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1. Full Text A Simplified Quantitative Method for Assessing Keratoconjunctivitis Sicca From the Sjögren's Syndrome International Registry
by Whitcher, John P and Shiboski, Caroline H and Shiboski, Stephen C and Heidenreich, Ana Maria and Kitagawa, Kazuko and Zhang, Shunhua and Hamann, Steffen and Larkin, Genevieve and McNamara, Nancy A and Greenspan, John S and Daniels, Troy E and Sjogrens Int Collaborative Clinica and Sjögren's International Collaborative Clinical Alliance Research Groups
American Journal of Ophthalmology, ISSN 0002-9394, 2010, Volume 149, Issue 3, pp. 405 - 415
Purpose To describe, apply, and test a new ocular grading system for assessing keratoconjunctivitis sicca (KCS) using lissamine green and fluorescein. Design... 
Ophthalmology | ROSE-BENGAL | CRITERIA | TESTS | SPECIFICITY | DRY EYE | SENSITIVITY | OPHTHALMOLOGY | LISSAMINE-GREEN | STAINING CHARACTERISTICS | International Classification of Diseases | Keratoconjunctivitis Sicca - classification | Prospective Studies | Coloring Agents | Humans | Middle Aged | Male | Lissamine Green Dyes | Young Adult | Keratoconjunctivitis Sicca - diagnosis | Sjogren's Syndrome - diagnosis | Fluorescein | Aged, 80 and over | Sjogren's Syndrome - classification | Adult | Female | Registries | Aged | Fluorescent Dyes | Cohort Studies | Medical colleges | Medical research | Rheumatoid arthritis | Analysis | Medicine, Experimental | Methods | Medicine | Pathology | Health Insurance Portability & Accountability Act 1996-US | Hospitals | Medical treatment | Human immunodeficiency virus--HIV | Rheumatology | Alliances
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2. Full Text Dysfunctional tear syndrome: dry eye disease and associated tear film disorders – new strategies for diagnosis and treatment
by Milner, Mark S and Beckman, Kenneth A and Luchs, Jodi I and Allen, Quentin B and Awdeh, Richard M and Berdahl, John and Boland, Thomas S and Buznego, Carlos and Gira, Joseph P and Goldberg, Damien F and Goldman, David and Goyal, Raj K and Jackson, Mitchell A and Katz, James and Kim, Terry and Majmudar, Parag A and Malhotra, Ranjan P and McDonald, Marguerite B and Rajpal, Rajesh K and Raviv, Tal and Rowen, Sheri and Shamie, Neda and Solomon, Jonathan D and Stonecipher, Karl and Tauber, Shachar and Trattler, William and Walter, Keith A and Waring, George O and Weinstock, Robert J and Wiley, William F and Yeu, Elizabeth
Current Opinion in Ophthalmology, ISSN 1040-8738, 01/2017, Volume 27 Suppl 1, Issue Suppl 1, pp. 3 - 47
Dysfunctional tear syndrome (DTS) is a common and complex condition affecting the ocular surface. The health and normal functioning of the ocular surface is... 
CYCLOSPORINE OPHTHALMIC EMULSION | CHRONIC BLEPHARITIS | MEIBOMIAN GLAND DYSFUNCTION | GOBLET-CELL-DENSITY | SEVERE KERATOCONJUNCTIVITIS SICCA | OCULAR SURFACE DISEASE | CORNEAL EPITHELIAL-CELLS | OPHTHALMOLOGY | VERSUS-HOST-DISEASE | LIPID LAYER THICKNESS | SCLERAL CONTACT-LENS | Keratoconjunctivitis Sicca - physiopathology | Dry Eye Syndromes - physiopathology | Humans | Dry Eye Syndromes - diagnosis | Blepharitis - physiopathology | Keratoconjunctivitis Sicca - therapy | Meibomian Glands - physiopathology | Keratoconjunctivitis Sicca - diagnosis | Blepharitis - diagnosis | Blepharitis - therapy | Dry Eye Syndromes - therapy | Tears - physiology | Eyelid Diseases - physiopathology | Supplement
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3. Full Text Tear Film Osmolarity: Determination of a Referent for Dry Eye Diagnosis
by Tomlinson, Alan and Khanal, Santosh and Ramaesh, Kanna and Diaper, Charles and McFadyen, Angus
Investigative Ophthalmology & Visual Science, ISSN 0146-0404, 10/2006, Volume 47, Issue 10, pp. 4309 - 4315
PURPOSE. To determine new referents, or cutoff levels for tear film hyperosmolarity in the diagnosis of keratoconjunctivitis sicca (KCS) and to assess their... 
