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Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 7519 - 12
In silico network-based methods have shown promising results in the field of drug development. Yet, most of networks used in the previous research have not... 
SYSTEM | DATABASE | RENIN | GENE | PATHWAY | MULTIDISCIPLINARY SCIENCES | TISSUE | KEGG | NEBIVOLOL | HYPERTENSION | BLOOD-PRESSURE | Hematologic Diseases - pathology | Liver - pathology | Metabolic Diseases - pathology | Respiratory Tract Diseases - metabolism | Kidney - pathology | Skin - metabolism | Hematologic Diseases - metabolism | Humans | Muscle, Skeletal - metabolism | Respiratory Tract Diseases - drug therapy | Respiratory Tract Diseases - genetics | Brain - metabolism | Musculoskeletal Diseases - pathology | Kidney - metabolism | Liver - drug effects | Muscle, Skeletal - drug effects | Myocardium - metabolism | Nervous System Diseases - metabolism | Nutrition Disorders - pathology | Computational Biology - methods | Kidney - drug effects | Liver - metabolism | Nervous System Diseases - drug therapy | Connective Tissue Diseases - metabolism | Neoplasms - drug therapy | Brain - drug effects | Connective Tissue Diseases - drug therapy | Connective Tissue Diseases - pathology | Lung - drug effects | Brain - pathology | Hematologic Diseases - genetics | Prescription Drugs - pharmacokinetics | Digestive System Diseases - pathology | Neoplasms - metabolism | Cardiovascular Diseases - drug therapy | Drugs, Investigational - pharmacokinetics | Respiratory Tract Diseases - pathology | Hematologic Diseases - drug therapy | Metabolic Diseases - drug therapy | Cardiovascular Diseases - pathology | Nervous System Diseases - genetics | Cardiovascular Diseases - genetics | Musculoskeletal Diseases - genetics | Neoplasms - genetics | Lung - metabolism | Skin - pathology | Nervous System Diseases - pathology | Lung - pathology | Musculoskeletal Diseases - drug therapy | Cardiovascular Diseases - metabolism | Musculoskeletal Diseases - metabolism | Nutrition Disorders - drug therapy | Nutrition Disorders - genetics | Myocardium - pathology | Organ Specificity | Digestive System Diseases - genetics | Algorithms | Digestive System Diseases - drug therapy | Nutrition Disorders - metabolism | Metabolic Diseases - metabolism | Digestive System Diseases - metabolism | Metabolic Diseases - genetics | Connective Tissue Diseases - genetics | Muscle, Skeletal - pathology | Neoplasms - pathology | Skin - drug effects | Drug development | Index Medicus
Journal Article
Clinical Journal of the American Society of Nephrology, ISSN 1555-9041, 10/2017, Volume 12, Issue 10, pp. 1595 - 1600
Background and objectives: RRT and doubling of serum creatinine are considered the objective hard end points in nephrology intervention trials. Because both... 
Creatinine | Nephrology | Diabetes mellitus, type 2 | Humans | Diabetic nephropathies | Tetrazoles | Linear models | Kidney | Glomerular filtration rate | Irbesartan | Losartan | Renal dialysis | Renal replacement therapy | Angiotensin II | Biphenyl compounds | SERUM CREATININE | CHOICE | DECISION | GFR | UROLOGY & NEPHROLOGY | START | IRBESARTAN | NEPHROPATHY | PROGRESSION | DECLINE | Up-Regulation | Angiotensin II Type 1 Receptor Blockers - adverse effects | Renal Insufficiency, Chronic - etiology | Diabetic Nephropathies - etiology | Health Status Indicators | Angiotensin II Type 1 Receptor Blockers - therapeutic use | Biphenyl Compounds - adverse effects | Diabetic Nephropathies - drug therapy | Biphenyl Compounds - therapeutic use | Glomerular Filtration Rate - drug effects | Diabetic Nephropathies - physiopathology | Time Factors | Clinical Decision-Making | Endpoint Determination | Diabetes Mellitus, Type 2 - complications | Kidney - physiopathology | Kidney - drug effects | Risk Factors | Proportional Hazards Models | Linear Models | Treatment Outcome | Biomarkers - blood | Renal Insufficiency, Chronic - physiopathology | Disease Progression | Renal Insufficiency, Chronic - prevention & control | Diabetes Mellitus, Type 2 - physiopathology | Losartan - therapeutic use | Creatinine - blood | Losartan - adverse effects | Tetrazoles - therapeutic use | Clinical Trials as Topic - methods | Tetrazoles - adverse effects | Diabetes Mellitus, Type 2 - drug therapy | Health Status | Research Design | Renal Dialysis | Index Medicus | irbesartan | Diabetic Nephropathies | glomerular filtration rate | Renal Replacement Therapy | Biphenyl Compounds | nephrology | kidney | creatinine | Diabetes Mellitus, Type 2 | Original | renal dialysis
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, pp. e53745 - e53745
Background: Ipilimumab, a cytotoxic T-lymphocyte antigen-4 (CTLA-4) blocking antibody, has been approved for the treatment of metastatic melanoma and induces... 
