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Molecules, ISSN 1420-3049, 11/2018, Volume 23, Issue 11, p. 2919
Inhibition of glycogen synthase kinase 3β (GSK-3β) is considered to be the central therapeutic approach against Alzheimer’s disease (AD). In the present study,... 
GSK-3β | Kangen-karyu | Salvia miltiorrhiza | Salvianolic acids | Alzheimer’s disease | salvianolic acids
Journal Article
MOLECULES, ISSN 1420-3049, 11/2018, Volume 23, Issue 11
Inhibition of glycogen synthase kinase 3 (GSK-3) is considered to be the central therapeutic approach against Alzheimer's disease (AD). In the present study,... 
SIGNALING PATHWAYS | salvianolic acids | DOCKING | BIOCHEMISTRY & MOLECULAR BIOLOGY | GSK-3-BETA | Kangen-karyu | MEMANTINE | CHEMISTRY, MULTIDISCIPLINARY | BETA | Salvia miltiorrhiza | SALVIA-MILTIORRHIZA | GSK3 | GSK-3 beta | EXTRACTS | Alzheimer's disease | INSIGHTS | KINASES
Journal Article
Drug Discoveries & Therapeutics, ISSN 1881-7831, 2017
Chinese prescription Kangen-karyu, comprised of six crude drugs, has received much attention due to its numerous biological activities. The present study... 
cognitive deficit | Kangen-karyu | dementia | aging | diabetes | diabetic nephropathy
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 10/2011, Volume 137, Issue 3, pp. 1135 - 1142
The aim of this research was to study the anti-diabetic efficacy and mechanisms of 34 herbs derived from Chinese traditional pharmacopeia. Several herbs have... 
Traditional Chinese medicine | Streptozotocin-induced diabetic mice | Antioxidation | Diabetes mellitus | Antidiabetic | TANG | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | HERBAL MEDICINE | MELLITUS | NEPHROPATHY | PLANT SCIENCES | INTEGRATIVE & COMPLEMENTARY MEDICINE | PHARMACOLOGY & PHARMACY | COMPLICATIONS | KANGEN-KARYU | NF-KAPPA-B | ALDOSE REDUCTASE | POLYSACCHARIDE | Glycoside Hydrolase Inhibitors | Diabetes Mellitus, Experimental - drug therapy | Kidney - pathology | Drugs, Chinese Herbal - pharmacology | Superoxide Dismutase - blood | Male | Diabetic Nephropathies - blood | Diabetes Mellitus, Experimental - blood | Aldehyde Reductase - blood | Kidney - metabolism | Hypoglycemic Agents - administration & dosage | Time Factors | Malondialdehyde - blood | Peptidyl-Dipeptidase A - metabolism | Female | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Drugs, Chinese Herbal - administration & dosage | Diabetic Nephropathies - prevention & control | Diabetic Nephropathies - pathology | Kidney - drug effects | Administration, Oral | Antioxidants - pharmacology | Hypoglycemic Agents - pharmacology | Blood Glucose - drug effects | Animals | Diabetes Mellitus, Experimental - pathology | Mice | Blood Glucose - metabolism | Plants, Medicinal | alpha-Glucosidases - metabolism | Hypertrophy | Antioxidants | Aldose reductase | Streptozocin | Analysis | Angiotensin converting enzyme | Angiotensin | Liquid chromatography | Superoxide | Medicine, Chinese | Diabetes | Sugars | Monosaccharides
Journal Article
Phytotherapy Research, ISSN 0951-418X, 05/2017, Volume 31, Issue 5, pp. 721 - 728
The present study was conducted to examine whether magnesium lithospermate B (MLB) extracted from Salviae miltiorrhizae radix was renoprotective in pathways... 
senescence | aging | inflammation | magnesium lithospermate B | renal damage | oxidative stress | CELLS | CHEMISTRY, MEDICINAL | NAD(P)H OXIDASE | INDUCED DIABETIC-RATS | CRUDE DRUG TANJIN | PROTECTIVE ROLE | PHARMACOLOGY & PHARMACY | PRESCRIPTION KANGEN-KARYU | KIDNEY | EXPRESSION | AGE | Reactive Oxygen Species - metabolism | Aging - drug effects | NADPH Oxidases - metabolism | ADP-Ribosylation Factors | Drugs, Chinese Herbal - pharmacology | Kidney Diseases - drug therapy | Rats | Male | NF-kappa B - metabolism | Rats, Sprague-Dawley | Inflammation - metabolism | Salvia miltiorrhiza - chemistry | Animals | Aging - physiology | Drugs, Chinese Herbal - chemistry | Cyclooxygenase 2 - metabolism | Oxidative Stress - drug effects | Mitogen-Activated Protein Kinases - metabolism | Phosphates | ADP-ribosylation factor | Oxidative stress | GTP-binding protein | Reactive oxygen species | Senescence | Renal function | Body weight | p53 Protein | Oxidase | Fuel consumption | Kinases | ADP | ADP-ribosylation factor 6 | NAD(P)H oxidase | Prostaglandin endoperoxide synthase | Proteins | NOX4 protein | Rodents | Aging | Magnesium | ADP-ribosylation | NF-κB protein | Oxygen | Kidneys | NADPH-diaphorase | Structural proteins | Oral administration | Aging (artificial) | MAP kinase | Nitric-oxide synthase | Urea | Salvia miltiorrhiza | Injury prevention | Protein kinase | Nitric oxide | Nicotinamide adenine dinucleotide | Nicotinamide | Cyclooxygenase-2
Journal Article
Journal Article
YONAGO ACTA MEDICA, ISSN 0513-5710, 06/2016, Volume 59, Issue 2, pp. 111 - 117
Background Ranitidine is a histamine 2 receptor antagonist, and daijokito is a Kampo (Chinese herbal medicine as practiced in Japan) formula, which is... 
