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1. Full Text Discoveries of Extrachromosomal Circles of DNA in Normal and Tumor Cells
by Paulsen, Teressa and Kumar, Pankaj and Koseoglu, M. Murat and Dutta, Anindya
Trends in Genetics, ISSN 0168-9525, 04/2018, Volume 34, Issue 4, pp. 270 - 278
While the vast majority of cellular DNA in eukaryotes is contained in long linear strands in chromosomes, we have long recognized some exceptions like... 
AMPLIFICATION | REPLICATION | HELA-CELLS | DROSOPHILA-MELANOGASTER | TELOMERE MAINTENANCE | KINETOPLAST DNA | GENETICS & HEREDITY | POLYDISPERSE CIRCULAR DNA | RDNA CIRCLES | DOUBLE-MINUTE CHROMOSOMES | BUOYANT-DENSITY | Neoplasms - metabolism | Eukaryotic Cells - chemistry | DNA, Chloroplast - chemistry | DNA, Neoplasm - metabolism | Saccharomyces cerevisiae - genetics | Humans | DNA, Chloroplast - genetics | Neoplastic Cells, Circulating - metabolism | DNA, Circular - genetics | Eukaryotic Cells - metabolism | DNA, Neoplasm - chemistry | Saccharomyces cerevisiae - metabolism | DNA, Mitochondrial - genetics | Neoplasms - genetics | Plants - genetics | Telomere - metabolism | Kinetoplastida - metabolism | DNA, Mitochondrial - chemistry | DNA, Kinetoplast - genetics | DNA, Mitochondrial - metabolism | DNA, Circular - chemistry | Neoplastic Cells, Circulating - chemistry | Chromosomes, Human - metabolism | DNA, Circular - metabolism | Plasmids - metabolism | Chromosomes, Human - chemistry | DNA, Chloroplast - metabolism | Telomere - chemistry | Plants - metabolism | Animals | DNA, Kinetoplast - chemistry | Kinetoplastida - genetics | Plasmids - chemistry | DNA, Kinetoplast - metabolism | DNA, Neoplasm - genetics | Neoplasms - pathology
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2. Full Text An approach for interlaboratory comparison of conventional and real-time PCR assays for diagnosis of human leishmaniasis
by Cruz, Israel and Millet, Aurélie and Carrillo, Eugenia and Chenik, Mehdi and Salotra, Poonam and Verma, Sandeep and Veland, Nicolás and Jara, Marlene and Adaui, Vanessa and Castrillón, Carlos and Arévalo, Jorge and Moreno, Javier and Cañavate, Carmen
Experimental Parasitology, ISSN 0014-4894, 07/2013, Volume 134, Issue 3, pp. 281 - 289
Protozoa of the genus are transmitted to humans by the bite of infected sandflies, and are the causative agents of leishmaniasis which ranges from cutaneous to... 
Diagnosis | Comparison | Leishmania | PCR | Interlaboratory | MEDIATED ISOTHERMAL AMPLIFICATION | LUTZOMYIA-LONGIPALPIS | SPECIES IDENTIFICATION | FRAGMENT-LENGTH-POLYMORPHISM | CUTANEOUS LEISHMANIASIS | POLYMERASE-CHAIN-REACTION | CLINICAL-SAMPLES | AZAR DERMAL LEISHMANIASIS | OLD-WORLD LEISHMANIA | VISCERAL LEISHMANIASIS | PARASITOLOGY | Leishmaniasis - diagnosis | Species Specificity | Humans | Sequence Analysis, DNA - standards | DNA, Kinetoplast - analysis | Real-Time Polymerase Chain Reaction - standards | Leishmania - classification | Case-Control Studies | DNA, Protozoan - analysis | DNA - blood | DNA - chemistry | Polymorphism, Restriction Fragment Length | Polymerase Chain Reaction - standards | DNA, Protozoan - chemistry | Sequence Analysis, DNA - methods | Leishmania - genetics | Leishmania - isolation & purification | Quality Control | Parasitology | Leishmaniasis | Sequence Analysis, DNA | DNA, Protozoan | DNA, Kinetoplast | Life Sciences | Microbiology and Parasitology | DNA | Polymerase Chain Reaction | Real-Time Polymerase Chain Reaction
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3. The structure and replication of kinetoplast DNA
by Shlomai, Joseph
Current Molecular Medicine, ISSN 1566-5240, 09/2004, Volume 4, Issue 6, pp. 623 - 647
Kinetoplast DNA (kDNA), the mitochondrial DNA of flagellated protozoa of the order Kinetoplastida, is unique in its structure, function and mode of... 
