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1. Full Text Randomized phase III trial of adjuvant pazopanib versus placebo after nephrectomy in patients with localized or locally advanced renal cell carcinoma
by Motzer, Robert J and Haas, Naomi B and Donskov, Frede and Gross-Goupil, Marine and Varlamov, Sergei and Kopyltsov, Evgeny and Lee, Jae Lyun and Melichar, Bohuslav and Rini, Brian I and Choueiri, Toni K and Zemanova, Milada and Wood, Lori A and Reaume, M. Neil and Stenzl, Arnulf and Chowdhury, Simon and Lim, Ho Yeong and McDermott, Ray and Michael, Agnieszka and Bao, Weichao and Carrasco-Alfonso, Marlene J and Aimone, Paola and Voi, Maurizio and Doehn, Christian and Russo, Paul and Sternberg, Cora N and PROTECT Investigators and PROTECT investigators and on behalf of the PROTECT investigators
Journal of Clinical Oncology, ISSN 0732-183X, 12/2017, Volume 35, Issue 35, pp. 3916 - 3923
PurposeThis phase III trial evaluated the efficacy and safety of pazopanib versus placebo in patients with locally advanced renal cell carcinoma (RCC) at high... 
THERAPY | EFFICACY | ONCOLOGY | SAFETY | HIGH-RISK | CLINICAL-TRIALS | SUNITINIB | SURVEILLANCE | Humans | Middle Aged | Carcinoma, Renal Cell - surgery | Male | Dose-Response Relationship, Drug | Young Adult | Kidney Neoplasms - surgery | Neoplasm Grading | Nephrectomy | Aged, 80 and over | Angiogenesis Inhibitors - therapeutic use | Placebos | Adult | Female | Chemotherapy, Adjuvant | Carcinoma, Renal Cell - drug therapy | Angiogenesis Inhibitors - adverse effects | Carcinoma, Renal Cell - blood supply | Carcinoma, Renal Cell - pathology | Disease-Free Survival | Sulfonamides - therapeutic use | Pyrimidines - therapeutic use | Pyrimidines - adverse effects | Sulfonamides - adverse effects | Kidney Neoplasms - pathology | Aged | Kidney Neoplasms - drug therapy | Kidney Neoplasms - blood supply | Index Medicus | ORIGINAL REPORTS
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2. Full Text Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche
by Grange, Cristina and Tapparo, Marta and Collino, Federica and Vitillo, Loriana and Damasco, Christian and Deregibus, Maria Chiara and Tetta, Ciro and Bussolati, Benedetta and Camussi, Giovanni
Cancer Research, ISSN 0008-5472, 08/2011, Volume 71, Issue 15, pp. 5346 - 5356
Recent studies suggest that tumor-derived microvesicles (MV) act as a vehicle for exchange of genetic information between tumor and stromal cells, engendering... 
HORIZONTAL TRANSFER | CIRCULATING MICRORNA | MESSENGER-RNA | ONCOLOGY | ENDOTHELIAL-CELLS | EXOSOMES | DIAGNOSTIC BIOMARKERS | OVARIAN-CANCER | TUMOR-DERIVED MICROVESICLES | EXPRESSION | MICRORNA SIGNATURES | Angiogenic Proteins - genetics | Neoplastic Stem Cells - cytology | Humans | Receptors, Cell Surface - analysis | Tumor Microenvironment | Transplantation, Heterologous | Antigens, CD - analysis | Endoglin | Immunomagnetic Separation | Lung Neoplasms - secondary | Matrix Metalloproteinase 9 - genetics | Exosomes - physiology | Epithelial-Mesenchymal Transition | Neovascularization, Pathologic - physiopathology | Antigens, Neoplasm - analysis | Angiogenic Proteins - biosynthesis | Carcinoma, Renal Cell - blood supply | Exosomes - secretion | Lung Neoplasms - blood supply | Matrix Metalloproteinase 9 - biosynthesis | Carcinoma, Renal Cell - pathology | Neoplasm Invasiveness | Cells, Cultured | MicroRNAs - biosynthesis | Mice, SCID | Neoplastic Stem Cells - transplantation | Animals | RNA, Neoplasm - biosynthesis | Endothelial Cells - cytology | Carcinoma, Renal Cell - secondary | Kidney Neoplasms - pathology | Exosomes - chemistry | Mice
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3. Full Text A Decade of Experience in Developing Preclinical Models of Advanced- or Early-Stage Spontaneous Metastasis to Study Antiangiogenic Drugs, Metronomic Chemotherapy, and the Tumor Microenvironment
by Kerbel, Robert S
Cancer Journal (United States), ISSN 1528-9117, 07/2015, Volume 21, Issue 4, pp. 274 - 283
The clinical circumstance of treating spontaneous metastatic disease, after resection of primary tumors, whether advanced/overt or microscopic in nature, is... 
