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1. Full Text Antifungal Susceptibilities of the Species of the Pseudallescheria boydii Complex
by Fèlix Gilgado and Carolina Serena and Josep Cano and Josepa Gené and Josep Guarro
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 12/2006, Volume 50, Issue 12, pp. 4211 - 4213
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VORICONAZOLE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | INFECTION | AMPHOTERICIN-B | SCEDOSPORIUM-APIOSPERMUM | Fluconazole - pharmacology | Pseudallescheria - drug effects | Humans | Scedosporium - drug effects | Peptides, Cyclic - pharmacology | Itraconazole - pharmacology | Ketoconazole - pharmacology | Microbial Sensitivity Tests | Scedosporium - isolation & purification | Voriconazole | Drug Resistance, Fungal | Pseudallescheria - isolation & purification | Quality Control | Antifungal Agents - pharmacology | Amphotericin B - pharmacology | Pyrimidines - pharmacology | Micafungin | Terbinafine | Naphthalenes - pharmacology | Triazoles - pharmacology | Lipoproteins - pharmacology | Echinocandins | Thiazoles - pharmacology | Candida - drug effects | Flucytosine - pharmacology | Quinazolines - pharmacology | Lipopeptides | Susceptibility
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2. Full Text Curcumin Modulates Efflux Mediated by Yeast ABC Multidrug Transporters and Is Synergistic with Antifungals
by Monika Sharma and Raman Manoharlal and Suneet Shukla and Nidhi Puri and Tulika Prasad and Suresh V. Ambudkar and Rajendra Prasad
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 08/2009, Volume 53, Issue 8, pp. 3256 - 3265
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RESISTANCE PROTEIN-1 ABCC1 | CDR1P | CANDIDA-ALBICANS | TURMERIC POWDER | HUMAN PATHOGENIC YEAST | AZOLE RESISTANCE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | DRUG-RESISTANCE | SACCHAROMYCES-CEREVISIAE | UP-REGULATION | P-GLYCOPROTEIN ABCB1 | Antifungal Agents - pharmacology | Fluconazole - pharmacology | Methotrexate - metabolism | Curcumin - pharmacology | Enzyme Inhibitors - pharmacology | Saccharomyces cerevisiae - drug effects | Candida albicans - metabolism | Pyrimidines - pharmacology | Rhodamines - metabolism | Cycloheximide - pharmacology | Itraconazole - pharmacology | Ketoconazole - pharmacology | Drug Synergism | Saccharomyces cerevisiae - metabolism | Triazoles - pharmacology | Miconazole - pharmacology | Voriconazole | Anisomycin - pharmacology | Biological Transport - drug effects | Multidrug Resistance-Associated Proteins - metabolism | Index Medicus | Susceptibility
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3. Full Text Identification and Characterization of Four Azole-Resistant erg3 Mutants of Candida albicans
by Claire M. Martel and Josie E. Parker and Oliver Bader and Michael Weig and Uwe Gross and Andrew G. S. Warrilow and Nicola Rolley and Diane E. Kelly and Steven L. Kelly
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 11/2010, Volume 54, Issue 11, pp. 4527 - 4533
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CONTRIBUTE | IN-VIVO | ANTIFUNGAL AGENTS | AMINO-ACID SUBSTITUTIONS | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | MECHANISMS | AMPHOTERICIN-B | MUTATIONS | FLUCONAZOLE RESISTANCE | SACCHAROMYCES-CEREVISIAE | AIDS PATIENTS | Antifungal Agents - pharmacology | Fluconazole - pharmacology | Ergosterol - metabolism | Oxidoreductases - genetics | Amphotericin B - pharmacology | Clotrimazole - pharmacology | Candida albicans - metabolism | Drug Resistance, Fungal - genetics | Pyrimidines - pharmacology | Azoles - pharmacology | Itraconazole - pharmacology | Ketoconazole - pharmacology | Candida albicans - genetics | Microbial Sensitivity Tests | Triazoles - pharmacology | Candida albicans - drug effects | Voriconazole | Mutation | Mechanisms of Resistance
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4. Full Text The tetrazole VT-1161 is a potent inhibitor of Trichophyton rubrum through its inhibition of T. rubrum CYP51
by Warrilow, Andrew G. S and Parker, Josie E and Price, Claire L and Garvey, Edward P and Hoekstra, William J and Schotzinger, Robert J and Wiederhold, Nathan P and Nes, W. David and Kelly, Diane E and Kelly, Steven L
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 07/2017, Volume 61, Issue 7
Prior to characterization of antifungal inhibitors that target CYP51, Trichophyton rubrum CYP51 was expressed in Escherichia coli, purified, and characterized.... 
