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Nature Cell Biology, ISSN 1465-7392, 03/2010, Volume 12, Issue 3, pp. 299 - 305
For most types of cancers, the cell at the origin of tumour initiation is still unknown. Here, we used mouse genetics to identify cells at the origin of basal... 
POPULATION | STEM-CELLS | SONIC HEDGEHOG | EPIDERMIS | HAIR FOLLICLE BULGE | KERATINOCYTES | CANCER | EXPRESSION | HUMAN HOMOLOG | MOUSE SKIN | CELL BIOLOGY | Epithelial Cells - metabolism | Cadherins - metabolism | Receptors, G-Protein-Coupled - metabolism | Skin - metabolism | Cell Count | Ear, External - pathology | Integrin beta4 - metabolism | Tail - pathology | Hair Follicle - pathology | Hedgehog Proteins - genetics | Neoplastic Stem Cells - metabolism | Kruppel-Like Transcription Factors - metabolism | Smoothened Receptor | Neoplastic Stem Cells - pathology | Cell Differentiation | Patched Receptors | Skin - pathology | Keratin-10 - metabolism | Epidermis - metabolism | Epidermis - pathology | RNA, Untranslated | Bacterial Proteins - genetics | Receptors, Cell Surface - metabolism | Epithelial Cells - pathology | Genes, Reporter - genetics | Mice, Transgenic | Carcinoma, Basal Cell - pathology | Mice, Inbred Strains | Clone Cells - metabolism | Keratin-14 - genetics | Carcinoma, Basal Cell - metabolism | Keratin-15 - metabolism | Keratin-19 - genetics | Proteins - genetics | Cell Lineage | Animals | Clone Cells - pathology | Proteins - metabolism | Models, Biological | Hair Follicle - metabolism | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Mice | Receptors, G-Protein-Coupled - genetics | Integrases - genetics | Keratin-15 - genetics | Luminescent Proteins - metabolism | Basal cell carcinoma | Stem cells | Genetic aspects | Cellular signal transduction | Research | Health aspects | Risk factors | Index Medicus
Journal Article
Journal Article
FEBS Journal, ISSN 1742-464X, 05/2016, Volume 283, Issue 9, pp. 1689 - 1700
Intervertebral discs ( IVD s) provide stability and flexibility to the spinal column; however, IVD s, and in particular the nucleus pulposus ( NP ), undergo a... 
intervertebral disc degeneration | Smad | BMP | mesenchymal stem cells | nucleus pulposus | BMP7 | REGENERATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MESENCHYMAL STEM-CELLS | TRANSPLANTATION | CROSS-TALK | LUMBAR-SPINE | IN-VITRO | NUCLEUS PULPOSUS CELLS | DISEASE | GROWTH | DIFFERENTIATION | RNA, Small Interfering - genetics | Bone Morphogenetic Protein 7 - genetics | Humans | Extracellular Matrix - metabolism | Intervertebral Disc Degeneration - metabolism | Intervertebral Disc Degeneration - therapy | Collagen Type II - metabolism | Intervertebral Disc Degeneration - pathology | Lentivirus - metabolism | Glucuronosyltransferase - genetics | Mesenchymal Stromal Cells - cytology | Smad1 Protein - genetics | Lentivirus - genetics | Intervertebral Disc - pathology | Chondrocytes - metabolism | Disease Models, Animal | Intervertebral Disc Degeneration - genetics | SOX9 Transcription Factor - metabolism | Chondrocytes - pathology | Rabbits | Genetic Vectors - chemistry | Signal Transduction | Bone Marrow Cells - cytology | Glycosaminoglycans - metabolism | Keratin-8 - genetics | Gene Expression Regulation | Genetic Vectors - metabolism | Mesenchymal Stromal Cells - metabolism | Intervertebral Disc - metabolism | Aggrecans - metabolism | Smad1 Protein - antagonists & inhibitors | Aggrecans - genetics | Collagen Type II - genetics | Keratin-19 - genetics | Animals | Glucuronosyltransferase - metabolism | Keratin-8 - metabolism | Bone Morphogenetic Protein 7 - metabolism | Smad1 Protein - metabolism | Keratin-19 - metabolism | Extracellular Matrix - pathology | SOX9 Transcription Factor - genetics | Bone Marrow Cells - metabolism | Mesenchymal Stem Cell Transplantation | RNA, Small Interfering - metabolism | Physiological aspects | Bone morphogenetic proteins | Cell differentiation | Analysis | Stem cells | Extracellular matrix | Spine | Rodents | Keratins | Therapy | Surgical implants | Smad protein | Mesenchyme | Collagen (type II) | Sox9 protein | Medical services | Differentiation (biology) | Electrochemical machining | Homeostasis | Nucleus pulposus | Remodeling | Intervertebral discs | Nuclei | Flexibility | Bone marrow | Degeneration | Effectiveness | Stability | Markers | Feasibility studies | Implantation | Columns (process) | Survival | Diseases | Overexpression | Disks | Feasibility | Chondroitin sulfate | Sulfate | Aggrecan | Viability | Bone morphogenetic protein 7 | Index Medicus
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 03/2014, Volume 306, Issue 6, pp. L534 - L542
MicroRNAs are small noncoding RNAs that inhibit protein expression. We have previously shown that the inhibition of the microRNA let-7d in epithelial cells... 
High-mobility group-A2 protein | Epithelial-to-mesenchymal transition | Idiopathic pulmonary fibrosis | Transforming growth factor-β | Fibrosis | microRNA | Slug | PHYSIOLOGY | METASTASIS | idiopathic pulmonary fibrosis | INDUCTION | EMT | high-mobility group-A2 protein | epithelial-to-mesenchymal transition | transforming growth factor-beta | TRANSITION | LOOP-HELIX PROTEINS | REGULATOR | RESPIRATORY SYSTEM | DISEASE | fibrosis | GROWTH-FACTOR | DIFFERENTIATION | IDIOPATHIC PULMONARY-FIBROSIS | Cell Proliferation | HMGB2 Protein - metabolism | Cadherins - metabolism | Humans | Actins - metabolism | Pulmonary Fibrosis - genetics | Lung - cytology | Cell Movement - genetics | Idiopathic Pulmonary Fibrosis - metabolism | Myofibroblasts - metabolism | Transfection | HMGA2 Protein - metabolism | Pulmonary Alveoli - metabolism | Epithelial-Mesenchymal Transition | Lung - metabolism | Pulmonary Fibrosis - metabolism | Wound Healing - genetics | Zonula Occludens-1 Protein - metabolism | Snail Family Transcription Factors | Fibroblasts - metabolism | Calcium-Binding Proteins - metabolism | Cells, Cultured | Transcription Factors - genetics | Fibronectins - metabolism | Transcription Factors - metabolism | Idiopathic Pulmonary Fibrosis - pathology | Fibroblasts - cytology | MicroRNAs - genetics | Keratin-19 - metabolism | Transforming Growth Factor beta - metabolism | MicroRNA | Physiological aspects | Fibroblasts | Phenotypic plasticity | Genetic research | Research | Transforming growth factors | Genotype & phenotype | Protein expression | Wound healing | Ribonucleic acid--RNA | Cells | Index Medicus | transforming growth factor-β
Journal Article
Gastroenterology, ISSN 0016-5085, 2011, Volume 141, Issue 2, pp. 731 - 741.e4
Background & Aims Animal studies have indicated that pancreatic exocrine acinar cells have phenotypic plasticity. In rodents, acinar cells can differentiate... 
