, 07/2016
  The company indicated its LOXO-101 Breakthrough Therapy Status application included data from the ongoing first stage dose-escalation trial of LOXO-101 in... 
Pediatrics | Oncology | Kinases | Tumors
Newspaper Article
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