Trichophyton rubrum | VT-1161 | Azole resistance | Substrate specificity | CYP51 | azole resistance | HUMAN ENZYME | TRYPANOSOMA-BRUCEI | CANDIDA-ALBICANS CYP51 | ESCHERICHIA-COLI | MICROBIOLOGY | SUBSTRATE PREFERENCES | TINEA-PEDIS | AZOLE ANTIFUNGAL AGENTS | MALASSEZIA-GLOBOSA | STRUCTURAL BASIS | substrate specificity | STEROL 14-ALPHA-DEMETHYLASE CYP51 | PHARMACOLOGY & PHARMACY | Antifungal Agents - pharmacology | Trichophyton - drug effects | Fluconazole - pharmacology | Tetrazoles - pharmacology | Voriconazole - pharmacology | Clotrimazole - pharmacology | Substrate Specificity | Azoles - pharmacology | Itraconazole - pharmacology | Ketoconazole - pharmacology | Microbial Sensitivity Tests | Candida albicans - drug effects | Pyridines - pharmacology | Sterol 14-Demethylase - metabolism | Drug Resistance, Fungal | Fungal Proteins - metabolism
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5. Full Text Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite
by Kazui, Miho and Nishiya, Yumi and Ishizuka, Tomoko and Hagihara, Katsunobu and Farid, Nagy A and Okazaki, Osamu and Ikeda, Toshihiko and Kurihara, Atsushi
Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 92 - 99
The aim of the current study is to identify the human cytochrome P450 (P450) isoforms involved in the two oxidative steps in the bioactivation of clopidogrel... 
MECHANISM-BASED INHIBITION | ANTIAGGREGATING ACTIVITY | POLYMORPHISMS | TICLOPIDINE | PHARMACOKINETICS | HEALTHY-SUBJECTS | PHARMACOLOGY & PHARMACY | PRASUGREL | PHARMACODYNAMICS | MONOCLONAL-ANTIBODIES | ATORVASTATIN | Microsomes - metabolism | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Sulfaphenazole - pharmacology | Microsomes - drug effects | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP1A2 - genetics | Antibodies - immunology | Omeprazole - pharmacology | Microsomes, Liver - enzymology | Platelet Aggregation Inhibitors - pharmacokinetics | Ticlopidine - pharmacokinetics | Oxidoreductases, N-Demethylating - metabolism | Aryl Hydrocarbon Hydroxylases - immunology | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Ticlopidine - analogs & derivatives | Oxidoreductases, N-Demethylating - immunology | Cytochrome P-450 CYP3A - metabolism | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | Theophylline - pharmacology | Kinetics | Cytochrome P-450 CYP2C9 | Theophylline - analogs & derivatives | Oxidoreductases, N-Demethylating - genetics | Glutathione - metabolism | Ketoconazole - pharmacology | Biotransformation - physiology | Cytochrome P-450 CYP1A2 Inhibitors | Microsomes, Liver - drug effects | Ticlopidine - metabolism | NADP - metabolism | Platelet Aggregation Inhibitors - metabolism | Cytochrome P-450 CYP3A - immunology | Cell Line | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cytochrome P-450 CYP1A2 - immunology | Biocatalysis | Mephenytoin - analogs & derivatives | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Mephenytoin - pharmacology | Antibodies - pharmacology | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP2C19 | Clopidogrel | Cytochrome P-450 CYP2B6
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6. Full Text Ibrutinib Dosing Strategies Based on Interaction Potential of CYP3A4 Perpetrators Using Physiologically Based Pharmacokinetic Modeling
by de Zwart, L and Snoeys, J and De Jong, J and Sukbuntherng, J and Mannaert, E and Monshouwer, M
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 11/2016, Volume 100, Issue 5, pp. 548 - 557
Based on ibrutinib pharmacokinetics and potential sensitivity towards CYP3A4‐mediated drug–drug interactions (DDIs), a physiologically based pharmacokinetic... 
