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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2001, Volume 98, Issue 24, pp. 13866 - 13871
PD-1 is an immunoreceptor that belongs to the immunoglobulin (Ig) superfamily and contains two tyrosine residues in the cytoplasmic region. Studies on... 
Proteins | Molecules | Biological Sciences | Phosphorylation | Receptors | Phosphatases | B lymphocytes | Cell lines | Ligands | Chimeras | Growth retardation | P62(DOK) | ACTIVATION | PROTEIN | MULTIDISCIPLINARY SCIENCES | ANTIGEN-RECEPTOR | MICE | SHP-1 | EXPRESSION | MEMBER | FAMILY | LYMPHOCYTES | Protein Tyrosine Phosphatase, Non-Receptor Type 11 | Calcium - metabolism | Humans | Protein Tyrosine Phosphatases - metabolism | Receptors, Antigen, B-Cell - metabolism | Antigens, CD - genetics | Receptors, IgG - metabolism | Antigens, CD - metabolism | Phosphotyrosine - metabolism | Receptors, IgG - genetics | Cell Division | Antigens, Surface - metabolism | Tumor Cells, Cultured | Protein Phosphatase 2 | Signal Transduction | Receptors, KIR | Antigens, Surface - genetics | Intracellular Signaling Peptides and Proteins | src Homology Domains | Tyrosine - metabolism | Animals | Apoptosis Regulatory Proteins | SH2 Domain-Containing Protein Tyrosine Phosphatases | Programmed Cell Death 1 Receptor | Mice | Receptors, Immunologic - genetics | Mitogen-Activated Protein Kinase 3 | Protein Tyrosine Phosphatase, Non-Receptor Type 6 | Receptors, Immunologic - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Physiological aspects | Protein tyrosine kinase | Immunoglobulins | Cellular signal transduction | B cells | Rodents | Immunology | phosphotyrosine | thyrosine phosphatase | Fc receptors | SH2 domain | PD-1 protein | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 2008, Volume 29, Issue 4, pp. 578 - 588
Many cellular responses, such as autoimmunity and cytotoxicity, are controlled by receptors with cytoplasmic immunoreceptor tyrosine-based inhibition motifs... 
MOLIMMUNO | MHC CLASS-I | NATURAL-KILLER-CELLS | ACTIVATION | COMPLEX | NK CELLS | C-CBL | IMMUNE SYNAPSE | IMMUNOLOGY | CLASS-I MOLECULES | UBIQUITIN LIGASES | SELF-TOLERANCE | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - immunology | Phosphorylation | Proto-Oncogene Proteins c-cbl - metabolism | Humans | Crk-Associated Substrate Protein - metabolism | Crk-Associated Substrate Protein - immunology | Receptors, Natural Killer Cell - immunology | Guanine Nucleotide-Releasing Factor 2 - metabolism | Histocompatibility Antigens Class I - metabolism | NK Cell Lectin-Like Receptor Subfamily D - immunology | Proto-Oncogene Proteins c-vav - immunology | Receptors, KIR - metabolism | Killer Cells, Natural - immunology | Proto-Oncogene Proteins c-crk - metabolism | Proto-Oncogene Proteins c-abl - immunology | Histocompatibility Antigens Class I - immunology | Receptors, Natural Killer Cell - metabolism | Guanine Nucleotide-Releasing Factor 2 - immunology | HLA Antigens - immunology | Rats | Proto-Oncogene Proteins c-crk - immunology | HLA Antigens - metabolism | Animals | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Amino Acid Motifs - immunology | Proto-Oncogene Proteins c-abl - metabolism | Killer Cells, Natural - metabolism | NK Cell Lectin-Like Receptor Subfamily D - metabolism | Receptors, KIR - immunology | Proto-Oncogene Proteins c-vav - metabolism | Proto-Oncogene Proteins c-cbl - immunology | Tyrosine | Phenols | Proteins | Antigens | Cytotoxicity | Ligands | Kinases | Immune system | Index Medicus
Journal Article
Molecular and Cellular Neuroscience, ISSN 1044-7431, 10/2016, Volume 76, pp. 52 - 58
The transcription factor Nrf2 and its repressor protein Keap1 play key roles in the regulation of antioxidant stress responses and both Keap1-Nrf2 signalling... 