antiangiogenic drugs | metronomic low-dose chemotherapy | spontaneous metastatic disease | experimental therapeutic investigations | 1ST-LINE TREATMENT | ANTITUMOR-ACTIVITY | PLUS PACLITAXEL | MOUSE MODELS | PHASE-III TRIAL | BREAST-CANCER | THERAPY | ONCOLOGY | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | DOUBLE-BLIND | ORAL TOPOTECAN | Neoplasm Transplantation | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Melanoma - blood supply | Administration, Metronomic | Humans | Ovarian Neoplasms - pathology | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Angiogenesis Inhibitors - administration & dosage | Neoplasm Metastasis - drug therapy | Colorectal Neoplasms - drug therapy | Angiogenesis Inhibitors - therapeutic use | Female | Ovarian Neoplasms - blood supply | Drug Evaluation, Preclinical | Ovarian Neoplasms - drug therapy | Disease Models, Animal | Tumor Microenvironment - drug effects | Colorectal Neoplasms - blood supply | Neoplasms - blood supply | Breast Neoplasms - blood supply | Melanoma - pathology | Breast Neoplasms - drug therapy | Neoplasms - drug therapy | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Neovascularization, Pathologic - drug therapy | Melanoma - drug therapy | Cell Line, Tumor | Kidney Neoplasms - pathology | Mice | Colorectal Neoplasms - pathology | Kidney Neoplasms - drug therapy | Kidney Neoplasms - blood supply
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4. Full Text VEGF exerts an angiogenesis-independent function in cancer cells to promote their malignant progression
by Cao, Ying and E, Guangqi and Wang, Enfeng and Pal, Krishnendu and Dutta, Shamit K and Bar-Sagi, Dafna and Mukhopadhyay, Debabrata
Cancer Research, ISSN 0008-5472, 08/2012, Volume 72, Issue 16, pp. 3912 - 3918
VEGF/vascular permeability factor (VEGF/VPF or VEGF-A) is a pivotal driver of cancer angiogenesis that is a central therapeutic target in the treatment of... 
CARCINOMA-CELLS | SURVIVAL | DOMAIN | NEUROPILIN-1 | ONCOLOGY | TUMOR-CELLS | ENDOTHELIAL GROWTH-FACTOR | Neuropilin-1 - genetics | RNA, Small Interfering - genetics | Kidney Neoplasms - genetics | Neuropilin-1 - metabolism | Humans | Carcinoma, Renal Cell - genetics | Kidney Neoplasms - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Breast Neoplasms - metabolism | Gene Knockdown Techniques | Neovascularization, Pathologic - pathology | Transfection | MCF-7 Cells | Female | Carcinoma, Renal Cell - blood supply | Cell Dedifferentiation - physiology | Signal Transduction | Carcinoma, Renal Cell - pathology | Breast Neoplasms - blood supply | Carcinoma, Renal Cell - metabolism | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Transformation, Neoplastic | Mice, Nude | Cell Line, Tumor | Kidney Neoplasms - pathology | Mice | Neovascularization, Pathologic - metabolism | RNA, Small Interfering - administration & dosage | Kidney Neoplasms - blood supply
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5. Full Text Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes
by Rodriguez, Paulo C and Ernstoff, Marc S and Hernandez, Claudia and Atkins, Michael and Zabaleta, Jovanny and Sierra, Rosa and Ochoa, Augusto C
Cancer Research, ISSN 0008-5472, 02/2009, Volume 69, Issue 4, pp. 1553 - 1560
Myeloid-derived suppressor cells (MDSC) producing arginase I are increased in the peripheral blood of patients with renal cell carcinoma (RCC). MDSC inhibit... 