TESTS | KERATOCONJUNCTIVITIS SICCA | FLUID | OSMOLALITY | OCULAR SURFACE DISEASE | CORNEAL EPITHELIUM | OPHTHALMOLOGY | RABBIT | PREVALENCE | MODEL | FLOW-RATE | Predictive Value of Tests | Osmolar Concentration | Keratoconjunctivitis Sicca - diagnosis | Tears - chemistry | Humans | Sensitivity and Specificity | ROC Curve | False Positive Reactions
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4. Full Text Assessment of tear film osmolarity using the TearLab™ osmometer in normal dogs and dogs with keratoconjunctivitis sicca
by Sebbag, Lionel and Park, Shin Ae and Kass, Philip H and Maggs, David J and Attar, Mayssa and Murphy, Christopher J
Veterinary Ophthalmology, ISSN 1463-5216, 07/2017, Volume 20, Issue 4, pp. 357 - 364
Objective To evaluate repeatability and reproducibility of tear osmolarity measured using the TearLab (TM) osmometer in normal dogs and to assess its... 
tear film | TearLab | dog | keratoconjunctivitis sicca | osmolarity | diagnostic tool | TESTS | TearLab (TM) | ELECTRICAL-IMPEDANCE | SJOGRENS-SYNDROME | TIME | MICROVOLUMES | FLUID OSMOLARITY | OSMOLALITY | VETERINARY SCIENCES | DRY EYE DISEASE | Reproducibility of Results | Tears - chemistry | Humans | Cyclosporine - therapeutic use | Animals | Dog Diseases - drug therapy | Osmolar Concentration | Keratoconjunctivitis Sicca - diagnosis | Dogs | Keratoconjunctivitis Sicca - drug therapy | Keratoconjunctivitis Sicca - veterinary | Female | Dog Diseases - diagnosis
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5. Full Text Severity of Sjogren's Syndrome Keratoconjunctivitis Sicca Increases with Increased Percentage of Conjunctival Antigen-Presenting Cells
by Pflugfelder, SC and Bian, F and Gumus, K and Farley, W and Stern, ME and De Paiva, CS
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 09/2018, Volume 19, Issue 9
This study investigated the relationship between clinical severity and percentage of conjunctival antigen-presenting cells (APCs) in Sjogren's syndrome... 
OCULAR SURFACE | Sjogren's syndrome | EYE DISEASE | antigen-presenting cells | TEAR | BIOCHEMISTRY & MOLECULAR BIOLOGY | dry eye | HLA-DR EXPRESSION | CHEMISTRY, MULTIDISCIPLINARY | DEFICIENCY | DENSITY | dendritic cells | THERAPY | goblet cells | EPITHELIAL-CELLS | FLOW-CYTOMETRIC ANALYSIS | Severity of Illness Index | Antigen-Presenting Cells - metabolism | Keratoconjunctivitis Sicca - etiology | Cell Count | Dendritic Cells - immunology | Humans | Sjogren's Syndrome - immunology | Immunophenotyping | Antigen-Presenting Cells - immunology | Goblet Cells - metabolism | Case-Control Studies | Goblet Cells - immunology | Antigen-Presenting Cells - pathology | Keratoconjunctivitis Sicca - diagnosis | Sjogren's Syndrome - diagnosis | Biomarkers | Sjogren's Syndrome - complications | Dendritic Cells - metabolism
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6. Full Text Salivary cytokine profiles in primary Sjögren's syndrome differ from those in non-sjögren sicca in terms of TNF-α levels and Th-1/Th-2 ratios
by Kang, Eun Ha and Lee, Yun Jong and Hyon, Joon Young and Yun, Pil Young and Song, Yeong Wook
Clinical and Experimental Rheumatology, ISSN 0392-856X, 2011, Volume 29, Issue 6, pp. 970 - 976
Objective To compare salivary cytokine profiles in patients with primary Sjogren's syndrome (pSS), non-SS sicca controls, and non-sicca controls, and to... 