ALS-FTLD | Oxidative stress | Keap1-Nrf2 | SQSTM1/p62 | ACTIVATE NRF2 | PHOSPHORYLATION | AUTOPHAGIC DEGRADATION | P62 | NEUROSCIENCES | UBIQUITINATION | TRANSCRIPTION FACTOR NRF2 | PATHWAY | ANTIOXIDANT RESPONSE | PAGETS-DISEASE | BONE | Response Elements | Signal Transduction | Amyotrophic Lateral Sclerosis - genetics | Humans | Kelch-Like ECH-Associated Protein 1 - metabolism | Mutation, Missense | Sequestosome-1 Protein - genetics | NF-E2-Related Factor 2 - metabolism | HEK293 Cells | Protein Binding | Frontotemporal Lobar Degeneration - genetics | Sequestosome-1 Protein - chemistry | Binding Sites | Sequestosome-1 Protein - metabolism | Antioxidants | Nervous system diseases | Genetic aspects | Analysis | Protein binding | Index Medicus | ARE, Antioxidant response element | NFE2L2, Nuclear factor erythroid 2-like 2 | p62, Sequestosome 1 | IKKβ, Inhibitor of nuclear factor kappa-B kinase subunit beta | RBM45, RNA binding motif protein 45 | KIR, Keap1-interacting region | SALS, Sporadic ALS | UBA, Ubiquitin-associated (domain) | Keap1, Kelch-like ECH-associated protein 1 | Nrf2, Nuclear erythroid 2-related factor 2 | p62 protein | ALS, Amyotrophic lateral sclerosis | p62 | mTORC1, Mammalian target of rapamycin complex 1 | LIR, LC3-interacting region | NQO1, NAD(P)H dehydrogenase, Quinone 1 | FTLD, Frontotemporal lobar degeneration | SOD1, Superoxide dismutase 1 | SQSTM1 | PDB, Paget's disease of bone | TDP-43, TAR DNA-binding protein 43
Journal Article
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 09/2003, Volume 23, Issue 17, pp. 6291 - 6299
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 08/2013, Volume 94, Issue 2, pp. 301 - 313
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 10, pp. 3546 - 3561
Inwardly rectifying potassium (Kir) channels establish and regulate the resting membrane potential of excitable cells in the heart, brain, and other peripheral... 
ISCHEMIA-REPERFUSION INJURY | RECTIFYING POTASSIUM CHANNELS | ACTIVATION | SULFHYDRATION | MECHANISM | K-ATP CHANNELS | BIOCHEMISTRY & MOLECULAR BIOLOGY | G-PROTEINS | H2S | CARDIOPROTECTION | PHOSPHOINOSITIDES | Hydrogen Sulfide - metabolism | Cricetulus | Sulfides - chemistry | Cystathionine gamma-Lyase - metabolism | Potassium Channels, Inwardly Rectifying - chemistry | Recombinant Fusion Proteins - metabolism | Oocytes - cytology | Phosphatidylinositol 4,5-Diphosphate - metabolism | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Potassium Channels, Inwardly Rectifying - antagonists & inhibitors | Sulfides - metabolism | Cystathionine gamma-Lyase - genetics | Phosphatidylinositol 4,5-Diphosphate - chemistry | G Protein-Coupled Inwardly-Rectifying Potassium Channels - antagonists & inhibitors | CHO Cells | Sulfides - pharmacology | Allosteric Regulation - drug effects | Recombinant Proteins - metabolism | Hydrogen Sulfide - pharmacology | Mutagenesis, Site-Directed | Oocytes - metabolism | Hydrogen Sulfide - chemistry | Xenopus laevis | G Protein-Coupled Inwardly-Rectifying Potassium Channels - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Potassium Channels, Inwardly Rectifying - genetics | Recombinant Fusion Proteins - chemistry | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Molecular Dynamics Simulation | Patch-Clamp Techniques | Animals | Protein Conformation | Mice | Mutation | Potassium Channels, Inwardly Rectifying - metabolism | Amino Acid Substitution | Index Medicus | GIRK channels | Signal Transduction | phosphatidylinositol 4,5-bisphosphate (PIP2) | stroke | phosphoinositide | ischemia | KATP channels | gasotransmitters | hydrogen sulfide | potassium channel | Kir3 or GIRK channels | inwardly rectifying K+ (Kir) channels | Kir3
Journal Article
Proteins: Structure, Function, and Bioinformatics, ISSN 0887-3585, 12/2016, Volume 84, Issue 12, pp. 1929 - 1937
Kir2.1 (also known as IRK1) plays key roles in regulation of resting membrane potential and cell excitability. To achieve its physiological roles, Kir2.1... 