kDNA replication | kDNA structure | Maxicircles | Trypanosomatids | Kinetoplast DNA | Minicircles | trypanosomatids/kinetoplast | MEDICINE, RESEARCH & EXPERIMENTAL | CELL-CYCLE REGULATION | HEMOFLAGELLATE LEISHMANIA-DONOVANI | GUIDE RNA GENES | TRYPANOSOMATID CRITHIDIA-FASCICULATA | HISTONE-LIKE PROTEINS | replication/kDNA structure/minicircles/maxicircles | BODONID BODO-SALTANS | DNA/kDNA | UNIVERSAL MINICIRCLE SEQUENCE | ZINC-FINGER PROTEIN | MITOCHONDRIAL TOPOISOMERASE-II | SEQUENCE-BINDING-PROTEIN | Kinetoplastida - chemistry | Trypanosomatina - genetics | Kinetoplastida - ultrastructure | DNA, Circular - genetics | Cell Nucleus - physiology | DNA-Binding Proteins - metabolism | DNA, Mitochondrial - genetics | Protozoan Proteins - metabolism | S Phase | Trypanosomatina - ultrastructure | DNA, Protozoan - ultrastructure | DNA, Protozoan - chemistry | DNA, Mitochondrial - chemistry | DNA, Kinetoplast - genetics | DNA, Mitochondrial - metabolism | DNA, Circular - chemistry | DNA Replication | Cell Nucleus - ultrastructure | Kinetoplastida - enzymology | DNA, Circular - isolation & purification | DNA, Kinetoplast - ultrastructure | Animals | DNA, Circular - ultrastructure | DNA, Kinetoplast - chemistry | Models, Biological | DNA, Catenated | DNA, Protozoan - genetics
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4. Full Text Screening and characterization of RAPD markers in viscerotropic Leishmania parasites
by Mkada-Driss, Imen and Lahmadi, Ramzi and Chakroun, Ahmed S and Talbi, Chiraz and Guerbouj, Souheila and Driss, Mehdi and Elamine, Elwaleed M and Cupolillo, Elisa and Mukhtar, Moawia M and Guizani, Ikram
PLoS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 10, p. e109773
Visceral leishmaniasis (VL) is mainly due to the Leishmania donovani complex. VL is endemic in many countries worldwide including East Africa and the... 
DONOVANI COMPLEX | CUTANEOUS LEISHMANIASIS | GENETIC-POLYMORPHISM | EASTERN SUDAN | OLD-WORLD LEISHMANIA | KINETOPLAST DNA | MULTIDISCIPLINARY SCIENCES | MOLECULAR EPIDEMIOLOGY | VIANNIA BRAZILIENSIS | AMPLIFIED POLYMORPHIC DNA | VISCERAL LEISHMANIASIS | Polymorphism, Restriction Fragment Length | Humans | Random Amplified Polymorphic DNA Technique | DNA, Protozoan - genetics | Genotype | Leishmania donovani - genetics | Leishmaniasis, Visceral - parasitology | Genetic Markers | Phylogeny | Sequence Analysis, DNA | Molecular Typing | Taxonomy | Pathogenesis | Genomes | Parasites | Medical diagnosis | Epidemiology | Gene sequencing | Parasitic diseases | Visceral leishmaniasis | Primers | Trends | Deoxyribonucleic acid--DNA | Vector-borne diseases | Pathogens | Microsatellites | Nucleotide sequence | Markers | Priming | Genetic diversity | Leishmaniasis | Clustering | Medical screening | Multiculturalism & pluralism | Amplification | Random amplified polymorphic DNA | Gene mapping | Leishmania donovani | DNA, Protozoan | Life Sciences | Microbiology and Parasitology | Leishmaniasis, Visceral | Deoxyribonucleic acid | DNA
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5. Full Text Redox control of protein-DNA interactions: From molecular mechanisms to significance in signal transduction, gene expression, and DNA replication
by Shlomai, Joseph
Antioxidants and Redox Signaling, ISSN 1523-0864, 11/2010, Volume 13, Issue 9, pp. 1429 - 1476
Protein-DNA interactions play a key role in the regulation of major cellular metabolic pathways, including gene expression, genome replication, and genomic... 
ZINC-FINGER MOTIF | HYPOXIA-INDUCIBLE FACTOR | TUMOR-NECROSIS-FACTOR | TRANSCRIPTION FACTOR NRF2 | UNIVERSAL MINICIRCLE SEQUENCE | MITOCHONDRIAL-COMPLEX-III | BIOCHEMISTRY & MOLECULAR BIOLOGY | ORIGIN RECOGNITION COMPLEX | ENDOCRINOLOGY & METABOLISM | SINGLE-STRANDED-DNA | NF-KAPPA-B | SEQUENCE-BINDING-PROTEIN | Protein Kinases - metabolism | Gene Expression | Cell Proliferation | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Signal Transduction | Reactive Nitrogen Species - metabolism | Humans | Transcriptional Activation | Tumor Suppressor Protein p53 - metabolism | DNA Replication | DNA, Kinetoplast - physiology | Transcription Factors - metabolism | Cell Cycle | DNA, Kinetoplast - metabolism | Physiological aspects | Research | DNA binding proteins | Gene expression | Free radicals (Chemistry)
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6. Full Text Network News: The Replication of Kinetoplast DNA
by Jensen, Robert E and Englund, Paul T
Annual Review of Microbiology, ISSN 0066-4227, 10/2012, Volume 66, Issue 1, pp. 473 - 491
One of the most fascinating and unusual features of trypanosomatids, parasites that cause disease in many tropical countries, is their mitochondrial DNA. This... 
