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PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, p. e107490
Interleukin-2 inducible tyrosine kinase (ITK) is expressed in T cells and plays a critical role in signalling through the T cell receptor. Evidence, mainly... 
TEC FAMILY KINASE | CYTOKINE PRODUCTION | TYROSINE KINASE | IFN-GAMMA | IGE PRODUCTION | MULTIDISCIPLINARY SCIENCES | ALLERGIC-ASTHMA | AIRWAY HYPERRESPONSIVENESS | T-CELL KINASE | MURINE B-CELLS | MICE LACKING | Spleen - immunology | Immunoglobulin G - blood | Ovalbumin - immunology | Male | Th2 Cells - immunology | Protein-Tyrosine Kinases - immunology | Protein-Tyrosine Kinases - genetics | Flow Cytometry | T-Lymphocytes - metabolism | Immunoglobulin G - immunology | Pneumonia - immunology | Female | Inducible T-Cell Co-Stimulator Protein - immunology | Cytokines - immunology | Pneumonia - genetics | Cytokines - metabolism | Receptors, Antigen, T-Cell, gamma-delta - metabolism | Enzyme Inhibitors - immunology | Mice, Transgenic | Receptors, Antigen, T-Cell, gamma-delta - immunology | CD3 Complex - metabolism | Enzyme Inhibitors - therapeutic use | Th2 Cells - metabolism | Blotting, Western | Mice, Knockout | Point Mutation | Animals | Pneumonia - drug therapy | Spleen - metabolism | CD3 Complex - immunology | Lymphocyte Count | T-Lymphocytes - immunology | Mice, Inbred BALB C | Inducible T-Cell Co-Stimulator Protein - metabolism | Amino Acid Substitution | Protein-Tyrosine Kinases - antagonists & inhibitors | Animal models | Interleukin | Lymphocytes T | Kinases | Lymph nodes | Antibody response | Proteins | Respiratory tract | T-cell receptor | Interleukin 2 | Germinal centers | Lymphocytes | Actin | Rodents | Respiratory tract diseases | Protein-tyrosine kinase | Tyrosine | Respiratory therapy | Ovalbumin | Cytokines | Medical treatment | Animal sciences | Transgenic mice | CD3 antigen | T cell receptors | Inflammation | Allergies | Asthma | Itk protein | Signaling | Molecular modelling | Inhibitors | Mutagenesis | ICOS protein | Point mutation | Alleles | Mice | Mutation | Laboratory animals | Chemokines
Journal Article
The FEBS Journal, ISSN 1742-464X, 06/2011, Volume 278, Issue 12, pp. 2001 - 2010
The TEC family is ancient and constitutes the second largest family of cytoplasmic tyrosine kinases. In 1993, loss‐of‐function mutations in the BTK gene were... 
RLK | ITK | TEC | TXK | BTK | AKT | BMX | X‐linked agammaglobulinemia | PH domain | lymphocyte | X-linked agammaglobulinemia | BIOCHEMISTRY & MOLECULAR BIOLOGY | T-CELL LYMPHOMA | IMMUNOGLOBULIN REPLACEMENT | MICE LACKING | MOLECULAR ANALYSIS | BRUTONS TYROSINE KINASE | LYMPHOPROLIFERATIVE SYNDROME | PROTEASOME INHIBITORS | MUTATION DATABASE | SH3 DOMAIN | Agammaglobulinemia - genetics | Genetic Diseases, X-Linked - enzymology | Protein-Tyrosine Kinases - metabolism | Humans | HIV Infections - enzymology | Intracellular Signaling Peptides and Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Protein-Tyrosine Kinases - genetics | Agammaglobulinemia - enzymology | Epstein-Barr Virus Infections - etiology | Protein-Tyrosine Kinases - chemistry | Epstein-Barr Virus Infections - genetics | Genetic Diseases, X-Linked - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Genetic Association Studies | Signal Transduction | Epstein-Barr Virus Infections - enzymology | Mutant Proteins - genetics | Models, Molecular | Mutant Proteins - metabolism | Recombinant Fusion Proteins - chemistry | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Mutant Proteins - chemistry | Recombinant Fusion Proteins - genetics | HIV Infections - drug therapy | Mice | Enzyme Activation | Mutation | Proteins | Tyrosine | Medical colleges | Epstein-Barr virus | Disease susceptibility | Non-Hodgkin's lymphomas | T cells | Health aspects | Phosphotransferases | Immunosuppressive agents
Journal Article
Journal Article
Journal Article
Blood, ISSN 0006-4971, 2013, Volume 122, Issue 15, pp. 2539 - 2549
Journal Article
Immunity, ISSN 1074-7613, 1999, Volume 11, Issue 4, pp. 399 - 409
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2014, Volume 193, Issue 2, pp. 688 - 699
T cell development in the thymus produces multiple lineages of cells, including innate T cells such as gamma delta TCR+ cells, invariant NKT cells,... 
NKT CELLS | TEC KINASE ITK | GAMMA-DELTA | CYTOKINE PRODUCTION | POSITIVE SELECTION | SIGNALING PATHWAY | IGE PRODUCTION | THYMOCYTE-THYMOCYTE INTERACTION | IN-VIVO | IMMUNOLOGY | MATURATION | Cell Proliferation | Antigens, CD1d - immunology | Thymocytes - metabolism | Receptors, Antigen, T-Cell, alpha-beta - immunology | T-Box Domain Proteins - immunology | Protein-Tyrosine Kinases - deficiency | Interleukin-15 - immunology | Protein-Tyrosine Kinases - immunology | CD4-Positive T-Lymphocytes - immunology | Cell Differentiation - genetics | Signal Transduction - immunology | Protein-Tyrosine Kinases - genetics | Flow Cytometry | Kruppel-Like Transcription Factors - metabolism | Natural Killer T-Cells - metabolism | CD8-Positive T-Lymphocytes - metabolism | Receptors, Antigen, T-Cell, gamma-delta - metabolism | Interleukin-4 - metabolism | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Rats | Receptors, Antigen, T-Cell, gamma-delta - immunology | Signal Transduction - genetics | Interleukin-15 - deficiency | Antigens, CD1d - metabolism | Promyelocytic Leukemia Zinc Finger Protein | T-Box Domain Proteins - metabolism | Mice, Knockout | Thymocytes - immunology | Cell Differentiation - immunology | Interleukin-4 - immunology | Animals | Interleukin-15 - genetics | Mice | Receptors, Antigen, T-Cell, alpha-beta - metabolism | CD8-Positive T-Lymphocytes - immunology | Kruppel-Like Transcription Factors - immunology | Natural Killer T-Cells - immunology
Journal Article
Journal Article