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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2011, Volume 108, Issue 26, pp. 10496 - 10501
Journal Article
Journal Article
Nature, ISSN 0028-0836, 05/2016, Volume 533, Issue 7603, pp. 338 - 345
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2009, Volume 52, Issue 23, pp. 7446 - 7457
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 40, pp. 17152 - 17157
Differences between the structures of bacterial, archaeal, and eukaryotic ribosomes account for the selective action of antibiotics. Even minor variations in... 
Ketolides | Antibiotics | Macrolides | Drug interactions | Ribosomes | Bacteria | Nucleotides | Electron density | Genetic mutation | Binding sites | Ribosome structure | Chloramphenicol | Telithromycin | Erythromycin | Clindamycin | PROTEIN | BACTERIAL RIBOSOME | RNA GENE | MULTIDISCIPLINARY SCIENCES | telithromycin | RESISTANCE MUTATIONS | CONFERRING RESISTANCE | erythromycin | DOMAIN-II | BINDING-SITE | chloramphenicol | MACROLIDE ANTIBIOTICS | ribosome structure | clindamycin | PLEUROMUTILINS | Haloarcula marismortui - genetics | Haloarcula marismortui - metabolism | Chloramphenicol - chemistry | Erythromycin - metabolism | Molecular Sequence Data | Ribosomes - metabolism | Deinococcus - metabolism | Deinococcus - genetics | Haloarcula marismortui - chemistry | X-Ray Diffraction | Anti-Bacterial Agents - chemistry | Base Sequence | Escherichia coli - metabolism | Ketolides - metabolism | Deinococcus - chemistry | Molecular Structure | Clindamycin - chemistry | Peptidyl Transferases - metabolism | Clindamycin - metabolism | Peptidyl Transferases - chemistry | Ribosomes - chemistry | Anti-Bacterial Agents - metabolism | Escherichia coli - chemistry | RNA, Ribosomal, 23S - chemistry | Erythromycin - chemistry | Escherichia coli - genetics | Ketolides - chemistry | RNA, Ribosomal, 23S - metabolism | Chloramphenicol - metabolism | Escherichia coli | Crystals | Genetic aspects | Research | Properties | Structure | Observations | Peptidyl transferases | Drugs | lincosamides | Pathogens | rRNA | rRNA 23S | Data processing | Ribosomal subunits | Ionizing radiation | Peptidyltransferase | Crystal structure | Tunnels | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 40, pp. 17158 - 17163
The increasing prevalence of antibiotic-resistant pathogens reinforces the need for structures of antibiotic-ribosome complexes that are accurate enough to... 
Molecules | Antibiotics | Macrolides | Drug interactions | Ribosomes | Drug design | Biochemistry | Potassium | Functional groups | Lactones | Structure-based drug design | Crystal structure | structure-based drug design | DESIGN | RNA | MULTIDISCIPLINARY SCIENCES | KETOLIDES | MITOCHONDRIAL-DNA | NUCLEOTIDE | CHLORAMPHENICOL ACETYLTRANSFERASE | PEPTIDYL TRANSFERASE CENTER | crystal structure | RESISTANCE | BINDING-SITE | MACROLIDE ANTIBIOTICS | Haloarcula marismortui - genetics | Haloarcula marismortui - metabolism | Chloramphenicol - chemistry | Azithromycin - metabolism | Bacterial Proteins - chemistry | Erythromycin - metabolism | Ribosomes - metabolism | Thermus thermophilus - metabolism | Deinococcus - metabolism | Deinococcus - genetics | Haloarcula marismortui - chemistry | Thermus thermophilus - genetics | Anti-Bacterial Agents - chemistry | Ketolides - metabolism | Deinococcus - chemistry | Molecular Structure | Binding Sites | Thermus thermophilus - chemistry | Azithromycin - chemistry | Ribosomes - chemistry | Anti-Bacterial Agents - metabolism | Erythromycin - chemistry | Ketolides - chemistry | Bacterial Proteins - metabolism | Chloramphenicol - metabolism | Crystals | Chemical properties | Research | Properties | Bacterial genetics | Structure | Observations | Antibacterial agents | Pathogens | lactones | Azithromycin | Macrolide antibiotics | Chloramphenicol | Telithromycin | Models | Erythromycin | Conformation | ANTIBIOTICS | CHLORAMPHENICOL | ESCHERICHIA COLI | LACTONES | SPECIFICITY | ERYTHROMYCIN | ELECTRON DENSITY | RIBOSOMES | 60 APPLIED LIFE SCIENCES | PATHOGENS | Biological Sciences
Journal Article
Infectious Disease Clinics of North America, ISSN 0891-5520, 12/2009, Volume 23, Issue 4, pp. 997 - 1026
The advanced macrolides, azithromycin and clarithromycin, and the ketolide, telithromycin, are structural analogs of erythromycin. They have several distinct... 
