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The journal of histochemistry and cytochemistry, ISSN 1551-5044, 2016, Volume 46, Issue 1, pp. 19 - 27
Agrin is a heparan sulfate proteoglycan (HSPG) that is highly concentrated in the synaptic basal lamina at the neuromuscular junction (NMJ). Agrin-like... 
Heparitin Sulfate/metabolism | Neuromuscular Junction/metabolism | Proteoglycans/metabolism | Enzyme-Linked Immunosorbent Assay | Heparan Sulfate Proteoglycans/metabolism | Agrin/biosynthesis | Humans | Rats | Muscle, Skeletal/metabolism | Kidney Cortex/cytology | Antibodies, Monoclonal | Bungarotoxins/metabolism | Immune Sera/metabolism | Microscopy, Immunoelectron | Kidney Glomerulus/cytology | Animals | Adult | Basement Membrane/metabolism | Fluorescent Antibody Technique, Indirect | Microscopy, Fluorescence | Glomerular basement membrane | Agrin | Perlecan | Heparan sulfate proteoglycan | ALPHA-DYSTROGLYCAN | HUMAN TISSUES | DOMAIN-III | RAT | RECEPTOR | PROTEINURIA | MONOCLONAL-ANTIBODY | WIDESPREAD EXPRESSION | CELL BIOLOGY | agrin | perlecan | EXTRACELLULAR-MATRIX | glomerular basement membrane | heparan sulfate proteoglycan | BINDING | Basement Membrane - ultrastructure | Kidney Cortex - metabolism | Neuromuscular Junction - metabolism | Muscle, Skeletal - metabolism | Heparitin Sulfate - metabolism | Kidney Glomerulus - ultrastructure | Agrin - biosynthesis | Immune Sera - metabolism | Kidney Glomerulus - metabolism | Bungarotoxins - metabolism | Kidney Glomerulus - cytology | Kidney Cortex - cytology | Proteoglycans - metabolism | Basement Membrane - metabolism | Neuromuscular Junction - ultrastructure | Heparan Sulfate Proteoglycans - metabolism | Agrin - immunology
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2011, Volume 481, Issue 7381, pp. 380 - 384
.... In the conventional view of mammalian cell metabolism, AcCoA is primarily generated from glucose-derived pyruvate through the citrate shuttle and ATP citrate lyase in the cytosol(1-3... 
FLUX ANALYSIS | DISTRIBUTIONS | FATTY-ACID SYNTHESIS | MULTIDISCIPLINARY SCIENCES | GROWTH | HYDROXYLATION | CELL-PROLIFERATION | SUPPRESSION | HIF-ALPHA | CANCER | DEHYDROGENASE | CD8-Positive T-Lymphocytes - cytology | Palmitic Acid - metabolism | Isocitrate Dehydrogenase - deficiency | Humans | Glutamine - metabolism | Kidney Neoplasms - metabolism | Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism | Oxygen - metabolism | Cell Hypoxia | Basic Helix-Loop-Helix Transcription Factors - metabolism | Acetyl Coenzyme A - biosynthesis | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Ketoglutaric Acids - metabolism | Lipogenesis | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Carbon - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Oxidation-Reduction | Carcinoma, Renal Cell - pathology | Cells, Cultured | Isocitrate Dehydrogenase - genetics | Acetyl Coenzyme A - metabolism | Citric Acid Cycle | Carcinoma, Renal Cell - metabolism | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Kidney Neoplasms - pathology | Physiological aspects | Hypoxia | Research | Lipid metabolism | Electron transport | Proteins | Confidence intervals | Metabolites | Lipids | Biosynthesis | Glucose | Experiments
Journal Article
Seminars in immunopathology, ISSN 1863-2300, 2011, Volume 34, Issue 1, pp. 43 - 62
The interaction of coagulation factors with the perivascular environment affects the development of disease in ways that extend beyond their traditional roles... 
