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Cell stem cell, ISSN 1934-5909, 2012, Volume 11, Issue 3, pp. 401 - 414
.... This protective effect of rapamycin is mediated by the increase in expression... 
MAMMALIAN TARGET | CANCER PATIENTS | RAPAMYCIN | HEAD | AGING PHENOTYPES | MANGANESE SUPEROXIDE-DISMUTASE | STRESS-RESPONSE | TUMOR | NECK | SKIN | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Cell Death - radiation effects | TOR Serine-Threonine Kinases - metabolism | Keratinocytes - radiation effects | Carcinoma, Squamous Cell - pathology | Epithelial Cells - drug effects | Humans | Cellular Senescence - drug effects | Cell Compartmentation - radiation effects | Mucositis - prevention & control | Mouth Mucosa - drug effects | TOR Serine-Threonine Kinases - antagonists & inhibitors | Mouth Mucosa - radiation effects | Mucositis - pathology | Stem Cells - enzymology | Mucositis - enzymology | Cellular Senescence - radiation effects | Cytoprotection - drug effects | Clone Cells | Oxidative Stress - radiation effects | Cell Death - drug effects | Head and Neck Neoplasms - enzymology | Mouth Mucosa - pathology | Keratinocytes - enzymology | Superoxide Dismutase - metabolism | Radiation, Ionizing | Carcinoma, Squamous Cell - enzymology | Epithelial Cells - radiation effects | Cells, Cultured | Stem Cells - radiation effects | Epithelial Cells - pathology | Radiation Injuries - enzymology | Sirolimus - pharmacology | Head and Neck Neoplasms - pathology | Keratinocytes - pathology | Animals | Keratinocytes - drug effects | Radiation Injuries - prevention & control | Epithelial Cells - enzymology | Cell Compartmentation - drug effects | Stem Cells - drug effects | Stem Cells - pathology | Radiation Injuries - pathology | Cell Proliferation - drug effects | Mice | Oxidative Stress - drug effects | Cytoprotection - radiation effects | Cell Proliferation - radiation effects
Journal Article
Biomaterials, ISSN 0142-9612, 2016, Volume 84, pp. 25 - 41
Abstract Curcumin (Cur) has been demonstrated to have wide pharmacological window including anti-oxidant and anti-inflammatory properties. However,... 
Advanced Basic Science | Dentistry | Photodegradation | Phototoxicity | Curcumin | Apoptosis/necrosis | Photoprotection | Nanoformulation | ACTIVATION | MATERIALS SCIENCE, BIOMATERIALS | MECHANISM | INDUCED APOPTOSIS | ENGINEERING, BIOMEDICAL | DNA-DAMAGE | MITOCHONDRIA | KERATINOCYTES | DEATH | BCL-2 | SUNLIGHT | BAX | DNA Breaks - drug effects | NIH 3T3 Cells | Reactive Oxygen Species - metabolism | Nanoparticles - chemistry | Apoptosis - drug effects | Apoptosis - radiation effects | Keratinocytes - radiation effects | Membrane Potential, Mitochondrial - radiation effects | Humans | Extracellular Signal-Regulated MAP Kinases - metabolism | Membrane Potential, Mitochondrial - drug effects | RNA, Messenger - metabolism | DNA Breaks - radiation effects | Photosensitizing Agents - pharmacology | Ultraviolet Rays | Protective Agents - pharmacology | Cytoprotection - drug effects | Oxidative Stress - radiation effects | Signal Transduction - radiation effects | Proto-Oncogene Proteins c-akt - metabolism | Keratinocytes - enzymology | Keratinocytes - ultrastructure | Cell Membrane - drug effects | Cell Membrane - radiation effects | Cell Line | Cell Survival - drug effects | Lactic Acid - chemistry | RNA, Messenger - genetics | Curcumin - pharmacology | Absorption, Radiation | Cell Survival - radiation effects | Animals | Cell Cycle Checkpoints - radiation effects | Keratinocytes - drug effects | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Polyglycolic Acid - chemistry | Drug Liberation | Mice | Molecular Docking Simulation | Oxidative Stress - drug effects | Cytoprotection - radiation effects | Nanoparticles | Genetic research | Analysis | Index Medicus | Biotechnology | Phosphorylation | Cascades | Sunlight | Exposure | Biological | Apoptosis
Journal Article
Development (Cambridge), ISSN 1477-9129, 2016, Volume 143, Issue 10, pp. 1674 - 1687
Journal Article
Nanomedicine, ISSN 1549-9634, 2010, Volume 6, Issue 3, pp. 427 - 441
Abstract Identification of pharmacological and toxicological profiles is of critical importance for the use of nanoparticles as drug carriers in nanomedicine and for the biosafety evaluation... 
