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Seminars in immunopathology, ISSN 1863-2300, 2011, Volume 34, Issue 1, pp. 43 - 62
The interaction of coagulation factors with the perivascular environment affects the development of disease in ways that extend beyond their traditional roles in the acute hemostatic cascade... 
Autoimmunity | Complement receptor 3 | Multiple sclerosis | Stroke | Alzheimer’s disease | Internal Medicine | Macrophages | Blood brain barrier | Inflammatory disease | Microglia | Biomedicine | Immunology | Rheumatoid arthritis | CD11b/CD18 | Atherosclerosis | Plasminogen | Anticoagulant therapy | Alzheimer's disease | ALZHEIMERS-DISEASE | IMMUNOLOGY | PATHOLOGY | GAMMA-C-DOMAIN | BINDING-SITE | CENTRAL-NERVOUS-SYSTEM | MULTIPLE-SCLEROSIS LESIONS | CRYSTAL-STRUCTURE | BLOOD-BRAIN-BARRIER | INTEGRIN ALPHA(M)BETA | PROTEASE-ACTIVATED RECEPTORS | PERIPHERAL ARTERIAL-DISEASE | Colitis - genetics | Humans | Brain Injuries - metabolism | Arthritis, Rheumatoid - metabolism | Bacterial Infections - genetics | Inflammation - metabolism | Blood Coagulation - immunology | Muscular Dystrophy, Duchenne - immunology | Alzheimer Disease - immunology | Fibrinogen - immunology | Thromboplastin - immunology | Pulmonary Fibrosis - immunology | Vascular Diseases - genetics | Brain Injuries - genetics | Thrombin - genetics | Kidney Diseases - immunology | Arthritis, Rheumatoid - genetics | Neoplasms - immunology | Colitis - metabolism | Muscular Dystrophy, Duchenne - genetics | Bacterial Infections - metabolism | Neoplasms - metabolism | Pulmonary Fibrosis - genetics | Spinal Cord Injuries - genetics | Kidney Diseases - genetics | Stroke - genetics | Brain Injuries - immunology | Neoplasms - genetics | Bacterial Infections - immunology | Pulmonary Fibrosis - metabolism | Colitis - immunology | Thrombin - immunology | Stroke - immunology | Kidney Diseases - metabolism | Multiple Sclerosis - metabolism | Vascular Diseases - immunology | Spinal Cord Injuries - metabolism | Multiple Sclerosis - genetics | Inflammation - immunology | Fibrinogen - genetics | Stroke - metabolism | Animals | Thromboplastin - genetics | Alzheimer Disease - metabolism | Fibrinogen - metabolism | Inflammation - genetics | Multiple Sclerosis - immunology | Blood Coagulation - genetics | Spinal Cord Injuries - immunology | Muscular Dystrophy, Duchenne - metabolism | Thrombin - metabolism | Thromboplastin - metabolism | Alzheimer Disease - genetics | Arthritis, Rheumatoid - immunology | Vascular Diseases - metabolism | Nervous system diseases | Bacterial infections | Oncology, Experimental | Thrombin | Inflammation | Anticoagulants (Medicine) | Research | Rheumatoid factor | Fibrin | Fibrinogen | Genetic research | Colitis | Cancer | Traumatic brain injury | Coagulation | Tissue factor | hemostasis | Spinal cord injury | Inflammatory diseases | Kidney | Signal transduction | Duchenne's muscular dystrophy | Neurodegenerative diseases | Therapeutic applications | Thrombosis | Coagulation factors | Infection | Molecular modelling | Fibrosis | Brain injury
Journal Article
PLoS genetics, ISSN 1553-7404, 2011, Volume 7, Issue 9, p. e1002292
Journal Article
Journal Article
Scientific reports, ISSN 2045-2322, 2017, Volume 7, Issue 1, pp. 7519 - 12
.... Furthermore, we employ the context-specific network for the analysis of drug effects with a proximity measure between drug targets and diseases... 