kDNA replication | minicircle | kDNA segregation | trypanosomes | maxicircle | AFRICAN TRYPANOSOMES | RNA INTERFERENCE | MICROBIOLOGY | TRYPANOSOMA-BRUCEI KINETOPLAST | MITOCHONDRIAL-DNA | MINICIRCLE REPLICATION | GENOME SEGREGATION | CRITHIDIA-FASCICULATA | CELL-CYCLE | UNIVERSAL MINICIRCLE | SEQUENCE-BINDING-PROTEIN | DNA, Kinetoplast - genetics | Trypanosomatina - genetics | DNA, Protozoan - metabolism | DNA, Kinetoplast - metabolism | DNA Replication | DNA, Circular - genetics | DNA, Protozoan - genetics | Nucleic Acid Conformation | DNA, Circular - metabolism | DNA replication | Research
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7. Full Text Physical and functional interaction between the condensin MukB and the decatenase topoisomerase IV in Escherichia coli
by Ryo Hayama and Kenneth J. Marians and Stephen C. Kowalczykowski
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2010, Volume 107, Issue 44, pp. 18826 - 18831
Proper geometric and topological organization of DNA is essential for all chromosomal processes. Two classes of proteins play major roles in organizing... 
Proteins | Plasmids | DNA | Escherichia coli | Mathematical topoi | Antibodies | Charge transfer devices | Kinetoplast DNA | Chromosomes | Chromosome segregation | Protein Structure, Tertiary | DNA Topoisomerase IV - metabolism | Chromosomes, Bacterial - genetics | Chromosomal Proteins, Non-Histone - metabolism | DNA, Bacterial - metabolism | Adenosine Triphosphatases - metabolism | DNA, Superhelical - genetics | Escherichia coli Proteins - metabolism | Multiprotein Complexes - genetics | Mutation, Missense | DNA-Binding Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | DNA-Binding Proteins - metabolism | Multiprotein Complexes - metabolism | Chromosomes, Bacterial - metabolism | DNA, Bacterial - genetics | DNA Replication - physiology | Escherichia coli - genetics | Escherichia coli - metabolism | Escherichia coli Proteins - genetics | Adenosine Triphosphatases - genetics | DNA Topoisomerase IV - genetics | DNA, Superhelical - metabolism | Amino Acid Substitution | Topoisomerases | Physiological aspects | Genetic aspects | Research | Properties | Bacterial genetics | DNA topoisomerase IV | Superhelical DNA | Condensin | Biological Sciences
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8. Full Text Phylogenetic Validation of the Genera Angomonas and Strigomonas of Trypanosomatids Harboring Bacterial Endosymbionts with the Description of New Species of Trypanosomatids and of Proteobacterial Symbionts
by Teixeira, Marta M.G and Borghesan, Tarcilla C and Ferreira, Robson C and Santos, Marcia A and Takata, Carmen S.A and Campaner, Marta and Nunes, Vania L.B and Milder, Regina V and de Souza, Wanderley and Camargo, Erney P
Protist, ISSN 1434-4610, 2011, Volume 162, Issue 3, pp. 503 - 524
We comparatively examined the nutritional, molecular and optical and electron microscopical characteristics of reference species and new isolates of... 
