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kelch-like ech-associated protein 1 - genetics (83) 83
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biology (74) 74
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adaptor proteins, signal transducing - metabolism (72) 72
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keap1, kelch-like ech-associated protein 1 (50) 50
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phosphorylation (48) 48
blotting, western (47) 47
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Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2018, Volume 61, Issue 17, pp. 8029 - 8047
.... Ubiquitination and subsequent degradation of the transcription factor NRF2 is mediated by Kelch-like ECH-associated protein-1 (KEAP1... 
CATION-PI INTERACTIONS | RECOGNITION MODEL | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | ANTIOXIDANT RESPONSE ELEMENT | TRANSCRIPTION FACTOR NRF2 | MECHANISM | COVALENT BINDING | IN-VIVO | KEAP1 | DISCOVERY | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 11/2006, Volume 399, Issue 3, pp. 373 - 385
... (Kelch-like ECH-associated protein 1). We have examined the function of the 155-amino-acid N-terminal polypeptide in Nrf1, along with its adjacent Neh2-like subdomain... 
Kelch-like ECH-associated protein 1 (Keap1) | Nuclear factor-erythroid 2 p45 subunit-related factor 2 (Nrf2) | Oxidative stress | Nuclear factor-erythroid 2 p45 subunit-related factor 1 (Nrf1) | Antioxidant response element | Endoplasmic reticulum | FACTOR TCF11 | nuclear factor-erythroid 2 p45 subunit-related factor 1 (Nrf1) | nuclear factor-erythroid 2 p45 subunit-related factor 2 (Nrf2) | DETOXIFYING ENZYMES | BIOCHEMISTRY & MOLECULAR BIOLOGY | Kelch-like ECH-associated protein 1 (Keap 1) | MEDIATED EXPRESSION | NUCLEAR EXPORT | reticulum | CONSENSUS SEQUENCE | GENE-EXPRESSION | EMBRYONIC LETHALITY | endoplasmic | antioxidant response element | oxidative stress | INDUCIBLE EXPRESSION | Cytoskeletal Proteins - genetics | Humans | Transcriptional Activation | DNA, Complementary - genetics | Cercopithecus aethiops | Endoplasmic Reticulum - metabolism | Molecular Sequence Data | Protein Transport - physiology | Structure-Activity Relationship | Nuclear Respiratory Factor 1 - genetics | Recombinant Fusion Proteins - metabolism | Cytoskeletal Proteins - deficiency | Cell Nucleus - metabolism | Nuclear Respiratory Factor 1 - metabolism | Fibroblasts | NF-E2-Related Factor 2 - genetics | Cytoskeletal Proteins - physiology | Kelch-Like ECH-Associated Protein 1 | Genes, Reporter | Protein Structure, Tertiary | Amino Acid Sequence | Mutagenesis, Site-Directed | Cells, Cultured | Nuclear Respiratory Factor 1 - chemistry | Rats | Nuclear Proteins - metabolism | Epithelial Cells | Amino Acid Motifs | Mice, Knockout | Adaptor Proteins, Signal Transducing - physiology | Animals | Adaptor Proteins, Signal Transducing - deficiency | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Mice | NF-E2-Related Factor 2 - chemistry | COS Cells | Neh2L, Nrf2-ECH homology 2-like | Nrf1, Nrf2, and Nrf3, nuclear factor-erythroid 2 p45 subunit-related factors 1, 2 and 3 | NuPAGE, Novex® PAGE | TCF11, transcription factor 11 | Gal4D, Gal4 DNA-binding domain | PBGD, porphobilinogen deaminase | SREBP, sterol-regulatory-element-binding protein | CNC, cap ‘n’ collar | Maf, musculoaponeurotic fibrosarcoma retrovirus transforming gene | NQO1, NAD(P)H:quinone oxidoreductase 1 | SV40, simian virus 40 | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | Luc, luciferase | nqo1-Luc | UAS, a Gal4-specific binding site | ARE, antioxidant response element | CREB, cyclic-AMP-response-element-binding protein | LDS, lithium dodecyl sulfate | bZIP, basic region-leucine zipper | FITC, fluorescein isothiocyanate | Keap1, Kelch-like ECH-associated protein 1 | DAPI, 4′,6-diamidino-2-phenylindole | P, promoter (as in P−1016 | TK, thymidine kinase promoter | β-gal, β-galactosidase | GCLM, glutamate cysteine ligase modifier | NTD, N-terminal domain | KO, knockout | MEF, mouse embryonic fibroblast | NHB, N-terminal homology box | endoplasmic reticulum
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 05/2017, Volume 486, Issue 3, pp. 620 - 625
Journal Article
Cell Metabolism, ISSN 1550-4131, 04/2018, Volume 27, Issue 4, pp. 935 - 943.e4
Journal Article
Journal of Biochemical and Molecular Toxicology, ISSN 1095-6670, 09/2011, Volume 25, Issue 5, pp. 320 - 329
...) expression in liver. Hepatocyte‐specific deletion of Kelch‐like ECH‐associated protein 1 (Keap1) activates Nrf2. Use of hepatocyte‐specific Keap1 deletion represents... 