Autoimmunity | Complement receptor 3 | Multiple sclerosis | Stroke | Alzheimer’s disease | Internal Medicine | Macrophages | Blood brain barrier | Inflammatory disease | Microglia | Biomedicine | Immunology | Rheumatoid arthritis | CD11b/CD18 | Atherosclerosis | Plasminogen | Anticoagulant therapy | Alzheimer's disease | ALZHEIMERS-DISEASE | IMMUNOLOGY | PATHOLOGY | GAMMA-C-DOMAIN | BINDING-SITE | CENTRAL-NERVOUS-SYSTEM | MULTIPLE-SCLEROSIS LESIONS | CRYSTAL-STRUCTURE | BLOOD-BRAIN-BARRIER | INTEGRIN ALPHA(M)BETA | PROTEASE-ACTIVATED RECEPTORS | PERIPHERAL ARTERIAL-DISEASE | Colitis - genetics | Humans | Brain Injuries - metabolism | Arthritis, Rheumatoid - metabolism | Bacterial Infections - genetics | Inflammation - metabolism | Blood Coagulation - immunology | Muscular Dystrophy, Duchenne - immunology | Alzheimer Disease - immunology | Fibrinogen - immunology | Thromboplastin - immunology | Pulmonary Fibrosis - immunology | Vascular Diseases - genetics | Brain Injuries - genetics | Thrombin - genetics | Kidney Diseases - immunology | Arthritis, Rheumatoid - genetics | Neoplasms - immunology | Colitis - metabolism | Muscular Dystrophy, Duchenne - genetics | Bacterial Infections - metabolism | Neoplasms - metabolism | Pulmonary Fibrosis - genetics | Spinal Cord Injuries - genetics | Kidney Diseases - genetics | Stroke - genetics | Brain Injuries - immunology | Neoplasms - genetics | Bacterial Infections - immunology | Pulmonary Fibrosis - metabolism | Colitis - immunology | Thrombin - immunology | Stroke - immunology | Kidney Diseases - metabolism | Multiple Sclerosis - metabolism | Vascular Diseases - immunology | Spinal Cord Injuries - metabolism | Multiple Sclerosis - genetics | Inflammation - immunology | Fibrinogen - genetics | Stroke - metabolism | Animals | Thromboplastin - genetics | Alzheimer Disease - metabolism | Fibrinogen - metabolism | Inflammation - genetics | Multiple Sclerosis - immunology | Blood Coagulation - genetics | Spinal Cord Injuries - immunology | Muscular Dystrophy, Duchenne - metabolism | Thrombin - metabolism | Thromboplastin - metabolism | Alzheimer Disease - genetics | Arthritis, Rheumatoid - immunology | Vascular Diseases - metabolism | Nervous system diseases | Bacterial infections | Oncology, Experimental | Thrombin | Inflammation | Anticoagulants (Medicine) | Research | Rheumatoid factor | Fibrin | Fibrinogen | Genetic research | Colitis | Cancer | Traumatic brain injury | Coagulation | Tissue factor | hemostasis | Spinal cord injury | Inflammatory diseases | Kidney | Signal transduction | Duchenne's muscular dystrophy | Neurodegenerative diseases | Therapeutic applications | Thrombosis | Coagulation factors | Infection | Molecular modelling | Fibrosis | Brain injury
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 4, p. e19194
The cofactor nicotinamide adenine dinucleotide (NAD+) has emerged as a key regulator of metabolism, stress resistance and longevity... 
