X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (1397) 1397
Publication (242) 242
Book Review (228) 228
Book Chapter (29) 29
Conference Proceeding (19) 19
Dissertation (6) 6
Reference (2) 2
Book / eBook (1) 1
Paper (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
keap1 (1094) 1094
index medicus (1024) 1024
nrf2 (864) 864
oxidative stress (788) 788
humans (691) 691
animals (555) 555
nf-e2-related factor 2 - metabolism (540) 540
biochemistry & molecular biology (473) 473
kelch-like ech-associated protein 1 (350) 350
mice (334) 334
antioxidants (320) 320
nf-e2-related factor 2 - genetics (301) 301
activation (299) 299
transcription factor nrf2 (299) 299
cancer (233) 233
respiratory system (217) 217
signal transduction (210) 210
cell biology (207) 207
proteins (203) 203
expression (199) 199
intracellular signaling peptides and proteins - metabolism (184) 184
pathway (181) 181
article (175) 175
male (174) 174
environment and public health (167) 167
gene-expression (165) 165
gene expression (164) 164
enzymes (160) 160
analysis (154) 154
antioxidant response element (154) 154
cell line, tumor (152) 152
apoptosis (150) 150
oncology (150) 150
pharmacology & pharmacy (146) 146
induction (144) 144
female (136) 136
digestive system (128) 128
reactive oxygen species - metabolism (124) 124
signal transduction - drug effects (124) 124
cell line (123) 123
oxidative stress - drug effects (123) 123
autophagy (118) 118
endocrinology & metabolism (117) 117
toxicology (114) 114
protein (113) 113
intracellular signaling peptides and proteins - genetics (110) 110
cells (109) 109
cul3-based e3 ligase (109) 109
inflammation (106) 106
antioxidants - metabolism (104) 104
ubiquitination (104) 104
antioxidant response (103) 103
genes (103) 103
transcription factors (101) 101
protein binding (100) 100
kelch-like ech-associated protein 1 - metabolism (98) 98
heme oxygenase-1 (91) 91
cells, cultured (89) 89
glutathione (89) 89
rats (89) 89
signaling pathway (88) 88
mutation (87) 87
physiological aspects (86) 86
antioxidant (84) 84
degradation (83) 83
nf-kappa-b (83) 83
oxidation-reduction (83) 83
adaptor proteins, signal transducing - metabolism (82) 82
biology (82) 82
mechanisms (82) 82
gene expression regulation (80) 80
transcription factor (80) 80
cysteine (79) 79
reactive oxygen species (79) 79
heme (78) 78
stress (77) 77
chemistry, medicinal (76) 76
phosphorylation (76) 76
medicine (75) 75
nadh dehydrogenase (75) 75
research (75) 75
gene (74) 74
ubiquitin (74) 74
antioxidants - pharmacology (73) 73
biophysics (73) 73
genetic aspects (73) 73
chemotherapy (72) 72
health aspects (69) 69
quinone (69) 69
ligases (68) 68
p62 (67) 67
binding (66) 66
lung-cancer (66) 66
mice, knockout (66) 66
transcription (66) 66
middle aged (65) 65
neurosciences (65) 65
kelch-like ech-associated protein 1 - genetics (63) 63
oxidative stress - physiology (63) 63
cytoskeletal proteins - metabolism (61) 61
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (1413) 1413
Japanese (6) 6
Korean (5) 5
Chinese (3) 3
French (2) 2
Russian (2) 2
German (1) 1
Polish (1) 1
Spanish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Topics in Current Chemistry, ISSN 0340-1022, 2013, Volume 329, pp. 133 - 162
Conference Proceeding
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 06/2015, Volume 63, Issue 22, pp. 5468 - 5475
Journal Article
CANCER DISCOVERY, ISSN 2159-8274, 11/2013, Volume 3, Issue 11, pp. 1272 - 1285
Autophagic elimination of defective mitochondria suppresses oxidative stress and preserves mitochondrial function. Here, the essential autophagy gene Atg7 was... 