Sicca | Sjögren's syndrome | Saliva | Cytokine | cytokine | Sjogren's syndrome | ACTIVATION | MESSENGER-RNA EXPRESSION | TIGHT JUNCTION STRUCTURE | NECROSIS-FACTOR-ALPHA | RHEUMATOLOGY | sicca | saliva | AUTOIMMUNE EXOCRINOPATHY | NONOBESE DIABETIC MOUSE | INTERFERON-GAMMA | GLAND CELL-LINE | DISEASE | ETANERCEPT | Tumor Necrosis Factor-alpha - metabolism | Salivary Glands - pathology | T-Lymphocytes, Helper-Inducer - metabolism | Cytokines - metabolism | Humans | Interleukin-4 - metabolism | Middle Aged | Keratoconjunctivitis Sicca - metabolism | Saliva - secretion | Male | Interferon-gamma - metabolism | Sjogren's Syndrome - metabolism | Keratoconjunctivitis Sicca - diagnosis | Sjogren's Syndrome - diagnosis | Salivary Glands - physiopathology | Secretory Rate | Female | Salivary Glands - metabolism
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7. Full Text Sensitivity and Specificity of a Point-of-Care Matrix Metalloproteinase 9 Immunoassay for Diagnosing Inflammation Related to Dry Eye
by Sambursky, Robert and Davitt, William F and Latkany, Robert and Tauber, Shachar and Starr, Christopher and Friedberg, Murray and Dirks, Monte S and McDonald, Marguerite
JAMA Ophthalmology, ISSN 2168-6165, 01/2013, Volume 131, Issue 1, pp. 24 - 28
OBJECTIVES To determine the clinical sensitivity, specificity, negative predictive value, and positive predictive value of a rapid point-of-care diagnostic... 
MATRIX METALLOPROTEINASES | KERATOCONJUNCTIVITIS SICCA | FLUID | DYSFUNCTIONAL TEAR SYNDROME | CORNEAL EPITHELIAL-CELLS | OCULAR SURFACE DISEASE | OPHTHALMOLOGY | CONJUNCTIVA | MMP-9 | EXPRESSION | CYCLOSPORINE | Keratoconjunctivitis Sicca - enzymology | Predictive Value of Tests | Prospective Studies | Humans | Middle Aged | Male | False Positive Reactions | Fluorophotometry | Conjunctiva - metabolism | Young Adult | Matrix Metalloproteinase 9 - metabolism | Keratoconjunctivitis Sicca - diagnosis | Sensitivity and Specificity | Aged, 80 and over | Immunoassay - methods | Adult | Female | Sjogren's Syndrome - enzymology | Tears - enzymology | Double-Blind Method | Tears - chemistry | Cornea - metabolism | Point-of-Care Systems | Sjogren's Syndrome - diagnosis | Adolescent | Aged | Fluorescein - metabolism | Eye | Immunoassay | Dry eye syndromes | Care and treatment | Usage | Control | Surgery | Causes of | Inflammation | Diagnosis | Evaluation | Medical tests | Metalloproteins
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8. Full Text Rethinking Dry Eye Disease: A Perspective on Clinical Implications
by Bron, Anthony J., FRCOphth, F.MedSci and Tomlinson, Alan, PhD, DSc, FCOptom and Foulks, Gary N., MD, FACS and Pepose, Jay S., MD, PhD and Baudouin, Christophe, MD, PhD and Geerling, Gerd, MD, FEBO and Nichols, Kelly K., OD, MPH, PhD and Lemp, Michael A., MD
Ocular Surface, The, ISSN 1542-0124, 2014, Volume 12, Issue 2, pp. S1 - S31
Abstract Publication of the DEWS report in 2007 established the state of the science of dry eye disease (DED). Since that time, new evidence suggests that a... 