Nuclear Factor‐E2‐Related Factor 2(nrfz | Kelch‐Like ECH‐Associated Protein 1(Kea‐p1) | nfe2Lz) Organic Anion‐Transporting Polypeptide (Oatp | Abcc4 | Multidrug‐Resistance‐Associated Protein(Mrp) | Kelch-Like ECH-Associated Protein 1(Kea-p1) | Nfe2Lz) Organic Anion-Transporting Polypeptide (Oatp | Multidrug-Resistance-Associated Protein(Mrp) | Nuclear Factor-E2-Related Factor 2(nrfz | Nuclear Factor-E2-Related Factor 2(nrfz, nfe2Lz) Organic Anion-Transporting Polypeptide (Oatp) | DIFFERENTIAL EXPRESSION | Kelch-Like ECH-Associated Protein 1(Keap1) | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE-LIVER | RECEPTOR | INDUCTION | TRANSCRIPTION FACTOR NRF2 | ANTIOXIDANT RESPONSE ELEMENT | TISSUE DISTRIBUTION | IN-VIVO | GENES | RESISTANCE | TOXICOLOGY | Cytoskeletal Proteins - genetics | Cytochrome P-450 Enzyme System - metabolism | Hepatocytes - metabolism | NAD(P)H Dehydrogenase (Quinone) - genetics | Organic Anion Transporters - metabolism | Cytoskeletal Proteins - deficiency | Hepatocytes - cytology | Organic Anion Transporters - genetics | Gene Deletion | Multidrug Resistance-Associated Proteins - genetics | NF-E2-Related Factor 2 - genetics | Glutamate-Cysteine Ligase - metabolism | Kelch-Like ECH-Associated Protein 1 | Drug Resistance, Multiple - genetics | Signal Transduction | Liver - metabolism | Gene Expression Regulation | Mice, Knockout | Animals | Adaptor Proteins, Signal Transducing - deficiency | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Cytochrome P-450 Enzyme System - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Glutamate-Cysteine Ligase - genetics | Liver - cytology | Mice | Multidrug Resistance-Associated Proteins - metabolism | Glutamate-cysteine ligase | Enzymes | biotransformation | organic anion transporting polypeptide | Cytochrome P450 | Liver | Sulfotransferase | mRNA | Internet | Gene expression | oxidoreductase | Catalytic subunits | Multidrug resistance-associated protein (Mrp) | Keap1 | nfe2l2 | Organic anion transporting polypeptide (Oatp) | Nrf2
Journal Article
Journal Article
Cell, ISSN 0092-8674, 07/2019, Volume 178, Issue 2, pp. 316 - 329.e18
Approximately 30% of human lung cancers acquire mutations in either Keap1 or Nfe2l2, resulting in the stabilization of Nrf2, the Nfe2l2 gene product, which... 
lung cancer | Bach1 | cullin-RING ubiquitin ligase | Fbxo22 | metastasis | Nrf2 | F-box proteins | Ho1 inhibitor | Heme | Keap1 | ubiquitin | CRL complexes | TRANSCRIPTION FACTORS | SIGNALING PATHWAY | CARBON-MONOXIDE | QUANTIFICATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NITRIC-OXIDE | HEME OXYGENASE-1 | INDUCTION | SUPPRESSION | EXPRESSION | REVEALS | CELL BIOLOGY | Heme Oxygenase-1 - metabolism | Basic-Leucine Zipper Transcription Factors - metabolism | Lung Neoplasms - mortality | Humans | Lung Neoplasms - metabolism | Transcriptional Activation | Lung Neoplasms - pathology | Male | F-Box Proteins - antagonists & inhibitors | Kelch-Like ECH-Associated Protein 1 - genetics | Heme Oxygenase-1 - genetics | Neoplasm Metastasis | RNA Interference | Female | NF-E2-Related Factor 2 - genetics | Basic-Leucine Zipper Transcription Factors - antagonists & inhibitors | F-Box Proteins - metabolism | Mice, Inbred C57BL | Kaplan-Meier Estimate | Kelch-Like ECH-Associated Protein 1 - metabolism | Receptors, Cytoplasmic and Nuclear - genetics | Basic-Leucine Zipper Transcription Factors - genetics | Heme Oxygenase-1 - antagonists & inhibitors | Mice, Knockout | Kelch-Like ECH-Associated Protein 1 - antagonists & inhibitors | Animals | NF-E2-Related Factor 2 - metabolism | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Cell Line, Tumor | Mice | F-Box Proteins - genetics | Cell Movement | RNA, Small Interfering - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Ubiquitin | Prevention | Medical colleges | Ligases | Analysis | Lung cancer | Metastasis | Cancer | pathology | RNA | Lung Neoplasms | F-Box Proteins | Receptors | genetics | Tumor | Heme Oxygenase-1 | Kelch-Like ECH-Associated Protein 1 | Cell Line | Small Interfering | antagonists & inhibitors | Inbred C57BL | Knockout | Cytoplasmic and Nuclear | mortality | NF-E2-Related Factor 2 | metabolism | Cancer and Oncology | Basic-Leucine Zipper Transcription Factors | Cancer och onkologi
Journal Article
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 01/2018, Volume 33, Issue 1, pp. 833 - 841
A new Keap1-Nrf2 protein-protein interaction (PPI) inhibitor ZJ01 was identified from our compound library by fluorescence polarization assay, surface plasmon resonance, molecular docking and molecular dynamics simulation... 