gating kinetics | weak interaction | targeted molecular dynamics | molecular dynamics | Kir channel | homology model | SYNDROME MUTATION | RECTIFYING POTASSIUM CHANNELS | SWISS-MODEL WORKSPACE | CRYSTAL-STRUCTURE | CYTOPLASMIC DOMAINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PARTICLE MESH EWALD | POTENTIAL FUNCTIONS | ANGSTROM RESOLUTION | BIOPHYSICS | K+-CHANNEL | MOLECULAR-DYNAMICS SIMULATIONS | Structure-Activity Relationship | Potassium Channels, Inwardly Rectifying - chemistry | Oocytes - cytology | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Protein Domains | Recombinant Proteins - metabolism | Gene Expression | Mutagenesis, Site-Directed | Protein Structure, Secondary | Oocytes - metabolism | Xenopus laevis | G Protein-Coupled Inwardly-Rectifying Potassium Channels - chemistry | Recombinant Proteins - chemistry | Potassium Channels, Inwardly Rectifying - genetics | Recombinant Proteins - genetics | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Membrane Potentials - physiology | Plasmids - metabolism | Molecular Dynamics Simulation | Patch-Clamp Techniques | Animals | Chickens | Plasmids - chemistry | Mice | Structural Homology, Protein | Mutation | Ion Channel Gating | Potassium Channels, Inwardly Rectifying - metabolism | Physiological aspects | Molecular dynamics | Information management | Analysis | Index Medicus | Targeted molecular dynamics | Homology model
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, pp. e87131 - e87131
The possibility to modulate ex vivo human NK cell differentiation towards specific phenotypes will contribute to a better understanding of NK cell... 
NATURAL-KILLER-CELLS | L-SELECTIN | MANNOSE RECEPTOR | IMMUNOTHERAPY | CD56(BRIGHT) | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | TRANSCRIPTION FACTOR | CANCER | SUBSET | T-CELLS | Receptors, CCR6 - immunology | Humans | Neoplasm Proteins - immunology | Antibody-Dependent Cell Cytotoxicity - immunology | Inhibitor of Differentiation Proteins - genetics | Receptors, IgG - metabolism | L-Selectin - immunology | Antigens, CD34 - immunology | Receptors, KIR - metabolism | Neoplasm Proteins - genetics | Fetal Blood - immunology | Immunotherapy, Adoptive - methods | Receptors, CXCR3 - metabolism | Antineoplastic Agents - immunology | Rituximab | Fetal Blood - cytology | Receptors, IgG - immunology | Reverse Transcriptase Polymerase Chain Reaction | Cell Differentiation - immunology | Inhibitor of Differentiation Proteins - immunology | K562 Cells | Receptors, CXCR3 - immunology | Cell Line, Tumor | Interleukin-2 - pharmacology | Killer Cells, Natural - drug effects | Killer Cells, Natural - metabolism | Antibodies, Monoclonal, Murine-Derived - pharmacology | Receptors, KIR - immunology | GATA3 Transcription Factor - genetics | Antigens, CD34 - metabolism | GATA3 Transcription Factor - immunology | L-Selectin - metabolism | Dose-Response Relationship, Drug | High Mobility Group Proteins - immunology | Cell Differentiation - genetics | Hematopoietic Stem Cells - immunology | Flow Cytometry | Interleukin-2 - immunology | Receptors, CCR6 - metabolism | Killer Cells, Natural - immunology | Antineoplastic Agents - pharmacology | Hematopoietic Stem Cells - drug effects | Antibodies, Monoclonal, Murine-Derived - immunology | Cells, Cultured | Hematopoietic Stem Cells - metabolism | Fetal Blood - metabolism | Cell Differentiation - drug effects | Antibody-Dependent Cell Cytotoxicity - drug effects | High Mobility Group Proteins - genetics | Fc receptors | Killer cells | Immunotherapy | Leukemia | Stem cells | Cell differentiation | Health aspects | Cytolytic activity | Lymphocyte receptors | Transcription factors | Toxicity | Differentiation (biology) | Cytotoxicity | Biology | Blood | NKG2 antigen | Receptors | Cord blood | Peripheral blood | Killer cell immunoglobulin-like receptors | Physiology | Natural killer cells | CD34 antigen | Cytokines | Maturation | Gynecology | CD62L protein | Interleukin 12 | T cell receptors | Pharmacology | CXCR3 protein | Gene expression | Obstetrics | Thrombosis | CCR6 protein | CD16 antigen | Major histocompatibility complex | Lymphocytes B | GATA-3 protein | Ligands | Umbilical cord | Chemokines | Cancer | Index Medicus
Journal Article
The Journal of Immunology, ISSN 0022-1767, 05/2002, Volume 168, Issue 10, pp. 5047 - 5057
Killer cell Ig-like receptors (KIR) are MHC class I-binding immunoreceptors that can suppress activation of human NK Cells through recruitment of the Src... 
