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Nature Cell Biology, ISSN 1465-7392, 03/2010, Volume 12, Issue 3, pp. 299 - 305
For most types of cancers, the cell at the origin of tumour initiation is still unknown. Here, we used mouse genetics to identify cells at the origin of basal... 
POPULATION | STEM-CELLS | SONIC HEDGEHOG | EPIDERMIS | HAIR FOLLICLE BULGE | KERATINOCYTES | CANCER | EXPRESSION | HUMAN HOMOLOG | MOUSE SKIN | CELL BIOLOGY | Epithelial Cells - metabolism | Cadherins - metabolism | Receptors, G-Protein-Coupled - metabolism | Skin - metabolism | Cell Count | Ear, External - pathology | Integrin beta4 - metabolism | Tail - pathology | Hair Follicle - pathology | Hedgehog Proteins - genetics | Neoplastic Stem Cells - metabolism | Kruppel-Like Transcription Factors - metabolism | Smoothened Receptor | Neoplastic Stem Cells - pathology | Cell Differentiation | Patched Receptors | Skin - pathology | Keratin-10 - metabolism | Epidermis - metabolism | Epidermis - pathology | RNA, Untranslated | Bacterial Proteins - genetics | Receptors, Cell Surface - metabolism | Epithelial Cells - pathology | Genes, Reporter - genetics | Mice, Transgenic | Carcinoma, Basal Cell - pathology | Mice, Inbred Strains | Clone Cells - metabolism | Keratin-14 - genetics | Carcinoma, Basal Cell - metabolism | Keratin-15 - metabolism | Keratin-19 - genetics | Proteins - genetics | Cell Lineage | Animals | Clone Cells - pathology | Proteins - metabolism | Models, Biological | Hair Follicle - metabolism | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Mice | Receptors, G-Protein-Coupled - genetics | Integrases - genetics | Keratin-15 - genetics | Luminescent Proteins - metabolism | Basal cell carcinoma | Stem cells | Genetic aspects | Cellular signal transduction | Research | Health aspects | Risk factors
Journal Article
Japanese Journal of Clinical Oncology, ISSN 0368-2811, 05/2012, Volume 42, Issue 5, pp. 375 - 386
Journal Article
Endocrinology, ISSN 0013-7227, 04/2010, Volume 151, Issue 4, pp. 1633 - 1642
Journal Article
FASEB Journal, ISSN 0892-6638, 07/2013, Volume 27, Issue 7, pp. 2742 - 2755
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2015, Volume 290, Issue 32, pp. 19999 - 20008
In this study, we investigated the effects of p63 modulation in epithelial plasticity in human keratinocytes. The p63 isoforms Delta Np63 alpha, Delta Np63... 
MIGRATION | STEM-CELLS | ACTIVATION | ZEB1 | REPRESSION | HUMAN ORAL KERATINOCYTES | BIOCHEMISTRY & MOLECULAR BIOLOGY | SENESCENCE | DIFFERENTIATION | MESENCHYMAL TRANSITION | SUPPRESSION | RNA, Small Interfering - genetics | Cadherins - metabolism | Humans | MicroRNAs - metabolism | Epithelial-Mesenchymal Transition - genetics | DNA-Binding Proteins - metabolism | Protein Isoforms - metabolism | Membrane Proteins - metabolism | Cadherins - genetics | Biomarkers - metabolism | Promoter Regions, Genetic | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction | Membrane Proteins - genetics | Gene Expression Regulation | Transcription Factors - antagonists & inhibitors | Keratin-14 - metabolism | Keratinocytes - cytology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Keratin-14 - genetics | Fibronectins - metabolism | Transcription Factors - metabolism | Feedback, Physiological | Phenotype | Histones - genetics | Membrane Proteins - antagonists & inhibitors | Keratinocytes - metabolism | Protein Binding | Fibronectins - genetics | MicroRNAs - genetics | Histones - metabolism | Primary Cell Culture | Protein Isoforms - antagonists & inhibitors | Protein Isoforms - genetics | RNA, Small Interfering - metabolism | epithelial-mesenchymal transition (EMT) | gene regulation | keratinocyte | epithelium | p63 | GRHL2 | Cell Biology
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 11, p. e47842
Birt-Hogg-Dube (BHD) is a tumor suppressor gene syndrome associated with fibrofolliculomas, cystic lung disease, and chromophobe renal cell carcinoma. In... 
