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Nature Genetics, ISSN 1061-4036, 09/2009, Volume 41, Issue 9, pp. 1027 - 1031
The primary cilium is an antenna-like structure that protrudes from the cell surface of quiescent/differentiated cells and participates in extracellular signal... 
NETWORK | INOSITOL-POLYPHOSPHATE 5-PHOSPHATASE | POLYCYSTIC KIDNEY-DISEASE | BIOLOGY | GENETICS & HEREDITY | DISORDERS | PROTEINS | FIBROBLASTS | Humans | Fluorescent Dyes - metabolism | Culture Media, Serum-Free | Male | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Fibroblasts - ultrastructure | Obesity - genetics | Embryo, Mammalian - metabolism | Intellectual Disability - genetics | Indoles - metabolism | Tubulin - metabolism | Cell Nucleus - metabolism | Transfection | Mice, Mutant Strains | Cilia - ultrastructure | Bardet-Biedl Syndrome - genetics | Chromones - pharmacology | Microsatellite Repeats | Fibroblasts - metabolism | Genetic Linkage | Cell Line | Green Fluorescent Proteins - metabolism | Phosphoric Monoester Hydrolases - genetics | Cilia - pathology | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Fluorescent Antibody Technique, Direct | Retinal Degeneration - genetics | Cells, Cultured | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Mice, Transgenic | Genetic Markers | Cilia - metabolism | Cilia - genetics | Pigment Epithelium of Eye - metabolism | Animals | Embryo, Mammalian - cytology | Signal Transduction - physiology | Fibroblasts - cytology | Mice | Polymorphism, Single Nucleotide | Mutation | Pigment Epithelium of Eye - cytology | Penis - abnormalities | Gene mutations | Genetic aspects | Cellular signal transduction | Research | Health aspects | Risk factors | Brain diseases | Proteins | Tissue | Scanning electron microscopy | Transmission electron microscopy | Cysts | Rodents | Cell division | Index Medicus
Journal Article
Journal Article
Nature, ISSN 0028-0836, 01/2012, Volume 481, Issue 7381, pp. 380 - 384
Acetyl coenzyme A (AcCoA) is the central biosynthetic precursor for fatty-acid synthesis and protein acetylation. In the conventional view of mammalian cell... 
FLUX ANALYSIS | DISTRIBUTIONS | FATTY-ACID SYNTHESIS | MULTIDISCIPLINARY SCIENCES | GROWTH | HYDROXYLATION | CELL-PROLIFERATION | SUPPRESSION | HIF-ALPHA | CANCER | DEHYDROGENASE | CD8-Positive T-Lymphocytes - cytology | Palmitic Acid - metabolism | Isocitrate Dehydrogenase - deficiency | Humans | Glutamine - metabolism | Kidney Neoplasms - metabolism | Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism | Oxygen - metabolism | Cell Hypoxia | Basic Helix-Loop-Helix Transcription Factors - metabolism | Acetyl Coenzyme A - biosynthesis | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Ketoglutaric Acids - metabolism | Lipogenesis | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Carbon - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Oxidation-Reduction | Carcinoma, Renal Cell - pathology | Cells, Cultured | Isocitrate Dehydrogenase - genetics | Acetyl Coenzyme A - metabolism | Citric Acid Cycle | Carcinoma, Renal Cell - metabolism | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Kidney Neoplasms - pathology | Physiological aspects | Hypoxia | Research | Lipid metabolism | Electron transport | Proteins | Confidence intervals | Metabolites | Lipids | Biosynthesis | Glucose | Experiments | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 4, pp. e19194 - e19194
The cofactor nicotinamide adenine dinucleotide (NAD+) has emerged as a key regulator of metabolism, stress resistance and longevity. Apart from its role as an... 
Biomarkers - metabolism | Sirtuin 1 - metabolism | Protein Carbonylation | Electron Transport | Oxidative Stress | Rats, Wistar | Antioxidants - metabolism | Tumor Suppressor Protein p53 - metabolism | Rats | Mitochondria - metabolism | Aldehydes - metabolism | Organ Specificity | Brain - metabolism | Poly Adenosine Diphosphate Ribose - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | Intracellular Space - metabolism | Female | Acetylation | DNA Damage | Enzyme Activation | Lipid Peroxidation | NAD - metabolism | Aging - metabolism | Antioxidants | Tyrosine | Niacinamide | Purines | Enzymes | Ionizing radiation | DNA damage | Tumor proteins | Sugars | Monosaccharides | Apoptosis | Dehydrogenases | Syngeneic grafts | Oxidative metabolism | Liver | p53 Protein | Lung | Neurobiology | Poly(ADP-ribose) | Lipid peroxidation | ADP | Proteins | Electron transport chain | Signal transduction | Mitochondria | Animal tissues | Aging | Physiology | Chronic obstructive pulmonary disease | Deoxyribonucleic acid--DNA | Peroxidation | Liver diseases | Longevity | Metabolism | Gene expression | Overexpression | Nicotinamide adenine dinucleotide | Nicotinamide | NADPH | Oxidative stress | Carbonyl compounds | Neurosciences | Senescence | Biosynthesis | DNA repair | NADH | Ribose | Rodents | Cell cycle | Age | Carbonyls | Kidneys | Organs | Poly(ADP-ribose) polymerase | Adenine | Histology | Pharmacology | Polymerase | NAD | Lungs | Intracellular | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2017, Volume 12, Issue 6, pp. e0179610 - e0179610
Objective To assess the prognostic roles of BAP1, PBRM1, pS6, PTEN, TGase2, PD-L1, CA9, PSMA, and Ki-67 tissue biomarkers in localized renal cell carcinoma... 
