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Biomaterials, ISSN 0142-9612, 2016, Volume 84, pp. 25 - 41
Abstract Curcumin (Cur) has been demonstrated to have wide pharmacological window including anti-oxidant and anti-inflammatory properties. However,... 
Advanced Basic Science | Dentistry | Photodegradation | Phototoxicity | Curcumin | Apoptosis/necrosis | Photoprotection | Nanoformulation | Engineering | Materials Science | Technology | Engineering, Biomedical | Materials Science, Biomaterials | Science & Technology | DNA Breaks - drug effects | NIH 3T3 Cells | Reactive Oxygen Species - metabolism | Nanoparticles - chemistry | Apoptosis - drug effects | Apoptosis - radiation effects | Keratinocytes - radiation effects | Membrane Potential, Mitochondrial - radiation effects | Humans | Extracellular Signal-Regulated MAP Kinases - metabolism | Membrane Potential, Mitochondrial - drug effects | RNA, Messenger - metabolism | DNA Breaks - radiation effects | Photosensitizing Agents - pharmacology | Ultraviolet Rays | Protective Agents - pharmacology | Cytoprotection - drug effects | Oxidative Stress - radiation effects | Signal Transduction - radiation effects | Proto-Oncogene Proteins c-akt - metabolism | Keratinocytes - enzymology | Keratinocytes - ultrastructure | Cell Membrane - drug effects | Cell Membrane - radiation effects | Cell Line | Cell Survival - drug effects | Lactic Acid - chemistry | RNA, Messenger - genetics | Curcumin - pharmacology | Absorption, Radiation | Cell Survival - radiation effects | Animals | Cell Cycle Checkpoints - radiation effects | Keratinocytes - drug effects | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Polyglycolic Acid - chemistry | Drug Liberation | Mice | Molecular Docking Simulation | Oxidative Stress - drug effects | Cytoprotection - radiation effects | Nanoparticles | Genetic research | Analysis | Index Medicus | Biotechnology | Phosphorylation | Cascades | Sunlight | Exposure | Biological | Apoptosis
Journal Article
International Journal of Oral & Maxillofacial Surgery, ISSN 0901-5027, 2013, Volume 42, Issue 8, pp. 939 - 948
...) as a model for studying the acute effects of ionizing radiation (IR) on the oral mucosa. TEM and native non-keratinizing oral mucosa (NNOM... 
Surgery | tissue engineering | cytokines | keratinocytes | oral mucosa | DNA damage | Life Sciences & Biomedicine | Dentistry, Oral Surgery & Medicine | Science & Technology | Gamma Rays | Cell Adhesion - radiation effects | Integrin alpha6 - analysis | Intracellular Signaling Peptides and Proteins - radiation effects | Keratinocytes - radiation effects | Humans | Middle Aged | DNA Repair - radiation effects | Integrin alpha6 - radiation effects | Male | Rad51 Recombinase - analysis | Basement Membrane - radiation effects | Epithelium - radiation effects | Interleukin-1beta - radiation effects | Keratin-19 - radiation effects | Mouth Mucosa - radiation effects | Integrin beta4 - analysis | Keratin-19 - analysis | Female | Cell Culture Techniques | Transforming Growth Factor beta1 - analysis | Connective Tissue - radiation effects | Tissue Engineering | Cell Differentiation - radiation effects | Mouth Mucosa - cytology | Integrin beta4 - radiation effects | Interleukin-1beta - analysis | Intracellular Signaling Peptides and Proteins - analysis | Desmoglein 3 - analysis | Vimentin - radiation effects | Radiation Dosage | Collagen Type IV - analysis | Vimentin - analysis | Desmoglein 3 - radiation effects | Fibroblasts - radiation effects | Rad51 Recombinase - radiation effects | Transforming Growth Factor beta1 - radiation effects | Collagen Type IV - radiation effects | Tumor Suppressor p53-Binding Protein 1 | DNA Damage - radiation effects | Cell Proliferation - radiation effects | Enzymes | Tissue engineering | Transforming growth factors | Keratin | Surgery, Plastic | Nuclear radiation | Analysis | Bone morphogenetic proteins | Tumor proteins | Enzyme-linked immunosorbent assay | Integrins | Protein binding | Index Medicus | Dentistry
Journal Article
PloS one, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, pp. e105263 - e105263
