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1. Full Text αv‐Integrin isoform expression in primary human tumors and brain metastases
by Vogetseder, Alexander and Thies, Svenja and Ingold, Barbara and Roth, Patrick and Weller, Michael and Schraml, Peter and Goodman, Simon L and Moch, Holger
International Journal of Cancer, ISSN 0020-7136, 11/2013, Volume 133, Issue 10, pp. 2362 - 2371
To determine whether metastasis to brain is associated with altered expression patterns of integrins, we investigated the expression of αvβ3, αvβ5, αvβ6 and... 
integrin | brain metastases | cilengitide | GLIOMA-CELLS | ACTIVATION | ANGIOGENESIS | HUMAN BREAST-CANCER | CELL-SURVIVAL | ALPHA(V)BETA EXPRESSION | ONCOLOGY | GROWTH | HUMAN-MELANOMA | CARCINOMA | Neoplasms - metabolism | Breast Neoplasms - secondary | Integrin alphaV - biosynthesis | Kidney Neoplasms - genetics | Humans | Lung Neoplasms - metabolism | Brain Neoplasms - pathology | Lung Neoplasms - pathology | Kidney Neoplasms - metabolism | Brain Neoplasms - metabolism | Breast Neoplasms - metabolism | Brain Neoplasms - secondary | Neoplasm Metastasis | Lung Neoplasms - secondary | Neoplasms - genetics | Melanoma - genetics | Female | Integrin alphaV - genetics | Integrin alphaV - metabolism | Lung Neoplasms - genetics | Melanoma - metabolism | Brain Neoplasms - genetics | Melanoma - pathology | Melanoma - secondary | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Protein Isoforms | Kidney Neoplasms - pathology | Kidney Neoplasms - secondary | Neoplasms - pathology
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2. Full Text Pazopanib in Locally Advanced or Metastatic Renal Cell Carcinoma: Results of a Randomized Phase III Trial
by Cora N. Sternberg and Ian D. Davis and Jozef Mardiak and Cezary Szczylik and Eunsik Lee and John Wagstaff and Carlos H. Barrios and Pamela Salman and Oleg A. Gladkov and Alexander Kavina and Juan J. Zarbá and Mei Chen and Lauren McCann and Lini Pandite and Debasish F. Roychowdhury and Robert E. Hawkins
Journal of Clinical Oncology, ISSN 0732-183X, 02/2010, Volume 28, Issue 6, pp. 1061 - 1068
Purpose Pazopanib is an oral angiogenesis inhibitor targeting vascular endothelial growth factor receptor, platelet-derived growth factor receptor, and c-Kit.... 
EQ-5D | INTERFERON-ALPHA | EFFICACY | ONCOLOGY | GW786034 | DOUBLE-BLIND | SUNITINIB | CANCER | Lung Neoplasms - drug therapy | Prognosis | Humans | Middle Aged | Bone Neoplasms - secondary | Male | Young Adult | Lung Neoplasms - secondary | Aged, 80 and over | Placebos | Adult | Female | Bone Neoplasms - drug therapy | Carcinoma, Renal Cell - drug therapy | Liver Neoplasms - secondary | Double-Blind Method | Liver Neoplasms - drug therapy | Survival Rate | Treatment Outcome | International Agencies | Sulfonamides - therapeutic use | Pyrimidines - therapeutic use | Carcinoma, Renal Cell - secondary | Kidney Neoplasms - pathology | Aged | Kidney Neoplasms - drug therapy | Neoplasm Staging
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3. Full Text Distribution of metastatic sites in patients with prostate cancer: A population‐based analysis
by Gandaglia, Giorgio and Abdollah, Firas and Schiffmann, Jonas and Trudeau, Vincent and Shariat, Shahrokh F and Kim, Simon P and Perrotte, Paul and Montorsi, Francesco and Briganti, Alberto and Trinh, Quoc‐Dien and Karakiewicz, Pierre I and Sun, Maxine
The Prostate, ISSN 0270-4137, 02/2014, Volume 74, Issue 2, pp. 210 - 216
BACKGROUND There is few data on what constitutes the distribution of metastatic sites in prostate cancer (PCa). The aim of our study was to systematically... 
