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American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 12/2013, Volume 188, Issue 11, pp. 1313 - 1320
Journal Article
NATURE CELL BIOLOGY, ISSN 1465-7392, 04/2011, Volume 13, Issue 4, pp. 434 - U208
The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type2 diabetes mellitus so far remains elusive.... 
CAENORHABDITIS-ELEGANS | LIPID-METABOLISM | SMALL RNAS | AKT/PROTEIN-KINASE-B | DOWN-REGULATION | FAT-METABOLISM | TYPE-2 DIABETES-MELLITUS | GENOME-WIDE ASSOCIATION | RECEPTOR SUBSTRATE-1 | ADIPOSE-TISSUE | CELL BIOLOGY
Journal Article
by Lin, AF and Hu, QS and Li, CL and Xing, Z and Ma, GL and Wang, C and Li, J and Ye, Y and Yao, J and Liang, K and Wang, SY and Park, PK and Marks, JR and Zhou, Y and Zhou, JW and Hung, MC and Liang, H and Hu, ZB and Shen, HB and Hawke, DH and Han, L and Zhou, YB and Lin, CR and Yang, LQ
NATURE CELL BIOLOGY, ISSN 1465-7392, 03/2017, Volume 19, Issue 3, pp. 238 - 251
Phosphatidylinositol-3,4,5-trisphosphate (Ptdlns(3,4,5)P-3 or PIP3) mediates signalling pathways as a second messenger in response to extracellular signals.... 
BREAST-CANCER | INOSITOL PHOSPHATES | IN-VITRO | PROTEIN-KINASE-B | LONG NONCODING RNA | SOLID TUMORS | SIGNALING PATHWAY | PLECKSTRIN HOMOLOGY DOMAIN | GLOBAL ANALYSIS | HIGH-AFFINITY BINDING | CELL BIOLOGY
Journal Article
Behavioural Brain Research, ISSN 0166-4328, 11/2019, Volume 373, p. 112080
Vagus nerve stimulation (VNS) is being explored as a potential therapeutic for Parkinson’s disease (PD). VNS is less invasive than other surgical treatments... 
Vagus nerve stimulation | Norepinephrine | Brain-derived neurotrophic factor | Dopamine | Parkinson’s disease | Tropomyosin receptor kinase B
Journal Article
MOLECULAR CELL, ISSN 1097-2765, 05/2004, Volume 14, Issue 3, pp. 395 - 403
Skeletal muscle size depends upon a dynamic balance between anabolic (or hypertrophic) and catabolic (or atrophic) processes. Previously, no link between the... 
MAMMALIAN TARGET | INSULIN | RAPAMYCIN | SKELETAL-MUSCLE | HYPERTROPHY | PROTEIN-KINASE-B | PROTEASOME PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | DIFFERENTIATION | IDENTIFICATION | CELL BIOLOGY
Journal Article
Molecular Cell, ISSN 1097-2765, 04/2008, Volume 30, Issue 2, pp. 203 - 213
Protein kinase B (PKB/Akt) is a well-established regulator of several essential cellular processes. Here, we report a route by which activated PKB promotes... 
CELLCYCLE | DNA | SIGNALING | DEPENDENT PROTEIN | COMPLEX | PROTEIN-KINASE-B | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | MDM2 | INDEPENDENT ACTIVATION | DAMAGE | P53 | REVEALS | CELL BIOLOGY
Journal Article
Nature, ISSN 0028-0836, 06/2007, Volume 447, Issue 7147, pp. 1012 - 1016
Type 2 diabetes mellitus, a disease with significant effects on the health and economy of Western societies, involves disturbances in both lipid and... 
INSULIN | ACTIVATION | PROTEIN-KINASE-B | GLUCONEOGENESIS | FATTY LIVER-DISEASE | GLUCOSE | MULTIDISCIPLINARY SCIENCES | CARDIOVASCULAR-DISEASE | PGC-1 | EXPRESSION | RECEPTOR-ALPHA | Proteins | Phosphorylation | Diabetes mellitus | Liver | Lipids | Kinases | Metabolism | Insulin
Journal Article
Molecular Cell, ISSN 1097-2765, 02/2017, Volume 65, Issue 3, pp. 416 - 431.e6
Protein kinase B/Akt regulates cellular metabolism, survival, and proliferation in response to hormones and growth factors. Hyperactivation of Akt is... 
protein kinase B/Akt | fluorescence correlation spectroscopy | fluorescence cross-correlation spectroscopy | signal transduction | cellular signaling | phosphatidylinositol-3,4,5-trisphosphate | cellular membranes | AGC kinases | protein phosphatases | allostery | Index Medicus
Journal Article
Cytokine, ISSN 1043-4666, 11/2019, Volume 123, pp. 154764 - 154764
Brain-derived neurotrophic factor (BDNF) has been reported to be involved in the pathogenesis of autoimmune diseases and tyrosine kinase B (TrkB) is the... 