Ketolides | Review | Glycylcyclines | Antimicrobials | Macrolides | INFECTIOUS DISEASES | COMMUNITY-ACQUIRED PNEUMONIA | ACUTE BACTERIAL EXACERBATIONS | IMMUNOLOGY | MYCOBACTERIUM-AVIUM COMPLEX | SINGLE-DOSE AZITHROMYCIN | HELICOBACTER-PYLORI INFECTION | IN-VITRO ACTIVITIES | SKIN-STRUCTURE INFECTIONS | ACUTE OTITIS-MEDIA | COMPLICATED INTRAABDOMINAL INFECTIONS | RESPIRATORY-TRACT INFECTIONS | Ketolides - pharmacology | Minocycline - pharmacology | Humans | Minocycline - analogs & derivatives | Tetracyclines - pharmacology | Anti-Bacterial Agents - therapeutic use | Azithromycin - pharmacokinetics | Minocycline - adverse effects | Macrolides - pharmacokinetics | Minocycline - therapeutic use | Ketolides - adverse effects | Ketolides - therapeutic use | Clarithromycin - pharmacokinetics | Macrolides - pharmacology | Anti-Bacterial Agents - adverse effects | Ketolides - pharmacokinetics | Bacterial Infections - drug therapy | Clarithromycin - adverse effects | Tetracyclines - pharmacokinetics | Clarithromycin - therapeutic use | Azithromycin - pharmacology | Azithromycin - adverse effects | Macrolides - adverse effects | Azithromycin - therapeutic use | Minocycline - pharmacokinetics | Anti-Bacterial Agents - pharmacokinetics | Anti-Bacterial Agents - pharmacology | Tetracyclines - adverse effects | Macrolides - therapeutic use | Clarithromycin - pharmacology | Tetracyclines - therapeutic use
Journal Article
Expert Opinion on Investigational Drugs, ISSN 1354-3784, 10/2014, Volume 23, Issue 10, pp. 1313 - 1319
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2019, Volume 182, p. 111662
Classical macrolides containing 14- or 15-membered aglycone lactone rings are basic and widely used antibacterial agents in clinical therapy. Macrolides exert... 
Azalides | Macrolactones | Ketolides | Antibiotics | Regioselective transformations | Biological activity
Journal Article
Journal Article
Science, ISSN 0036-8075, 1/2006, Volume 311, Issue 5759, pp. 374 - 377
Microbial resistance to antibiotics currently spans all known classes of natural and synthetic compounds. It has not only hindered our treatment of infections... 
Antibiotics | Antibiotic resistance | Streptomyces | Bacteria | Reports | Libraries | Biosynthesis | Soil bacteria | Soil mechanics | Genetic mutation | Genetic screening | UNITED-STATES | RESISTANCE GENES | STREPTOCOCCUS-PNEUMONIAE | VANCOMYCIN | IN-VITRO ACTIVITIES | DETERMINANTS | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | GRAM-POSITIVE PAT