NRF2 ACTIVATION | GENE | ONCOLOGY | KEAP1 | MAMMARY TUMORIGENESIS | MUTATIONS | STRESS | CANCER | P62 | PROGRESSION | IMPAIRMENT
Journal Article
Frontiers in Oncology, 05/2017, Volume 7, Issue MAY
Journal Article
Journal Article
Breast Cancer Research and Treatment, ISSN 0167-6806, 2/2012, Volume 132, Issue 1, pp. 175 - 187
Journal Article
Antioxidants (Basel, Switzerland), ISSN 2076-3921, 08/2019, Volume 8, Issue 8, p. 295
Ampelopsis grossedentata, also called vine tea, has been used as a traditional beverage in China for centuries. Vine tea contains rich polyphenols and shows... 
Nrf2/Keap1 | dihydromyricetin | antioxidant ability | Ampelopsis grossedentata
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2017, Volume 114, Issue 23, pp. E4676 - E4685
The activity of the transcription factor nuclear factor-erythroid 2 p45-derived factor 2 (NRF2) is orchestrated and amplified through enhanced transcription of... 
Antiinflammatory responses | KEAP1/NRF2/ARE signaling | Huntington's disease | Human neural stem cells | NRF2 inducer | human neural stem cells | OXIDATIVE STRESS | MICROGLIAL ACTIVATION | PROTEIN | PROTEASOMAL DEGRADATION | MULTIDISCIPLINARY SCIENCES | KEAP1 | antiinflammatory responses | NEURODEGENERATIVE DISEASES | TRANSCRIPTION FACTOR NRF2 | GENE | CUL3-BASED E3 LIGASE | MOUSE MODEL | Microglia - metabolism | Humans | Middle Aged | Protein Conformation - drug effects | Male | Kelch-Like ECH-Associated Protein 1 - chemistry | Brain - metabolism | Neuroprotective Agents - pharmacology | HEK293 Cells | Adult | Female | Disease Models, Animal | Cytokines - metabolism | Microglia - drug effects | Signal Transduction | Mice, Inbred C57BL | Cells, Cultured | Rats | Kelch-Like ECH-Associated Protein 1 - metabolism | Huntington Disease - metabolism | MPTP Poisoning - prevention & control | Brain - drug effects | Macrophages - metabolism | Animals | MPTP Poisoning - metabolism | NF-E2-Related Factor 2 - metabolism | Huntington Disease - genetics | Macrophages - drug effects | Aged | Mice | NF-E2-Related Factor 2 - chemistry | Neural Stem Cells - metabolism | Huntingtons disease | Transcription factors | Cytokines | Astrocytes | Stem cell transplantation | Activation | Inflammation | Patients | Microglia | Proteins | Interleukin 6 | Antioxidants | Monocytes | Allografts | Stem cells | Interleukin 1 | Neural stem cells | Mutation | Human behavior | Interleukin 8 | Ubiquitin-protein ligase | Index Medicus | Biological Sciences | PNAS Plus | NRF2 | ARE signaling | Huntington’s disease
Journal Article
Annual Review of Pharmacology and Toxicology, ISSN 0362-1642, 1/2019, Volume 59, Issue 1, pp. 555 - 575
The transcription factor nuclear factor erythroid 2 (NF-E2)-related factor 2 (NRF2) is a central regulator of redox, metabolic, and protein homeostasis that... 
KEAP1 | therapeutics | cancer | clinical trials | disease | NRF2 | CANCER-CELLS | OXIDATIVE STRESS | LEUCINE-ZIPPER | E3 LIGASE | TRANSCRIPTION FACTOR NRF2 | E3-UBIQUITIN LIGASE COMPLEX | MOUSE MODEL | PHARMACOLOGY & PHARMACY | TOXICOLOGY | NF-KAPPA-B | NRF2-KEAP1 SIGNALING PATHWAY | KEAP1 GENE PROMOTER
Journal Article
Life sciences, 08/2019, pp. 116826 - 116826
AIMSHepatitis is a kind of liver dysfunction and usually refers to a variety of pathogenic factors. Circular RNA (circRNA) participates in diverse diseases.... 