bone metastases | prostate cancer | metastatic disease | sites of metastases | ENDOCRINOLOGY & METABOLISM | UROLOGY & NEPHROLOGY | PATTERNS | BONE | SPREAD | CARCINOMA | Kidney Neoplasms - epidemiology | Prevalence | United States | Humans | Middle Aged | Bone Neoplasms - secondary | Thoracic Neoplasms - epidemiology | Bone Neoplasms - epidemiology | Male | Liver Neoplasms - epidemiology | Brain Neoplasms - secondary | Adrenal Gland Neoplasms - epidemiology | Lung Neoplasms - secondary | Aged, 80 and over | Adrenal Gland Neoplasms - secondary | Retrospective Studies | Liver Neoplasms - secondary | Databases, Factual | Prostatic Neoplasms - pathology | Lymphatic Metastasis | Lung Neoplasms - epidemiology | Thoracic Neoplasms - secondary | Aged | Kidney Neoplasms - secondary | Brain Neoplasms - epidemiology | Liver cancer | Cancer patients | Care and treatment | Metastasis | Prostate cancer | Medical research
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4. Full Text Summary Report on the Graded Prognostic Assessment: An Accurate and Facile Diagnosis-Specific Tool to Estimate Survival for Patients With Brain Metastases
by Paul W. Sperduto and Norbert Kased and David Roberge and Zhiyuan Xu and Ryan Shanley and Xianghua Luo and Penny K. Sneed and Samuel T. Chao and Robert J. Weil and John Suh and Amit Bhatt and Ashley W. Jensen and Paul D. Brown and Helen A. Shih and John Kirkpatrick and Laurie E. Gaspar and John B. Fiveash and Veronica Chiang and Jonathan P.S. Knisely and Christina Maria Sperduto and Nancy Lin and Minesh Mehta
Journal of Clinical Oncology, ISSN 0732-183X, 02/2012, Volume 30, Issue 4, pp. 419 - 425
Purpose Our group has previously published the Graded Prognostic Assessment (GPA), a prognostic index for patients with brain metastases. Updates have been... 
TRIAL | ONCOLOGY | RANDOMIZED PHASE-III | VALIDATION | CLASSIFICATION | PARTITIONING ANALYSIS RPA | INDEX | RADIATION | CANCER | Prognosis | Carcinoma, Renal Cell - pathology | Brain Neoplasms - diagnosis | Humans | Lung Neoplasms - pathology | Male | Melanoma - pathology | Brain Neoplasms - secondary | Neoplasm Metastasis | Neoplasm Grading | Breast Neoplasms - pathology | Survival Analysis | Female | Kidney Neoplasms - pathology | Retrospective Studies | Gdln2 | Neur1 | Original Reports | Bios4 | Neur5 | Psc12 | Radn
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5. Full Text Sunitinib administered on 2/1 schedule in patients with metastatic renal cell carcinoma: The RAINBOW analysis
by Bracarda, Sergio and Iacovelli, R and Boni, L and Rizzo, M and Derosa, L and Rossi, M and Galli, L and Procopio, G and Sisani, M and Longo, F and Santoni, M and Morelli, F and Di Lorenzo, G and Altavilla, A and Porta, C and Camerini, A and Escudier, B and Martignetti, Angelo and Ricotta, Riccardo and Gasparro, Donatello and Sabbatini, Roberto and Ceresoli, Giovanni Luca and Mosca, Alessandra and Santini, Daniele and Caserta, Claudia and Cavanna, Luigi and Massari, Francesco and Sava, Teodoro and Boni, Corrado and Verzoni, Elena and Cartenì, Giacomo and Hamzaj, Alketa and Rainbow Grp and Rainbow Group
Annals of Oncology, ISSN 0923-7534, 10/2015, Volume 26, Issue 10, pp. 2107 - 2113
Background: First-line sunitinib is recommended in metastatic renal cell carcinoma (mRCC), but it is frequently associated with relevant toxicities and... 