INTERLEUKIN-2 | CANCER-PATIENTS | DENDRITIC CELLS | MECHANISM | ONCOLOGY | IMMUNOTHERAPY | NEUTROPHILS | DIFFERENTIATION | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | ANTIGEN | Myeloid Cells - enzymology | Antigens, CD - immunology | Immunotherapy - methods | Species Specificity | Humans | Arginase - metabolism | Kidney Neoplasms - immunology | Antibodies, Monoclonal - therapeutic use | Male | Carcinoma, Renal Cell - immunology | Bevacizumab | Antibodies, Monoclonal, Humanized | Neoplasm Metastasis | Myeloid Cells - immunology | Angiogenesis Inhibitors - therapeutic use | Carcinoma, Renal Cell - enzymology | Female | Granulocytes - pathology | Carcinoma, Renal Cell - blood supply | Carcinoma, Renal Cell - pathology | RNA, Messenger - genetics | Neutrophils - immunology | Granulocytes - enzymology | Animals | Kidney Neoplasms - enzymology | Kidney Neoplasms - pathology | Mice | Myeloid Cells - pathology | Arginine - metabolism | Granulocytes - immunology | Kidney Neoplasms - blood supply
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6. Full Text Nanoparticle-Mediated Drug Delivery to Tumor Vasculature Suppresses Metastasis
by Eric A. Murphy and Bharat K. Majeti and Leo A. Barnes and Milan Makale and Sara M. Weis and Kimberly Lutu-Fuga and Wolfgang Wrasidlo and David A. Cheresh
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2008, Volume 105, Issue 27, pp. 9343 - 9348
Integrin ανβ3 is found on a subset of tumor blood vessels where it is associated with angiogenesis and malignant tumor growth. We designed an ανβ3-targeted... 
Cardiovascular system | Angiogenesis | Microscopy | Renal cell carcinoma | Antineoplastics | Blood vessels | Metastasis | Tumors | Integrins | Cancer | Intravital microscopy | Liposome | Antiangiogenic | Pancreatic cancer | REGRESSION | intravital microscopy | ANGIOGENESIS | RGD PEPTIDES | antiangiogenic | MULTIDISCIPLINARY SCIENCES | PANCREATIC-CANCER | DOXORUBICIN | ORTHOTOPIC MODEL | liposome | BREAST-CANCER | pancreatic cancer | renal cell carcinoma | ALPHA-V-BETA-3 | VX-2 RABBIT TUMORS | INTEGRIN ALPHA(V)BETA ANTAGONISTS | Endothelium - pathology | Doxorubicin - therapeutic use | Carcinoma, Renal Cell - pathology | Pancreatic Neoplasms - blood supply | Pancreatic Neoplasms - pathology | Angiogenesis Inhibitors - pharmacology | Neoplasms - blood supply | Integrin alphaVbeta3 - metabolism | Drug Delivery Systems | Neovascularization, Pathologic - pathology | Nanoparticles | Xenograft Model Antitumor Assays | Endothelium - drug effects | Animals | Neoplasm Metastasis - drug therapy | Cell Line, Tumor | Kidney Neoplasms - pathology | Mice | Neoplasms - pathology | Oligopeptides - pharmacology | Doxorubicin - pharmacology | Disease Models, Animal | Doxorubicin - administration & dosage | Control | Blood-vessels | Physiological aspects | Genetic aspects | Carcinoma, Renal cell | Research | Neovascularization | Risk factors | Methods | Biological Sciences