Ophthalmology | Point-of-care testing | Inflammation | Osmolarity | Dry eye disease | Aqueous-deficient dry eye disease | Meibomian gland dysfunction | point-of-care testing | dry eye disease | meibomian gland dysfunction | inflammation | osmolarity | aqueous-deficient dry eye disease | IMPRESSION CYTOLOGY SPECIMENS | IN-SITU KERATOMILEUSIS | OPTICAL COHERENCE TOMOGRAPHY | OCULAR SURFACE DISEASE | CORNEAL EPITHELIAL-CELLS | CONTACT-LENS WEAR | OPHTHALMOLOGY | TEAR-FILM OSMOLARITY | NONPRESERVED METHYLPREDNISOLONE THERAPY | BREAK-UP TIME | Keratoconjunctivitis Sicca - physiopathology | Keratoconjunctivitis Sicca - therapy | Osmolar Concentration | Dry Eye Syndromes - physiopathology | Keratoconjunctivitis Sicca - diagnosis | Humans | Dry Eye Syndromes - therapy | Tears - physiology | Dry Eye Syndromes - diagnosis | Meibomian Glands - physiology | Blinking - physiology
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9. Full Text Effect of Rebamipide Ophthalmic Suspension on Signs and Symptoms of Keratoconjunctivitis Sicca in Sjögren Syndrome Patients With or Without Punctal Occlusions
by Arimoto, Atsushi and Kitagawa, Kazuko and Mita, Norihiro and Takahashi, Yoriko and Shibuya, Eri and Sasaki, Hiroshi
Cornea, ISSN 0277-3740, 08/2014, Volume 33, Issue 8, pp. 806 - 811
PURPOSE:The aim of this study was to investigate the efficacy of 2% rebamipide suspension in treatment of keratoconjunctivitis sicca (KCS) in patients with... 
treatment | rebamipide ophthalmic suspension | keratoconjunctivitis sicca | Sjögren syndrome | MULTICENTER | ACTIVATION | EFFICACY | CORNEAL EPITHELIAL-CELLS | INCREASES | DRY EYE | DOUBLE-BLIND | OPHTHALMOLOGY | CONJUNCTIVAL GOBLET CELLS | Sjogren syndrome | CLASSIFICATION CRITERIA | OPC-12759 | Alanine - therapeutic use | Antibodies, Antinuclear - immunology | Autoantibodies - blood | Humans | Middle Aged | Male | Purinergic P2Y Receptor Agonists - therapeutic use | Sjogren's Syndrome - metabolism | Fluorophotometry | Alanine - analogs & derivatives | Alanine - administration & dosage | Keratoconjunctivitis Sicca - diagnosis | Nasolacrimal Duct - surgery | Quinolones - therapeutic use | Keratoconjunctivitis Sicca - drug therapy | Mucins - metabolism | Aged, 80 and over | Ophthalmic Solutions | Adult | Female | Suspensions | Eyelids - surgery | Purinergic P2Y Receptor Agonists - administration & dosage | Sjogren's Syndrome - drug therapy | Keratoconjunctivitis Sicca - metabolism | Antioxidants - therapeutic use | Quinolones - administration & dosage | Sjogren's Syndrome - diagnosis | Antioxidants - administration & dosage | Aged | Tears - physiology
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10. Full Text Efficacy of HL036 versus Cyclosporine A in the Treatment of Naturally Occurring Canine Keratoconjunctivitis Sicca
by Lee, Han-Byul and Choi, Hyun-Ji and Cho, Sung-Min and Kang, Suzie and Ahn, Hyea Kyung and Song, Yeon Jung and Kim, Young Ju and Son, Woo-Chan
Current Eye Research, ISSN 0271-3683, 07/2018, Volume 43, Issue 7, pp. 889 - 895
Purposes: To (i) evaluate the efficacy and safety of HL036, a tumor-necrosis factor (TNF)-α-blocking protein, in the treatment of naturally occurring canine... 