INHIBITION | POPULATION PHARMACOKINETICS | IN-VITRO DATA | FLUVOXAMINE | ALPHA-1-ACID GLYCOPROTEIN | KETOCONAZOLE | PHARMACOLOGY & PHARMACY | MIDAZOLAM CLEARANCE | HEALTHY-VOLUNTEERS | DRUG-DRUG INTERACTIONS | PREDICTION | Carbamazepine - pharmacology | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Pyrimidines - blood | Humans | Male | Ketoconazole - pharmacology | Azithromycin - pharmacology | Drug Dosage Calculations | Cytochrome P-450 CYP3A Inducers - pharmacology | Drug Interactions | Models, Biological | Pyrazoles - blood | Benzoxazines - pharmacology | Pyrimidines - pharmacokinetics | Rifampin - pharmacology | Pyrazoles - pharmacokinetics | Fluvoxamine | Dosage and administration | Research | Pharmacokinetics | Rifampin | Drug interactions | Analysis
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7. Full Text The investigational drug VT-1129 is a highly potent inhibitor of Cryptococcus species CYP51 but only weakly inhibits the human enzyme
by Warrilow, Andrew G. S and Parker, Josie E and Price, Claire L and Nes, W. David and Garvey, Edward P and Hoekstra, William J and Schotzinger, Robert J and Kelly, Diane E and Kelly, Steven L
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 08/2016, Volume 60, Issue 8, pp. 4530 - 4538
Cryptococcosis is a life-threatening disease often associated with HIV infection. Three Cryptococcus species CYP51 enzymes were purified and catalyzed the 14... 
CANDIDA-ALBICANS | NEOFORMANS | STEROL 14-ALPHA-DEMETHYLASE | ESCHERICHIA-COLI | MOLECULAR TYPE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | HUMAN LIVER-MICROSOMES | EPIDEMIOLOGIC CUTOFF VALUES | AZOLE ANTIFUNGAL AGENTS | AIDS PATIENTS | LANOSTEROL 14-ALPHA-DEMETHYLASE | Antifungal Agents - pharmacology | Cryptococcus - metabolism | Antifungal Agents - adverse effects | Fluconazole - pharmacology | Tetrazoles - pharmacology | Ergosterol - metabolism | Voriconazole - adverse effects | Voriconazole - pharmacology | Humans | Clotrimazole - pharmacology | Fluconazole - adverse effects | Lanosterol - analogs & derivatives | Enzyme Activation - drug effects | Itraconazole - pharmacology | Ketoconazole - pharmacology | Pyridines - adverse effects | Clotrimazole - adverse effects | Itraconazole - adverse effects | Lanosterol - metabolism | Pyridines - pharmacology | Sterol 14-Demethylase - metabolism | Ketoconazole - adverse effects | Tetrazoles - adverse effects | Cryptococcus - drug effects
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8. Full Text Crystal structure of the new investigational drug candidate VT-1598 in complex with Aspergillus fumigatus sterol 14α-demethylase provides insights into its broad-spectrum Antifungal Activity
by Hargrove, Tatiana Y and Garvey, Edward P and Hoekstra, William J and Yates, Christopher M and Wawrzak, Zdzislaw and Rachakonda, Girish and Villalta, Fernando and Lepesheva, Galina I and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 07/2017, Volume 61, Issue 7
Within the past few decades, the incidence and complexity of human fungal infections have increased, and therefore, the need for safer and more efficient,... 
VT-1598 | Fungal infections | Inhibition | Sterol 14α-demethylase (CYP51) | Aspergillus fumigatus | X-ray structure | HUMAN ENZYME | TRYPANOSOMA-CRUZI | CHAGAS-DISEASE | CANDIDIASIS | inhibition | MICROBIOLOGY | INVASIVE FUNGAL-INFECTIONS | HIGHLY POTENT INHIBITOR | fungal infections | CYP51 | MURINE MODEL | IN-VITRO | sterol 14 alpha-demethylase (CYP51) | PHARMACOLOGY & PHARMACY | ALBICANS | Antifungal Agents - pharmacology | Aspergillus fumigatus - drug effects | Fluconazole - pharmacology | Drugs, Investigational - pharmacology | Tetrazoles - pharmacology | Voriconazole - pharmacology | Sterol 14-Demethylase - genetics | Aspergillus fumigatus - enzymology | Aspergillus fumigatus - genetics | Ketoconazole - pharmacology | Candida albicans - genetics | Microbial Sensitivity Tests | Triazoles - pharmacology | Candida albicans - drug effects | Pyridines - pharmacology | Sterol 14-Demethylase - metabolism | Candida albicans - enzymology
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9. Full Text In vitro activities of a wide panel of antifungal drugs against various Scopulariopsis and Microascus species
by Skóra, Magdalena and Bulanda, Małgorzata and Jagielski, Tomasz
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 09/2015, Volume 59, Issue 9, pp. 5827 - 5829
The in vitro activities of 11 antifungal drugs against 68 Scopulariopsis and Microascus strains were investigated. Amphotericin B, 5-fluorocytosine,... 
