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Gynecologic Oncology, ISSN 0090-8258, 2005, Volume 99, Issue 2, pp. 267 - 277
When ovarian carcinoma is diagnosed in stage I, up to 90% of patients can be cured with surgery and currently available chemotherapy. At present, less than 25%... 
HK6 | Claudin 3 | Tumor markers | HK10 | Ovarian carcinoma | CA125 | Osteopontin | FACTOR VEGF | DIAGNOSIS | tumor markers | osteopontin | ovarian carcinoma | SERUM | HUMAN TISSUE KALLIKREINS | OBSTETRICS & GYNECOLOGY | BREAST-CANCER | claudin 3 | ONCOLOGY | GENE-EXPRESSION | PATIENT SURVIVAL | CARCINOMA | ENDOTHELIAL GROWTH-FACTOR | Epididymal Secretory Proteins - biosynthesis | Immunohistochemistry | Vascular Endothelial Growth Factor A - biosynthesis | Epithelial Cells - metabolism | Kallikreins - biosynthesis | Humans | Membrane Glycoproteins - biosynthesis | Middle Aged | Antigens, Neoplasm - biosynthesis | GPI-Linked Proteins | Ovarian Neoplasms - pathology | beta-Defensins | Sialoglycoproteins - biosynthesis | Antigens - blood | CA-125 Antigen - biosynthesis | CA-19-9 Antigen - biosynthesis | Antigens, Neoplasm - blood | Female | Kallikreins - blood | Ovarian Neoplasms - metabolism | CA-19-9 Antigen - blood | Membrane Proteins - blood | Cystadenoma - metabolism | CA-125 Antigen - blood | Vascular Endothelial Growth Factor A - blood | Membrane Glycoproteins - blood | Ovarian Neoplasms - blood | Sialoglycoproteins - blood | Epithelial Cells - pathology | Glycoproteins - blood | Cystadenoma - blood | Claudin-3 | Mucin-1 | Mucins - blood | Biomarkers, Tumor - blood | Glycoproteins - biosynthesis | Mucins - biosynthesis | Membrane Proteins - biosynthesis | Epididymal Secretory Proteins - metabolism | Antigens - biosynthesis | Neoplasm Staging | Biomarkers, Tumor - biosynthesis | Antigens | Chemotherapy | Oncology, Experimental | Flexible response (Strategy) | Research | Universities and colleges | Deterrence (Strategy) | Cancer | Ovarian cancer
Journal Article
Journal Article
Blood, ISSN 0006-4971, 01/2015, Volume 125, Issue 4, pp. 710 - 719
The precise mechanism for reduced thrombosis in prekallikrein null mice (Klkb1(-/-)) is unknown. Klkb1(-/-) mice have delayed carotid artery occlusion times on... 
PLASMA KALLIKREIN | MOLECULAR-WEIGHT KININOGEN | ENDOTHELIAL-CELLS | IN-VIVO | NITRIC-OXIDE | FACTOR EXPRESSION | VASCULAR-PERMEABILITY | DEFICIENT MICE | CONTACT ACTIVATION | HEMATOLOGY | FACTOR-XII | Epoprostenol - genetics | Receptor, Bradykinin B2 - genetics | Receptors, G-Protein-Coupled - metabolism | Epoprostenol - biosynthesis | Peptide Fragments - pharmacology | Carotid Artery Thrombosis - metabolism | Pyrones - pharmacology | Sirtuin 1 - genetics | Thromboplastin - antagonists & inhibitors | Nerve Tissue Proteins - biosynthesis | Synaptotagmins - biosynthesis | Carotid Artery Thrombosis - chemically induced | Prekallikrein | Thromboplastin - biosynthesis | Proto-Oncogene Proteins - metabolism | Kruppel-Like Transcription Factors - biosynthesis | Proto-Oncogene Proteins - antagonists & inhibitors | Angiotensin II - pharmacology | Receptor, Bradykinin B2 - biosynthesis | Sirtuin 1 - biosynthesis | Proto-Oncogene Proteins - genetics | Imidazoles - pharmacology | Angiotensin II - analogs & derivatives | Sulfonamides - pharmacology | Nerve Tissue Proteins - genetics | Sirtuin 1 - antagonists & inhibitors | Mice, Knockout | Naphthalenes - pharmacology | Animals | Partial Thromboplastin Time | Thromboplastin - genetics | Receptors, G-Protein-Coupled - antagonists & inhibitors | Mice | Receptors, G-Protein-Coupled - genetics | Synaptotagmins - genetics | Carotid Artery Thrombosis - genetics | Carotid Artery Thrombosis - pathology | Kruppel-Like Transcription Factors - antagonists & inhibitors | Kruppel-Like Transcription Factors - genetics | RNA, Messenger | Index Medicus | Abridged Index Medicus | Thrombosis and Hemostasis
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2016, Volume 113, Issue 16, pp. 4482 - 4487
Journal Article
Marine Drugs, ISSN 1660-3397, 12/2018, Volume 16, Issue 12, p. 493
The green alga Chlamydomonas reinhardtii was recently been shown to be an effective bio-manufacturing platform for the production of recombinant proteins. The... 