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7. Full Text A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer
by Wu, Sherry Y and Rupaimoole, Rajesha and Shen, Fangrong and Pradeep, Sunila and Pecot, Chad V and Ivan, Cristina and Nagaraja, Archana S and Gharpure, Kshipra M and Pham, Elizabeth and Hatakeyama, Hiroto and McGuire, Michael H and Haemmerle, Monika and Vidal-Anaya, Viviana and Olsen, Courtney and Rodriguez-Aguayo, Cristian and Filant, Justyna and Ehsanipour, Ehsan A and Herbrich, Shelley M and Maiti, Sourindra N and Huang, Li and Kim, Ji Hoon and Zhang, Xinna and Han, Hee-Dong and Armaiz-Pena, Guillermo N and Seviour, Elena G and Tucker, Sue and Zhang, Min and Yang, Da and Cooper, Laurence J. N and Ali-Fehmi, Rouba and Bar-Eli, Menashe and Lee, Ju-Seog and Ram, Prahlad T and Baggerly, Keith A and Lopez-Berestein, Gabriel and Hung, Mien-Chie and Sood, Anil K
Nature Communications, ISSN 2041-1723, 04/2016, Volume 7, Issue 1, p. 11169
A deeper mechanistic understanding of tumour angiogenesis regulation is needed to improve current anti-angiogenic therapies. Here we present evidence from... 
EPITHELIAL-MESENCHYMAL TRANSITION | IN-VITRO | COLORECTAL-CANCER | MULTIDISCIPLINARY SCIENCES | EARLY GROWTH RESPONSE-1 | CELL-PROLIFERATION | OVARIAN-CANCER | TUMOR ANGIOGENESIS | PROGNOSTIC VALUE | EXPRESSION | MICRORNAS 192 | Genetic Therapy | Kidney Neoplasms - genetics | Phosphatidylcholines | Homeodomain Proteins - metabolism | Humans | MicroRNAs - metabolism | Gene Regulatory Networks | Ovarian Neoplasms - genetics | Early Growth Response Protein 1 - genetics | Female | Ovarian Neoplasms - blood supply | Kidney Neoplasms - therapy | Down-Regulation | Early Growth Response Protein 1 - physiology | Tumor Burden | Homeodomain Proteins - genetics | Animals | Cell Line, Tumor | Ovarian Neoplasms - therapy | Neovascularization, Pathologic - genetics | Mice | MicroRNAs - genetics | MicroRNAs - physiology | Homeodomain Proteins - physiology | Early Growth Response Protein 1 - metabolism | Kidney Neoplasms - blood supply
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8. Full Text Radiotherapy for renal-cell carcinoma
by De Meerleer, Gert, Prof and Khoo, Vincent, MD and Escudier, Bernard, MD and Joniau, Steven, PhD and Bossi, Alberto, MD and Ost, Piet, MD and Briganti, Alberto, MD and Fonteyne, Valérie, MD and Van Vulpen, Marco, MD and Lumen, Nicolaas, PhD and Spahn, Martin, MD and Mareel, Marc, Prof
Lancet Oncology, The, ISSN 1470-2045, 2014, Volume 15, Issue 4, pp. e170 - e177
Summary Renal-cell carcinoma is considered to be a radioresistant tumour, but this notion might be wrong. If given in a few (even single) fractions, but at a... 
