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1. Full Text Substrate affinity differentially influences protein kinase C regulation and inhibitor potency
by Sommese, Ruth F and Sivaramakrishnan, Sivaraj
The Journal of biological chemistry, ISSN 0021-9258, 10/2016, Volume 291, Issue 42, pp. 21963 - 21970
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Kinase C-alpha - antagonists & inhibitors | Protein Kinase Inhibitors - chemistry | Sf9 Cells | Animals | Protein Kinase C-alpha - metabolism | Protein Kinase C-alpha - chemistry | Humans | Protein Kinase C-alpha - genetics | Fluorescence Resonance Energy Transfer | Substrate Specificity | Spodoptera | Index Medicus | inhibitor | Enzymology | fluorescence resonance energy transfer (FRET) | phosphorylation | protein kinase C (PKC) | substrate specificity
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2. Full Text A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle
by Goode, Benjamin and Mondal, Gourish and Hyun, Michael and Ruiz, Diego Garrido and Lin, Yu-Hsiu and Van Ziffle, Jessica and Joseph, Nancy M and Onodera, Courtney and Talevich, Eric and Grenert, James P and Hewedi, Iman H and Snuderl, Matija and Brat, Daniel J and Kleinschmidt-Demasters, Bette K and Rodriguez, Fausto J and Louis, David N and Yong, William H and Lopes, M. Beatriz and Rosenblum, Marc K and Butowski, Nicholas and Tihan, Tarik and Bollen, Andrew W and Phillips, Joanna J and Wiita, Arun P and Yeh, Iwei and Jacobson, Matthew P and Bastian, Boris C and Perry, Arie and Solomon, David A
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1 - 8
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Brain | Protein kinase C | Astrocytes | Brain tumors | Brain cancer | Extracellular signal-regulated kinase | Ventricles (cerebral) | Glial cells | Kinases | Missense mutation | Glioma | Mutation | Ventricle | Tumors | Index Medicus
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3. Full Text MicroRNAā€328 is associated with (nonā€small) cell lung cancer (NSCLC) brain metastasis and mediates NSCLC migration
by Arora, Shilpi and Ranade, Aarati R and Tran, Nhan L and Nasser, Sara and Sridhar, Shravan and Korn, Ronald L and Ross, Julianna T.D and Dhruv, Harshil and Foss, Kristen M and Sibenaller, Zita and Ryken, Timothy and Gotway, Michael B and Kim, Seungchan and Weiss, Glen J
International journal of cancer, ISSN 0020-7136, 12/2011, Volume 129, Issue 11, pp. 2621 - 2631
migration | microRNA | brain metastasis | biomarker | nonā€small cell lung cancer | non-small cell lung cancer | Life Sciences & Biomedicine | Oncology | Science & Technology | Tumors of the respiratory system and mediastinum | Biological and medical sciences | Medical sciences | Tumors | Pneumology | RNA, Small Interfering - genetics | Cell Proliferation | Oligonucleotide Array Sequence Analysis | Protein Kinase C-alpha - metabolism | Carcinoma, Squamous Cell - genetics | Humans | Middle Aged | Protein Kinase C-alpha - genetics | Lung Neoplasms - pathology | Male | Gene Expression Profiling | Brain Neoplasms - secondary | Carcinoma, Non-Small-Cell Lung - secondary | Biomarkers, Tumor - metabolism | Adult | Female | Adenocarcinoma - genetics | Tumor Cells, Cultured | Lung Neoplasms - genetics | Protein Kinase C-alpha - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - genetics | RNA, Messenger - genetics | Brain Neoplasms - genetics | Reverse Transcriptase Polymerase Chain Reaction | Cell Adhesion | Adenocarcinoma - secondary | Blotting, Western | Carcinoma, Squamous Cell - secondary | Aged | Biomarkers, Tumor - genetics | MicroRNAs - genetics | Cell Movement | Index Medicus
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4. Full Text Direct evidence that PKCĪ± positively regulates wound reā€epithelialization: correlation with changes in desmosomal adhesiveness
by Thomason, Helen A and Cooper, Nichola H and Ansell, David M and Chiu, Maybo and Merrit, Anita J and Hardman, Matthew J and Garrod, David R
The Journal of pathology, ISSN 0022-3417, 07/2012, Volume 227, Issue 3, pp. 346 - 356
