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1. Full Text Antifungal Susceptibilities of the Species of the Pseudallescheria boydii Complex
by Fèlix Gilgado and Carolina Serena and Josep Cano and Josepa Gené and Josep Guarro
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 12/2006, Volume 50, Issue 12, pp. 4211 - 4213
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Fluconazole - pharmacology | Pseudallescheria - drug effects | Humans | Scedosporium - drug effects | Peptides, Cyclic - pharmacology | Itraconazole - pharmacology | Ketoconazole - pharmacology | Microbial Sensitivity Tests | Scedosporium - isolation & purification | Voriconazole | Drug Resistance, Fungal | Pseudallescheria - isolation & purification | Quality Control | Antifungal Agents - pharmacology | Amphotericin B - pharmacology | Pyrimidines - pharmacology | Micafungin | Terbinafine | Naphthalenes - pharmacology | Triazoles - pharmacology | Lipoproteins - pharmacology | Echinocandins | Thiazoles - pharmacology | Candida - drug effects | Flucytosine - pharmacology | Quinazolines - pharmacology | Lipopeptides | Index Medicus | Susceptibility
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2. Full Text Curcumin Modulates Efflux Mediated by Yeast ABC Multidrug Transporters and Is Synergistic with Antifungals
by Monika Sharma and Raman Manoharlal and Suneet Shukla and Nidhi Puri and Tulika Prasad and Suresh V. Ambudkar and Rajendra Prasad
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 08/2009, Volume 53, Issue 8, pp. 3256 - 3265
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Antifungal Agents - pharmacology | Fluconazole - pharmacology | Methotrexate - metabolism | Curcumin - pharmacology | Enzyme Inhibitors - pharmacology | Saccharomyces cerevisiae - drug effects | Candida albicans - metabolism | Pyrimidines - pharmacology | Rhodamines - metabolism | Cycloheximide - pharmacology | Itraconazole - pharmacology | Ketoconazole - pharmacology | Drug Synergism | Saccharomyces cerevisiae - metabolism | Triazoles - pharmacology | Miconazole - pharmacology | Voriconazole | Anisomycin - pharmacology | Biological Transport - drug effects | Multidrug Resistance-Associated Proteins - metabolism | Index Medicus | Susceptibility
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3. Full Text Identification and Characterization of Four Azole-Resistant erg3 Mutants of Candida albicans
by Claire M. Martel and Josie E. Parker and Oliver Bader and Michael Weig and Uwe Gross and Andrew G. S. Warrilow and Nicola Rolley and Diane E. Kelly and Steven L. Kelly
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 11/2010, Volume 54, Issue 11, pp. 4527 - 4533
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Antifungal Agents - pharmacology | Fluconazole - pharmacology | Ergosterol - metabolism | Oxidoreductases - genetics | Amphotericin B - pharmacology | Clotrimazole - pharmacology | Candida albicans - metabolism | Drug Resistance, Fungal - genetics | Pyrimidines - pharmacology | Azoles - pharmacology | Itraconazole - pharmacology | Ketoconazole - pharmacology | Candida albicans - genetics | Microbial Sensitivity Tests | Triazoles - pharmacology | Candida albicans - drug effects | Voriconazole | Mutation | Index Medicus | Mechanisms of Resistance
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4. Full Text Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite
by Kazui, Miho and Nishiya, Yumi and Ishizuka, Tomoko and Hagihara, Katsunobu and Farid, Nagy A and Okazaki, Osamu and Ikeda, Toshihiko and Kurihara, Atsushi
Drug metabolism and disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 92 - 99
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Microsomes - metabolism | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Sulfaphenazole - pharmacology | Microsomes - drug effects | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP1A2 - genetics | Antibodies - immunology | Omeprazole - pharmacology | Microsomes, Liver - enzymology | Platelet Aggregation Inhibitors - pharmacokinetics | Ticlopidine - pharmacokinetics | Oxidoreductases, N-Demethylating - metabolism | Aryl Hydrocarbon Hydroxylases - immunology | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Ticlopidine - analogs & derivatives | Oxidoreductases, N-Demethylating - immunology | Cytochrome P-450 CYP3A - metabolism | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | Theophylline - pharmacology | Kinetics | Cytochrome P-450 CYP2C9 | Theophylline - analogs & derivatives | Oxidoreductases, N-Demethylating - genetics | Glutathione - metabolism | Ketoconazole - pharmacology | Biotransformation - physiology | Cytochrome P-450 CYP1A2 Inhibitors | Microsomes, Liver - drug effects | Ticlopidine - metabolism | NADP - metabolism | Platelet Aggregation Inhibitors - metabolism | Cytochrome P-450 CYP3A - immunology | Cell Line | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cytochrome P-450 CYP1A2 - immunology | Biocatalysis | Mephenytoin - analogs & derivatives | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Mephenytoin - pharmacology | Antibodies - pharmacology | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP2C19 | Clopidogrel | Cytochrome P-450 CYP2B6 | Index Medicus
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5. Full Text Genome-Wide Expression Profiling of the Response to Azole, Polyene, Echinocandin, and Pyrimidine Antifungal Agents in Candida albicans
by Teresa T. Liu and Robin E. B. Lee and Katherine S. Barker and Richard E. Lee and Lai Wei and Ramin Homayouni and P. David Rogers
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 06/2005, Volume 49, Issue 6, pp. 2226 - 2236
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Antifungal Agents - pharmacology | Oligonucleotide Array Sequence Analysis - methods | Humans | Polyenes - pharmacology | Amphotericin B - pharmacology | Peptides, Cyclic - pharmacology | Gene Expression Profiling | Candida albicans - metabolism | Fungal Proteins - genetics | Pyrimidines - pharmacology | Azoles - pharmacology | Ketoconazole - pharmacology | Candida albicans - genetics | Microbial Sensitivity Tests | Candida albicans - drug effects | Genome, Fungal | Echinocandins | Flucytosine - pharmacology | Fungal Proteins - pharmacology | Gene Expression Regulation, Bacterial | Lipopeptides | Fungal Proteins - metabolism | Index Medicus | Mechanisms of Action | Physiological Effects
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6. Full Text The tetrazole VT-1161 is a potent inhibitor of Trichophyton rubrum through its inhibition of T. rubrum CYP51
by Warrilow, Andrew G. S and Parker, Josie E and Price, Claire L and Garvey, Edward P and Hoekstra, William J and Schotzinger, Robert J and Wiederhold, Nathan P and Nes, W. David and Kelly, Diane E and Kelly, Steven L
Antimicrobial agents and chemotherapy, ISSN 0066-4804, 07/2017, Volume 61, Issue 7
Trichophyton rubrum | VT-1161 | Azole resistance | Substrate specificity | CYP51 | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Antifungal Agents - pharmacology | Trichophyton - drug effects | Fluconazole - pharmacology | Tetrazoles - pharmacology | Voriconazole - pharmacology | Clotrimazole - pharmacology | Substrate Specificity | Azoles - pharmacology | Itraconazole - pharmacology | Ketoconazole - pharmacology | Microbial Sensitivity Tests | Candida albicans - drug effects | Pyridines - pharmacology | Sterol 14-Demethylase - metabolism | Drug Resistance, Fungal | Fungal Proteins - metabolism | Index Medicus
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7. Full Text Ibrutinib Dosing Strategies Based on Interaction Potential of CYP3A4 Perpetrators Using Physiologically Based Pharmacokinetic Modeling
by de Zwart, L and Snoeys, J and De Jong, J and Sukbuntherng, J and Mannaert, E and Monshouwer, M
Clinical pharmacology and therapeutics, ISSN 0009-9236, 11/2016, Volume 100, Issue 5, pp. 548 - 557
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Carbamazepine - pharmacology | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Pyrimidines - blood | Humans | Cyclopropanes | Male | Ketoconazole - pharmacology | Azithromycin - pharmacology | Drug Dosage Calculations | Cytochrome P-450 CYP3A Inducers - pharmacology | Drug Interactions | Models, Biological | Pyrazoles - blood | Benzoxazines - pharmacology | Pyrimidines - pharmacokinetics | Rifampin - pharmacology | Pyrazoles - pharmacokinetics | Fluvoxamine | Alkynes | Dosage and administration | Research | Pharmacokinetics | Rifampin | Drug interactions | Analysis | Index Medicus | Abridged Index Medicus
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8. Full Text Crystal structure of the new investigational drug candidate VT-1598 in complex with Aspergillus fumigatus sterol 14α-demethylase provides insights into its broad-spectrum Antifungal Activity
by Hargrove, Tatiana Y and Garvey, Edward P and Hoekstra, William J and Yates, Christopher M and Wawrzak, Zdzislaw and Rachakonda, Girish and Villalta, Fernando and Lepesheva, Galina I and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Antimicrobial agents and chemotherapy, ISSN 0066-4804, 07/2017, Volume 61, Issue 7