Hematology, Oncology and Palliative Medicine | APOPTOSIS | ABSCOPAL | ONCOLOGY | STEREOTACTIC BODY RADIOTHERAPY | POSTOPERATIVE RADIOTHERAPY | METASTASES | TUMOR RESPONSE | DOSE-PER-FRACTION | CERAMIDE | CANCER | RADIATION-THERAPY | Carcinoma, Renal Cell - pathology | Humans | Kidney Neoplasms - immunology | Radiosurgery | Treatment Outcome | Kidney Neoplasms - radiotherapy | Chemoradiotherapy | Carcinoma, Renal Cell - immunology | Carcinoma, Renal Cell - radiotherapy | Animals | Dose Fractionation | Kidney Neoplasms - pathology | Radiotherapy, Adjuvant | Dose-Response Relationship, Radiation | Carcinoma, Renal Cell - blood supply | Kidney Neoplasms - blood supply | Carcinoma | Radiotherapy | Nuclear radiation | Cancer
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9. Full Text Stage-specific inhibitory effects and associated mechanisms of silibinin on tumor progression and metastasis in transgenic adenocarcinoma of the mouse prostate model
by Raina, Komal and Rajamanickam, Subapriya and Singh, Rana P and Deep, Gagan and Chittezhath, Manesh and Agarwal, Rajesh
Cancer Research, ISSN 0008-5472, 08/2008, Volume 68, Issue 16, pp. 6822 - 6830
Herein, using transgenic adenocarcinoma of the mouse prostate (TRAMP) model, we assessed the "stage-specific" efficacy of silibinin feeding against prostate... 
EPITHELIAL-MESENCHYMAL TRANSITION | MATRIX | POTENTIAL TARGET | TRAMP MODEL | ANGIOGENESIS | ONCOLOGY | MICE | AGENTS | CANCER CHEMOPREVENTION | ENDOTHELIAL GROWTH-FACTOR | Humans | Body Weight - drug effects | Male | Vascular Endothelial Growth Factor A - metabolism | Kidney Neoplasms - prevention & control | Biomarkers, Tumor | Immunoenzyme Techniques | Lung Neoplasms - secondary | Prostate - drug effects | Prostatic Intraepithelial Neoplasia - blood supply | Female | Neovascularization, Pathologic - prevention & control | Prostatic Neoplasms - prevention & control | Tumor Cells, Cultured | Liver Neoplasms - secondary | Disease Models, Animal | Lung Neoplasms - blood supply | Liver Neoplasms - prevention & control | Prostatic Neoplasms - blood supply | Prostatic Neoplasms - pathology | Silymarin - therapeutic use | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Mice, Transgenic | Adenocarcinoma - secondary | Blotting, Western | Disease Progression | Adenocarcinoma - blood supply | Xenograft Model Antitumor Assays | Antioxidants - therapeutic use | Milk Thistle | Adenocarcinoma - prevention & control | Animals | Liver Neoplasms - blood supply | Lung Neoplasms - prevention & control | Mice, Nude | Prostatic Intraepithelial Neoplasia - secondary | Prostatic Intraepithelial Neoplasia - prevention & control | Cell Proliferation - drug effects | Mice | Kidney Neoplasms - secondary | Neoplasm Staging | Kidney Neoplasms - blood supply | Apoptosis | Cell Movement | Nitric Oxide Synthase Type II - metabolism
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10. Full Text Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480
by Xin, Hong and Herrmann, Andreas and Reckamp, Karen and Zhang, Wang and Pal, Sumanta and Hedvat, Michael and Zhang, Chunyan and Liang, Wei and Scuto, Anna and Weng, Shaobu and Morosini, Deborah and Cao, Zhu A and Zinda, Michael and Figlin, Robert and Huszar, Dennis and Jove, Richard and Yu, Hua
Cancer Research, ISSN 0008-5472, 11/2011, Volume 71, Issue 21, pp. 6601 - 6610
STAT3 has important functions in both tumor cells and the tumor microenvironment to facilitate cancer progression. The STAT regulatory kinase Janus-activated... 