PROSTHETIC VALVE | BROAD-SPECTRUM | RESISTANT | CIRROSUS | SUSCEPTIBILITY | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | AGENTS | INFECTION | DERMATOPHYTES | COMBINATION | BREVICAULIS | Antifungal Agents - pharmacology | Fluconazole - pharmacology | Voriconazole - pharmacology | Amphotericin B - pharmacology | Ascomycota - drug effects | Itraconazole - pharmacology | Ketoconazole - pharmacology | Microbial Sensitivity Tests | Triazoles - pharmacology | Scopulariopsis - drug effects | Flucytosine - pharmacology | Drug Resistance, Fungal | Lipopeptides | Echinocandins - pharmacology | Susceptibility
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10. Full Text Genome-Wide Expression Profiling of the Response to Azole, Polyene, Echinocandin, and Pyrimidine Antifungal Agents in Candida albicans
by Teresa T. Liu and Robin E. B. Lee and Katherine S. Barker and Richard E. Lee and Lai Wei and Ramin Homayouni and P. David Rogers
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 06/2005, Volume 49, Issue 6, pp. 2226 - 2236
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Antifungal Agents - pharmacology | Oligonucleotide Array Sequence Analysis - methods | Humans | Polyenes - pharmacology | Amphotericin B - pharmacology | Peptides, Cyclic - pharmacology | Gene Expression Profiling | Candida albicans - metabolism | Fungal Proteins - genetics | Pyrimidines - pharmacology | Azoles - pharmacology | Ketoconazole - pharmacology | Candida albicans - genetics | Microbial Sensitivity Tests | Candida albicans - drug effects | Genome, Fungal | Echinocandins | Flucytosine - pharmacology | Fungal Proteins - pharmacology | Gene Expression Regulation, Bacterial | Lipopeptides | Fungal Proteins - metabolism | Mechanisms of Action | Physiological Effects
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11. Full Text Evaluation of Cytochrome P450 3A4-Mediated Drug–Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation
by Budha, Nageshwar R and Ji, Tao and Musib, Luna and Eppler, Steve and Dresser, Mark and Chen, Yuan and Jin, Jin Y
Clinical Pharmacokinetics, ISSN 0312-5963, 11/2016, Volume 55, Issue 11, pp. 1435 - 1445
Cobimetinib is eliminated mainly through cytochrome P450 (CYP) 3A4-mediated hepatic metabolism in humans. A clinical drug–drug interaction (DDI) study with the... 
Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | METABOLISM | POPULATION PHARMACOKINETICS | EFAVIRENZ | KETOCONAZOLE | PHARMACOLOGY & PHARMACY | PHARMACOGENETICS | ITRACONAZOLE | CLINICAL PHARMACOKINETICS | CANCER | DISPOSITION | PREDICTION | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Administration, Oral | Area Under Curve | Erythromycin - pharmacology | Humans | Azetidines - pharmacokinetics | Fluvoxamine - pharmacology | Diltiazem - pharmacology | Cytochrome P-450 CYP3A Inducers - pharmacology | Drug Interactions | Cytochrome P-450 CYP3A - metabolism | Models, Biological | Computer Simulation | Benzoxazines - pharmacology | Piperidines - pharmacokinetics | Retrospective Studies | Rifampin - pharmacology
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12. Full Text Investigation into CYP3A4-mediated drug–drug interactions on midostaurin in healthy volunteers
by Dutreix, Catherine and Munarini, Florence and Lorenzo, Sebastien and Roesel, Johannes and Wang, Yanfeng
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 12/2013, Volume 72, Issue 6, pp. 1223 - 1234
Midostaurin (PKC412), a multitargeted tyrosine kinase inhibitor that targets FMS-related tyrosine kinase 3 and KIT, is in clinical trials for the treatment for... 