...) upon human skin have not been investigated so thoroughly. Nevertheless, recent studies have proven their harmful effects and involvement in carcinogenesis and immunosuppression... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Epidermis - metabolism | Lipid Peroxidation - radiation effects | Epidermis - radiation effects | Reactive Oxygen Species - metabolism | Apoptosis - radiation effects | Keratinocytes - radiation effects | Skin - metabolism | Humans | Up-Regulation - radiation effects | Radiation | Down-Regulation - radiation effects | Gene Expression - radiation effects | Ultraviolet Rays - adverse effects | Fibroblasts - radiation effects | Keratinocytes - metabolism | Skin - radiation effects | Oxidative Stress - radiation effects | DNA Damage - radiation effects | Fibroblasts - metabolism | Oxidative stress | Reactive oxygen species | Genes | Gene regulation | DNA damage | Lipid peroxidation | Homeostasis | Lipids | Innate immunity | Genomes | Biodiversity | Immunity | Carcinogenesis | Proteins | Glucose metabolism | Carcinogens | Biological effects | Pathways | Fibroblasts | Aging | Extracellular matrix | Lipid metabolism | Damage accumulation | Public health | Injury analysis | Deoxyribonucleic acid--DNA | Peroxidation | Oxygen | Thymine | Heat shock proteins | Keratinocytes | Exposure | Light therapy | Gene expression | Metabolism | Immunosuppression | Ultraviolet radiation | Sunburn & sun tanning | Nitric oxide | Skin | Dimers | Cellular stress response | Apoptosis | Heat shock | Cancer | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
PloS one, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, pp. e83392 - e83392
.... These include processes related to skin cancer development, progression and metastasis. However, little is known about the role of microRNA as an intermediary in the carcinogenic processes following exposure to UV-radiation... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Keratinocytes - radiation effects | Humans | Neoplasms, Radiation-Induced - etiology | MicroRNAs - metabolism | Carcinogenesis - metabolism | Carcinogenesis - radiation effects | Neoplasms, Radiation-Induced - genetics | Computer Simulation | Signal Transduction - radiation effects | Promoter Regions, Genetic | Membrane Proteins - genetics | Carcinogenesis - genetics | Cells, Cultured | MicroRNAs - radiation effects | Monomeric GTP-Binding Proteins - genetics | Gene Expression - radiation effects | Neoplasms, Radiation-Induced - metabolism | Ultraviolet Rays - adverse effects | Skin Neoplasms - metabolism | Keratinocytes - metabolism | Regulatory Elements, Transcriptional | Skin Neoplasms - genetics | Gene Regulatory Networks - radiation effects | MicroRNAs - genetics | Skin Neoplasms - etiology | Epigenetic inheritance | Ionizing radiation | MicroRNA | Analysis | Development and progression | Skin | Skin cancer | Phosphorylation | Radiation | Homology | Biology | Regulatory sequences | Metastasis | Carcinogenesis | Metastases | Liver cancer | Carcinogens | Pathways | miRNA | Deoxyribonucleic acid--DNA | Medical research | Dermatology | U.V. radiation | Melanoma | Keratinocytes | Exposure | Gene expression | Ribonucleic acid--RNA | Signaling | Ultraviolet radiation | MicroRNAs | Irradiation | Cancer | Apoptosis | Index Medicus | RNA | Deoxyribonucleic acid | Ribonucleic acid | DNA
Journal Article
Cell stem cell, ISSN 1934-5909, 09/2012, Volume 11, Issue 3, pp. 401 - 414
... the repopulating capacity of the epithelial stem cell compartment. This is frequently the case in cancer patients receiving radiation or chemotherapy, many of whom develop mucositis, a debilitating condition involving painful and deep mucosal ulcerations... 
Cell & Tissue Engineering | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Death - radiation effects | TOR Serine-Threonine Kinases - metabolism | Keratinocytes - radiation effects | Carcinoma, Squamous Cell - pathology | Epithelial Cells - drug effects | Humans | Cellular Senescence - drug effects | Cell Compartmentation - radiation effects | Mucositis - prevention & control | Mouth Mucosa - drug effects | TOR Serine-Threonine Kinases - antagonists & inhibitors | Mouth Mucosa - radiation effects | Mucositis - pathology | Stem Cells - enzymology | Mucositis - enzymology | Cellular Senescence - radiation effects | Cytoprotection - drug effects | Clone Cells | Oxidative Stress - radiation effects | Cell Death - drug effects | Head and Neck Neoplasms - enzymology | Mouth Mucosa - pathology | Keratinocytes - enzymology | Superoxide Dismutase - metabolism | Radiation, Ionizing | Carcinoma, Squamous Cell - enzymology | Epithelial Cells - radiation effects | Cells, Cultured | Stem Cells - radiation effects | Epithelial Cells - pathology | Radiation Injuries - enzymology | Sirolimus - pharmacology | Head and Neck Neoplasms - pathology | Keratinocytes - pathology | Animals | Keratinocytes - drug effects | Radiation Injuries - prevention & control | Epithelial Cells - enzymology | Cell Compartmentation - drug effects | Stem Cells - drug effects | Stem Cells - pathology | Radiation Injuries - pathology | Cell Proliferation - drug effects | Mice | Oxidative Stress - drug effects | Cytoprotection - radiation effects | Cell Proliferation - radiation effects | Index Medicus
Journal Article
Radiation research, ISSN 0033-7587, 2013, Volume 179, Issue 1, pp. 53 - 61
.... In this study, we demonstrate annexin A2 nuclear translocation in human skin organotypic culture and murine epidermal cells after exposure to X radiation (10–200 cGy... 