STAT3 ACTIVATION | APOPTOSIS | IMMUNITY | METASTATIC NICHE | ANGIOGENESIS | ONCOLOGY | MYELOID CELLS | UP-REGULATION | CANCER | EXPRESSION | TUMOR MICROENVIRONMENT | Pyrazoles - therapeutic use | Humans | Lung Neoplasms - pathology | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Recombinant Fusion Proteins - antagonists & inhibitors | Stromal Cells - enzymology | Lung Neoplasms - secondary | Neoplasm Metastasis - drug therapy | Mammary Neoplasms, Experimental - pathology | Stromal Cells - drug effects | Female | Antineoplastic Agents - pharmacology | Carcinoma, Renal Cell - blood supply | Lung Neoplasms - blood supply | Pyrazoles - pharmacology | Tumor Microenvironment - drug effects | Mammary Neoplasms, Experimental - prevention & control | Carcinoma, Renal Cell - pathology | Pyrimidines - pharmacology | Janus Kinases - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Lung Neoplasms - prevention & control | Mice, Nude | Neovascularization, Pathologic - drug therapy | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Carcinoma, Renal Cell - secondary | Kidney Neoplasms - pathology | Mice | Mice, Inbred BALB C | Protein Kinase Inhibitors - pharmacology | STAT3 Transcription Factor - antagonists & inhibitors
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11. Full Text Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells
by Xin, Hong and Zhang, Chunyan and Herrmann, Andreas and Du, Yan and Figlin, Robert and Yu, Hua
Cancer Research, ISSN 0008-5472, 03/2009, Volume 69, Issue 6, pp. 2506 - 2513
The novel multitargeted tyrosine kinase inhibitor sunitinib is used as an antiangiogenic agent for the treatment of several types of cancer, including... 
TRANSFORMATION | ACTIVATION | THERAPY | EFFICACY | ONCOLOGY | SRC | MUTATIONS | CANCER | SU11248 | Apoptosis - drug effects | Humans | Kidney Neoplasms - immunology | Carcinoma, Renal Cell - immunology | Neovascularization, Pathologic - pathology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Carcinoma, Renal Cell - drug therapy | Carcinoma, Renal Cell - blood supply | Signal Transduction | Carcinoma, Renal Cell - pathology | Cell Growth Processes - drug effects | Pyrroles - pharmacology | Von Hippel-Lindau Tumor Suppressor Protein - immunology | Animals | Cell Line, Tumor | Basic Helix-Loop-Helix Transcription Factors - immunology | Kidney Neoplasms - pathology | Neovascularization, Pathologic - genetics | Mice | STAT3 Transcription Factor - immunology | Kidney Neoplasms - drug therapy | STAT3 Transcription Factor - antagonists & inhibitors | Kidney Neoplasms - blood supply
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12. Full Text Targeted therapy: An elusive cancer target
by Brown, Carolyn
Nature, ISSN 0028-0836, 09/2016, Volume 537, Issue 7620, pp. S106 - S108
Kidney Neoplasms - genetics | Humans | Kidney Neoplasms - immunology | Carcinoma, Renal Cell - genetics | Neoplasm Recurrence, Local - drug therapy | Carcinoma, Renal Cell - immunology | Neoplasm Recurrence, Local - immunology | Neoplasm Recurrence, Local - pathology | Neovascularization, Pathologic - enzymology | Immunotherapy | Angiogenesis Inhibitors - therapeutic use | Neovascularization, Pathologic - prevention & control | Carcinoma, Renal Cell - drug therapy | Carcinoma, Renal Cell - blood supply | Molecular Targeted Therapy - adverse effects | Neoplasm Recurrence, Local - prevention & control | Angiogenesis Inhibitors - pharmacology | Antineoplastic Combined Chemotherapy Protocols | Treatment Outcome | Clinical Trials as Topic | Neovascularization, Pathologic - drug therapy | Survival Analysis | Neovascularization, Pathologic - genetics | Kidney Neoplasms - drug therapy | Kidney Neoplasms - blood supply | Care and treatment | Angiogenesis inhibitors | Carcinoma, Renal cell | Patient outcomes
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13. Full Text Neuropilin-2 promotes extravasation and metastasis by interacting with endothelial α5 integrin
by Cao, Ying and Hoeppner, Luke H and Bach, Steven and Guangqi, E and Guo, Yan and Wang, Enfeng and Wu, Jianmin and Cowley, Mark J and Chang, David K and Waddell, Nicola and Grimmond, Sean M and Biankin, Andrew V and Daly, Roger J and Zhang, Xiaohui and Mukhopadhyay, Debabrata
Cancer Research, ISSN 0008-5472, 07/2013, Volume 73, Issue 14, pp. 4579 - 4590
Metastasis, the leading cause of cancer death, requires tumor cell intravasation, migration through the bloodstream, arrest within capillaries, and... 