Internal Medicine | Lysosomes | Mitochondria | Target treatment | Alzheimer disease | Single-walled carbon nanotubes | Organelles | MEDICINE, RESEARCH & EXPERIMENTAL | BIOCOMPATIBILITY | RATS | NANOSCIENCE & NANOTECHNOLOGY | MAMMALIAN-CELLS | DELIVERY | NANOPARTICLES | REACTIVE OXYGEN | IN-VIVO | HUMAN EPIDERMAL-KERATINOCYTES | CYTOTOXICITY | Memory - drug effects | Organ Specificity - drug effects | Drug Carriers - adverse effects | Intestinal Absorption - drug effects | Drug Carriers - toxicity | Mitochondria - ultrastructure | Autophagy - drug effects | Alzheimer Disease - pathology | Lysosomes - metabolism | Nanotubes, Carbon - toxicity | Brain - ultrastructure | Spectrum Analysis, Raman | Lysosomes - drug effects | Cell Survival - drug effects | Alzheimer Disease - physiopathology | Reproducibility of Results | Subcellular Fractions - drug effects | Acetylcholine - pharmacology | Alzheimer Disease - drug therapy | Nanotubes, Carbon - ultrastructure | Mitochondria - metabolism | Mitochondria - drug effects | Subcellular Fractions - metabolism | Brain - drug effects | Lysosomes - ultrastructure | Acetylcholine - administration & dosage | Animals | Nanomedicine - methods | Brain - pathology | Nanotubes, Carbon - adverse effects | Drug Carriers - pharmacokinetics | Mice | Health Status | Index Medicus
Journal Article
Experimental dermatology, ISSN 1600-0625, 2009, Volume 18, Issue 6, pp. 553 - 561
:  Solar ultraviolet (UV) radiation, particularly its UVB (290–320 nm) component, is the primary cause of many adverse biological effects including photoageing and skin cancer... 
ultraviolet radiation | photoageing | human reconstituted skin | matrix metalloproteinases | DNA damage | pomegranate | Photoageing | Ultraviolet radiation | Matrix metalloproteinases | Human reconstituted skin | Pomegranate | CUTANEOUS CARCINOGENESIS | CELL NUCLEAR ANTIGEN | DNA-DAMAGE | INDUCED OXIDATIVE DAMAGE | KAPPA-B | RADIATION-INDUCED IMMUNOSUPPRESSION | DERMATOLOGY | PUNICA-GRANATUM POMEGRANATE | BOTANICAL ANTIOXIDANTS | DERMAL FIBROBLASTS | HUMAN EPIDERMAL-KERATINOCYTES | Matrix Metalloproteinases - genetics | Keratinocytes - radiation effects | Plant Extracts - pharmacology | Skin - metabolism | Coculture Techniques | Humans | Proto-Oncogene Proteins c-jun - biosynthesis | Proto-Oncogene Proteins c-fos - biosynthesis | Male | Protein Processing, Post-Translational - drug effects | Enzyme Induction - drug effects | Radiation-Protective Agents - pharmacology | Radiation-Protective Agents - isolation & purification | Oxidative Stress - radiation effects | Phosphorylation - drug effects | Drug Evaluation, Preclinical | Infant, Newborn | Matrix Metalloproteinases - biosynthesis | Organoids - radiation effects | DNA Damage - drug effects | Punicaceae - chemistry | Plant Oils - pharmacology | Protein Processing, Post-Translational - radiation effects | Plant Extracts - isolation & purification | Plant Oils - isolation & purification | Tropoelastin - biosynthesis | Ultraviolet Rays - adverse effects | Phosphorylation - radiation effects | Fibroblasts - radiation effects | Keratinocytes - drug effects | Tropoelastin - genetics | Skin - radiation effects | Fibroblasts - drug effects | Organoids - drug effects | Proto-Oncogene Proteins c-fos - genetics | Oxidative Stress - drug effects | DNA Damage - radiation effects | Enzyme Induction - radiation effects | Skin - drug effects | Antioxidants | Immunohistochemistry | Carbocyclic compounds | Anthocyanin | Tannins | Pyrimidines | DNA | Guanosine | Radiation | Chromophores | Skin cancer
Journal Article
Journal of Dental Research, ISSN 0022-0345, 6/2013, Volume 92, Issue 6, pp. 518 - 523
Journal Article
Scientific reports, ISSN 2045-2322, 2015, Volume 5, Issue 1, pp. 11596 - 11596
Novel antimicrobials and new approaches to developing them are urgently needed. Repurposing already-approved drugs with well-characterized toxicology... 