dry eye disease | cyclosporine A | HL036 | TNF-α blocker | Canine keratoconjunctivitis sicca | ANTIBODIES | DROPS | ACTIVATION | OCULAR-SURFACE | TNF-alpha blocker | CLINICAL-EVALUATION | THERAPY | INFLAMMATION | IN-VIVO | DOGS | OPHTHALMOLOGY | Male | Treatment Outcome | Random Allocation | Conjunctiva - pathology | Animals | Keratoconjunctivitis Sicca - diagnosis | Conjunctiva - drug effects | Cyclosporine - administration & dosage | Dogs | Keratoconjunctivitis Sicca - drug therapy | Ophthalmic Solutions | Female | Administration, Topical | Immunosuppressive Agents - administration & dosage | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Disease Models, Animal
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11. Full Text Rose bengal staining of the temporal conjunctiva differentiates sjögren's syndrome from keratoconjunctivitis sicca
by Caffery, Barbara and Simpson, Trefford and Wang, Sunny and Bailey, Denis and McComb, John and Rutka, John and Slomovic, Allan and Bookman, Arthur
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 05/2010, Volume 51, Issue 5, pp. 2381 - 2387
PURPOSE. To compare the clinical presentation of 231 patients with primary Sjogren's syndrome (pSS) with 89 patients with aqueous-deficient dry eye... 
EPITHELIAL-CELLS | DISEASE | GENE-EXPRESSION | OPHTHALMOLOGY | TEAR FILM | SYMPTOMS | SALIVARY-GLAND | CLASSIFICATION CRITERIA | CLINICAL SIGNS | DRY EYE SYNDROME | LISSAMINE GREEN | Conjunctiva - pathology | Algorithms | Keratoconjunctivitis Sicca - diagnosis | Sjogren's Syndrome - diagnosis | Humans | Middle Aged | Staining and Labeling | Female | Male | Fluorescent Dyes | Rose Bengal
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12. Full Text Evaluation of Tear Osmolarity in Non-Sjögren and Sjögren Syndrome Dry Eye Patients With the TearLab System
by Szalai, Eszter and Berta, András and Szekanecz, Zoltán and Szûcs, Gabriella and Módis, László
Cornea, ISSN 0277-3740, 08/2012, Volume 31, Issue 8, pp. 867 - 871
PURPOSE:To evaluate tear osmolarity with the recently introduced TearLab system (TearLab Corporation, San Diego, CA) in patients with non-Sjögren syndrome dry... 