VT-1598 | Fungal infections | Inhibition | Sterol 14α-demethylase (CYP51) | Aspergillus fumigatus | X-ray structure | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Antifungal Agents - pharmacology | Aspergillus fumigatus - drug effects | Fluconazole - pharmacology | Drugs, Investigational - pharmacology | Tetrazoles - pharmacology | Voriconazole - pharmacology | Sterol 14-Demethylase - genetics | Aspergillus fumigatus - enzymology | Aspergillus fumigatus - genetics | Ketoconazole - pharmacology | Candida albicans - genetics | Microbial Sensitivity Tests | Triazoles - pharmacology | Candida albicans - drug effects | Pyridines - pharmacology | Sterol 14-Demethylase - metabolism | Candida albicans - enzymology | Index Medicus
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9. Full Text Investigation into CYP3A4-mediated drug–drug interactions on midostaurin in healthy volunteers
by Dutreix, Catherine and Munarini, Florence and Lorenzo, Sebastien and Roesel, Johannes and Wang, Yanfeng
Cancer chemotherapy and pharmacology, ISSN 0344-5704, 12/2013, Volume 72, Issue 6, pp. 1223 - 1234
Rifampicin | Medicine & Public Health | Ketoconazole | FMS-related tyrosine kinase 3 (FLT3) inhibitor | Midostaurin | Oncology | Cancer Research | Midazolam | Pharmacology/Toxicology | Pharmacokinetics | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Science & Technology | Biological and medical sciences | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Humans | Middle Aged | Male | Staurosporine - analogs & derivatives | Antineoplastic Agents - administration & dosage | Staurosporine - pharmacokinetics | Ketoconazole - pharmacology | Enzyme Inhibitors - administration & dosage | Young Adult | Tandem Mass Spectrometry | Drug Interactions | Chromatography, Liquid | Enzyme Induction - drug effects | Adult | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Cytochrome P-450 CYP3A - biosynthesis | Drug Administration Schedule | Enzyme Inhibitors - pharmacology | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP3A - metabolism | Rifampin - pharmacology | Midazolam - pharmacology | Staurosporine - pharmacology | Staurosporine - administration & dosage | Drug interactions | Cytochrome P-450 | Index Medicus | Original
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10. Full Text The investigational drug VT-1129 is a highly potent inhibitor of Cryptococcus species CYP51 but only weakly inhibits the human enzyme
by Warrilow, Andrew G. S and Parker, Josie E and Price, Claire L and Nes, W. David and Garvey, Edward P and Hoekstra, William J and Schotzinger, Robert J and Kelly, Diane E and Kelly, Steven L
Antimicrobial agents and chemotherapy, ISSN 0066-4804, 08/2016, Volume 60, Issue 8, pp. 4530 - 4538
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Antifungal Agents - pharmacology | Cryptococcus - metabolism | Antifungal Agents - adverse effects | Fluconazole - pharmacology | Tetrazoles - pharmacology | Ergosterol - metabolism | Voriconazole - adverse effects | Voriconazole - pharmacology | Humans | Clotrimazole - pharmacology | Fluconazole - adverse effects | Lanosterol - analogs & derivatives | Enzyme Activation - drug effects | Itraconazole - pharmacology | Ketoconazole - pharmacology | Pyridines - adverse effects | Clotrimazole - adverse effects | Itraconazole - adverse effects | Lanosterol - metabolism | Pyridines - pharmacology | Sterol 14-Demethylase - metabolism | Ketoconazole - adverse effects | Tetrazoles - adverse effects | Cryptococcus - drug effects | Index Medicus
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11. Full Text In vitro activities of a wide panel of antifungal drugs against various Scopulariopsis and Microascus species
by Skóra, Magdalena and Bulanda, Małgorzata and Jagielski, Tomasz
Antimicrobial agents and chemotherapy, ISSN 0066-4804, 09/2015, Volume 59, Issue 9, pp. 5827 - 5829
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Antifungal Agents - pharmacology | Fluconazole - pharmacology | Voriconazole - pharmacology | Amphotericin B - pharmacology | Ascomycota - drug effects | Itraconazole - pharmacology | Ketoconazole - pharmacology | Microbial Sensitivity Tests | Triazoles - pharmacology | Scopulariopsis - drug effects | Flucytosine - pharmacology | Drug Resistance, Fungal | Lipopeptides | Echinocandins - pharmacology | Index M