Sunitinib | Toxicity | Treatment schedule | mRCC | sunitinib | treatment schedule | toxicity | TRIAL | INTERFERON-ALPHA | MANAGEMENT | THERAPY | ONCOLOGY | OUTCOMES | CANCER | DOSING SCHEDULE | Bone Neoplasms - mortality | Lung Neoplasms - drug therapy | Prognosis | Follow-Up Studies | Lung Neoplasms - mortality | Humans | Middle Aged | Bone Neoplasms - secondary | Male | Antineoplastic Agents - therapeutic use | Liver Neoplasms - mortality | Lung Neoplasms - secondary | Aged, 80 and over | Adult | Female | Retrospective Studies | Bone Neoplasms - drug therapy | Carcinoma, Renal Cell - drug therapy | Liver Neoplasms - secondary | Pyrroles - therapeutic use | Carcinoma, Renal Cell - pathology | Liver Neoplasms - drug therapy | Carcinoma, Papillary - drug therapy | Survival Rate | Kidney Neoplasms - mortality | Carcinoma, Papillary - pathology | Carcinoma, Papillary - mortality | Carcinoma, Renal Cell - mortality | Indoles - therapeutic use | Kidney Neoplasms - pathology | Aged | Kidney Neoplasms - drug therapy | Neoplasm Staging | Index Medicus
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6. Full Text SWITCH: A Randomised, Sequential, Open-label Study to Evaluate the Efficacy and Safety of Sorafenib-sunitinib Versus Sunitinib-sorafenib in the Treatment of Metastatic Renal Cell Cancer
by Eichelberg, Christian and Vervenne, Walter L and De Santis, Maria and Fischer von Weikersthal, Ludwig and Goebell, Peter J and Lerchenmüller, Christian and Zimmermann, Uwe and Bos, Monique M.E.M and Freier, Werner and Schirrmacher-Memmel, Silke and Staehler, Michael and Pahernik, Sascha and Los, Maartje and Schenck, Marcus and Flörcken, Anne and van Arkel, Cornelis and Hauswald, Kirsten and Indorf, Martin and Gottstein, Dana and Michel, Maurice S
European Urology, ISSN 0302-2838, 2015, Volume 68, Issue 5, pp. 837 - 847
Abstract Background Understanding how to sequence targeted therapies for metastatic renal cell carcinoma (mRCC) is important for maximisation of clinical... 
Urology | Sunitinib | Sequential therapy | Renal cell carcinoma | Sorafenib | ANTITUMOR-ACTIVITY | STRATEGIES | PHASE-III TRIAL | 2ND-LINE THERAPY | INTERFERON-ALPHA | TEMSIROLIMUS | UROLOGY & NEPHROLOGY | POOLED ANALYSIS | ELDERLY-PATIENTS | CARCINOMA | PROGRESSION | Niacinamide - analogs & derivatives | Lung Neoplasms - drug therapy | Lymph Nodes - pathology | Humans | Middle Aged | Bone Neoplasms - secondary | Male | Indoles - administration & dosage | Brain Neoplasms - secondary | Lung Neoplasms - secondary | Pyrroles - administration & dosage | Aged, 80 and over | Adult | Female | Bone Neoplasms - drug therapy | Carcinoma, Renal Cell - drug therapy | Liver Neoplasms - secondary | Liver Neoplasms - drug therapy | Proportional Hazards Models | Brain Neoplasms - drug therapy | Niacinamide - administration & dosage | Disease-Free Survival | Phenylurea Compounds - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Carcinoma, Renal Cell - secondary | Kidney Neoplasms - pathology | Aged | Kidney Neoplasms - drug therapy | Antimitotic agents | Care and treatment | Metastasis | Antineoplastic agents | Cancer | Index Medicus
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7. Full Text Survival after complete surgical resection of multiple metastases from renal cell carcinoma
by Alt, Angela L and Boorjian, Stephen A and Lohse, Christine M and Costello, Brian A and Leibovich, Bradley C and Blute, Michael L
Cancer, ISSN 0008-543X, 07/2011, Volume 117, Issue 13, pp. 2873 - 2882
BACKGROUND: Although a role for resection of solitary metastases from renal cell carcinoma (RCC) has been described, the utility of surgery in patients with... 