Human kallikrein | Signal peptide | Secretory vector | Chlamydomonas reinhardtii | signal peptide | secretory vector | CHEMISTRY, MEDICINAL | GENE | human kallikrein | PROMOTER | EXPRESSION
Journal Article
Prostate, ISSN 0270-4137, 2014, Volume 74, Issue 12, pp. 1222 - 1230
BACKGROUND: To monitor systemic disease activity, the potential of circulating tumor cells (CTCs) bears great promise. As surrogate for CTCs we measured KLK3,... 
circulating tumor cells | biomarkers | CTC | MITOXANTRONE | FUSION TRANSCRIPTS | CHEMOTHERAPY | CIRCULATING TUMOR-CELLS | MESSENGER-RNA | MEN | ENDOCRINOLOGY & METABOLISM | UROLOGY & NEPHROLOGY | INCREASED SURVIVAL | PCR ASSAY | ANTIGEN | ABIRATERONE | Leukocytes, Mononuclear - metabolism | Kallikreins - biosynthesis | Prospective Studies | Humans | Middle Aged | Oncogene Proteins, Fusion - biosynthesis | Antigens, Neoplasm - biosynthesis | Male | Prostatic Neoplasms, Castration-Resistant - genetics | Young Adult | RNA, Messenger - biosynthesis | Taxoids - therapeutic use | Prostate-Specific Antigen - biosynthesis | Adult | Female | Gene Expression Regulation, Neoplastic - drug effects | Prostate-Specific Antigen - genetics | Antigens, Neoplasm - genetics | Nucleic Acid Hybridization | Leukocytes, Mononuclear - drug effects | Kallikreins - genetics | Treatment Outcome | Prostatic Neoplasms, Castration-Resistant - drug therapy | Prostatic Neoplasms, Castration-Resistant - metabolism | Leukocytes, Mononuclear - pathology | Oncogene Proteins, Fusion - genetics | Aged | Biomarkers, Tumor - genetics | Longitudinal Studies | Biomarkers, Tumor - biosynthesis | Antimitotic agents | Care and treatment | RNA | Prostate-specific antigen | Analysis | Genetic research | Kallikrein | DNA synthesis | Antineoplastic agents | Prostate cancer
Journal Article
Investigational New Drugs, ISSN 0167-6997, 10/2014, Volume 32, Issue 5, pp. 995 - 1004
Background: ASP9521 is a first-in-class orally available inhibitor of the enzyme 17 β-hydroxysteroid dehydrogenase type 5 (17 βHSD5; AKR1C3), catalysing the... 
Castration-resistant prostate cancer | Testosterone | Androgen deprivation therapy | Medicine & Public Health | Androgen synthesis | AKR1C3 | Oncology | Pharmacology/Toxicology | 17beta-hydroxysteroid dehydrogenase type 5 | ONCOLOGY | DEPRIVATION | GUIDELINES | RECEPTOR | PHARMACOLOGY & PHARMACY | DIHYDROTESTOSTERONE | Cell Count | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Prostatic Neoplasms, Castration-Resistant - pathology | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Piperidines - pharmacology | Antineoplastic Agents - adverse effects | Dihydrotestosterone - blood | Indoles - pharmacology | Piperidines - pharmacokinetics | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Kallikreins - blood | Testosterone - blood | Androgen Antagonists - pharmacokinetics | Prostatic Neoplasms, Castration-Resistant - blood | Androgen Antagonists - pharmacology | Treatment Outcome | Prostatic Neoplasms, Castration-Resistant - drug therapy | Prostate-Specific Antigen - blood | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Indoles - adverse effects | Aldo-Keto Reductase Family 1 Member C3 | Piperidines - therapeutic use | Piperidines - adverse effects | Androgen Antagonists - therapeutic use | Indoles - pharmacokinetics | Indoles - therapeutic use | Aged | Androgen Antagonists - adverse effects | Complications and side effects | Care and treatment | Patient outcomes | Androgen suppression therapy | Research | Prostate cancer | Health aspects | Studies | Androgens | Analysis | Pharmacology | Metastasis | Cancer therapies | Index Medicus
Journal Article
FASEB Journal, ISSN 0892-6638, 12/2005, Volume 19, Issue 14, pp. 2057 - 2059
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 1931-857X, 03/2005, Volume 288, Issue 3, pp. 483 - 492
In diabetes, mesangial cell proliferation and extracellular matrix expansion are critical components in the development of glomerulosclerosis. We reported that... 
