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Nature, ISSN 0028-0836, 03/2005, Volume 434, Issue 7033, pp. 605 - 611
Journal Article
Science, ISSN 0036-8075, 5/2012, Volume 336, Issue 6081, pp. 593 - 597
The telomere end-protection problem is defined by the aggregate of DNA damage signaling and repair pathways that require repression at telomeres. To define the... 
Telomeres | Yeasts | Quantification | Lymphocytes | DNA | DNA damage | REPORTS | Cell cycle | Ataxia telangiectasia | Repression | Chromosomes | JOINING PATHWAY | POT1 PROTEINS | MAMMALIAN TELOMERES | SGS1 | MULTIDISCIPLINARY SCIENCES | DYSFUNCTIONAL TELOMERES | DOUBLE-STRAND BREAKS | HOMOLOGOUS RECOMBINATION | NHEJ | YEAST KU | Telomere - ultrastructure | Antigens, Nuclear - metabolism | Telomeric Repeat Binding Protein 1 - genetics | Telomeric Repeat Binding Protein 1 - metabolism | Homologous Recombination | DNA Breaks, Double-Stranded | DNA Ligases - metabolism | DNA-Binding Proteins - metabolism | Poly-ADP-Ribose Binding Proteins | Telomere-Binding Proteins - genetics | DNA End-Joining Repair | Telomere - metabolism | Telomere-Binding Proteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Signal Transduction | Cell Cycle Proteins - metabolism | Cells, Cultured | Ataxia Telangiectasia Mutated Proteins | Xenopus Proteins | DNA-Binding Proteins - genetics | Telomere Homeostasis | Mice, Knockout | Poly(ADP-ribose) Polymerases - metabolism | Animals | Antigens, Nuclear - genetics | Cell Cycle | Ku Autoantigen | DNA Repair | DNA Ligase ATP | Telomeric Repeat Binding Protein 2 - metabolism | Mice | Poly (ADP-Ribose) Polymerase-1 | Telomeric Repeat Binding Protein 2 - genetics | Tumor Suppressor p53-Binding Protein 1 | Proteins | Physiological aspects | Research | Health aspects | DNA repair | Telomerase
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2017, Volume 67, Issue 3, pp. 387 - 399.e5
The DNA-mediated innate immune response underpins anti-microbial defenses and certain autoimmune diseases. Here we used immunoprecipitation, mass spectrometry,... 
HEXIM1 | DNA-PK | innate immune response | herpesvirus | paraspeckles | cGAS | NEAT1 | interferon stimulatory DNA | DEFENSE | PROTEIN | INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | SENSOR | POLYMERASE-II | 7SK RNA | BINDING | GMP-AMP SYNTHASE | P-TEFB | CELL BIOLOGY | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Octamer Transcription Factors - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Herpesvirus 8, Human - immunology | RNA, Long Noncoding - immunology | PTB-Associated Splicing Factor - genetics | RNA Interference | Calcium-Binding Proteins - immunology | Octamer Transcription Factors - genetics | Nucleotidyltransferases - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Signal Transduction | Membrane Proteins - genetics | RNA-Binding Proteins - immunology | PTB-Associated Splicing Factor - metabolism | Nuclear Matrix-Associated Proteins - metabolism | PTB-Associated Splicing Factor - immunology | DNA - metabolism | Host-Pathogen Interactions | Nuclear Matrix-Associated Proteins - genetics | HeLa Cells | RNA-Binding Proteins - metabolism | Calcium-Binding Proteins - genetics | RNA-Binding Proteins - genetics | Multiprotein Complexes | Human Umbilical Vein Endothelial Cells - immunology | Intracellular Signaling Peptides and Proteins - immunology | Human Umbilical Vein Endothelial Cells - virology | Interferon Regulatory Factor-3 - genetics | Ku Autoantigen - genetics | Transfection | HEK293 Cells | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Octamer Transcription Factors - metabolism | Interferon Regulatory Factor-3 - immunology | Calcium-Binding Proteins - metabolism | DNA - immunology | Nuclear Matrix-Associated Proteins - immunology | Ku Autoantigen - immunology | Membrane Proteins - immunology | Nuclear Proteins - metabolism | Ku Autoantigen - metabolism | RNA, Long Noncoding - genetics | Immunity, Innate | Nuclear Proteins - immunology | DNA - genetics | Interferon Regulatory Factor-3 - metabolism | Nucleotidyltransferases - genetics | Protein Binding | Nucleotidyltransferases - immunology | RNA, Long Noncoding - metabolism | RNA sequencing | Immune response | RNA | DNA | Genetic research | Interferon | Biological response modifiers | Mass spectrometry | Human Umbilical Vein Endothelial Cells | Nuclear Matrix-Associated Proteins | Herpesvirus 8, Human | RNA-Binding Proteins | Life Sciences | Interferon Regulatory Factor-3 | Genetics | Calcium-Binding Proteins | Intracellular Signaling Peptides and Proteins | PTB-Associated Splicing Factor | Nuclear Proteins | Membrane Proteins | Nucleotidyltransferases | Ku Autoantigen | Octamer Transcription Factors | RNA, Long Noncoding
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2016, Volume 291, Issue 53, pp. 26987 - 27006
DNA double-strand break (DSB) repair by non-homologous end joining (NHEJ) in human cells is initiated by Ku heterodimer binding to a DSB, followed by... 