kidney cancer | metastases | renal cell carcinoma | nephrectomy | metastasectomy | POSTOPERATIVE PROGNOSTIC NOMOGRAM | LONG-TERM SURVIVAL | PULMONARY RESECTION | NATURAL-HISTORY | SYSTEMIC THERAPY | CANCER | RADICAL NEPHRECTOMY | INTERFERON-ALPHA | ONCOLOGY | CLINICAL-TRIALS | RECURRENCE | Bone Neoplasms - mortality | Prognosis | Carcinoma, Renal Cell - pathology | Lung Neoplasms - mortality | Humans | Middle Aged | Bone Neoplasms - secondary | Carcinoma, Renal Cell - surgery | Male | Survival Rate | Treatment Outcome | Bone Neoplasms - surgery | Kidney Neoplasms - mortality | Carcinoma, Renal Cell - mortality | Kidney Neoplasms - surgery | Lung Neoplasms - secondary | Nephrectomy | Carcinoma, Renal Cell - secondary | Aged, 80 and over | Adult | Kidney Neoplasms - pathology | Lung Neoplasms - surgery | Aged | Lesions | Mortality | survival | Cancer | surgery
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8. Full Text Secondary malignant neoplasms after Wilms tumor: An international collaborative study
by Breslow, Norman E and Lange, Jane M and Friedman, Debra L and Green, Daniel M and Hawkins, Mike M and Murphy, Michael F.G and Neglia, Joseph P and Olsen, Jørgen H and Peterson, Susan M and Stiller, Charles A and Robison, Leslie L
International Journal of Cancer, ISSN 0020-7136, 08/2010, Volume 127, Issue 3, pp. 657 - 666
A combined cohort of 8,884 North American, 2,893 British and 1,574 Nordic subjects with Wilms tumor (WT) diagnosed before 15 years of age during 1960–2004 was... 
childhood cancer | Wilms tumor | secondary malignant neoplasm | Secondary malignant neoplasm | Childhood cancer | DIAGNOSIS | PROGNOSIS | RISK | RENAL TUMORS | CHILDHOOD-CANCER SURVIVOR | CHEMOTHERAPY | CHILDREN | TRIAL | ONCOLOGY | MYELOID-LEUKEMIA | Neoplasms, Second Primary - complications | Humans | Adolescent | Survival Analysis | Wilms Tumor - complications | Kidney Neoplasms - complications | Child | Neoplasms, Second Primary - classification | Neoplasms, Second Primary - pathology | Cohort Studies | Incidence
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9. Full Text Diagnosis-Specific Prognostic Factors, Indexes, and Treatment Outcomes for Patients With Newly Diagnosed Brain Metastases: A Multi-Institutional Analysis of 4,259 Patients
by Sperduto, Paul W., M.D., M.P.P and Chao, Samuel T., M.D and Sneed, Penny K., M.D and Luo, Xianghua, Ph.D and Suh, John, M.D and Roberge, David, M.D and Bhatt, Amit, M.D and Jensen, Ashley W., M.D and Brown, Paul D., M.D and Shih, Helen, M.D and Kirkpatrick, John, M.D., Ph.D and Schwer, Amanda, M.D and Gaspar, Laurie E., M.D and Fiveash, John B., M.D and Chiang, Veronica, M.D and Knisely, Jonathan, M.D and Sperduto, Christina Maria and Mehta, Minesh, M.D
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2010, Volume 77, Issue 3, pp. 655 - 661
Purpose Controversy endures regarding the optimal treatment of patients with brain metastases (BMs). Debate persists, despite many randomized trials, perhaps... 
