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Scientific reports, ISSN 2045-2322, 2017, Volume 7, Issue 1, pp. 7519 - 12
.... Furthermore, we employ the context-specific network for the analysis of drug effects with a proximity measure between drug targets and diseases... 
SYSTEM | DATABASE | RENIN | GENE | PATHWAY | MULTIDISCIPLINARY SCIENCES | TISSUE | KEGG | NEBIVOLOL | HYPERTENSION | BLOOD-PRESSURE | Hematologic Diseases - pathology | Liver - pathology | Metabolic Diseases - pathology | Respiratory Tract Diseases - metabolism | Kidney - pathology | Skin - metabolism | Hematologic Diseases - metabolism | Humans | Muscle, Skeletal - metabolism | Respiratory Tract Diseases - drug therapy | Respiratory Tract Diseases - genetics | Brain - metabolism | Musculoskeletal Diseases - pathology | Kidney - metabolism | Liver - drug effects | Muscle, Skeletal - drug effects | Myocardium - metabolism | Nervous System Diseases - metabolism | Nutrition Disorders - pathology | Computational Biology - methods | Kidney - drug effects | Liver - metabolism | Nervous System Diseases - drug therapy | Connective Tissue Diseases - metabolism | Neoplasms - drug therapy | Brain - drug effects | Connective Tissue Diseases - drug therapy | Connective Tissue Diseases - pathology | Lung - drug effects | Brain - pathology | Hematologic Diseases - genetics | Prescription Drugs - pharmacokinetics | Digestive System Diseases - pathology | Neoplasms - metabolism | Cardiovascular Diseases - drug therapy | Drugs, Investigational - pharmacokinetics | Respiratory Tract Diseases - pathology | Hematologic Diseases - drug therapy | Metabolic Diseases - drug therapy | Cardiovascular Diseases - pathology | Nervous System Diseases - genetics | Cardiovascular Diseases - genetics | Musculoskeletal Diseases - genetics | Neoplasms - genetics | Lung - metabolism | Skin - pathology | Nervous System Diseases - pathology | Lung - pathology | Musculoskeletal Diseases - drug therapy | Cardiovascular Diseases - metabolism | Musculoskeletal Diseases - metabolism | Nutrition Disorders - drug therapy | Nutrition Disorders - genetics | Myocardium - pathology | Organ Specificity | Digestive System Diseases - genetics | Algorithms | Digestive System Diseases - drug therapy | Nutrition Disorders - metabolism | Metabolic Diseases - metabolism | Digestive System Diseases - metabolism | Metabolic Diseases - genetics | Connective Tissue Diseases - genetics | Muscle, Skeletal - pathology | Neoplasms - pathology | Skin - drug effects | Drug development
Journal Article
Kidney international, ISSN 0085-2538, 2012, Volume 81, Issue 10, pp. 942 - 948
Despite the availability of renal replacement therapy, acute kidney injury (AKI) is associated with high mortality and morbidity. In humans, it is difficult to... 
acute kidney injury | extrarenal complications | inflammation | pathophysiology | Inflammation | Pathophysiology | Extrarenal complications | Acute kidney injury | ISCHEMIA/REPERFUSION INJURY | MECHANICAL VENTILATION | ACUTE LUNG INJURY | ACUTE-RENAL-FAILURE | BILATERAL-NEPHRECTOMY | INTENSIVE-CARE | RESPIRATORY-DISTRESS-SYNDROME | ISCHEMIA-REPERFUSION INJURY | UROLOGY & NEPHROLOGY | CONGESTIVE-HEART-FAILURE | CRITICALLY-ILL PATIENTS | Brain Diseases - metabolism | Liver - pathology | Lung Diseases - metabolism | Reactive Oxygen Species - metabolism | Heart Diseases - metabolism | Kidney - pathology | Oxidative Stress | Humans | Liver Diseases - pathology | Liver - physiopathology | Brain Diseases - physiopathology | Lung Diseases - etiology | Brain - metabolism | Kidney - metabolism | Acute Kidney Injury - complications | Liver Diseases - etiology | Myocardium - metabolism | Inflammation Mediators - metabolism | Lung - metabolism | Brain Diseases - etiology | Kidney - physiopathology | Lung - pathology | Signal Transduction | Acute Kidney Injury - pathology | Heart Diseases - physiopathology | Brain - physiopathology | Liver - metabolism | Myocardium - pathology | Lung - physiopathology | Acute Kidney Injury - physiopathology | Heart Diseases - etiology | Animals | Brain Diseases - pathology | Brain - pathology | Lung Diseases - physiopathology | Liver Diseases - physiopathology | Lung Diseases - pathology | Acute Kidney Injury - metabolism | Liver Diseases - metabolism | Heart Diseases - pathology | Apoptosis
Journal Article
Circulation (New York, N.Y.), ISSN 1524-4539, 2019, Volume 139, Issue 10, pp. e56 - e66
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 10/2017, Volume 101, Issue 4, pp. 552 - 563
The Sonic Hedgehog (SHH) pathway is a key signaling pathway orchestrating embryonic development, mainly of the CNS and limbs. In vertebrates, SHH signaling is... 