Human Umbilical Vein Endothelial Cells | Neuropilin-2 - metabolism | Kidney Neoplasms - genetics | Adenocarcinoma - pathology | Pancreatic Neoplasms - metabolism | Prognosis | Prospective Studies | Neoplastic Cells, Circulating - pathology | Humans | Carcinoma, Renal Cell - genetics | Neoplastic Cells, Circulating - metabolism | Male | Kidney Neoplasms - metabolism | Cell Movement - genetics | Neoplasm Metastasis | Adenocarcinoma - metabolism | Neuropilin-2 - genetics | Female | Adenocarcinoma - genetics | Carcinoma, Renal Cell - blood supply | Cell Adhesion - genetics | Carcinoma, Renal Cell - pathology | Endothelial Cells - metabolism | Neoplasm Invasiveness | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - genetics | Zebrafish | Adenocarcinoma - blood supply | Carcinoma, Renal Cell - metabolism | Animals | Mice, Nude | Integrin alpha5 - metabolism | Cell Line, Tumor | Kidney Neoplasms - pathology | Mice | Endothelial Cells - pathology | Integrin alpha5 - genetics | Kidney Neoplasms - blood supply | extravasation | renal cell carcinoma | pancreatic cancer | endothelial cells | metastasis | Neuropilin | adhesion | integrin
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14. Full Text Reversible Epithelial to Mesenchymal Transition and Acquired Resistance to Sunitinib in Patients with Renal Cell Carcinoma: Evidence from a Xenograft Study
by Hammers, H.J and Verheul, H.M.W and Salumbides, B and Sharma, R and Rudek, M and Jaspers, J and Shah, P and Ellis, L and Shen, L and Paesante, S and Dykema, K and Furge, K and Teh, B and Netto, G and Pili, R
Molecular Cancer Therapeutics, ISSN 1535-7163, 2010, Volume 9, Issue 6, pp. 1525 - 1535
Tyrosine kinase inhibitors (TKI) targeting angiogenesis via inhibition of the vascular endothelial growth factor pathway have changed the medical management of... 
ACTIVATION | ANGIOGENESIS | ONCOLOGY | IN-VIVO | TYROSINE KINASE INHIBITOR | HUMAN CANCERS | ANTITUMOR-ACTIVITY | HYPOXIA | SU11248 | ENDOTHELIAL GROWTH-FACTOR | Kidney Neoplasms - genetics | Pericytes - drug effects | Humans | Mesoderm - drug effects | Carcinoma, Renal Cell - genetics | Angiogenesis Inhibitors - blood | Pericytes - pathology | Angiogenesis Inhibitors - therapeutic use | Indoles - pharmacology | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Gene Expression Regulation, Neoplastic - drug effects | Carcinoma, Renal Cell - drug therapy | Pyrroles - therapeutic use | Carcinoma, Renal Cell - blood supply | Epithelium - drug effects | Epithelium - pathology | Carcinoma, Renal Cell - pathology | Indoles - blood | Angiogenesis Inhibitors - pharmacology | Microvessels - drug effects | Pyrroles - blood | Disease Progression | Xenograft Model Antitumor Assays | Phenotype | Pyrroles - pharmacology | Animals | Mice, Nude | Protein Kinase Inhibitors - therapeutic use | Skin Neoplasms - secondary | Cell Line, Tumor | Indoles - therapeutic use | Kidney Neoplasms - pathology | Mice | Protein Kinase Inhibitors - pharmacology | Kidney Neoplasms - drug therapy | Mesoderm - pathology | Kidney Neoplasms - blood supply | Drug Resistance, Neoplasm - drug effects | renal cell carcinoma | angiogenesis inhibitors | Vascular endothelial growth factor | resistance
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