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1. Full Text Crystal Structures of the Kainate Receptor GluR5 Ligand Binding Core Dimer with Novel GluR5-Selective Antagonists
by Mayer, Mark L and Ghosal, Alokesh and Dolman, Nigel P and Jane, David E and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
The Journal of neuroscience, ISSN 0270-6474, 03/2006, Volume 26, Issue 11, pp. 2852 - 2861
Glutamate receptor | Kainate | Antagonist | Structure | Crystallography | Gating | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Excitatory Amino Acid Antagonists - metabolism | Receptors, Kainic Acid - chemistry | Protein Conformation - drug effects | Thymine - analogs & derivatives | Receptors, AMPA - chemistry | Alanine - chemistry | Crystallography, X-Ray | Receptors, Kainic Acid - antagonists & inhibitors | Oocytes | Quinoxalines - pharmacology | Alanine - analogs & derivatives | Recombinant Fusion Proteins - antagonists & inhibitors | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Excitatory Amino Acid Antagonists - chemistry | Thymine - pharmacology | Binding Sites | Alanine - pharmacology | Thymine - metabolism | Thymine - chemistry | Glutamic Acid - pharmacology | Xenopus laevis | Models, Molecular | Rats | Alanine - metabolism | Excitatory Amino Acid Antagonists - pharmacology | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - metabolism | Recombinant Fusion Proteins - chemistry | Patch-Clamp Techniques | Animals | Hydrogen Bonding | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - chemistry | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology | Protein Binding | Glutamic Acid - metabolism | Glutamic Acid - chemistry | Receptors, AMPA - antagonists & inhibitors | Index Medicus | BIOLOGY | GENES | CRYSTAL STRUCTURE | MATERIALS SCIENCE | CHAINS | DIMERS | CONFORMATIONAL CHANGES | gating | crystallography | kainate | antagonist | glutamate receptor | structure
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2. Full Text Ligands for Glutamate Receptors:  Design and Therapeutic Prospects
by Bräuner-Osborne, Hans and Egebjerg, Jan and Nielsen, Elsebet Ø and Madsen, Ulf and Krogsgaard-Larsen, Povl
Journal of medicinal chemistry, ISSN 0022-2623, 07/2000, Volume 43, Issue 14, pp. 2609 - 2645
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Glutamatergic system (aspartate and other excitatory aminoacids) | Medical sciences | Neuropharmacology | Neurotransmitters. Neurotransmission. Receptors | Pharmacology. Drug treatments | Excitatory Amino Acid Antagonists - metabolism | Receptors, Glutamate - metabolism | Excitatory Amino Acid Antagonists - therapeutic use | Excitatory Amino Acid Agonists - therapeutic use | Receptors, Kainic Acid - chemistry | Humans | Receptors, AMPA - chemistry | Receptors, Kainic Acid - antagonists & inhibitors | Receptors, Metabotropic Glutamate - metabolism | Receptors, Kainic Acid - agonists | Receptors, Glutamate - drug effects | N-Methylaspartate - antagonists & inhibitors | Synapses - metabolism | Drug Design | N-Methylaspartate - agonists | Excitatory Amino Acid Antagonists - chemistry | Receptors, Metabotropic Glutamate - chemistry | Receptors, AMPA - metabolism | Excitatory Amino Acid Agonists - metabolism | N-Methylaspartate - metabolism | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Receptors, Glutamate - chemistry | Receptors, Kainic Acid - metabolism | Animals | Receptors, AMPA - agonists | Ligands | N-Methylaspartate - chemistry | Receptors, Metabotropic Glutamate - agonists | Excitatory Amino Acid Agonists - chemistry | Receptors, Metabotropic Glutamate - antagonists & inhibitors | Receptors, AMPA - antagonists & inhibitors | Index Medicus
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3. Full Text Concise Synthesis of (+)-allo-Kainic Acid via MgI2‑Mediated Tandem Aziridine Ring Opening–Formal [3 + 2] Cycloaddition