MEDICINE, RESEARCH & EXPERIMENTAL | daijokito | ranitidine | CYTOCHROME-P450 | TALINOLOL | RATS | P-GLYCOPROTEIN | TRADITIONAL HERBAL MEDICINE | METABOLISM | ORAL BIOAVAILABILITY | pharmacokinetics | KANGEN-KARYU | drug-drug interaction | EXPRESSION
Journal Article
The American Journal of Chinese Medicine, ISSN 0192-415X, 2014, Volume 42, Issue 4, pp. 987 - 1005
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 2010, Volume 131, Issue 2, pp. 377 - 385
Administration of Kangen-kary (KK) for 3 weeks improves memory deficits of aged SAMP8, an animal model of aging, in the object recognition test (ORT) and the... 
Aging | Kangen-karyu | Brain-derived neurotrophic factor | Neuro-plasticity-related signaling | Vascular endothelial growth factor | Dementia | CHEMISTRY, MEDICINAL | ANGIOGENESIS | SCOPOLAMINE | PAEONIFLORIN | IMPAIRMENT | PLANT SCIENCES | INTEGRATIVE & COMPLEMENTARY MEDICINE | RADIAL MAZE | CALCIUM | NEUROGENESIS | PHARMACOLOGY & PHARMACY | MICE | PROTEIN-KINASE-II | AGE | Phosphorylation | Calcium - metabolism | Receptors, N-Methyl-D-Aspartate - metabolism | Drugs, Chinese Herbal - pharmacology | Memory Disorders - metabolism | Neuronal Plasticity - drug effects | Male | Anxiety - drug therapy | Vascular Endothelial Growth Factor A - metabolism | Magnoliopsida | RNA, Messenger - metabolism | Vascular Endothelial Growth Factor A - genetics | Cerebral Cortex - metabolism | Vascular Endothelial Growth Factor Receptor-2 - genetics | Behavior, Animal - drug effects | Brain-Derived Neurotrophic Factor - metabolism | Cerebral Cortex - drug effects | Drugs, Chinese Herbal - therapeutic use | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Disease Models, Animal | Down-Regulation | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Cognition - drug effects | Maze Learning - drug effects | Mice, Inbred Strains | Animals | Memory Disorders - drug therapy | Aging - physiology | Signal Transduction - drug effects | Cyclic AMP Response Element-Binding Protein - metabolism | Mice | Brain | Analysis | Memory
Journal Article
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 2009, Volume 124, Issue 2, pp. 263 - 269
In the present study, we investigated the effects of Kangen-karyu, a traditional Chinese prescription comprising six herbs, on diabetes. Kangen-karyu extract... 
Oxidative stress | Kangen-karyu | Streptozotocin | Advanced glycation endproduct | CHEMISTRY, MEDICINAL | LIPID-PEROXIDATION | CHRONIC LIVER-DISEASE | INJURY | SCAVENGER RECEPTORS | KAPPA-B | PLANT SCIENCES | INTEGRATIVE & COMPLEMENTARY MEDICINE | PROTECTIVE ROLE | ANTIOXIDANT | DENSITY-LIPOPROTEIN | PHARMACOLOGY & PHARMACY | PROTEINS | END-PRODUCTS | Hypertriglyceridemia - drug therapy | Diabetes Mellitus, Experimental - drug therapy | Oxidative Stress | Rats, Wistar | Cholesterol - blood | Drugs, Chinese Herbal - pharmacology | Male | NF-kappa B - metabolism | Magnoliopsida | Hypoglycemic Agents - administration & dosage | Lysine - metabolism | Phytotherapy | Diabetes Mellitus, Experimental - metabolism | Drugs, Chinese Herbal - therapeutic use | Hypoglycemic Agents - therapeutic use | Malondialdehyde - metabolism | Liver - metabolism | Rats | Hypertriglyceridemia - metabolism | Antioxidants - pharmacology | Hypolipidemic Agents - pharmacology | Hypoglycemic Agents - pharmacology | Antioxidants - therapeutic use | Animals | Glycation End Products, Advanced - metabolism | Antioxidants - administration & dosage | Cyclooxygenase 2 - metabolism | Hypolipidemic Agents - administration & dosage | Triglycerides - blood | Hypolipidemic Agents - therapeutic use | Blood Glucose - metabolism | Plants, Medicinal | Nitric Oxide Synthase Type II - metabolism
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 2010, Volume 129, Issue 3, pp. 299 - 305
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 2007, Volume 109, Issue 1, pp. 113 - 120
We investigated the effects of Chinese prescription Kangen-karyu on high glucose-induced oxidative stress using LLC-PK cells, renal tubular cells, which are... 
NF-κB | Oxidative stress | Reactive oxygen species | COX-2 | Kangen-karyu | iNOS | High glucose
Journal Article