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1. Full Text Tackling the cancer stem cells-what challenges do they pose?
by Pattabiraman, Diwakar R and Weinberg, Robert A
Nature Reviews Drug Discovery, ISSN 1474-1776, 2014, Volume 13, Issue 7, pp. 497 - 512
Since their identification in 1994, cancer stem cells (CSCs) have been objects of intensive study. Their properties and mechanisms of formation have become a... 
EPITHELIAL-MESENCHYMAL TRANSITION | PROGENITOR CELLS | GROWTH-FACTOR-BETA | TGF-BETA | SIDE POPULATION CELLS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ENDOTHELIAL-CELLS | ALDEHYDE DEHYDROGENASE 1 | KINASE-C-ALPHA | TUMOR-ASSOCIATED MACROPHAGES | PHARMACOLOGY & PHARMACY | ACUTE MYELOID-LEUKEMIA | Neoplasms - metabolism | Neoplastic Stem Cells - metabolism | Neoplastic Stem Cells - drug effects | Humans | Neoplastic Stem Cells - pathology | Epithelial-Mesenchymal Transition - drug effects | Antineoplastic Agents - therapeutic use | Gene Expression Regulation, Neoplastic - drug effects | Neoplasms - pathology | Neoplasms - drug therapy | Care and treatment | Cell research | Stem cells | Cancer cells | Innovations | Physiological aspects | Cellular signal transduction | Research | Cancer | CSC | Targeting | Cancer Stem Cell | EMT | Epithelial-Mesenchymal Transition
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2. Full Text The Role of the GluR2 Subunit in AMPA Receptor Function and Synaptic Plasticity
by Isaac, John T.R and Ashby, Michael C and McBain, Chris J
Neuron, ISSN 0896-6273, 2007, Volume 54, Issue 6, pp. 859 - 871
The AMPA receptor (AMPAR) GluR2 subunit dictates the critical biophysical properties of the receptor, strongly influences receptor assembly and trafficking,... 
CA2+-PERMEABLE AMPA | CALCIUM-PERMEABLE AMPA | NEOCORTICAL NEURONS | DOMAIN-CONTAINING PROTEINS | IONOTROPIC GLUTAMATE RECEPTORS | IN-VIVO | INTERNEURON DIVERSITY SERIES | KINASE-C-ALPHA | LONG-TERM POTENTIATION | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | Animals | Neuronal Plasticity - physiology | Receptors, AMPA - physiology | Calcium - metabolism | Models, Biological | Synapses - physiology | Receptors, AMPA - chemistry | Editing | Permeability | Gene expression | Polyamines | Rodents
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3. Full Text Urea and ammonia metabolism and the control of renal nitrogen excretion
by Weiner, I. David and Mitch, William E and Sands, Jeff M
Clinical Journal of the American Society of Nephrology, ISSN 1555-9041, 08/2015, Volume 10, Issue 8, pp. 1444 - 1458
Renal nitrogen metabolism primarily involves urea and ammonia metabolism, and is essential to normal health. Urea is the largest circulating pool of nitrogen,... 
URINARY CONCENTRATING DEFECT | MEMBRANE ACCUMULATION | SODIUM-BICARBONATE | DIETARY-PROTEIN | MEDULLARY COLLECTING DUCTS | KINASE-C-ALPHA | UROLOGY & NEPHROLOGY | CHRONIC UREMIC PATIENTS | CHRONIC KIDNEY-DISEASE | GLUTAMINE TRANSPORTER | MOLECULAR-MECHANISMS | Kidney - metabolism | Animals | Ammonia - metabolism | Kidney Concentrating Ability | Models, Biological | Humans | Membrane Transport Proteins - metabolism | Urea - metabolism | Water-Electrolyte Balance | Renal Elimination | Renal Physiology | acidosis | urea
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4. Full Text Signaling effectors underlying pathologic growth and remodeling of the heart
by Van Berlo, Jop H and Maillet, Marjorie and Molkentin, Jeffery D
Journal of Clinical Investigation, ISSN 0021-9738, 01/2013, Volume 123, Issue 1, pp. 37 - 45
Cardiovascular disease is the number one cause of mortality in the Western world. The heart responds to many cardiopathological conditions with hypertrophic... 