Glomerulosclerosis | Connective tissue growth factor | Diabetic nephropathy | PHYSIOLOGY | FACTOR-BETA | TGF-BETA | glomerulosclerosis | connective tissue growth factor | INSULIN | RENAL KALLIKREIN | TISSUE GROWTH-FACTOR | HUMAN MESANGIAL CELLS | KININ | HIGH GLUCOSE | UROLOGY & NEPHROLOGY | ACTIVATED PROTEIN-KINASES | EXPRESSION | diabetic nephropathy | Oncogene Protein pp60(v-src) - metabolism | DNA, Complementary - genetics | Intercellular Signaling Peptides and Proteins - biosynthesis | Male | Glomerular Mesangium - cytology | RNA - isolation & purification | Glomerular Mesangium - metabolism | Up-Regulation - physiology | DNA, Complementary - biosynthesis | Kidney Glomerulus - metabolism | Glomerular Mesangium - drug effects | Bradykinin - biosynthesis | Bradykinin - pharmacology | Collagen Type II - biosynthesis | Diabetic Nephropathies - pathology | Diabetic Nephropathies - metabolism | Immediate-Early Proteins - biosynthesis | Cells, Cultured | Mitogen-Activated Protein Kinases - biosynthesis | Receptor, Bradykinin B2 - biosynthesis | Rats | Kidney Glomerulus - pathology | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | Blotting, Western | Bradykinin - physiology | RNA - biosynthesis | Collagen Type I - biosynthesis | Receptors, Transforming Growth Factor beta - biosynthesis | Animals | Diabetes Mellitus, Experimental - pathology | Signal Transduction - physiology | Connective Tissue Growth Factor
Journal Article
Gynecologic Oncology, ISSN 0090-8258, 2006, Volume 103, Issue 2, pp. 405 - 416
To identify novel molecular biomarkers useful for the early diagnosis and therapy of ovarian cancer by gene expression profiling. To compare the genetic... 
Claudins | Mammaglobin 2 | Gene expression profiling | Primary ovarian tumor cultures | Ovarian cancer | Kallikreins | kallikreins | ovarian cancer | EARLY-STAGE | MARKERS | CLOSTRIDIUM-PERFRINGENS ENTEROTOXIN | MAMMAGLOBIN B | HUMAN TISSUE KALLIKREINS | OBSTETRICS & GYNECOLOGY | B7 FAMILY-MEMBER | CANCER DIAGNOSIS | EPITHELIUM | ONCOLOGY | T-CELL-ACTIVATION | mammaglobin 2 | MICROARRAYS | gene expression profiling | claudins | primary ovarian tumor cultures | Immunohistochemistry | Kallikreins - biosynthesis | Humans | Middle Aged | Cystadenocarcinoma, Serous - metabolism | Ovarian Neoplasms - pathology | Gene Expression Profiling | Cystadenocarcinoma, Serous - genetics | Cystadenocarcinoma, Serous - pathology | Mammaglobin A | Ovarian Neoplasms - genetics | Aged, 80 and over | Adult | Female | Ovarian Neoplasms - metabolism | Tumor Cells, Cultured | Uteroglobin - biosynthesis | Neoplasm Proteins - genetics | Membrane Proteins - genetics | Neoplasm Proteins - biosynthesis | Kallikreins - genetics | Uteroglobin - genetics | Epithelial Cells - pathology | Reverse Transcriptase Polymerase Chain Reaction | Claudin-4 | Claudin-3 | Membrane Proteins - biosynthesis | Biopsy | Aged | Biomarkers, Tumor - genetics | Biomarkers, Tumor - biosynthesis | Care and treatment | Immunocytochemistry | Kallikrein | Genetic aspects | Biological markers | Gene expression | Cancer | Tumors
Journal Article
Journal Article