Ionizing radiation | Cell nucleus | Epidermal cells | Genes | Keratinocytes | Skin | Signals | Directional control | Annexins | Radiation dosage | Biology | Life Sciences & Biomedicine - Other Topics | Biophysics | Life Sciences & Biomedicine | Radiology, Nuclear Medicine & Medical Imaging | Science & Technology | Transcription, Genetic - drug effects | Cell Death - radiation effects | Skin - cytology | Humans | Annexin A2 - deficiency | Transcription, Genetic - radiation effects | NF-kappa B - metabolism | Stem Cells - cytology | Transcriptome - radiation effects | Stress, Physiological - radiation effects | Cell Differentiation - genetics | Cell Death - genetics | Cell Nucleus - radiation effects | Stress, Physiological - drug effects | Cell Death - drug effects | Homeostasis - drug effects | Active Transport, Cell Nucleus - genetics | Active Transport, Cell Nucleus - radiation effects | Cell Differentiation - radiation effects | Stress, Physiological - genetics | Gene Silencing | Stem Cells - radiation effects | Radiation Tolerance - genetics | Homeostasis - radiation effects | Transcriptome - drug effects | X-Rays - adverse effects | Radiation Tolerance - drug effects | Tumor Necrosis Factor-alpha - pharmacology | Animals | Annexin A2 - genetics | Cell Differentiation - drug effects | Active Transport, Cell Nucleus - drug effects | Stem Cells - drug effects | Mice | Cell Nucleus - drug effects | Annexin A2 - metabolism | Homeostasis - genetics | Index Medicus | Space life sciences | RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT
Journal Article
Scientific reports, ISSN 2045-2322, 10/2016, Volume 6, Issue 1, pp. 35065 - 35065
UV irradiation is a major environmental factor causing skin dryness, aging and cancer. UVB in particular triggers cumulative DNA damage, oxidative stress and... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Computational Biology - methods | Reactive Oxygen Species - metabolism | Microtubule-Associated Proteins - genetics | Keratinocytes - radiation effects | Humans | Cells, Cultured | Keratinocytes - cytology | Mitochondrial Proteins - genetics | Healthy Volunteers | Cell Survival - radiation effects | Gene Knockdown Techniques | Mitochondrial Dynamics - radiation effects | Microscopy, Confocal | Mitochondria - genetics | GTP Phosphohydrolases - genetics | Mitochondria - radiation effects | DNA Damage | Apoptosis | Oxidative stress | U.V. radiation | DNA damage | Keratinocytes | Confocal microscopy | Guanosine triphosphatases | Mitochondrial DNA | Mitochondria | Ultraviolet radiation | Morphology | Computer applications | Dynamin | Skin | Fitness | Cancer | Index Medicus | Bioengineering | Biotechnology | Genomics | Computational Biology/methods | Cellular Biology | Cell Survival/radiation effects | Microtubule-Associated Proteins/genetics | Life Sciences | Image Processing | Imaging | Computer Science | Biomolecules | Subcellular Processes | GTP Phosphohydrolases/genetics | Mitochondria/radiation effects | Reactive Oxygen Species/metabolism | Keratinocytes/radiation effects | Mitochondrial Dynamics/radiation effects | Biochemistry, Molecular Biology | Keratinocytes/cytology | Mitochondria/genetics | Mitochondrial Proteins/genetics | Molecular biology
Journal Article
Biochemical and biophysical research communications, ISSN 0006-291X, 06/2010, Volume 397, Issue 2, pp. 350 - 354
Proteins are folded properly in the endoplasmic reticulum (ER). Various stress such as hypoxia, ischemia and starvation interfere with the ER function, causing... 
ER stress | Environmental UVB | HaCaT cells | ATF6 | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Membrane Proteins - radiation effects | Keratinocytes - radiation effects | eIF-2 Kinase - metabolism | Humans | Stress, Physiological | Endoplasmic Reticulum - metabolism | X-Box Binding Protein 1 | Endoribonucleases - radiation effects | DNA-Binding Proteins - metabolism | Ubiquitination | Cell Nucleus - metabolism | Ultraviolet Rays | Cell Nucleus - radiation effects | Protein-Serine-Threonine Kinases - radiation effects | Membrane Proteins - metabolism | Signal Transduction - radiation effects | Protein Folding - radiation effects | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Transcription Factors - radiation effects | DNA-Binding Proteins - radiation effects | Endoribonucleases - metabolism | Environmental Exposure | Activating Transcription Factor 6 - radiation effects | Regulatory Factor X Transcription Factors | Transcription Factors - metabolism | Activating Transcription Factor 6 - metabolism | Keratinocytes - metabolism | Active Transport, Cell Nucleus - drug effects | Endoplasmic Reticulum - radiation effects | Ubiquitin | Stress (Psychology) | Index Medicus | APOPTOSIS | IRRADIATION | ENDOPLASMIC RETICULUM | RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS | ANOXIA | ULTRAVIOLET RADIATION | BIOLOGICAL RADIATION EFFECTS | ISCHEMIA | RADIATION DOSES | PROTEINS
Journal Article