MEDICINE, RESEARCH & EXPERIMENTAL | HIGH-BLOOD-PRESSURE | MYOCARDIAL-INFARCTION | BETA-ADRENERGIC-RECEPTOR | IN-VIVO | KINASE-C-ALPHA | T-CELL LYMPHOMA | LEFT-VENTRICULAR MASS | PROTEIN PHOSPHATASE 2A | ENHANCES CARDIAC CONTRACTILITY | HISTONE DEACETYLASE | Arrhythmias, Cardiac - mortality | Humans | Heart Failure - physiopathology | Cardiomegaly - pathology | Arrhythmias, Cardiac - physiopathology | Arrhythmias, Cardiac - pathology | Ventricular Remodeling | Cardiomegaly - mortality | Heart Failure - etiology | Disease Models, Animal | Heart Failure - mortality | Arrhythmias, Cardiac - metabolism | Death, Sudden - epidemiology | Signal Transduction | Cardiomegaly - drug therapy | Cardiomegaly - physiopathology | Arrhythmias, Cardiac - etiology | Clinical Trials as Topic | Heart Failure - metabolism | Heart Failure - pathology | Cardiomegaly - complications | Heart Failure - drug therapy | Arrhythmias, Cardiac - drug therapy | Animals | Cardiomegaly - metabolism | Heart | Physiological aspects | Care and treatment | Cardiovascular diseases | Health aspects | Risk factors | Review Series
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5. Full Text Glucose enhances aggrecan expression in chondrocytes via the PKC/p38-miR141-3p signaling pathway
by Wu, TJ and Fong, YC and Lin, CY and Huang, YL and Tang, CH
JOURNAL OF CELLULAR PHYSIOLOGY, ISSN 0021-9541, 09/2018, Volume 233, Issue 9, pp. 6878 - 6887
Aggrecan is a high molecular weight proteoglycan that plays a critical role in cartilage structure and the function of joints, providing intervertebral disc... 
prolotherapy | glucose | PHYSIOLOGY | osteoarthritis | INVOLVEMENT | KINASE-C-ALPHA | CELL BIOLOGY | aggrecan | CROSS-TALK | MICRORNA-141-3P | DEXTROSE PROLOTHERAPY | ROLES | microRNA | MESENCHYMES | INJECTIONS | KNEE OSTEOARTHRITIS | REGULATES CHONDROGENESIS | Osteoarthritis | Dextrose | Glucose
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6. Full Text Hypoxic gene activation by lipopolysaccharide in macrophages: Implication of hypoxia-inducible factor 1α
by Blouin, Caroline C and Pagé, Elisabeth L and Soucy, Guylaine M and Richard, Darren E
Blood, ISSN 0006-4971, 02/2004, Volume 103, Issue 3, pp. 1124 - 1130
Hypoxia-inducible factor 1 (HIF-1) regulates many genes induced by low oxygen conditions. The expression of important hypoxic genes such as glucose transporter... 
RAT HEPATOCYTES | SIGNALING PATHWAY | KINASE-C-ALPHA | NITRIC-OXIDE | TUMOR-SUPPRESSOR PROTEIN | FACTOR EXPRESSION | SMOOTH-MUSCLE-CELLS | FACTOR-I | HEMATOLOGY | TRANSCRIPTION FACTOR | ENDOTHELIAL GROWTH-FACTOR
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7. Full Text Protein Kinase C α Is a Central Signaling Node and Therapeutic Target for Breast Cancer Stem Cells
by Tam, Wai Leong and Lu, Haihui and Buikhuisen, Joyce and Soh, Boon Seng and Lim, Bing and Lim, Elgene and Reinhardt, Ferenc and Wu, Zhenhua Jeremy and Krall, Jordan A and Bierie, Brian and Guo, Wenjun and Chen, Xi and Liu, Xiaole Shirley and Brown, Myles and Weinberg, Robert A
Cancer Cell, ISSN 1535-6108, 09/2013, Volume 24, Issue 3, pp. 347 - 364
The epithelial-mesenchymal transition program becomes activated during malignant progression and can enrich for cancer stem cells (CSCs). We report that... 
EPITHELIAL-MESENCHYMAL TRANSITION | HETEROGENEITY | ONCOLOGY | PHOSPHORYLATION | DISEASE | DETERMINANT | SENSITIVITY | FACTOR RECEPTOR INHIBITION | GROWTH-FACTOR | LINES | FIBROBLASTS | CELL BIOLOGY | Protein Kinase C-alpha - metabolism | Humans | Gene Expression Regulation, Neoplastic | Antineoplastic Agents - therapeutic use | Gene Expression Profiling | Extracellular Signal-Regulated MAP Kinases - metabolism | Epithelial-Mesenchymal Transition - genetics | Breast Neoplasms - metabolism | Receptor, Epidermal Growth Factor - metabolism | Neoplastic Stem Cells - metabolism | Cell Transformation, Neoplastic - genetics | Female | Antineoplastic Agents - pharmacology | Snail Family Transcription Factors | Protein Kinase C-alpha - antagonists & inhibitors | Proto-Oncogene Proteins c-fos - metabolism | Breast Neoplasms - drug therapy | Cell Transformation, Neoplastic - metabolism | Transcription Factors - metabolism | Breast Neoplasms - genetics | Signal Transduction - drug effects | Protein Kinase Inhibitors - therapeutic use | Receptors, Platelet-Derived Growth Factor - metabolism | Cell Line, Tumor | Proto-Oncogene Proteins c-fos - genetics | Protein Kinase Inhibitors - pharmacology | Twist-Related Protein 1 - metabolism | Cluster Analysis
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8. Full Text Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment
by Honigmann, A and Bogaart, G. van den and Iraheta, E and Risselada, H.J and Milovanovic, D and Mueller, V and Mullar, S and Diederichsen, U and Fasshauer, D and Grubmuller, H and Hell, S.W and Eggeling, C and Kuhnel, K and Jahn, R
Nature Structural & Molecular Biology, ISSN 1545-9993, 2013, Volume 20, Issue 6, pp. 679 - 686
Synaptic-vesicle exocytosis is mediated by the vesicular Ca(2+) sensor synaptotagmin-1. Synaptotagmin-1 interacts with the SNARE protein syntaxin-1A and acidic... 