Biomarkers - metabolism | Sirtuin 1 - metabolism | Protein Carbonylation | Electron Transport | Oxidative Stress | Rats, Wistar | Antioxidants - metabolism | Tumor Suppressor Protein p53 - metabolism | Rats | Mitochondria - metabolism | Aldehydes - metabolism | Organ Specificity | Brain - metabolism | Poly Adenosine Diphosphate Ribose - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | Intracellular Space - metabolism | Female | Acetylation | DNA Damage | Enzyme Activation | Lipid Peroxidation | NAD - metabolism | Aging - metabolism | Antioxidants | Tyrosine | Niacinamide | Purines | Enzymes | Ionizing radiation | DNA damage | Tumor proteins | Sugars | Monosaccharides | Apoptosis | Dehydrogenases | Syngeneic grafts | Oxidative metabolism | Liver | p53 Protein | Neurobiology | Poly(ADP-ribose) | Lipid peroxidation | Proteins | Electron transport chain | Signal transduction | Mitochondria | Animal tissues | Aging | Physiology | Chronic obstructive pulmonary disease | Deoxyribonucleic acid--DNA | Peroxidation | Liver diseases | Adenosine diphosphate | Longevity | Metabolism | Gene expression | Overexpression | Nicotinamide adenine dinucleotide | Nicotinamide | Oxidative stress | Carbonyl compounds | Neurosciences | Senescence | Biosynthesis | DNA repair | NADH | Ribose | Rodents | Cell cycle | Age | Carbonyls | Kidneys | Organs | Poly(ADP-ribose) polymerase | Adenine | Histology | Pharmacology | Polymerase | NAD | Lungs | Intracellular | Deoxyribonucleic acid | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2017, Volume 12, Issue 6, p. e0179610
Objective To assess the prognostic roles of BAP1, PBRM1, pS6, PTEN, TGase2, PD-L1, CA9, PSMA, and Ki-67 tissue biomarkers in localized renal cell carcinoma... 
SURVIVAL | MORTALITY | CARBONIC-ANHYDRASE-IX | PROTEIN | MULTIDISCIPLINARY SCIENCES | CANCER INCIDENCE | METASTASES | OUTCOMES | KI67 | EXPRESSION | TUMORS | Immunohistochemistry | Prognosis | Tissue Array Analysis | Humans | Middle Aged | Ki-67 Antigen - metabolism | Male | Kidney Neoplasms - metabolism | Porphyrins - metabolism | Neoplasm Recurrence, Local - mortality | Neoplasm Recurrence, Local - pathology | Glutamate Carboxypeptidase II - metabolism | Neoplasm Grading | Antigens, Neoplasm - metabolism | Antigens, Surface - metabolism | Biomarkers, Tumor - metabolism | Ubiquitin Thiolesterase - metabolism | Adult | Female | Carbonic Anhydrase IX - metabolism | Retrospective Studies | Tumor Suppressor Proteins - metabolism | Neoplasm Recurrence, Local - metabolism | Carcinoma, Renal Cell - pathology | PTEN Phosphohydrolase - metabolism | Nuclear Proteins - metabolism | Survival Rate | Kidney Neoplasms - mortality | Transcription Factors - metabolism | Carcinoma, Renal Cell - metabolism | Carcinoma, Renal Cell - mortality | Disease-Free Survival | B7-H1 Antigen - metabolism | Transglutaminases - metabolism | Sulfonamides - metabolism | Kidney Neoplasms - pathology | Aged | Neoplasm Staging | GTP-Binding Proteins - metabolism | Genetic aspects | Carcinoma, Renal cell | Research | Biological markers | Biometrics | Metastasis | Kinases | Epidemiology | Cancer therapies | Urology | Proteins | Nephrectomy | Quality | Growth factors | Age | Antigens | Markers | Hazards | Patients | Survival | Disease prevention | Hospitals | Medical prognosis | PD-L1 protein | Biomarkers | Death | Mutation | Diabetes | Prostate cancer | PTEN protein | Clear cell-type renal cell carcinoma | Kidney transplantation | Tumors
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 05/2007, Volume 34, Issue 5, pp. 425 - 431
SUMMARY • It is known that stress causes disruption of homeostasis and an imbalanced anti-oxidant status in several organs. The aim of the present study was to... 