by Arena, Giada and Chen, C. Chun and Leonori, Daniele and Aggarwal, Varinder K
Organic letters, ISSN 1523-7060, 08/2013, Volume 15, Issue 16, pp. 4250 - 4253
Alloys - chemistry | Kainic Acid - chemical synthesis | Vinyl Compounds - chemistry | Cyclization | Stereoisomerism | Molecular Structure | Alloys - chemical synthesis | Aziridines - chemistry | Cycloaddition Reaction | Pyrrolidines - chemistry | Kainic Acid - chemistry | Index Medicus
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4. Full Text Total Syntheses of (−)-α-Kainic Acid and (+)-α-Allokainic Acid via Stereoselective C−H Insertion and Efficient 3,4-Stereocontrol
by Jung, Young Chun and Yoon, Cheol Hwan and Turos, Edward and Yoo, Kyung Soo and Jung, Kyung Woon
Journal of organic chemistry, ISSN 0022-3263, 12/2007, Volume 72, Issue 26, pp. 10114 - 10122
Organic chemistry | Chemistry | Heterocyclic compounds | Heterocyclic compounds with only one n hetero atom and condensed derivatives | Preparations and properties | Exact sciences and technology | Kainic Acid - chemical synthesis | Cyclization | Stereoisomerism | Molecular Conformation | Kainic Acid - chemistry | Kainic Acid - analogs & derivatives | Index Medicus | dephenylsulfonylation | kainic acid | γ-lactam | C-H insertion | allokainic acid
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5. Full Text Asiatic acid and maslinic acid attenuated kainic acid-induced seizure through decreasing hippocampal inflammatory and oxidative stress
by Wang, Zhi-hong and Mong, Mei-chin and Yang, Ya-chen and Yin, Mei-chin
Epilepsy research, ISSN 0920-1211, 01/2018, Volume 139, pp. 28 - 34
Asiatic acid | Seizure | Maslinic acid | Calcium release | Glutamine | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Triterpenes - pharmacology | Antioxidants - chemistry | Apoptosis - drug effects | Oxidative Stress - physiology | Seizures - drug therapy | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Male | Seizures - metabolism | Hippocampus - drug effects | Anticonvulsants - pharmacology | PC12 Cells | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Kainic Acid | Dose-Response Relationship, Drug | Triterpenes - chemistry | Hippocampus - immunology | Mice, Inbred C57BL | Rats | Pentacyclic Triterpenes - pharmacology | Antioxidants - pharmacology | Pentacyclic Triterpenes - chemistry | Animals | Anticonvulsants - chemistry | Apoptosis - physiology | Oxidative Stress - drug effects | COX-2 inhibitors | Medical colleges | Nervous system diseases | Interleukins | RNA | Functional foods | Ligases | Nerve growth factor | Seizures (Medicine) | Glutamate | Index Medicus
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6. Full Text Activation and Desensitization Mechanism of AMPA Receptor-TARP Complex by Cryo-EM
by Chen, Shanshuang and Zhao, Yan and Wang, Yuhang and Shekhar, Mrinal and Tajkhorshid, Emad and Gouaux, Eric
Cell (Cambridge), ISSN 0092-8674, 09/2017, Volume 170, Issue 6, pp. 1234 - 1246.e14
ligand gated ion channel | chemical synapse | glutamate receptor | membrane protein | structural biology | synapse | neurotransmitter | ion channel gating | Kainic Acid - pharmacology | Receptors, AMPA - chemistry | Models, Molecular | Rats | Excitatory Amino Acid Agonists - pharmacology | Cryoelectron Microscopy | Quisqualic Acid - chemistry | Animals | Receptors, AMPA - agonists | Calcium Channels - chemistry | Excitatory Amino Acid Agonists - chemistry | Kainic Acid - chemistry | Quisqualic Acid - pharmacology | Proteins | Glutamate | Analysis | Index Medicus
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7. Full Text Positron Emission Tomography (PET) Ligand Development for Ionotropic Glutamate Receptors: Challenges and Opportunities for Radiotracer Targeting N-Methyl- d -aspartate (NMDA), α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA), and Kainate Receptors