SYSTEM | DATABASE | RENIN | GENE | PATHWAY | MULTIDISCIPLINARY SCIENCES | TISSUE | KEGG | NEBIVOLOL | HYPERTENSION | BLOOD-PRESSURE | Hematologic Diseases - pathology | Liver - pathology | Metabolic Diseases - pathology | Respiratory Tract Diseases - metabolism | Kidney - pathology | Skin - metabolism | Hematologic Diseases - metabolism | Humans | Muscle, Skeletal - metabolism | Respiratory Tract Diseases - drug therapy | Respiratory Tract Diseases - genetics | Brain - metabolism | Musculoskeletal Diseases - pathology | Kidney - metabolism | Liver - drug effects | Muscle, Skeletal - drug effects | Myocardium - metabolism | Nervous System Diseases - metabolism | Nutrition Disorders - pathology | Computational Biology - methods | Kidney - drug effects | Liver - metabolism | Nervous System Diseases - drug therapy | Connective Tissue Diseases - metabolism | Neoplasms - drug therapy | Brain - drug effects | Connective Tissue Diseases - drug therapy | Connective Tissue Diseases - pathology | Lung - drug effects | Brain - pathology | Hematologic Diseases - genetics | Prescription Drugs - pharmacokinetics | Digestive System Diseases - pathology | Neoplasms - metabolism | Cardiovascular Diseases - drug therapy | Drugs, Investigational - pharmacokinetics | Respiratory Tract Diseases - pathology | Hematologic Diseases - drug therapy | Metabolic Diseases - drug therapy | Cardiovascular Diseases - pathology | Nervous System Diseases - genetics | Cardiovascular Diseases - genetics | Musculoskeletal Diseases - genetics | Neoplasms - genetics | Lung - metabolism | Skin - pathology | Nervous System Diseases - pathology | Lung - pathology | Musculoskeletal Diseases - drug therapy | Cardiovascular Diseases - metabolism | Musculoskeletal Diseases - metabolism | Nutrition Disorders - drug therapy | Nutrition Disorders - genetics | Myocardium - pathology | Organ Specificity | Digestive System Diseases - genetics | Algorithms | Digestive System Diseases - drug therapy | Nutrition Disorders - metabolism | Metabolic Diseases - metabolism | Digestive System Diseases - metabolism | Metabolic Diseases - genetics | Connective Tissue Diseases - genetics | Muscle, Skeletal - pathology | Neoplasms - pathology | Skin - drug effects | Drug development
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2010, Volume 329, Issue 5993, pp. 841 - 845
African Americans have higher rates of kidney disease than European Americans. Here, we show that, in African Americans, focal segmental glomerulosclerosis (FSGS... 
Haplotypes | Kidneys | Focal segmental glomerulosclerosis | REPORTS | Diabetic nephropathies | African Americans | Disease risk | Kidney diseases | Chromosomes | Genetic mutation | Genotypes | 9 GENE MYH9 | POLYMORPHISMS | POSITIVE SELECTION | MULTIDISCIPLINARY SCIENCES | NATURAL-SELECTION | RHODESIENSE | HUMAN SERUM | STAGE RENAL-DISEASE | GENOME | Sequence Deletion | Lipoproteins, HDL - genetics | Lipoproteins, HDL - blood | Glomerulosclerosis, Focal Segmental - genetics | Humans | Lipoproteins, HDL - metabolism | Myosin Heavy Chains - genetics | Kidney Failure, Chronic - ethnology | Molecular Motor Proteins - genetics | Case-Control Studies | Trypanosoma brucei rhodesiense - metabolism | Apolipoproteins - genetics | Glomerulosclerosis, Focal Segmental - ethnology | Trypanosomiasis, African - genetics | Recombinant Proteins - metabolism | Genetic Predisposition to Disease | Genetic Association Studies | Apolipoproteins - metabolism | Gene Frequency | Africa | Selection, Genetic | African Americans - genetics | Logistic Models | Apolipoproteins - blood | Immunity, Innate | Linkage Disequilibrium | Kidney Failure, Chronic - genetics | Trypanosomiasis, African - parasitology | Alleles | Apolipoprotein L1 | Hypertension - complications | Polymorphism, Single Nucleotide | Cohort Studies | Kidney Failure, Chronic - etiology | Genetic aspects | Demographic aspects | Health aspects | Proteins | Mutation | Population genetics
Journal Article
American journal of human genetics, ISSN 0002-9297, 2016, Volume 98, Issue 6, pp. 1193 - 1207
Journal Article
Journal Article
Nature medicine, ISSN 1546-170X, 2018, Volume 24, Issue 11, pp. 1721 - 1731
Chronic kidney disease (CKD), a condition in which the kidneys are unable to clear waste products, affects 700 million people globally... 
FIBROSIS | MEDICINE, RESEARCH & EXPERIMENTAL | ALLELES | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESISTANT NEPHROTIC SYNDROME | RISK | LOCI | VARIANT | CELL BIOLOGY | EPITHELIAL-CELLS | PROXIMAL TUBULE | EXPRESSION | GENOME-WIDE ASSOCIATION | Genetic Predisposition to Disease | Genome-Wide Association Study | Kidney Tubules, Proximal - pathology | Kidney - pathology | Gene Expression Regulation - genetics | Humans | Cell Compartmentation - genetics | Signal Transduction - genetics | Kidney Glomerulus - pathology | Renal Insufficiency, Chronic - physiopathology | Kidney - metabolism | Animals | Transforming Growth Factor beta - genetics | Tumor Suppressor Proteins - genetics | Adaptor Proteins, Signal Transducing - genetics | Kidney Tubules, Proximal - metabolism | Renal Insufficiency, Chronic - genetics | Kidney Glomerulus - metabolism | Polymorphism, Single Nucleotide - genetics | Mice | Disease Models, Animal | Quantitative Trait Loci - genetics | Quantitative trait loci | Kidneys | Chronic kidney failure | Genetic variation | Physiological aspects | Development and progression | Genetic aspects | Health aspects | Nucleotide sequence | Genes | Genomes | Genetic diversity | Ribonucleic acid--RNA | Gene expression | Renal tubules | Gene sequencing | Proteins | Pathways | Genetic analysis | Kidney diseases | Gene mapping | compartment-specific | renal disease | eQTL
Journal Article