TYROSINE-PHOSPHATASE 1C | ACTIVATION | DISTINCT PATHWAYS | NEGATIVE REGULATION | IMMUNOLOGY | MEDIATED INHIBITION | MOTIF | CYTOTOXICITY | ASSOCIATION | FC-GAMMA-RIIB | CUTTING EDGE | Cytotoxicity Tests, Immunologic | Phosphorylation | Protein Binding - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 11 | Receptors, Immunologic - physiology | Humans | Receptors, KIR2DL4 | Molecular Sequence Data | Cytoplasm - metabolism | Protein Tyrosine Phosphatases - metabolism | Cell Culture Techniques - methods | Vaccinia virus - genetics | Signal Transduction - immunology | Protein Tyrosine Phosphatases - genetics | Receptors, Immunologic - biosynthesis | Peptide Fragments - immunology | Killer Cells, Natural - immunology | Phosphotyrosine - physiology | Receptors, KIR3DL1 | Tumor Cells, Cultured | Peptide Fragments - genetics | Protein Phosphatase 1 | Vaccinia virus - enzymology | Amino Acid Sequence | Cell Line | Cytoplasm - enzymology | Cytotoxicity, Immunologic - genetics | Peptide Fragments - metabolism | Protein Tyrosine Phosphatases - biosynthesis | Mutagenesis, Site-Directed | Receptors, KIR | Intracellular Signaling Peptides and Proteins | Protein Binding - immunology | Killer Cells, Natural - enzymology | Cytoplasm - immunology | Amino Acid Motifs - immunology | SH2 Domain-Containing Protein Tyrosine Phosphatases | src Homology Domains - immunology | Killer Cells, Natural - metabolism | Amino Acid Motifs - genetics | Receptors, Immunologic - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 | Receptors, Immunologic - metabolism | Protein Structure, Tertiary - physiology | Protein Tyrosine Phosphatases - physiology | Index Medicus | Abridged Index Medicus
Journal Article
Nature, ISSN 0028-0836, 08/2011, Volume 476, Issue 7358, pp. 96 - 101
Natural killer (NK) cells have an important role in the control of viral infections, recognizing virally infected cells through a variety of activating and... 
MHC CLASS-I | RESPONSES | NATURAL-KILLER-CELLS | RECOGNITION | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | HLA-B | INHIBITORY RECEPTOR | BINDING-SITE | KIR3DL1 | VIRAL PEPTIDES | env Gene Products, Human Immunodeficiency Virus - immunology | Human Immunodeficiency Virus Proteins - immunology | Humans | env Gene Products, Human Immunodeficiency Virus - metabolism | Host-Pathogen Interactions - immunology | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | Antibodies, Neutralizing - immunology | env Gene Products, Human Immunodeficiency Virus - genetics | HIV-1 - physiology | Receptors, KIR2DL2 - genetics | Adaptation, Physiological - genetics | Receptors, KIR - metabolism | Receptors, KIR2DL2 - deficiency | Killer Cells, Natural - immunology | CD4-Positive T-Lymphocytes - virology | Receptors, KIR - deficiency | Receptors, KIR - genetics | Receptors, KIR2DL2 - immunology | Viral Regulatory and Accessory Proteins - immunology | HIV Infections - virology | Receptors, KIR2DL2 - chemistry | Viral Regulatory and Accessory Proteins - genetics | Genotype | HIV-1 - genetics | Viral Regulatory and Accessory Proteins - metabolism | Polymorphism, Genetic | Human Immunodeficiency Virus Proteins - metabolism | Adaptation, Physiological - immunology | HIV-1 - immunology | Virus Replication | Human Immunodeficiency Virus Proteins - genetics | Decision Trees | Immune Evasion - immunology | Receptors, KIR - immunology | Evolution, Molecular | Killer cells | Immune response | Management | Research | Observations | HIV infection | Hepatitis | Viruses | Immunology | Acids | Multivariate analysis | Viral infections | Index Medicus
Journal Article