Rifampicin | Medicine & Public Health | Ketoconazole | FMS-related tyrosine kinase 3 (FLT3) inhibitor | Midostaurin | Oncology | Cancer Research | Midazolam | Pharmacology/Toxicology | Pharmacokinetics | FLT3 | MARKER | 4-BETA-HYDROXYCHOLESTEROL | ACUTE MYELOID-LEUKEMIA | KINASE INHIBITOR | FMS-related tyrosine kinase 3 (FLT 3) inhibitor | SYSTEMIC MASTOCYTOSIS | PKC412 | TIME-DEPENDENT PHARMACOKINETICS | ONCOLOGY | PHARMACOLOGY & PHARMACY | MAST-CELL DISORDERS | Humans | Middle Aged | Male | Staurosporine - analogs & derivatives | Antineoplastic Agents - administration & dosage | Staurosporine - pharmacokinetics | Ketoconazole - pharmacology | Enzyme Inhibitors - administration & dosage | Young Adult | Tandem Mass Spectrometry | Drug Interactions | Chromatography, Liquid | Enzyme Induction - drug effects | Adult | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Cytochrome P-450 CYP3A - biosynthesis | Drug Administration Schedule | Enzyme Inhibitors - pharmacology | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP3A - metabolism | Rifampin - pharmacology | Midazolam - pharmacology | Staurosporine - pharmacology | Staurosporine - administration & dosage | Drug interactions | Cytochrome P-450 | Original
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13. Full Text Human adrenocarcinoma (H295R) cells for rapid in vitro determination of effects on steroidogenesis: Hormone production
by Hecker, Markus and Newsted, John L and Murphy, Margaret B and Higley, Eric B and Jones, Paul D and Wu, Rudolf and Giesy, John P
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2006, Volume 217, Issue 1, pp. 114 - 124
To identify and prioritize chemicals that may alter steroidogenesis, an in vitro screening assay based on measuring alterations in hormone production was... 
Endocrine disruption | Chemical screening | Steroidogenesis | Steroid hormones | ADRENOCORTICAL CARCINOMA-CELLS | MALE RATS | STEROID-BIOSYNTHESIS INHIBITORS | MINNOW PIMEPHALES-PROMELAS | steroidogenesis | endocrine disruption | FUNGICIDE PROCHLORAZ | STABLY EXPRESSES | LINE | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | AROMATASE CYP19 ACTIVITY | TOXICOLOGY | steroid hormones | chemical screening | VINCLOZOLIN | Antifungal Agents - pharmacology | Cell Survival - drug effects | Estradiol - metabolism | Fadrozole - pharmacology | Gonadal Steroid Hormones - metabolism | Aminoglutethimide - pharmacology | Enzyme-Linked Immunosorbent Assay | Aromatase Inhibitors - pharmacology | Humans | Adrenal Cortex - metabolism | Imidazoles - pharmacology | Adrenal Cortex - pathology | Fungicides, Industrial - pharmacology | Ketoconazole - pharmacology | Dose-Response Relationship, Drug | Testosterone - metabolism | Endocrine Disruptors - pharmacology | Adrenocortical Carcinoma - metabolism | Progesterone - metabolism | Cell Line, Tumor | Oxazoles - pharmacology | Adrenal Cortex - drug effects | Enzymes | Cell research | Safety and security measures | Ketoconazole | Estrogen | Gene expression | Testosterone | Aminoglutethimide | Analysis | Progesterone | Enzyme-linked immunosorbent assay | Cancer | Food | HYDROXYPREGNENONE | PROGESTERONE | DOSES | TESTOSTERONE | ENZYMES | IN VITRO | ESTRADIOL | CARCINOMAS | ENZYME IMMUNOASSAY | 60 APPLIED LIFE SCIENCES
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14. Full Text In Vitro and In Vivo Studies of the Antiparasitic Activity of Sterol 14α-Demethylase (CYP51) Inhibitor VNI against Drug-Resistant Strains of Trypanosoma cruzi
by Maria de Nazaré Correia Soeiro and Elen Mello de Souza and Cristiane França da Silva and Denise da Gama Jaen Batista and Marcos Meuser Batista and Beatriz Philot Pavão and Julianna Siciliano Araújo and Claudia Alessandra Fortes Aiub and Patrícia Bernardino da Silva and Jessica Lionel and Constança Britto and Kwangho Kim and Gary Sulikowski and Tatiana Y. Hargrove and Michael R. Waterman and Galina I. Lepesheva