by Fu, Hualong and Chen, Zhen and Josephson, Lee and Li, Zijing and Liang, Steven H
Journal of medicinal chemistry, ISSN 0022-2623, 01/2019, Volume 62, Issue 2, pp. 403 - 419
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Central Nervous System - metabolism | Radiopharmaceuticals - chemistry | Receptors, Kainic Acid - chemistry | Humans | Receptors, AMPA - chemistry | Receptors, N-Methyl-D-Aspartate - metabolism | Receptors, Ionotropic Glutamate - metabolism | Positron-Emission Tomography - methods | Central Nervous System - diagnostic imaging | Receptors, Kainic Acid - metabolism | Animals | Receptors, N-Methyl-D-Aspartate - chemistry | Ligands | Receptors, Ionotropic Glutamate - chemistry | Receptors, AMPA - metabolism | Index Medicus
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8. Full Text Metal–organic framework UiO-66 modified magnetite@silica core–shell magnetic microspheres for magnetic solid-phase extraction of domoic acid from shellfish samples
by Zhang, Wenmin and Yan, Zhiming and Gao, Jia and Tong, Ping and Liu, Wei and Zhang, Lan
Journal of Chromatography A, ISSN 0021-9673, 06/2015, Volume 1400, pp. 10 - 18
HPLC–MS/MS | Magnetic solid-phase extraction | Core–shell magnetic microsphere | Domoic acid | Metal–organic frameworks | Core-shell magnetic microsphere | HPLC-MS/MS | Metal-organic frameworks | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Biochemical Research Methods | Chemistry, Analytical | Science & Technology | Microscopy, Electron, Transmission | Microscopy, Electron, Scanning | Food Analysis - methods | Food Contamination - analysis | Silicon Dioxide - chemistry | Kainic Acid - analogs & derivatives | Ferrosoferric Oxide - chemistry | Kainic Acid - isolation & purification | Microspheres | Tandem Mass Spectrometry | Magnetic Phenomena | X-Ray Diffraction | Solid Phase Extraction | Chromatography, Liquid | Shellfish - analysis | Magnetite | Safety and security measures | Silica | Analysis | Food
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9. Full Text The Neuroprotective Efficacy of Cell-Penetrating Peptides TAT, Penetratin, Arg-9, and Pep-1 in Glutamic Acid, Kainic Acid, and In Vitro Ischemia Injury Models Using Primary Cortical Neuronal Cultures
by Meloni, Bruno P and Meloni, Bruno P and Craig, Amanda J and Craig, Amanda J and Milech, Nadia and Milech, Nadia and Hopkins, Richard M and Hopkins, Richard M and Watt, Paul M and Watt, Paul M and Knuckey, Neville W and Knuckey, Neville W
Cellular and molecular neurobiology, ISSN 0272-4340, 3/2014, Volume 34, Issue 2, pp. 173 - 181
Neurosciences | Penetratin | Biomedicine | TAT | Excitotoxicity | Neurobiology | Pep-1 | Arg-9 | Cell-penetrating peptides | In vitro ischemia | Cell Biology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Cysteamine - pharmacology | Neurons - pathology | Cerebral Cortex - pathology | Molecular Sequence Data | Cell-Penetrating Peptides - pharmacology | Neuroprotective Agents - pharmacology | Carrier Proteins - pharmacology | Inhibitory Concentration 50 | Carrier Proteins - chemistry | Neurons - metabolism | Kainic Acid - toxicity | Neurons - drug effects | Oligopeptides - chemistry | Cell-Penetrating Peptides - chemistry | Ischemia - pathology | Amino Acid Sequence | Cell Survival - drug effects | Peptides - chemistry | Cysteamine - chemistry | Cells, Cultured | Rats | Neurotoxins - toxicity | Gene Products, tat - chemistry | Rats, Sprague-Dawley | Cysteamine - analogs & derivatives | Peptides - pharmacology | Animals | Models, Biological | Gene Products, tat - pharmacology | Glutamic Acid - toxicity | Oligopeptides - pharmacology | Proteins | Glucose metabolism | Nervous system diseases | Ischemia | Neurons | Analysis | Amino acids | Nucleic acids | Glucose | Glutamate | Dextrose | Index Medicus
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