polymicrogyria | developmental defects | hypomorphic variants | congenital ataxia | ciliopathies | SUFU | Joubert syndrome | Sonic Hedgehog | molar tooth sign | GLI3 | Congenital ataxia | Hypomorphic variants | Developmental defects | Ciliopathies | Polymicrogyria | Molar tooth sign | SHH | SIGNALING PATHWAY | GENETICS & HEREDITY | PLANAR CELL POLARITY | CEREBELLAR DEVELOPMENT | GLI PROTEINS | MUTATIONS | KIF7 | MEDULLOBLASTOMA | PHENOTYPIC SPECTRUM | PRIMARY CILIA | Abnormalities, Multiple - pathology | Skin - metabolism | Humans | Zinc Finger Protein Gli3 | Hedgehog Proteins - metabolism | Male | Bone Diseases, Developmental - genetics | Mutation, Missense | Cerebellum - abnormalities | Bone Diseases, Developmental - pathology | Gene Expression Regulation, Developmental | Kruppel-Like Transcription Factors - metabolism | Kidney Diseases, Cystic - genetics | Craniofacial Abnormalities - pathology | Female | Child | Abnormalities, Multiple - genetics | Craniofacial Abnormalities - genetics | Repressor Proteins - metabolism | Skin - pathology | Fibroblasts - metabolism | Repressor Proteins - chemistry | Signal Transduction | Cells, Cultured | Repressor Proteins - genetics | Eye Abnormalities - genetics | Fibroblasts - pathology | Genes, Recessive | Sequence Analysis, DNA | Cerebellum - pathology | Kidney Diseases, Cystic - pathology | Nerve Tissue Proteins - metabolism | Eye Abnormalities - pathology | Retina - abnormalities | Retina - pathology | Cohort Studies | Embryonic development | Usage | Gene mutations | Analysis | Nucleotide sequencing | Research | Diagnosis | Children | Health aspects | DNA sequencing
Journal Article
Journal of virology, ISSN 1098-5514, 2017, Volume 91, Issue 1
Porcine circovirus-associated disease (PCVAD) is clinically manifested by postweaning multisystemic wasting syndrome (PMWS... 
Porcine dermatitis and nephropathy syndrome | Abortion | Porcine circovirus | MOLECULAR CHARACTERIZATION | CONVENTIONAL PIGS | GNOTOBIOTIC PIGS | RESPIRATORY-DISEASE COMPLEX | abortion | FAMILY CIRCOVIRIDAE | GENETIC-ANALYSIS | TYPE-2 PCV2 | porcine circovirus | GENOME SEQUENCE | VIROLOGY | SYNDROME PMWS | porcine dermatitis and nephropathy syndrome | MULTISYSTEMIC WASTING SYNDROME | Immunologic Surveillance | Capsid - chemistry | Lymph Nodes - pathology | Kidney - pathology | Swine Diseases - virology | Abortion, Spontaneous - virology | Porcine Postweaning Multisystemic Wasting Syndrome - pathology | Antigens, Viral - genetics | Phylogeny | Dermatitis - epidemiology | Swine Diseases - epidemiology | Abortion, Spontaneous - epidemiology | Lung - virology | Porcine Postweaning Multisystemic Wasting Syndrome - epidemiology | Canada - epidemiology | Swine | Circovirus - genetics | Capsid Proteins - immunology | Porcine Postweaning Multisystemic Wasting Syndrome - mortality | Female | Fetus | Porcine Postweaning Multisystemic Wasting Syndrome - virology | North Carolina - epidemiology | Skin - virology | Skin - pathology | Genome, Viral | Abortion, Spontaneous - pathology | Acute Disease | Lung - pathology | RNA Replicase - genetics | Dermatitis - virology | Swine Diseases - pathology | Lymph Nodes - virology | Antigens, Viral - immunology | Capsid - immunology | Circovirus - immunology | Dermatitis - pathology | Circovirus - isolation & purification | Animals | Abortion, Spontaneous - mortality | Survival Analysis | Dermatitis - mortality | Kidney - virology | Swine Diseases - mortality | Circovirus - classification | RNA Replicase - immunology | Capsid Proteins - genetics
Journal Article
Cell and Tissue Research, ISSN 0302-766X, 1/2009, Volume 335, Issue 1, pp. 143 - 151
Journal Article
Human Pathology, ISSN 0046-8177, 2015, Volume 49, pp. 27 - 32
Summary Complex I deficiency causes Leigh syndrome, fatal infant lactic acidosis, and neonatal cardiomyopathy. Mutations in more than 100 nuclear DNA and... 