Radiology | Hematology, Oncology and Palliative Medicine | radiotherapy | Brain metastases | prognosis | stereotactic radiosurgery | COST-EFFECTIVENESS | PARTITIONING ANALYSIS RPA | RADIATION-THERAPY | TRIAL | ONCOLOGY | NEUROCOGNITIVE FUNCTION | RANDOMIZED PHASE-III | ACCELERATED-FRACTIONATION | SINGLE METASTASES | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Carcinoma, Non-Small-Cell Lung - radiotherapy | Gastrointestinal Neoplasms | Prognosis | Age Factors | Humans | Middle Aged | Lung Neoplasms | Small Cell Lung Carcinoma - drug therapy | Small Cell Lung Carcinoma - secondary | Brain Neoplasms - secondary | Carcinoma, Non-Small-Cell Lung - secondary | Karnofsky Performance Status | Small Cell Lung Carcinoma - radiotherapy | Retrospective Studies | Brain Neoplasms - radiotherapy | Carcinoma, Renal Cell - drug therapy | Kidney Neoplasms | Brain Neoplasms - diagnosis | Melanoma - radiotherapy | Treatment Outcome | Brain Neoplasms - drug therapy | Melanoma - secondary | Carcinoma, Renal Cell - radiotherapy | Analysis of Variance | Carcinoma, Renal Cell - secondary | Melanoma - drug therapy | Skin Neoplasms | Selection Bias | Aged | Combined Modality Therapy - methods | Carcinoma, Non-Small-Cell Lung - drug therapy | Care and treatment | Metastasis | Patient outcomes | Analysis | SURGERY | METASTASES | NERVOUS SYSTEM | CENTRAL NERVOUS SYSTEM | MEDICINE | NUCLEAR MEDICINE | ORGANS | THERAPY | RADIOLOGY AND NUCLEAR MEDICINE | RADIOTHERAPY | BODY | BRAIN | RADIOLOGY
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10. Full Text Secondary Analysis of RTOG 9508, a Phase 3 Randomized Trial of Whole-Brain Radiation Therapy Versus WBRT Plus Stereotactic Radiosurgery in Patients With 1-3 Brain Metastases; Poststratified by the Graded Prognostic Assessment (GPA)
by Sperduto, Paul W., MD, MPP, FASTRO and Shanley, Ryan, MS and Luo, Xianghua, PhD and Andrews, David, MD and Werner-Wasik, Maria, MD and Valicenti, Richard, MD and Bahary, Jean-Paul, MD and Souhami, Luis, MD, FASTRO and Won, Minhee, MA and Mehta, Minesh, MD, FASTRO
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2014, Volume 90, Issue 3, pp. 526 - 531
Purpose Radiation Therapy Oncology Group (RTOG) 9508 showed a survival advantage for patients with 1 but not 2 or 3 brain metastasis (BM) treated with... 
Radiology | Hematology, Oncology and Palliative Medicine | SURVIVAL | LUNG | MANAGEMENT | ONCOLOGY | VALIDATION | ASSESSMENT INDEX | CLINICAL-PRACTICE | CANCER | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | BREAST | Prognosis | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Combined Modality Therapy - mortality | Brain Neoplasms - surgery | Cranial Irradiation - methods | Melanoma - secondary | Young Adult | Regression Analysis | Brain Neoplasms - secondary | Breast Neoplasms - pathology | Aged, 80 and over | Adult | Female | Kidney Neoplasms - pathology | Aged | Combined Modality Therapy - methods | Radiosurgery - mortality | Brain Neoplasms - mortality | Brain Neoplasms - radiotherapy | Radiosurgery - methods | Cranial Irradiation - mortality | Sects | Care and treatment | Analysis | Surgery | Radiosurgery | Radiation | Clinical trials | Metastasis | Public health | SURGERY | PATIENTS | SURVIVAL TIME | MAMMARY GLANDS | NEOPLASMS | LUNGS | METASTASES | RADIOLOGY AND NUCLEAR MEDICINE | RADIOTHERAPY | COMPARATIVE EVALUATIONS | BRAIN
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