Gastroenterology and Hepatology | Metaplasia | Reprogramming | Exocrine Pancreas | Tissue Engineering | BETA-CELLS | INTRAEPITHELIAL NEOPLASIA | HUMAN EXOCRINE PANCREAS | ADULT HUMAN PANCREAS | IN-VITRO | NOTCH SIGNALING PATHWAY | GENERATION | MICE | GROWTH-FACTOR | DIFFERENTIATION | GASTROENTEROLOGY & HEPATOLOGY | Cell Proliferation | Chymotrypsin - metabolism | Humans | Glycoproteins - metabolism | Carbonic Anhydrase II - metabolism | Ki-67 Antigen - metabolism | Cell Transdifferentiation - genetics | RNA, Messenger - metabolism | Pancreatic Ducts - metabolism | Antigens, CD - metabolism | Cell Transdifferentiation - physiology | Peptides - metabolism | Pancreas, Exocrine - cytology | Cell Lineage - genetics | Genes, Reporter | Hepatocyte Nuclear Factor 1-beta - metabolism | Plant Lectins - pharmacokinetics | Biomarkers - metabolism | SOX9 Transcription Factor - metabolism | Green Fluorescent Proteins - metabolism | Promoter Regions, Genetic | Pancreatic Ducts - cytology | Transduction, Genetic | Cell Survival | Cells, Cultured | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Signal Transduction - genetics | AC133 Antigen | Cell Lineage - physiology | Phenotype | Signal Transduction - physiology | Pancreas, Exocrine - metabolism | Keratin-19 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Keratin | Epidermal growth factor | Analysis | Fluorescein | Fluorescence | Cystic fibrosis | Diabetes | Universities and colleges | Research | Protein kinases | Index Medicus | Abridged Index Medicus
Journal Article
Breast Cancer Research, ISSN 1465-5411, 03/2014, Volume 16, Issue 2, pp. R23 - R23
Journal Article
Hepatology, ISSN 0270-9139, 11/2012, Volume 56, Issue 5, pp. 1804 - 1816
Journal Article
Experimental Dermatology, ISSN 0906-6705, 07/2008, Volume 17, Issue 7, pp. 592 - 609
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, pp. e87368 - e87368
There are several animal models illustrating dry eye pathophysiology. Current study would like to establish an ex vivo tissue culture model for characterizing... 
OCULAR SURFACE EPITHELIUM | MATRIX METALLOPROTEINASES | MUCIN GENE-EXPRESSION | KERATOCONJUNCTIVITIS SICCA | MULTIDISCIPLINARY SCIENCES | CORNEAL EPITHELIAL-CELLS | SQUAMOUS METAPLASIA | LACRIMAL GLAND | FLOW-CYTOMETRIC ANALYSIS | BENZALKONIUM CHLORIDE | INFLAMMATORY MARKERS | Immunohistochemistry | Tumor Necrosis Factor-alpha - metabolism | Epithelial Cells - metabolism | Homeodomain Proteins - metabolism | Humans | Keratin-10 - genetics | Keratin-16 - genetics | Conjunctiva - metabolism | Conjunctiva - pathology | Matrix Metalloproteinase 9 - metabolism | Time Factors | Interleukin-1beta - metabolism | Mucins - metabolism | Repressor Proteins - metabolism | Keratin-10 - metabolism | Gene Expression | Enzyme-Linked Immunosorbent Assay | Mucin-4 - metabolism | Keratin-16 - metabolism | Dry Eye Syndromes - genetics | PAX6 Transcription Factor | Air | Reverse Transcriptase Polymerase Chain Reaction | Mucin-4 - genetics | Keratin-19 - genetics | Eye Proteins - metabolism | Dry Eye Syndromes - metabolism | Mucin 5AC - genetics | Mucin 5AC - metabolism | Keratin-19 - metabolism | Tissue Culture Techniques - methods | Mucins - genetics | Paired Box Transcription Factors - metabolism | Apoptosis | Keratin | Analysis | Mucins | Cell culture | Cornea | Animal models | Media (culture) | Wnt protein | Disease | Laboratories | Science | Tissue culture | Eye | Signal transduction | Epidermal growth factor | Air conditioners | MUC16 gene | Explants | Immunoglobulins | Air exposure | Cultures | Inflammation | Tumor necrosis factor-α | IL-1β | Gelatinase B | Pax6 protein | Metaplasia | Signaling | Mucin | Antibiotics | Stromal cells | Cholera | Index Medicus
Journal Article