SURVIVAL | MORTALITY | CARBONIC-ANHYDRASE-IX | PROTEIN | MULTIDISCIPLINARY SCIENCES | CANCER INCIDENCE | METASTASES | OUTCOMES | KI67 | EXPRESSION | TUMORS | Immunohistochemistry | Prognosis | Tissue Array Analysis | Humans | Middle Aged | Ki-67 Antigen - metabolism | Male | Kidney Neoplasms - metabolism | Porphyrins - metabolism | Neoplasm Recurrence, Local - mortality | Neoplasm Recurrence, Local - pathology | Glutamate Carboxypeptidase II - metabolism | Neoplasm Grading | Antigens, Neoplasm - metabolism | Antigens, Surface - metabolism | Biomarkers, Tumor - metabolism | Ubiquitin Thiolesterase - metabolism | Adult | Female | Carbonic Anhydrase IX - metabolism | Retrospective Studies | Tumor Suppressor Proteins - metabolism | Neoplasm Recurrence, Local - metabolism | Carcinoma, Renal Cell - pathology | PTEN Phosphohydrolase - metabolism | Nuclear Proteins - metabolism | Survival Rate | Kidney Neoplasms - mortality | Transcription Factors - metabolism | Carcinoma, Renal Cell - metabolism | Carcinoma, Renal Cell - mortality | Disease-Free Survival | B7-H1 Antigen - metabolism | Transglutaminases - metabolism | Sulfonamides - metabolism | Kidney Neoplasms - pathology | Aged | Neoplasm Staging | GTP-Binding Proteins - metabolism | Genetic aspects | Carcinoma, Renal cell | Research | Biological markers | Biometrics | Slopes | Metastasis | Kinases | Epidemiology | Cancer therapies | Urology | Proteins | Nephrectomy | Quality | Bioindicators | Growth factors | Age | Antigens | Markers | Hazards | Patients | Survival | Disease prevention | Hospitals | Medical prognosis | PD-L1 protein | Biomarkers | Death | Mutation | Diabetes | Prostate cancer | PTEN protein | Clear cell-type renal cell carcinoma | Cancer | Kidney transplantation | Tumors | Index Medicus
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2010, Volume 648, Issue 1, pp. 179 - 187
Previously, we have reported that Corni Fructus possessed hypoglycemic and hypocholesterolemic effects in streptozotocin-induced type 1 diabetic rats and... 
Oxidative stress | Hyperglycemia | Advanced glycation endproducts | Loganin | db/db mice | Dyslipidemia | Db/db mice | LIPID-METABOLISM | RATS | HACHIMI-JIO-GAN | KAPPA-B | MORRONISIDE | INSULIN-RESISTANCE | DISEASE | PHARMACOLOGY & PHARMACY | TISSUES | GLYCATION END-PRODUCTS | Gene Expression Regulation, Enzymologic - drug effects | Liver - pathology | Kidney - pathology | Iridoids - isolation & purification | Body Weight - drug effects | Male | Hematologic Tests | Diabetes Mellitus, Type 2 - metabolism | RNA, Messenger - metabolism | Inflammation - complications | Cornus - chemistry | Kidney - metabolism | Liver - drug effects | Inflammation - drug therapy | Lipid Metabolism - genetics | Lysine - metabolism | Sterol Regulatory Element Binding Protein 2 - metabolism | Fatty Acids - metabolism | Diabetes Mellitus, Type 2 - complications | Sterol Regulatory Element Binding Protein 1 - metabolism | Biomarkers - metabolism | Lysine - analogs & derivatives | Kidney - drug effects | Liver - metabolism | RNA, Messenger - genetics | Cholesterol - metabolism | Triglycerides - metabolism | Organ Size - drug effects | Animals | Transcription Factor RelA - metabolism | Iridoids - pharmacology | Glycation End Products, Advanced - metabolism | Cyclooxygenase 2 - metabolism | Lipid Metabolism - drug effects | Glucose - metabolism | Drinking - drug effects | Iridoids - therapeutic use | Mice | Diabetes Mellitus, Type 2 - pathology | Oxidative Stress - drug effects | PPAR alpha - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Nitric Oxide Synthase Type II - metabolism | Hypercholesterolemia | RNA | Type 1 diabetes | Analysis | Inflammation | Protein binding | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2008, Volume 118, Issue 1, pp. 217 - 228
Loss of the tumor suppressor gene von Hippel-Lindau (VHL) plays a key role in the oncogenesis of clear cell renal cell carcinoma (CCRCC). The loss leads to... 