REPAIR PROTEINS | STRUCTURAL INSIGHTS | DAMAGE RESPONSE | BIOLOGICAL MACROMOLECULES | SMALL-ANGLE SCATTERING | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEPENDENT PROTEIN-KINASE | DOUBLE-STRAND BREAKS | X-RAY-SCATTERING | IONIZING-RADIATION | Phosphorylation | Immunoprecipitation | Humans | DNA Breaks, Double-Stranded | DNA-Activated Protein Kinase - chemistry | DNA-Binding Proteins - metabolism | Poly-ADP-Ribose Binding Proteins | DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics | Ku Autoantigen - genetics | DNA Ligase ATP - genetics | X-Ray Diffraction | DNA-Activated Protein Kinase - genetics | DNA-Activated Protein Kinase - metabolism | DNA Ligase ATP - metabolism | Nuclear Proteins - genetics | Cross-Linking Reagents | DNA End-Joining Repair - genetics | Ku Autoantigen - chemistry | Models, Molecular | Scattering, Small Angle | Nuclear Proteins - metabolism | Ku Autoantigen - metabolism | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Blotting, Western | DNA-(Apurinic or Apyrimidinic Site) Lyase - chemistry | DNA-(Apurinic or Apyrimidinic Site) Lyase - metabolism | DNA Ligase ATP - chemistry | Protein Binding | Protein Conformation | HeLa Cells | DNA-dependent serine/threonine protein kinase (DNA-PK) | small-angle x-ray scattering (SAXS) | INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY | intrinsically disordered protein | XRCC4 | BASIC BIOLOGICAL SCIENCES | APLF | DNA ligase IV | non-homologous end joining | Ku | protein complex | DNA repair | DNA and Chromosomes | small-angle X-ray scattering (SAXS) | DNA-dependent serine | threonine protein kinase (DNA-PK)
Journal Article
Nature Cell Biology, ISSN 1465-7392, 08/2009, Volume 11, Issue 8, pp. 980 - 987
The ends of linear eukaryotic chromosomes are protected by telomeres, which serve to ensure proper chromosome replication and to prevent spurious recombination... 
REPAIR | KU HETERODIMER | COLOCALIZATION | DYSFUNCTIONAL TELOMERES | DOUBLE-STRAND BREAKS | S-PHASE | YEAST TELOMERES | BINDING PROTEIN | SACCHAROMYCES-CEREVISIAE | G-TAILS | CELL BIOLOGY | Saccharomyces cerevisiae - genetics | Recombinant Fusion Proteins - metabolism | DNA, Single-Stranded - genetics | Nuclear Pore Complex Proteins - genetics | Saccharomyces cerevisiae - metabolism | Haploidy | Telomere-Binding Proteins - genetics | Telomerase - genetics | Chromatin Immunoprecipitation | Rad52 DNA Repair and Recombination Protein - metabolism | Replication Protein A - genetics | S Phase | Cell Cycle Proteins - genetics | G2 Phase | Telomerase - metabolism | Telomere - metabolism | Telomere-Binding Proteins - metabolism | Telomere - genetics | Nuclear Pore Complex Proteins - metabolism | Cell Cycle Proteins - metabolism | Replication Protein A - metabolism | Saccharomyces cerevisiae Proteins - genetics | Nuclear Pore - metabolism | Rad52 DNA Repair and Recombination Protein - genetics | DNA Repair | Adaptor Proteins, Signal Transducing - genetics | Saccharomyces cerevisiae Proteins - metabolism | Recombinant Fusion Proteins - genetics | Luminescent Proteins - genetics | DNA Damage | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Microscopy, Fluorescence | Luminescent Proteins - metabolism | Physiological aspects | DNA replication | Research | Telomerase | DNA damage | Index Medicus
Journal Article
PLoS Pathogens, ISSN 1553-7366, 10/2013, Volume 9, Issue 10, p. e1003649
Journal Article
Journal Article
eLife, ISSN 2050-084X, 2013, Volume 2, p. e01222
Spontaneous DNA breaks instigate genomic changes that fuel cancer and evolution, yet direct quantification of double-strand breaks (DSBs) has been limited.... 