EPITHELIAL-MESENCHYMAL TRANSITION | SPONTANEOUS PNEUMOTHORAX | FLCN | TUBEROUS SCLEROSIS COMPLEX | MULTIDISCIPLINARY SCIENCES | RHO | MTOR ACTIVATION | MUTATIONS | DESMOPLAKIN | BHD | FAMILY | Hair - abnormalities | Humans | Hair - metabolism | Wound Healing | Adherens Junctions - metabolism | Catenins - metabolism | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | Epidermis - abnormalities | Integrases - metabolism | Zonula Occludens-1 Protein - metabolism | Proto-Oncogene Proteins - metabolism | Cell Line | Desmosomes - metabolism | Epidermis - metabolism | Epidermis - pathology | Hair - pathology | Tumor Suppressor Proteins - metabolism | gamma Catenin - metabolism | Proto-Oncogene Proteins - genetics | Keratin-14 - metabolism | Proto-Oncogene Proteins - deficiency | Cell Adhesion | Animals | Models, Biological | rho GTP-Binding Proteins - metabolism | Dogs | Protein Binding | Mice | Plakophilins - metabolism | Cell Movement | Physiological aspects | Keratin | Genetic aspects | Genes | Tumors | TOR protein | Eyelid | Pathogenesis | Hyperplasia | Cell junctions | Critical care | Cardiovascular disease | Biology | Recombinase | Kinases | Autophagy | Medical schools | Cell adhesion & migration | Cell adhesion molecules | Proteins | Animal tissues | Cell adhesion | Polarity | Tumorigenesis | p0071 Protein | Biomedical engineering | Medical research | Lung diseases | RhoA protein | Epidermis | Adherens junctions | Rapamycin | Adhesion | Rho-associated kinase | Flox | Medicine | Signaling | Hospitals | Tumor suppressor genes | Mutation | Emphysema | Prostate | Cytoplasm | Clear cell-type renal cell carcinoma | Kidney transplantation | Cancer
Journal Article
Journal Article
Journal Article
Journal of Comparative Pathology, ISSN 0021-9975, 05/2013, Volume 148, Issue 4, pp. 298 - 306
Journal Article
Bone, ISSN 8756-3282, 2013, Volume 54, Issue 1, pp. 157 - 168
Abstract Proteins of the extracellular matrix often have multiple functions to facilitate complex tasks ranging from signaling to structural support. Here we... 
Orthopedics | Ameloblastin | Osteoclasts | Extracellular matrix | ERK 1/2 | Integrin | PROTEIN | PROLIFERATION | IDENTIFICATION | RHOA | CELL ATTACHMENT | ADHESION | EPITHELIAL RESTS | GROWTH | ENDOCRINOLOGY & METABOLISM | DIFFERENTIATION | EXPRESSION | Humans | Actins - metabolism | Periodontal Ligament - growth & development | Molar - diagnostic imaging | Dental Enamel Proteins - genetics | Monocytes - metabolism | Periodontal Ligament - drug effects | Periodontal Ligament - metabolism | RNA, Messenger - metabolism | Tooth Root - metabolism | Cell Differentiation - genetics | Molar - growth & development | RANK Ligand - pharmacology | Bone Resorption - metabolism | Bone Marrow Cells - drug effects | Phosphorylation - drug effects | Tooth Root - diagnostic imaging | Dental Enamel Proteins - metabolism | Molar - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Osteogenesis - genetics | Epithelium - drug effects | Cell Adhesion - genetics | Epithelium - growth & development | Epithelium - metabolism | Osteogenesis - drug effects | RNA, Messenger - genetics | Gene Expression Regulation, Developmental - drug effects | Mice, Transgenic | Up-Regulation - genetics | Keratin-14 - metabolism | Cell Adhesion - drug effects | Osteoclasts - metabolism | Tooth Root - pathology | Molar - ultrastructure | Monocytes - drug effects | Radiography | Up-Regulation - drug effects | Animals | MAP Kinase Signaling System - drug effects | Cell Differentiation - drug effects | Tooth Root - ultrastructure | Bone Resorption - pathology | Integrin alpha2beta1 - metabolism | Mice | Osteoclasts - enzymology | Bone Marrow Cells - metabolism | Osteoclasts - drug effects | Polymerization | Genetic engineering | Muscle proteins | Analysis | Integrins | Phosphorylation | Teeth | Extracellular signal-regulated kinase | AKT protein | Dentistry | Bone (trabecular) | Osteoclastogenesis | Signal transduction | AMBN protein | Bone mass | Actin | Cell adhesion | Bone marrow | Mandibles | Cementum | ERK 1
Journal Article
Human Pathology, ISSN 0046-8177, 2013, Volume 44, Issue 2, pp. 164 - 172
Journal Article