MEDICINE, RESEARCH & EXPERIMENTAL | HIF-1 | TUMOR SUPPRESSION | CYCLIN D1 | PATHWAY | GENE ALTERATIONS | VHL | KIDNEY | FATE | EXPRESSION | CANCER | Neoplasm Transplantation | RNA, Small Interfering - genetics | Humans | Carcinoma, Renal Cell - genetics | Male | Intracellular Signaling Peptides and Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | Cell Transformation, Neoplastic - genetics | Serrate-Jagged Proteins | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Membrane Proteins - metabolism | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Carcinoma, Renal Cell - drug therapy | Intracellular Signaling Peptides and Proteins - genetics | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Carcinoma, Renal Cell - pathology | Membrane Proteins - genetics | RNA, Small Interfering - pharmacology | Intercellular Signaling Peptides and Proteins - genetics | Signal Transduction - genetics | Receptor, Notch1 - metabolism | Cell Transformation, Neoplastic - metabolism | Cyclin-Dependent Kinase Inhibitor p27 | Carcinoma, Renal Cell - metabolism | Animals | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Mice | Cell Transformation, Neoplastic - drug effects | Receptor, Notch1 - antagonists & inhibitors | Cell Transformation, Neoplastic - pathology | Receptor, Notch1 - genetics | Calcium-Binding Proteins - genetics | Care and treatment | Enzyme inhibitors | Tumor suppressor genes | Dosage and administration | Genetic aspects | Carcinoma, Renal cell | Research | Health aspects | Index Medicus | Abridged Index Medicus | RNA; Small Interfering/genetics/pharmacology | Membrane Proteins/genetics/metabolism | Mice; Nude | Signal Transduction/drug effects/genetics | Intracellular Signaling Peptides and Proteins/genetics/metabolism | Basic Helix-Loop-Helix Transcription Factors/genetics/metabolism | Receptor; Notch1/antagonists & inhibitors/genetics/metabolism | Von Hippel-Lindau Tumor Suppressor Protein/genetics/metabolism | Cell Transformation; Neoplastic/drug effects/genetics/metabolism/pathology | Cyclin-Dependent Kinase Inhibitor p21/genetics/metabolism | Cell Line; Tumor | Intercellular Signaling Peptides and Proteins/genetics/metabolism | Calcium-Binding Proteins/genetics/metabolism | Carcinoma; Renal Cell/drug therapy/genetics/metabolism/pathology
Journal Article
FASEB Journal, ISSN 0892-6638, 2005, Volume 19, Issue 13, pp. 1890 - 1892
Journal Article
Amino Acids, ISSN 0939-4451, 1/2017, Volume 49, Issue 1, pp. 129 - 138
High levels of methionine (Met) and methionine sulfoxide (MetO) are found in several genetic abnormalities. Oxidative stress is involved in the pathophysiology... 
Life Sciences | Biochemistry, general | Oxidative stress | Analytical Chemistry | Life Sciences, general | Methionine sulfoxide | Biochemical Engineering | Proteomics | Neurobiology | Methionine | Delta aminolevulinic dehydratase | LIPID-PEROXIDATION | ANTIOXIDANTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DELTA-AMINOLEVULINATE DEHYDRATASE | DAMAGE | HYPERMETHIONINEMIA | METABOLISM | FAT | ADENOSYLTRANSFERASE I/III DEFICIENCY | PROTEINS | RESIDUES | Glycine N-Methyltransferase - metabolism | Liver - pathology | Reactive Oxygen Species - metabolism | Kidney - pathology | Rats, Wistar | Glycine N-Methyltransferase - deficiency | Male | Methionine - pharmacology | Porphobilinogen Synthase - metabolism | Amino Acid Metabolism, Inborn Errors - metabolism | Kidney - metabolism | Sulfhydryl Compounds - metabolism | Liver - drug effects | Methionine - analogs & derivatives | Injections, Subcutaneous | Female | Urea - metabolism | Amino Acid Metabolism, Inborn Errors - pathology | Superoxide Dismutase - metabolism | Glutathione Peroxidase - metabolism | Amino Acid Metabolism, Inborn Errors - chemically induced | Kidney - drug effects | Methionine - metabolism | Liver - metabolism | Rats | Thiobarbituric Acid Reactive Substances - metabolism | Cholesterol - metabolism | Enzyme Activation - drug effects | Triglycerides - metabolism | Catalase - metabolism | Animals | Glucose - metabolism | Oxidative Stress - drug effects | Lipid Peroxidation | Enzymes | Urea | Liver | Physiological aspects | Amino acids | Triglycerides | Superoxide | Index Medicus
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 10/2017, Volume 32, Issue 10, pp. 2049 - 2061
Journal Article