GFP | Human | synthetic biology | Mouse | spontaneous DNA breaks | endogenous DNA damage | fluorescent-protein fusions | DNA double-strand breaks | E. coli | GENOMIC INSTABILITY | STRESS-INDUCED MUTATION | GAM GENE | ADAPTIVE MUTATION | ESCHERICHIA-COLI K-12 | BIOLOGY | DOUBLE-STRAND BREAKS | NUCLEAR FOCI | REPLICATION STRESS | BACTERIOPHAGE-MU | KU PROTEIN | Protein Engineering - methods | Humans | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | DNA Breaks, Double-Stranded | Recombinant Fusion Proteins - metabolism | Viral Proteins - metabolism | DNA-Binding Proteins - metabolism | Chromosomes, Bacterial - metabolism | Escherichia coli - metabolism | DNA Helicases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Genes, Reporter | Green Fluorescent Proteins - metabolism | Chromosomes, Bacterial - chemistry | Cytidine Deaminase - genetics | Bacteriophage mu - chemistry | Gene Expression Regulation | Viral Proteins - genetics | DNA - metabolism | DNA-Binding Proteins - genetics | Proteins - genetics | DNA Helicases - metabolism | DNA - chemistry | Synthetic Biology | Animals | Proteins - metabolism | Ku Autoantigen | Escherichia coli - genetics | Cytidine Deaminase - metabolism | Recombinant Fusion Proteins - genetics | Mice | HeLa Cells | Tumor Suppressor p53-Binding Protein 1 | Cytosine deaminase | DNA damage | Biochemistry | Genomes | RNA polymerase | Double-strand break repair | Experiments | Cancer therapies | Mammalian cells | Medicine | Proteins | E coli | S phase | Cell cycle | DNA methylation | Bacteria | Cytosine | Mutation | Molecular biology | Deoxyribonucleic acid--DNA | Cancer
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 09/2011, Volume 194, Issue 5, pp. 705 - 720
DNA double-strand break (DSB) resection, which results in RPA-bound single-stranded DNA (ssDNA), is activated in S phase by Cdk2. RPA-ssDNA activates the... 
CYCLE CHECKPOINT CONTROL | DAMAGE RESPONSE | MRE11-RAD50-NBS1 COMPLEX | HOMOLOGOUS RECOMBINATION | RPA PHOSPHORYLATION | CELL-FREE-EXTRACTS | SACCHAROMYCES-CEREVISIAE | REPLICATION STRESS | DNA-END-RESECTION | WERNER-SYNDROME PROTEIN | CELL BIOLOGY | Protein Kinases - metabolism | Chromatin - metabolism | Meiosis - physiology | Nuclear Envelope - physiology | Antigens, Nuclear - metabolism | RecQ Helicases - metabolism | Humans | Werner Syndrome Helicase | DNA Repair - physiology | Endonucleases - metabolism | DNA Breaks, Double-Stranded | CDC2 Protein Kinase - metabolism | DNA-Binding Proteins - metabolism | MRE11 Homologue Protein | Cell Nucleus - metabolism | Protein Binding - drug effects | Phosphorylation - drug effects | Protein-Serine-Threonine Kinases - metabolism | Rad51 Recombinase - metabolism | Cyclin-Dependent Kinase 2 - metabolism | Tumor Suppressor Proteins - metabolism | CDC2 Protein Kinase - antagonists & inhibitors | DNA, Single-Stranded - metabolism | Xenopus laevis | Cell Cycle Proteins - metabolism | Replication Protein A - metabolism | Ataxia Telangiectasia Mutated Proteins | Xenopus Proteins - antagonists & inhibitors | Cell Division - physiology | DNA Helicases - metabolism | Animals | Cell-Free System | Ku Autoantigen | Mitosis - physiology | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | S Phase - physiology | Checkpoint Kinase 1 | Xenopus Proteins - metabolism | Ovum | Protein Kinase Inhibitors - pharmacology | HeLa Cells | Histones - metabolism | Protein Binding - physiology
Journal Article