Pathology | Metabolic disease | Lethal neonatal lactic acidosis | Whole-exome sequencing | Mitochondriopathy | Complex I deficiency | ACAD9 defect | Mitochondrial hyperplasia | Multiorgan failure | DIAGNOSIS | CARDIOMYOPATHY | PATHOLOGY | GENE | DNA | EXPRESSION | Immunohistochemistry | Fibroblasts - enzymology | Diaphragm - pathology | Mitochondria, Heart - pathology | Electron Transport Complex I - deficiency | Humans | Hyperplasia | Male | Cardiomyopathy, Hypertrophic - enzymology | Acyl-CoA Dehydrogenases - genetics | Leigh Disease - pathology | Muscle Weakness - genetics | Amino Acid Metabolism, Inborn Errors - genetics | Autopsy | DNA Mutational Analysis | Electron Transport Complex I - genetics | Fatal Outcome | Muscle Weakness - pathology | Acyl-CoA Dehydrogenases - deficiency | Amino Acid Metabolism, Inborn Errors - pathology | Kidney Tubules - pathology | Infant, Newborn | Multiple Organ Failure - pathology | Acyl-CoA Dehydrogenase - genetics | Cardiomyopathy, Hypertrophic - genetics | Genetic Predisposition to Disease | Mitochondria, Liver - pathology | Mitochondria, Heart - enzymology | Fibroblasts - pathology | Leigh Disease - genetics | Acidosis, Lactic - pathology | Cardiomyopathy, Hypertrophic - diagnosis | Mitochondrial Diseases - enzymology | Phenotype | Acyl-CoA Dehydrogenase - deficiency | Kidney Tubules - enzymology | Acidosis - diagnosis | Multiple Organ Failure - enzymology | Acidosis - genetics | Amino Acid Metabolism, Inborn Errors - enzymology | Mitochondrial Diseases - pathology | Muscle Weakness - diagnosis | Acidosis, Lactic - genetics | Cause of Death | Acidosis, Lactic - enzymology | Amino Acid Metabolism, Inborn Errors - diagnosis | DNA, Mitochondrial - genetics | Muscle Weakness - enzymology | Transfection | Mitochondrial Diseases - genetics | Mitochondria, Muscle - enzymology | Mitochondria, Muscle - pathology | Leigh Disease - enzymology | Cells, Cultured | Multiple Organ Failure - genetics | Codon, Nonsense | Mitochondria, Liver - enzymology | Multiple Organ Failure - diagnosis | Diaphragm - enzymology | Acidosis - pathology | Leigh Disease - diagnosis | Acidosis - enzymology | Mitochondrial Diseases - diagnosis | Acidosis, Lactic - diagnosis | Cardiomyopathy, Hypertrophic - pathology | Infants (Newborn) | Muscles | Genetic aspects | Mitochondrial DNA | Liver | Heart | Urine | Cytochrome | Antigens | Enzymes | Cytomegalovirus | Cardiomyopathy | Defects | Musculoskeletal system | Databases | Rodents | Fibroblasts | Oxidation | Mutation | Metabolic disorders | Deoxyribonucleic acid--DNA
Journal Article