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 09/2013, Volume 57, Issue 9, pp. 4151 - 4163
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TARGET | ACUTE-PHASE | PARASITE LOAD | BIOSYNTHESIS | CHRONIC CHAGAS-DISEASE | KETOCONAZOLE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | EPIMASTIGOTES | RAVUCONAZOLE | CHEMOTHERAPY | BENZNIDAZOLE | Chagas Disease - parasitology | 14-alpha Demethylase Inhibitors - chemistry | Protozoan Proteins - antagonists & inhibitors | Golgi Apparatus - drug effects | Imidazoles - chemistry | Male | Trypanocidal Agents - chemistry | Endoplasmic Reticulum - ultrastructure | Trypanosoma cruzi - enzymology | Protozoan Proteins - metabolism | Oxadiazoles - pharmacology | Endoplasmic Reticulum - drug effects | Oxadiazoles - chemistry | Trypanosoma cruzi - ultrastructure | Golgi Apparatus - ultrastructure | Microscopy, Electron, Transmission | Nitroimidazoles - pharmacology | Drug Resistance - drug effects | Imidazoles - pharmacology | Triazoles - pharmacology | Animals | Trypanosoma cruzi - growth & development | 14-alpha Demethylase Inhibitors - pharmacology | Trypanocidal Agents - pharmacology | Chagas Disease - mortality | Chagas Disease - drug therapy | Trypanosoma cruzi - drug effects | Mice | Sterol 14-Demethylase - metabolism | Thiazoles - pharmacology | Index Medicus | Experimental Therapeutics
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15. Full Text Co‐administration of rivaroxaban with drugs that share its elimination pathways: pharmacokinetic effects in healthy subjects
by Mueck, Wolfgang and Kubitza, Dagmar and Becka, Michael
British Journal of Clinical Pharmacology, ISSN 0306-5251, 09/2013, Volume 76, Issue 3, pp. 455 - 466
AimsThe anticoagulant rivaroxaban is an oral, direct Factor Xa inhibitor for the management of thromboembolic disorders. Metabolism and excretion involve... 
cytochrome | glycoprotein | rivaroxaban | drug interactions | healthy subjects | 450 | P-glycoprotein | Rivaroxaban | Healthy subjects | Cytochrome P450 | Drug interactions | BAY-59-7939 | SAFETY | PREVENTION | PHARMACODYNAMICS | cytochrome P450 | PROTEASE INHIBITORS | IN-VITRO | FACTOR-XA INHIBITOR | ERYTHROMYCIN | PHARMACOLOGY & PHARMACY | LIVER-MICROSOMES | Anticoagulants - administration & dosage | Cytochrome P-450 Enzyme Inhibitors | Erythromycin - pharmacology | Ketoconazole - administration & dosage | Humans | Middle Aged | Cytochrome P-450 Enzyme System - metabolism | Midazolam - administration & dosage | Substrate Specificity | Metabolic Clearance Rate | Thiophenes - administration & dosage | Ketoconazole - pharmacology | Enzyme Inhibitors - administration & dosage | Young Adult | Drug Interactions | Enzyme Inhibitors - pharmacokinetics | Clarithromycin - pharmacokinetics | Clarithromycin - administration & dosage | Adult | Morpholines - administration & dosage | Enzyme Inhibitors - pharmacology | Ketoconazole - pharmacokinetics | Midazolam - pharmacokinetics | Cytochrome P-450 CYP3A - administration & dosage | Erythromycin - administration & dosage | ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors | ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism | Thiophenes - pharmacokinetics | Erythromycin - pharmacokinetics | Cytochrome P-450 CYP3A - metabolism | Adolescent | Anticoagulants - pharmacokinetics | Morpholines - pharmacokinetics | Clarithromycin - pharmacology | Midazolam - pharmacology | Ketoconazole | Protease inhibitors | Fluconazole | Proteases | Cytochrome P-450 | Dosage and administration | Anticoagulants (Medicine) | Erythromycin | Thromboembolism | Index Medicus
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