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Oncogene, ISSN 0950-9232, 06/2013, Volume 32, Issue 23, pp. 2848 - 2857
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive neoplastic disease. Gemcitabine, the currently used chemotherapeutic drug for PDAC, elicits only minor... 
eIF4E phosphorylation | MNK2 alternative splicing | drug resistance | MAMMALIAN TARGET | VARIANTS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INITIATION-FACTOR 4E | PROLIFERATION | TRANSLATION | MNK2 | CELL BIOLOGY | OVEREXPRESSION | ONCOLOGY | GENETICS & HEREDITY | EIF4E | KINASES | Phosphorylation | Pancreatic Neoplasms - metabolism | Humans | Middle Aged | Carcinoma, Pancreatic Ductal - metabolism | Eukaryotic Initiation Factor-4E - metabolism | Deoxycytidine - pharmacology | Drug Resistance, Neoplasm | Intracellular Signaling Peptides and Proteins - metabolism | Pancreatic Neoplasms - drug therapy | RNA Splicing | Isoenzymes - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Aged, 80 and over | Adult | Antimetabolites, Antineoplastic - pharmacology | Carcinoma, Pancreatic Ductal - mortality | Pancreatic Neoplasms - mortality | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Cell Survival - drug effects | Signal Transduction | Isoenzymes - genetics | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Kaplan-Meier Estimate | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Drug Synergism | Carcinoma, Pancreatic Ductal - drug therapy | Serine-Arginine Splicing Factors | Cell Line, Tumor | Aged | Protein Processing, Post-Translational | Deoxycytidine - analogs & derivatives | Isoenzymes - antagonists & inhibitors | RNA-Binding Proteins - metabolism | Apoptosis | Adenocarcinoma | Complications and side effects | Gemcitabine | Pancreatic cancer | Physiological aspects | Genetic aspects | Cellular signal transduction | Dosage and administration | Research | Drug therapy | Ribonucleic acid--RNA | Cells | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2019, Volume 162, pp. 735 - 751
The mitogen-activated protein kinase-interacting kinases 1 and 2 (MNK1 and MNK2) phosphorylate eukaryotic initiation factor 4E (eIF4E) and play important roles... 
Mnk | Selective inhibitor | Thieno[2,3-d]pyrimidine | eIF4E inhibition | CHEMISTRY, MEDICINAL | ACTIVATED PROTEIN-KINASE | PHOSPHORYLATION | INITIATION-FACTOR 4E | DISCOVERY | TRANSLATIONAL CONTROL | POTENT | INTERACTING KINASES | EXPRESSION | BINDING | EIF4E | Index Medicus
Journal Article
The EMBO Journal, ISSN 0261-4189, 04/1997, Volume 16, Issue 8, pp. 1909 - 1920
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2017, Volume 139, pp. 762 - 772
Journal Article
ChemMedChem, ISSN 1860-7179, 05/2014, Volume 9, Issue 5, pp. 962 - 972
Journal Article
Journal Article
MOLECULAR AND CELLULAR BIOLOGY, ISSN 0270-7306, 08/2004, Volume 24, Issue 15, pp. 6539 - 6549
Mnk1 and Mnk2 are protein kinases that are directly phosphorylated and activated by extracellular signal-regulated kinase (ERK) or p38 mitogen-activated... 
SIGNAL-TRANSDUCTION | ADULT CARDIOCYTES | FACTOR EIF-4E | CAP-BINDING PROTEIN | ACTIVATED PROTEIN-KINASE | CYCLIN D1 | EIF4E PHOSPHORYLATION | POSTTRANSCRIPTIONAL LEVELS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSLATION INITIATION | D1 MESSENGER-RNA | CELL BIOLOGY
Journal Article
CHEMMEDCHEM, ISSN 1860-7179, 05/2014, Volume 9, Issue 5, pp. 962 - 972
Phosphorylation of eIF4E by human mitogen-activated protein kinase (MAPK)-interacting kinases (Mnks) is crucial for human tumourigenesis and development.... 
ACTIVATION | CHEMISTRY, MEDICINAL | apoptosis | CRYSTAL-STRUCTURES | GLIDE | KINASE INHIBITORS | CONFORMATION | CGP57380 | eIF4E phosphorylation | CDK INHIBITORS | ACCURATE DOCKING | GROWTH | PHARMACOLOGY & PHARMACY | SELECTIVITY | anticancer drug discovery | Mnk inhibitors
Journal Article
Journal of Cell Science, ISSN 0021-9533, 2013, Volume 126, Issue 18, pp. 4195 - 4207
Plectin is a versatile cytolinker of the plakin family conferring cell resilience to mechanical stress in stratified epithelia and muscles. It acts as a... 
Plakin | Cytoskeleton | Plectin | Protein phosphorylation | Intermediate filaments | ACTIVATED PROTEIN-KINASE | MECHANISM | DESMOPLAKIN | IDENTIFICATION | CELL BIOLOGY | VIMENTIN | INTEGRIN ALPHA-6-BETA-4 | SUBSTRATE | INHIBITOR | STRESS | BINDING
Journal Article
Science Signaling, ISSN 1945-0877, 02/2012, Volume 5, Issue 211, pp. ra14 - ra14
Journal Article