C2B DOMAIN | NEUROTRANSMITTER RELEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE-C-ALPHA | LIPID INTERACTIONS | SNARE | CELL BIOLOGY | MEMBRANE-FUSION | SYNAPTOTAGMIN-I | BIOPHYSICS | PKC-ALPHA-C2 DOMAIN | STED NANOSCOPY | BINDING | Synaptic Vesicles - metabolism | Models, Molecular | Rats | Crystallography, X-Ray | Synaptotagmin I - chemistry | Syntaxin 1 - metabolism | Exocytosis | PC12 Cells | Phosphatidylinositol 4,5-Diphosphate - metabolism | Animals | Models, Biological | Synaptotagmin I - metabolism | Protein Binding | Protein Conformation | Membrane fusion | Crystals | Synaptic vesicles | Phospholipids | Research | Properties | Structure | Observations | Membrane proteins | Phosphates | Lipids | Membranes | Molecular biology | Binding sites | Crystal structure
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9. Full Text The microRNA-200 family: Small molecules with novel roles in cancer development, progression and therapy
by Humphries, Brock and Yang, Chengfeng
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 9, pp. 6472 - 6498
MicroRNAs (miRNAs) are a large family of small non-coding RNAs that negatively regulate protein-coding gene expression post-transcriptionally via base pairing... 
Cancer therapeutic target | Cancer metastasis | MicroRNA | Mir-200 | Cancer initiation | KINASE-C-ALPHA | DOWN-REGULATION | cancer initiation | E-CADHERIN | INDUCED MALIGNANT-TRANSFORMATION | MIR-200 FAMILY | NEGATIVE FEEDBACK LOOP | cancer therapeutic target | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | GASTRIC-CANCER | miR-200 | PROSTATE-CANCER | microRNA | cancer metastasis | Neoplasms - metabolism | Predictive Value of Tests | Cell Proliferation | Prognosis | Neoplasm Invasiveness | Humans | Gene Expression Regulation, Neoplastic | MicroRNAs - metabolism | Antineoplastic Agents - therapeutic use | Cell Transformation, Neoplastic - metabolism | Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | Neoplasm Metastasis | Animals | Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | Epithelial-Mesenchymal Transition | Biomarkers, Tumor - metabolism | Biomarkers, Tumor - genetics | MicroRNAs - genetics | Cell Transformation, Neoplastic - pathology | Neoplasms - pathology | Cell Movement
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10. Full Text Glutamate transporters: confining runaway excitation by shaping synaptic transmission
by Tzingounis, Anastassios V and Wadiche, Jacques I
Nature Reviews Neuroscience, ISSN 1471-003X, 12/2007, Volume 8, Issue 12, pp. 935 - 947
Traditionally, glutamate transporters have been viewed as membrane proteins that harness the electrochemical gradient to slowly transport glutamate from the... 
AMINO-ACID TRANSPORTER | CEREBELLAR PURKINJE-CELLS | KINASE-C-ALPHA | BERGMANN GLIAL-CELLS | LONG-TERM POTENTIATION | RAT-BRAIN | TIME-COURSE | GATED CHLORIDE CHANNEL | CLIMBING FIBER | NEUROSCIENCES | PARALLEL FIBER | Amino Acid Transport System X-AG - physiology | Amino Acid Transport System X-AG - chemistry | Amino Acid Transport System X-AG - metabolism | Animals | Neuronal Plasticity - physiology | Synaptic Transmission - physiology | Humans | Glutamic Acid - physiology | Glutamic Acid - metabolism | Glutamic Acid - chemistry | Cloning | Analysis | Neural transmission | Cell-mediated cytotoxicity | Regulation | Research | Glutamate
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