Index Medicus
Journal Article
Oncotarget, ISSN 1949-2553, 02/2018, Volume 9, Issue 14, pp. 11665 - 11676
We have recently reported that activation of Brd4 is associated with the presence of autophagy in NPMc+ and MLL AML cells. In order to determine the mechanisms... 
AML | Keap1 | Autophagy | Brd4
Journal Article
Gene, ISSN 0378-1119, 04/2019, Volume 691, pp. 8 - 17
In human pancreatic β-cells, oxidative stress and cellular injures can be induced by H O treatment. The KEAP1/NRF2 axis is a key antioxidant signaling pathway.... 
NRF2 | Pancreatic β-cell | H | KEAP1 | Apoptosis | O
Journal Article
MOLECULAR AND CELLULAR BIOLOGY, ISSN 0270-7306, 07/2019, Volume 39, Issue 13
The nuclear factor (erythroid 2)-like 2 (NRF2 or NFE2L2) transcription factor regulates the expression of many genes that are critical in maintaining cellular... 
molecular biology | CRISPR | autophagy | signal transduction | BIOCHEMISTRY & MOLECULAR BIOLOGY | KEAP1 | KEAP1-NRF2 PATHWAY | CELL-PROLIFERATION | SUBSTRATE ADAPTER | CANCER | CELL BIOLOGY | PERSISTENT ACTIVATION | NRF2 | SIGNALING PATHWAY | GENE-EXPRESSION | genomics | KEAP1/NRF2 PATHWAY | THIOREDOXIN REDUCTASE | gene reporters | oxidative stress | NFE2L2
Journal Article
Cell Reports, ISSN 2211-1247, 07/2019, Volume 28, Issue 3, pp. 746 - 758.e4
The Keap1-Nrf2 system plays a central role in the oxidative stress response; however, the identity of the reactive oxygen species sensor within Keap1 remains... 
Keap1 | oxidative stress response | Nrf2 | reactive cysteine residues | NRF2 | STRUCTURAL BASIS | COVALENT MODIFICATION | SENSOR KEAP1 | NITRIC-OXIDE | THIOREDOXIN REDUCTASE | DISULFIDE BOND | INDUCTION | CYSTEINE RESIDUES | PHASE-2 RESPONSE | CELL BIOLOGY
Journal Article
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, ISSN 1040-8428, 08/2017, Volume 116, pp. 89 - 98
Keapl-Nrf2 pathway is continuously involved in the cytoprotection from oxidative stress generated due to various factors either extrinsic or intrinsic in... 
Oxidative stress | MEDIATED DOWN-REGULATION | GLUTATHIONE S-TRANSFERASES | Tumor suppressor | BREAST-CANCER | LUNG-CANCER | TRANSCRIPTION FACTOR NRF2 | ANTIOXIDANT RESPONSE ELEMENT | UBIQUITIN LIGASE COMPLEX | ONCOLOGY | Nrf2 | SIGNALING PATHWAY | Keap1 | KEAP1 GENE | Tumor promoter | HEMATOLOGY | Cancer
Journal Article
Head & Neck, ISSN 1043-3074, 05/2015, Volume 37, Issue 5, pp. 727 - 734
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2009, Volume 47, Issue 9, pp. 1310 - 1317
The J series of cyclopentenone prostaglandins (PGs) such as 15-deoxy-Δ -PGJ (15d-PGJ ) are electrophilic lipid signaling mediators derived from the... 
Keap1 | 15-Deoxy-Δ12,14-prostaglandin J2 | Thiol modification | Nrf2 | Redox regulation
Journal Article
Ageing Research Reviews, ISSN 1568-1637, 09/2019, Volume 54
A failure in redox homeostasis is a common hallmark of Alzheimer’s Disease (AD) and Parkinson’s Disease (PD), two age-dependent neurodegenerative disorders... 
Oxidative stress | Alzheimer’s disease | Nrf2 | Keap1 | Parkinson’s disease
Journal Article