tear osmolarity | dry eye syndrome | keratoconjunctivitis sicca | Sjögren syndrome | FILM OSMOLARITY | TESTS | JNK | CORNEAL EPITHELIAL-CELLS | OCULAR SURFACE DISEASE | KERATOCONJUNCTIVITIS-SICCA | DENSITY | HYPEROSMOLARITY | DYNAMICS | OPHTHALMOLOGY | Sjogren syndrome | Staining and Labeling - methods | Prospective Studies | Tears - chemistry | Humans | Middle Aged | Male | Osmolar Concentration | Keratoconjunctivitis Sicca - diagnosis | Sjogren's Syndrome - diagnosis | Reagent Kits, Diagnostic | Adolescent | Aged, 80 and over | Adult | Female | Aged
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13. Full Text Episcleral cyclosporine A implants for the management of unilateral keratoconjunctivitis sicca in an 8‐year‐old mare
by Mackenzie, Catriona J and Carslake, Harry B and Robin, Matthew and Kent, Rebecca J and Malalana, Fernando
Veterinary Ophthalmology, ISSN 1463-5216, 01/2017, Volume 20, Issue 1, pp. 79 - 83
An 8‐year‐old mare was presented for investigation of a 1‐month history of blepharospasm, eyelid swelling, corneal edema, and ocular discharge of the right eye... 
horse | cyclosporine A | dry eye | implant | keratoconjunctivitis sicca | ocular | DRUG-DELIVERY | SCHIRMER TEAR TEST | EQUINE | HYPOTHYROIDISM | FRACTURE | DOGS | VETERINARY SCIENCES | CANINE | GLAND | Horse Diseases - diagnosis | Horse Diseases - drug therapy | Drug Implants - administration & dosage | Drug Implants - therapeutic use | Administration, Ophthalmic - veterinary | Cyclosporine - therapeutic use | Animals | Keratoconjunctivitis Sicca - diagnosis | Keratoconjunctivitis Sicca - pathology | Cyclosporine - administration & dosage | Keratoconjunctivitis Sicca - drug therapy | Horses | Keratoconjunctivitis Sicca - veterinary | Female | Horse Diseases - pathology | Sclera | Cyclosporine
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14. Full Text Systemic lupus erythematosus: An update for ophthalmologists
by Papagiannuli, Efrosini, MD, MRCOphth and Rhodes, Benjamin, PhD, FRCP and Wallace, Graham R., PhD and Gordon, Caroline, PhD, FRCP and Murray, Philip I., PhD, FRCOphth and Denniston, Alastair K., PhD, FRCOphth
Survey of Ophthalmology, ISSN 0039-6257, 2016, Volume 61, Issue 1, pp. 65 - 82
Abstract Systemic lupus erythematosus (SLE) is a life-threatening multisystem inflammatory condition that may affect almost any part of the eye. We provide an... 
Ophthalmology | systemic lupus erythematosus | anti-phospholipid syndrome | Sjogren syndrome | keratoconjunctivitis sicca | lupus retinopathy | Lupus retinopathy | Systemic lupus erythematosus | Anti-phospholipid syndrome | Keratoconjunctivitis sicca | MONOCLONAL-ANTIBODY | CONNECTIVE-TISSUE DISEASE | ANTIPHOSPHOLIPID SYNDROME | DOUBLE-BLIND | INTRAVENOUS CYCLOPHOSPHAMIDE | OPHTHALMOLOGY | OCULAR MANIFESTATIONS | STEM-CELL TRANSPLANTATION | CLASSIFICATION CRITERIA | MYCOPHENOLATE-MOFETIL | INDUCTION TREATMENT | Antiphospholipid Syndrome - diagnosis | Retinal Diseases - diagnosis | Sjogren's Syndrome - etiology | Keratoconjunctivitis Sicca - etiology | Antiphospholipid Syndrome - etiology | Humans | Eye Diseases - etiology | Retinal Diseases - therapy | Lupus Erythematosus, Systemic - etiology | Lupus Erythematosus, Systemic - therapy | Eye Diseases - diagnosis | Lupus Erythematosus, Systemic - diagnosis | Keratoconjunctivitis Sicca - therapy | Keratoconjunctivitis Sicca - diagnosis | Sjogren's Syndrome - therapy | Retinal Diseases - etiology | Sjogren's Syndrome - diagnosis | Antiphospholipid Syndrome - therapy | Eye Diseases - therapy | Lupus | Hospitals | Collagen | Therapeutics | Homeopathy | Materia medica and therapeutics | Index Medicus
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