immobilization-cold stress | rat | glutathione | protein oxidation | cold stress | anti-oxidant enzymes | lipid peroxidation | immobilization stress | anti‐oxidant enzymes | immobilization–cold stress | Cold stress | Protein oxidation | Rat | Anti-oxidant enzymes | Immobilization-cold stress | Lipid peroxidation | Immobilization stress | Glutathione | CATALASE | ENZYME-ACTIVITIES | DEFENSE | PHYSIOLOGY | GLUCOCORTICOIDS | GLUTATHIONE-PEROXIDASE | BODY-WEIGHT | METABOLISM | AGE-RELATED-CHANGES | PHARMACOLOGY & PHARMACY | BRAIN | EXPOSURE | Protein Carbonylation | Rats, Wistar | Glutathione - metabolism | Zinc - metabolism | Antioxidants - metabolism | Male | Stress, Psychological - psychology | Immobilization - psychology | Kidney - metabolism | Myocardium - metabolism | Copper - metabolism | Corticosterone - blood | Weight Gain | Superoxide Dismutase - metabolism | Glutathione Peroxidase - metabolism | Cold Temperature | Liver - metabolism | Rats | Thiobarbituric Acid Reactive Substances - metabolism | Kidney - cytology | Liver - chemistry | Lipid Peroxidation - physiology | Myocardium - cytology | Catalase - metabolism | Animals | Selenium - metabolism | Models, Biological | Weight Loss | Kidney - chemistry | Liver - cytology | Liver, cytology | Thiobarbituric Acid Reactive Substances, metabolism | Superoxide Dismutase, metabolism | Zinc, metabolism | Antioxidants, metabolism | Kidney, metabolism | Glutathione, metabolism | Myocardium, metabolism | Immobilization, psychology | Corticosterone, blood | Catalase, metabolism | Selenium, metabolism | Liver, chemistry | Cold | Copper, metabolism | Lipid Peroxidation, physiology | Myocardium, cytology | Kidney, chemistry | Liver, metabolism | Glutathione Peroxidase, metabolism | Stress, Psychological, psychology | Kidney, cytology | Antioxidants | Comparative analysis | Oxidation-reduction reaction
Journal Article
Amino acids, ISSN 1438-2199, 2016, Volume 49, Issue 1, pp. 129 - 138
.... Oxidative stress is involved in the pathophysiology of many inborn errors of metabolism. However, little is known about the role of oxidative damage in hepatic and renal changes in hypermethioninemia... 
Life Sciences | Biochemistry, general | Oxidative stress | Analytical Chemistry | Life Sciences, general | Methionine sulfoxide | Biochemical Engineering | Proteomics | Neurobiology | Methionine | Delta aminolevulinic dehydratase | LIPID-PEROXIDATION | ANTIOXIDANTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DELTA-AMINOLEVULINATE DEHYDRATASE | DAMAGE | HYPERMETHIONINEMIA | METABOLISM | FAT | ADENOSYLTRANSFERASE I/III DEFICIENCY | PROTEINS | RESIDUES | Glycine N-Methyltransferase - metabolism | Liver - pathology | Reactive Oxygen Species - metabolism | Kidney - pathology | Rats, Wistar | Glycine N-Methyltransferase - deficiency | Male | Methionine - pharmacology | Porphobilinogen Synthase - metabolism | Amino Acid Metabolism, Inborn Errors - metabolism | Kidney - metabolism | Sulfhydryl Compounds - metabolism | Liver - drug effects | Methionine - analogs & derivatives | Injections, Subcutaneous | Female | Urea - metabolism | Amino Acid Metabolism, Inborn Errors - pathology | Superoxide Dismutase - metabolism | Glutathione Peroxidase - metabolism | Amino Acid Metabolism, Inborn Errors - chemically induced | Kidney - drug effects | Methionine - metabolism | Liver - metabolism | Rats | Thiobarbituric Acid Reactive Substances - metabolism | Cholesterol - metabolism | Enzyme Activation - drug effects | Triglycerides - metabolism | Catalase - metabolism | Animals | Glucose - metabolism | Oxidative Stress - drug effects | Lipid Peroxidation | Enzymes | Urea | Liver | Physiological aspects | Amino acids | Triglycerides | Superoxide | Index Medicus
Journal Article