Keap1 | protein-protein interaction inhibitor | cytoprotective | Nrf2 | septic cardiomyopathy | protein–protein interaction inhibitor | ACTIVATION | CHEMISTRY, MEDICINAL | H9C2 CARDIOMYOCYTES | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-PROTEIN INTERACTION | ATOMIC CHARGES | KAPPA-B | PATHWAY | FORCE-FIELD | DYSFUNCTION | INFLAMMATORY RESPONSE | Small Molecule Libraries - pharmacology | NF-E2-Related Factor 2 - antagonists & inhibitors | Reactive Oxygen Species - metabolism | Male | Structure-Activity Relationship | Lipopolysaccharides - antagonists & inhibitors | Dose-Response Relationship, Drug | Kelch-Like ECH-Associated Protein 1 - genetics | RNA, Messenger - biosynthesis | Protein Binding - drug effects | RNA, Messenger - antagonists & inhibitors | Cytoprotection - drug effects | NF-E2-Related Factor 2 - genetics | Molecular Structure | Cardiomyopathies - drug therapy | Mice, Inbred C57BL | Cells, Cultured | Models, Molecular | Rats | Small Molecule Libraries - chemical synthesis | Kelch-Like ECH-Associated Protein 1 - metabolism | Kelch-Like ECH-Associated Protein 1 - antagonists & inhibitors | Small Molecule Libraries - chemistry | Reactive Oxygen Species - antagonists & inhibitors | Animals | Cardiomyopathies - metabolism | NF-E2-Related Factor 2 - metabolism | Lipopolysaccharides - pharmacology | Mice | Cytokines - antagonists & inhibitors | Cytokines - biosynthesis | Cardiomyopathies - chemically induced | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2017, Volume 292, Issue 34, pp. 14108 - 14121
.... It is well-known that Nrf2 is regulated at the protein level by proteasomal degradation via Kelch-like ECH-associated protein 1 (Keap1... 
antioxidant | APIGENIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | molecular pharmacology | KEAP1 | translation control | PROTEIN-KINASE KINASE | MAMMALIAN-CELLS | nuclear factor 2 (erythroid-derived 2-like factor) (NFE2L2) (Nrf2) | TRANSCRIPTION FACTOR NRF2 | EPITHELIAL-CELLS | PATHWAY | DISEASE | WISTAR ALBINO RATS | oxidative stress | Luciferases - metabolism | Humans | NF-E2-Related Factor 2 - agonists | Antioxidant Response Elements - drug effects | Stilbenes - pharmacology | Recombinant Fusion Proteins - metabolism | Luciferases - genetics | Kelch-Like ECH-Associated Protein 1 - genetics | Proteolysis - drug effects | Cell Nucleus - metabolism | Proteasome Endopeptidase Complex - drug effects | HEK293 Cells | NF-E2-Related Factor 2 - genetics | Peptide Fragments - genetics | Peptide Fragments - metabolism | Kelch-Like ECH-Associated Protein 1 - metabolism | Antioxidants - pharmacology | Recombinant Fusion Proteins - chemistry | Hep G2 Cells | Gene Expression Regulation - drug effects | Kelch-Like ECH-Associated Protein 1 - antagonists & inhibitors | Peptide Fragments - chemistry | Small Molecule Libraries | Active Transport, Cell Nucleus - drug effects | NF-E2-Related Factor 2 - metabolism | CRISPR-Cas Systems | Genes, Reporter - drug effects | Mutation | NF-E2-Related Factor 2 - chemistry | Proteasome Endopeptidase Complex - metabolism | Cell Nucleus - drug effects | Apigenin - pharmacology | Protein Synthesis and Degradation
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2016, Volume 291, Issue 45, pp. 23719 - 23733
KEAP1 is a substrate adaptor protein for a CUL3-based E3 ubiquitin ligase. Ubiquitylation and degradation of th