Brain-derived neurotrophic factor | tyrosine kinase B | T lymphocyte | Systemic involvement | Index Medicus
Journal Article
Cancer Discovery, ISSN 2159-8274, 05/2012, Volume 2, Issue 5, pp. 401 - 404
The cBio Cancer Genomics Portal (http://cbioportal.org) is an open-access resource for interactive exploration of multidimensional cancer genomics data sets,... 
NETWORK | MUTATIONS | ONCOLOGY | OVARIAN-CARCINOMA | GENES | Internet | Neoplasms - genetics | Database Management Systems | Genomics | Humans | Databases, Factual | Index Medicus
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 05/2008, Volume 68, Issue 9, pp. 3429 - 3439
B-Raf is the most mutated gene in melanoma; however, the mechanism through which it promotes early melanomas remains uncertain. Most nevi contain activated... 
ONCOLOGY | BRAF MUTATIONS | RAF | THERAPEUTIC TARGET | GROWTH-FACTORS | TUMOR | MALIGNANT-MELANOMA | ACTIVATED AKT | CELL-CYCLE PROGRESSION | PROTEIN-KINASE B | NEVI
Journal Article
Nature, ISSN 0028-0836, 05/2003, Volume 423, Issue 6939, pp. 550 - 555
Hepatic gluconeogenesis is absolutely required for survival during prolonged fasting or starvation, but is inappropriately activated in diabetes mellitus.... 
CARBOXYKINASE GTP GENE | FORKHEAD TRANSCRIPTION FACTOR | PHOSPHOENOLPYRUVATE CARBOXYKINASE | PROTEIN-KINASE-B | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | COACTIVATOR PGC-1 | FACTOR FKHR | FACTOR FOXO1 | EXPRESSION | BETA
Journal Article
Cell, ISSN 0092-8674, 06/2007, Volume 129, Issue 5, pp. 957 - 968
Ras proteins signal through direct interaction with a number of effector enzymes, including type I phosphoinositide (PI) 3-kinases. Although the ability of Ras... 
CELLBIO | HUMDISEASE | SIGNALING | TRANSFORMATION | ACTIVATION | INHIBITION | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEFICIENT | GROWTH-FACTOR | CANCER | PROTEIN-KINASE B | VEGF RECEPTOR-3 | DROSOPHILA | CELL BIOLOGY
Journal Article
International Journal of Immunopathology and Pharmacology, ISSN 0394-6320, 2012, Volume 25, Issue 3, pp. 627 - 636
Journal Article
MOLECULAR THERAPY, ISSN 1525-0016, 02/2010, Volume 18, Issue 2, pp. 413 - 420
To enhance the strength of activation afforded by tumor antigen-specific receptors, we investigated the effect of adding combined CD28 and 4-1BB costimulatory... 
MEDICINE, RESEARCH & EXPERIMENTAL | BCL-X-L | IMMUNITY | EFFECTOR FUNCTION | PROTEIN-KINASE B | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IN-VIVO | GENETICS & HEREDITY | COSTIMULATION | LIGAND | ADOPTIVE IMMUNOTHERAPY | ANTITUMOR EFFICACY | LYMPHOCYTES
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 11/2010, Volume 299, Issue 5, pp. 1535 - 1545
Selective serotonin reuptake inhibitors (SSRIs) are known to reduce post-myocardial infarction-induced morbidity and mortality. However, the molecular... 
Endothelial nitric oxide synthase | Protein kinase B | Akt
Journal Article
Nature Genetics, ISSN 1061-4036, 08/2012, Volume 44, Issue 8, pp. 934 - 940
Journal Article
Current Cancer Drug Targets, ISSN 1568-0096, 05/2008, Volume 8, Issue 3, pp. 187 - 198
PTEN/PI3K/AKT constitutes an important pathway regulating the signaling of multiple biological processes such as apoptosis, metabolism, cell proliferation and... 
PTEN | AKT | Drug discovery |