REGRESSION | TRIAL | INDUCED SARCOIDOSIS | CTLA-4 BLOCKADE | AUTOIMMUNITY | SAFETY | MULTIDISCIPLINARY SCIENCES | MONOCLONAL-ANTIBODY | PATIENT | HYPOPHYSITIS | CANCER | Skin Neoplasms - drug therapy | Humans | Ipilimumab | Middle Aged | Antibodies, Monoclonal - adverse effects | Antibodies, Monoclonal - therapeutic use | Male | Antineoplastic Agents - therapeutic use | Neoplasm Metastasis | Liver - drug effects | Antineoplastic Agents - adverse effects | Aged, 80 and over | Endocrine System - drug effects | Adult | Female | Retrospective Studies | Antibodies, Monoclonal - immunology | Kidney - drug effects | Antineoplastic Agents - immunology | Pancreas - drug effects | Gastrointestinal Tract - drug effects | Melanoma - pathology | CTLA-4 Antigen - immunology | Nervous System - drug effects | Melanoma - drug therapy | Respiratory System - drug effects | Aged | Skin - drug effects | Antimitotic agents | Antigens | Care and treatment | Algorithms | Lymphocytes | Melanoma | Skin | Metastasis | Antineoplastic agents | Skin cancer | Cancer | Aseptic meningitis | Guillain-Barre syndrome | Exanthema | Central nervous system | Blocking antibodies | Cytotoxicity | Oncology | Lymphocytes T | Metastases | CTLA-4 protein | Intestine | Gastroenterology | Meningitis | Internal medicine | Hematology | Sarcoidosis | Dermatology | Management | Regression analysis | Patients | Eosinophilia | Morbidity | Inflammatory bowel disease | Pathology | Side effects | Hospitals | Perforations | Medical prognosis | Antitumor activity | Autoimmune diseases | Endocrinology | Index Medicus
Journal Article
Journal Article
Journal Article
Lancet, The, ISSN 0140-6736, 2011, Volume 377, Issue 9784, pp. 2181 - 2192
Summary Background Lowering LDL cholesterol with statin regimens reduces the risk of myocardial infarction, ischaemic stroke, and the need for coronary... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | UNITED-KINGDOM HEART | DESIGN | METAANALYSIS | REQUIRING PROLONGED OBSERVATION | EFFICACY | CARDIOVASCULAR EVENTS | SAFETY | HEMODIALYSIS | OUTCOMES | PARTICIPANTS | Confidence Intervals | Simvastatin - adverse effects | Follow-Up Studies | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Ezetimibe | Renal Dialysis - methods | Male | Reference Values | Cholesterol, LDL - analysis | Kidney Function Tests | Renal Insufficiency, Chronic - drug therapy | Dose-Response Relationship, Drug | Renal Insufficiency, Chronic - therapy | Renal Dialysis - mortality | Time Factors | Renal Insufficiency, Chronic - mortality | Adult | Female | Renal Insufficiency, Chronic - diagnosis | Drug Therapy, Combination | Severity of Illness Index | Hypolipidemic Agents - adverse effects | Double-Blind Method | Drug Administration Schedule | Risk Assessment | Simvastatin - administration & dosage | Cholesterol, LDL - drug effects | Treatment Outcome | Azetidines - administration & dosage | Hypolipidemic Agents - administration & dosage | Survival Analysis | Aged | Simvastatin | Low density lipoproteins | Physiological aspects | Drug therapy, Combination | Research | Kidney diseases | Diagnosis | Drug therapy | Health aspects | Studies | Heart failure | Cardiac arrhythmia | Medical imaging | Hospitals | Compliance | Cardiovascular disease | Blood pressure | Family medical history | Cholesterol | Cancer | Index Medicus | Abridged Index Medicus | Mortality | myocardial infarction | cholesterol | councils | Dialysis | medical research | stroke | Kidney | Fast track | Pharmaceutical Sciences | Basic Medicine | PHARMACY | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | FARMACI | Farmaceutiska vetenskaper
Journal Article