phylogeny | Trypanosomatids | Betaproteobacteria | evolution | endosymbiont | co-divergence | Endosymbiont | Evolution | Phylogeny | Co-divergence | CRITHIDIA-DEANEI | INSECT TRYPANOSOMATIDS | HERPETOMONAS | MICROBIOLOGY | SUBUNIT RIBOSOMAL-RNA | IDENTIFICATION | BRAZIL | GENUS CRITHIDIA | DNA | SP-NOV | KINETOPLASTIDA | Betaproteobacteria - classification | Trypanosomatina - genetics | Trypanosomatina - isolation & purification | Molecular Sequence Data | DNA, Bacterial - chemistry | Betaproteobacteria - ultrastructure | DNA, Ribosomal - chemistry | Symbiosis - genetics | Ribosome Subunits, Small - genetics | Likelihood Functions | Trypanosomatina - classification | Base Sequence | Trypanosomatina - ultrastructure | DNA, Protozoan - chemistry | DNA Barcoding, Taxonomic - methods | DNA, Ribosomal - genetics | Betaproteobacteria - isolation & purification | Microscopy, Electron, Transmission | Microscopy, Electron, Scanning | DNA, Kinetoplast - genetics | DNA, Intergenic - genetics | Sequence Analysis, DNA | Betaproteobacteria - genetics | DNA, Intergenic - chemistry | Polymorphism, Genetic | Biological Evolution | DNA, Bacterial - genetics | DNA, Kinetoplast - chemistry | RNA, Ribosomal, 16S - genetics | DNA, Protozoan - genetics | Phosphates | Discovery and exploration | Ribosomal RNA | Sugars | Monosaccharides
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9. Full Text Antiparasitic compounds that target DNA
by Wilson, W. David and Tanious, Farial A and Mathis, Amanda and Tevis, Denise and Hall, James Edwin and Boykin, David W
Biochimie, ISSN 0300-9084, 2008, Volume 90, Issue 7, pp. 999 - 1014
Designed, synthetic heterocyclic diamidines have excellent activity against eukaryotic parasites that cause diseases such as sleeping sickness and leishmania... 
Antiparasitic drugs | Kinetoplast DNA | DNA topology | Heterocyclic diamidines | DNA binding | MINOR-GROOVE COMPLEX | AROMATIC DICATION | HUMAN AFRICAN TRYPANOSOMIASIS | antiparasitic drugs | BIOCHEMISTRY & MOLECULAR BIOLOGY | kinetoplast DNA | QUANTITATIVE-ANALYSIS | SURFACE PLASMON RESONANCE | MOLECULAR RECOGNITION | NUCLEIC-ACID INTERACTIONS | heterocyclic diamidines | ANTIPROTOZOAL ACTIVITY | BINDING-PROPERTIES | Humans | Models, Molecular | Pentamidine - analogs & derivatives | Nucleic Acid Conformation - drug effects | Drug Delivery Systems | Animals | Heterocyclic Compounds - chemistry | Pentamidine - chemistry | DNA, Protozoan - drug effects | Antiparasitic Agents - pharmacology | Eukaryota - drug effects | DNA, Protozoan - chemistry | Antiparasitic Agents - chemistry | Pentamidine - pharmacology
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10. Full Text A naturally chimeric type IIA topoisomerase in Aquifex aeolicus highlights an evolutionary path for the emergence of functional paralogs
by Elsa M. Tretter and Jeffrey C. Lerman and James M. Berger and Kiyoshi Mizuuchi
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2010, Volume 107, Issue 51, pp. 22055 - 22059
Bacteria frequently possess two type IIA DNA topoisomerases, gyrase and topo IV, which maintain chromosome topology by variously supercoiling, relaxing, and... 
Proteins | Enzymes | DNA | Escherichia coli | Mathematical topoi | Phylogenetics | Evolution | Charge transfer devices | Kinetoplast DNA | Topology | Protein evolution | Chromosome dynamics | DNA binding proteins | TOPOLOGY | protein evolution | MECHANISM | MULTIDISCIPLINARY SCIENCES | GYRASE | RELAXATION | ESCHERICHIA-COLI DNA | BINDING PROTEIN | CLEAVAGE | chromosome dynamics | ALIGNMENT | C-TERMINAL DOMAIN | Protein Structure, Tertiary | DNA Topoisomerase IV - chemistry | DNA Topoisomerase IV - metabolism | DNA Gyrase - chemistry | DNA, Bacterial - metabolism | DNA, Superhelical - genetics | Holoenzymes - chemistry | DNA, Bacterial - chemistry | Bacteria - genetics | DNA Gyrase - metabolism | DNA, Bacterial - genetics | Holoenzymes - metabolism | DNA Gyrase - genetics | DNA, Superhelical - chemistry | Bacteria - enzymology | DNA Topoisomerase IV - genetics | Holoenzymes - genetics | DNA, Superhelical - metabolism | Evolution, Molecular | Bacterial proteins | Physiological aspects | Genetic aspects | Research | Properties | Bacterial genetics | Protein binding | Biological Sciences
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11. Full Text Structural determinants of the catalytic inhibition of human topoisomerase IIα by salicylate analogs and salicylate-based drugs
by Bau, Jason T and Kurz, Ebba U
Biochemical Pharmacology, ISSN 0006-2952, 06/2014, Volume 89, Issue 4, pp. 464 - 476
We previously identified salicylate as a novel catalytic inhibitor of human DNA topoisomerase II (topo II; EC 5.99.1.3) that preferentially targets the alpha... 
Salicylate | Sulfasalazine | Catalytic inhibitor | Diflunisal | Topoisomerase II | DOSE ASPIRIN | ACID | MECHANISM | POISONS | CLEAVAGE | CANCER | GREEN TEA | HORMONE | DISEASE | PHARMACOLOGY & PHARMACY |