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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 40, pp. 17152 - 17157
Differences between the structures of bacterial, archaeal, and eukaryotic ribosomes account for the selective action of antibiotics. Even minor variations in... 
Ketolides | Antibiotics | Macrolides | Drug interactions | Ribosomes | Bacteria | Nucleotides | Electron density | Genetic mutation | Binding sites | Ribosome structure | Chloramphenicol | Telithromycin | Erythromycin | Clindamycin | BACTERIAL RIBOSOME | RNA GENE | MULTIDISCIPLINARY SCIENCES | telithromycin | RESISTANCE MUTATIONS | CONFERRING RESISTANCE | 23S | erythromycin | DOMAIN-II | BINDING-SITE | chloramphenicol | ARCHAEON HALOBACTERIUM-HALOBIUM | MACROLIDE ANTIBIOTICS | ribosome structure | clindamycin | SUBUNIT | Haloarcula marismortui - genetics | Haloarcula marismortui - metabolism | Chloramphenicol - chemistry | Erythromycin - metabolism | Molecular Sequence Data | Ribosomes - metabolism | Deinococcus - metabolism | Deinococcus - genetics | Haloarcula marismortui - chemistry | X-Ray Diffraction | Anti-Bacterial Agents - chemistry | Base Sequence | Escherichia coli - metabolism | Ketolides - metabolism | Deinococcus - chemistry | Molecular Structure | Clindamycin - chemistry | Peptidyl Transferases - metabolism | Clindamycin - metabolism | Peptidyl Transferases - chemistry | Ribosomes - chemistry | Anti-Bacterial Agents - metabolism | Escherichia coli - chemistry | RNA, Ribosomal, 23S - chemistry | Erythromycin - chemistry | Escherichia coli - genetics | Ketolides - chemistry | RNA, Ribosomal, 23S - metabolism | Chloramphenicol - metabolism | Escherichia coli | Crystals | Genetic aspects | Research | Properties | Structure | Observations | Peptidyl transferases | Eukaryotes | E coli | Peptides | Ribonucleic acid--RNA | Bacteriology | Index Medicus | Drugs | lincosamides | Pathogens | rRNA | rRNA 23S | Data processing | Ribosomal subunits | Ionizing radiation | Peptidyltransferase | Crystal structure | Tunnels | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 40, pp. 17158 - 17163
The increasing prevalence of antibiotic-resistant pathogens reinforces the need for structures of antibiotic-ribosome complexes that are accurate enough to... 
Molecules | Antibiotics | Macrolides | Drug interactions | Ribosomes | Drug design | Biochemistry | Potassium | Functional groups | Lactones | Structure-based drug design | Crystal structure | structure-based drug design | DESIGN | RNA | MULTIDISCIPLINARY SCIENCES | MITOCHONDRIAL-DNA | 70S RIBOSOME | CHLORAMPHENICOL ACETYLTRANSFERASE | PEPTIDYL TRANSFERASE CENTER | crystal structure | RESISTANCE | BINDING-SITE | MACROLIDE ANTIBIOTICS | COLI RIBOSOMES | Haloarcula marismortui - genetics | Haloarcula marismortui - metabolism | Chloramphenicol - chemistry | Azithromycin - metabolism | Bacterial Proteins - chemistry | Erythromycin - metabolism | Ribosomes - metabolism | Thermus thermophilus - metabolism | Deinococcus - metabolism | Deinococcus - genetics | Haloarcula marismortui - chemistry | Thermus thermophilus - genetics | Anti-Bacterial Agents - chemistry | Ketolides - metabolism | Deinococcus - chemistry | Molecular Structure | Binding Sites | Thermus thermophilus - chemistry | Azithromycin - chemistry | Ribosomes - chemistry | Anti-Bacterial Agents - metabolism | Erythromycin - chemistry | Ketolides - chemistry | Bacterial Proteins - metabolism | Chloramphenicol - metabolism | Crystals | Chemical properties | Research | Properties | Bacterial genetics | Structure | Observations | Antibacterial agents | Bacteria | Pharmacology | Ribonucleic acid--RNA | Drug resistance | Bacteriology | Index Medicus | Pathogens | lactones | Azithromycin | Macrolide antibiotics | Chloramphenicol | Telithromycin | Models | Erythromycin | Conformation | ANTIBIOTICS | CHLORAMPHENICOL | ESCHERICHIA COLI | LACTONES | SPECIFICITY | ERYTHROMYCIN | ELECTRON DENSITY | RIBOSOMES | 60 APPLIED LIFE SCIENCES | PATHOGENS | Biological Sciences
Journal Article
Journal Article
Nature, ISSN 0028-0836, 05/2016, Volume 533, Issue 7603, pp. 338 - 345
Journal Article
Journal Article
Monatshefte für Chemie - Chemical Monthly, ISSN 0026-9247, 11/2015, Volume 146, Issue 11, pp. 1913 - 1919
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 05/2019, Volume 169, pp. 1 - 20
Journal Article
Journal Article
Chemical Biology & Drug Design, ISSN 1747-0277, 11/2017, Volume 90, Issue 5, pp. 641 - 652
Journal Article