SOFT-TISSUE INFECTIONS | IN-VITRO | ANTIBIOTICS | CA-MRSA SKIN | ANTIOXIDANT | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | COMPOUND | DRUGS | AUREUS | EXPRESSION | Methicillin Resistance - drug effects | Skin - microbiology | Skin - metabolism | Humans | Biofilms - growth & development | Host-Pathogen Interactions - drug effects | Organoselenium Compounds - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Microbial Sensitivity Tests | Female | Staphylococcal Infections - microbiology | Biofilms - drug effects | Methicillin-Resistant Staphylococcus aureus - physiology | Cell Survival - drug effects | Staphylococcal Infections - drug therapy | Methicillin-Resistant Staphylococcus aureus - drug effects | Cells, Cultured | Drug Repositioning | Azoles - pharmacology | Mupirocin - pharmacology | Drug Synergism | Daptomycin - pharmacology | Bacterial Toxins - metabolism | Methicillin-Resistant Staphylococcus aureus - metabolism | Animals | Keratinocytes - drug effects | Anti-Bacterial Agents - pharmacology | Mice, Inbred BALB C | Skin - drug effects | Cytokines | Therapeutic applications | Clinical isolates | Staphylococcus infections | Protein biosynthesis | Antimicrobial agents | Inflammation | Vancomycin | Tumor necrosis factor-α | Drug resistance | Bactericidal activity | Methicillin | Interleukin 6 | Biofilms | Interleukin 1 | Tumor necrosis factor-TNF | Skin diseases | Monocyte chemoattractant protein 1 | Index Medicus
Journal Article
Marine drugs, ISSN 1660-3397, 2019, Volume 17, Issue 8, p. 451
Journal Article
International journal of nanomedicine, ISSN 1178-2013, 2016, Volume 11, pp. 3859 - 3874
.... Here, we systematically investigated the effects of ZnO NPs on non-tumorigenic human epidermal keratinocytes, which were used as a test model for this in vitro study, at the epigenetic and molecular levels... 
Histone modification | Reactive oxygen species | ZnO nanoparticle | P53-Bax mitochondrial apoptosis pathway | Cell cycle G2/M arrest | CANCER-CELLS | GOLD NANOPARTICLES | OXIDATIVE STRESS | histone modification | cell cycle G2/M arrest | DNA-DAMAGE | DOUBLE-STRAND BREAKS | NANOSCIENCE & NANOTECHNOLOGY | REPAIR | GENOTOXICITY | HISTONE H3 | p53-Bax mitochondrial apoptosis pathway | reactive oxygen species | PHARMACOLOGY & PHARMACY | CYTOTOXICITY | CYCLE | Chromatin - metabolism | Reactive Oxygen Species - metabolism | Nanoparticles - chemistry | Apoptosis - drug effects | Humans | G2 Phase Cell Cycle Checkpoints - drug effects | Epigenesis, Genetic - drug effects | Lysine - metabolism | Cell Line | Cell Survival - drug effects | M Phase Cell Cycle Checkpoints - drug effects | Nanoparticles - ultrastructure | Zinc Oxide - pharmacology | Keratinocytes - cytology | Up-Regulation - drug effects | Acetylation - drug effects | Keratinocytes - drug effects | Methylation - drug effects | Signal Transduction - drug effects | Models, Biological | Epidermal Cells | Cell Proliferation - drug effects | Nanoparticles - administration & dosage | DNA Damage | Histones - metabolism | Nanoparticles | Epigenetic inheritance | Chromatin | Zinc oxide | Skin | Methylation | Apoptosis | Cell culture | Scanning electron microscopy | Oxidative stress | DNA damage | Cytotoxicity | Nanomaterials | Biochemistry | Metastasis | Gene expression | Cancer therapies | DNA repair | Zinc oxides | Cell cycle | DNA methylation | Epigenetics | Deoxyribonucleic acid--DNA
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 05/2015, Volume 20, Issue 5, pp. 9344 - 9357
Journal Article