desmosome | wound healing | PKCĪ± | keratinocyte | hyperā€adhesion | reā€epithelialization | Pathology | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Proliferation | Desmosomes - drug effects | Protein Kinase C-alpha - metabolism | Calcium - metabolism | Humans | Protein Kinase C-alpha - genetics | Desmosomes - enzymology | Desmosomes - pathology | Dose-Response Relationship, Drug | Time Factors | Keratinocytes - enzymology | Wound Healing - drug effects | Protein Kinase C-alpha - deficiency | Cell Line | Protein Kinase C-alpha - antagonists & inhibitors | Signal Transduction | Mice, Inbred C57BL | Genotype | Mice, Transgenic | Cell Adhesion - drug effects | Mice, Knockout | Point Mutation | Keratinocytes - pathology | Phenotype | Animals | Keratinocytes - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Apoptosis | Cell Movement | Index Medicus
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5. Full Text Mitotic lamin disassembly is triggered by lipid-mediated signaling
by Mall, Moritz and Walter, Thomas and GorjƔnƔcz, MƔtyƔs and Davidson, Iain F and Ly-Hartig, Thi Bach Nga and Ellenberg, Jan and Mattaj, Iain W
The Journal of cell biology, ISSN 0021-9525, 09/2012, Volume 198, Issue 6, pp. 981 - 990
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Amino Acid Sequence | Cell Line | Protein Kinase C - genetics | Protein Kinase C beta | CDC2 Protein Kinase - genetics | Phosphorylation | Lamin Type B - genetics | Protein Kinase C-alpha - metabolism | Signal Transduction | Humans | Protein Kinase C-alpha - genetics | Molecular Sequence Data | Organic Chemicals - metabolism | Nuclear Proteins - metabolism | Mitosis - genetics | Lamin Type B - metabolism | CDC2 Protein Kinase - metabolism | Mitosis - physiology | RNA Interference | Protein Kinase C - metabolism | HeLa Cells | Nuclear Proteins - genetics | Lipid Metabolism - physiology | Physiological aspects | Lipids | Eukaryotes | Research | Mitosis | Health aspects | Cell division | Kinases | Index Medicus | CDC2 Protein Kinase | Organic Chemicals | Quantitative Methods | Lamin Type B | Computer Vision and Pattern Recognition | Lipid Metabolism | Nuclear Proteins | Life Sciences | Image Processing | Computer Science | Protein Kinase C-alpha | Bioinformatics | Protein Kinase C
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6. Full Text Biological or pharmacological activation of protein kinase C alpha constrains hepatitis E virus replication
by Wang, Wenshi and Wang, Yijin and Debing, Yannick and Zhou, Xinying and Yin, Yuebang and Xu, Lei and Herrera Carrillo, Elena and Brandsma, Johannes H and Poot, Raymond A and Berkhout, Ben and Neyts, Johan and Peppelenbosch, Maikel P and Pan, Qiuwei
Antiviral research, ISSN 0166-3542, 04/2017, Volume 140, pp. 1 - 12
PKCĪ± | ISG | PMA | AP-1 | Hepatitis E virus | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Science & Technology | Virology | Protein Kinase C-alpha - antagonists & inhibitors | Virus Replication - drug effects | Antiviral Agents - pharmacology | Hepatitis E - drug therapy | Tetradecanoylphorbol Acetate - pharmacology | Protein Kinase C-alpha - metabolism | Signal Transduction | Transcription Factor AP-1 - genetics | Humans | Protein Kinase C-alpha - genetics | Transcriptional Activation | DNA Replication | Protein Kinase Inhibitors - isolation & purification | Transcription Factor AP-1 - metabolism | Host-Pathogen Interactions | Hepatitis E virus - physiology | Hepatocytes - virology | Protein Kinase Inhibitors - pharmacology | Cell Culture Techniques | Enzyme Activation | Antiviral Agents - isolation & purification | Protein Kinase C-alpha - deficiency | Replicon | Medical colleges | Hepatitis E | Analysis | Medical genetics | Interferon | Biological response modifiers | Health aspects | Drug approval | Protein kinases | Cells | Medical research | Luciferase | Medicine, Experimental | Index Medicus
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7. Full Text Structural Basis of Protein Kinase CĪ± Regulation by the C-Terminal Tail
by Yang, Yuan and Shu, Chang and Li, Pingwei and Igumenova, Tatyana I
Biophysical journal, ISSN 0006-3495, 04/2018, Volume 114, Issue 7, pp. 1590 - 1603
Life Sciences & Biomedicine | Biophysics | Science & Technology | Amino Acid Sequence | Animals | Protein Kinase C-alpha - metabolism | Calcium - metabolism | Protein Kinase C-alpha - chemistry | Protein Kinase C-alpha - genetics | Hydrophobic and Hydrophilic Interactions | Protein Domains | Rats | Mutation | Static Electricity | Amino Acid Motifs | Index Medicus | Proteins
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8. Full Text Inhibition of FcĪµRI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes
by Melendez, Alirio J and Harnett, Margaret M and Pushparaj, Peter N and Wong, Ws Fred and Tay, Hwee Kee and McSharry, Charles P and Harnett, William
Nature medicine, ISSN 1078-8956, 11/2007, Volume 13, Issue 11, pp. 1375 - 1381
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Calcium - metabolism | Humans | Protein Kinase C-alpha - genetics | Protein Kinase C-alpha - biosynthesis | Calcium - antagonists & inhibitors | Signal Transduction - immunology | Bone Marrow Cells - immunology | Helminth Proteins - physiology | Mast Cells - metabolism | Female | Cell Line | Mast Cells - immunology | Protein Kinase C-alpha - antagonists & inhibitors | Receptors, IgE - physiology | Mast Cells - parasitology | Cells, Cultured | Rats | Receptors, IgE - antagonists & inhibitors | Cell Degranulation - immunology | Bone Marrow Cells - parasitology | Animals | Down-Regulation - immunology | Filarioidea - immunology | Mice | Mice, Inbred BALB C | Bone Marrow Cells - metabolism | Index Medicus
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9. Full Text Protein Kinase C Ī± Is a Central Signaling Node and Therapeutic Target for Breast Cancer Stem Cells
by Tam, WaiĀ Leong and Lu, Haihui and Buikhuisen, Joyce and Soh, BoonĀ Seng and Lim, Elgene and Reinhardt, Ferenc and Wu, ZhenhuaĀ Jeremy and Krall, JordanĀ A and Bierie, Brian and Guo, Wenjun and Chen, Xi and Liu, XiaoleĀ Shirley and Brown, Myles and Lim, Bing and Weinberg, RobertĀ A
Cancer cell, ISSN 1535-6108, 09/2013, Volume 24, Issue 3, pp. 347 - 364
Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Kinase C-alpha - metabolism | Humans | Gene Expression Regulation, Neoplastic | Antineoplastic Agents - therapeutic use | Gene Expression Profiling | Extracellular Signal-Regulated MAP Kinases - metabolism | Epithelial-Mesenchymal Transition - genetics | Breast Neoplasms - metabolism | Receptor, Epidermal Growth Factor - metabolism | Neoplastic Stem Cells - metabolism | Cell Transformation, Neoplastic - genetics | Female | Antineoplastic Agents - pharmacology | Snail Family Transcription Factors | Protein Kinase C-alpha - antagonists & inhibitors | Proto-Oncogene Proteins c-fos - metabolism | Breast Neoplasms - drug therapy | Cell Transformation, Neoplastic - metabolism | Transcription Factors - metabolism | Breast Neoplasms - genetics | Signal Transduction - drug effects | Protein Kinase Inhibitors - therapeutic use | Receptors, Platelet-Derived Growth Factor - metabolism | Cell Line, Tumor | Proto-Oncogene Proteins c-fos - genetics | Protein Kinase Inhibitors - pharmacology | Twist-Related Protein 1 - metabolism | Cluster Analysis | Index Medicus
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10. Full Text The role of regulatory domains in maintaining autoinhibition in the multidomain kinase PKCĪ±
by Sommese, Ruth F and Ritt, Michael and Swanson, Carter J and Sivaramakrishnan, Sivaraj
The Journal of biological chemistry, ISSN 0021-9258, 02/2017, Volume 292, Issue 7, pp. 2873 - 2880
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Kinase C-alpha - antagonists & inhibitors | Catalytic Domain | Sf9 Cells | Animals | Protein Kinase C-alpha - metabolism | Protein Kinase C-alpha - chemistry | Humans | Fluorescence Resonance Energy Transfer | Substrate Specificity | Catalysis | Mutation | Protein Transport | Index Medicus | protein domain | inhibition mechanism | Signal Transduction | fluorescence resonance energy transfer (FRET) | protein kinase C (PKC) | protein translocation
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