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Kidney international, ISSN 0085-2538, 2012, Volume 82, Issue 12, pp. 1271 - 1283
.... We also established a renal proximal tubule–specific autophagy-related gene 7–knockout mouse model shown to be defective in both basal and cisplatin-induced autophagy in kidneys... 
acute kidney injury | autophagy | Atg7 | cisplatin | ischemia–reperfusion | Ischemia-reperfusion | APOPTOSIS | ACTIVATION | ACUTE-RENAL-FAILURE | PATHOLOGICAL ROLE | ischemia-reperfusion | CISPLATIN NEPHROTOXICITY | CELL-DEATH | PATHOPHYSIOLOGY | UROLOGY & NEPHROLOGY | MICE | BODY FORMATION | SELF-DIGESTION | Microtubule-Associated Proteins - genetics | Blood Urea Nitrogen | JNK Mitogen-Activated Protein Kinases - metabolism | Acute Kidney Injury - genetics | Autophagy - drug effects | Reperfusion Injury - blood | Chloroquine - pharmacology | Time Factors | Reperfusion Injury - chemically induced | Acute Kidney Injury - chemically induced | Microtubule-Associated Proteins - deficiency | Reperfusion Injury - genetics | Cytoprotection | Disease Models, Animal | Kidney Tubules, Proximal - pathology | Reperfusion Injury - pathology | Signal Transduction | Acute Kidney Injury - pathology | Acute Kidney Injury - blood | Mice, Inbred C57BL | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Biomarkers - blood | Sirolimus - pharmacology | Acute Kidney Injury - prevention & control | Cisplatin | Mice, Knockout | Autophagy-Related Protein 7 | Animals | Reperfusion Injury - prevention & control | Kidney Tubules, Proximal - metabolism | Creatinine - blood | Mice | Enzyme Activation | Apoptosis | Kidney Tubules, Proximal - drug effects
Journal Article
Kidney international, ISSN 0085-2538, 2012, Volume 82, Issue 2, pp. 172 - 183
Journal Article
Journal Article
Journal of the American Society of Nephrology, ISSN 1533-3450, 2016, Volume 27, Issue 11, pp. 3356 - 3367
Journal Article
Bone, ISSN 8756-3282, 2012, Volume 51, Issue 3, pp. 621 - 628
.... It is still controversial whether αKlotho is expressed in the kidney proximal tubule, the principal site of phosphate reabsorption... 
Orthopedics | Mice | Fibroblast growth factor-23 | Klotho | Phosphate homeostasis | Kidney | HYPOPHOSPHATEMIA | TRANSPORT | ENDOCRINOLOGY & METABOLISM | RECEPTOR | CELL | Phosphates | Fibroblast growth factors | Rapid Communication
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 3, p. e33258
.... We found that HIF-1 alpha is stabilized in proximal tubule cells during ischemia and unexpectedly in late reperfusion, when oxygen tension is normal... 
ACUTE KIDNEY INJURY | ISCHEMIA/REPERFUSION INJURY | ACTIVATION | ERYTHROPOIETIN | EPITHELIAL-CELLS | FACTOR-1-ALPHA | DISEASE | BIOLOGY | GENE-EXPRESSION | NITRIC-OXIDE | LOW-OXYGEN TENSION | Immunohistochemistry | Oxygen - pharmacology | Transcription, Genetic - drug effects | Kidney Tubular Necrosis, Acute - complications | TOR Serine-Threonine Kinases - metabolism | Humans | Middle Aged | Male | Transplantation, Homologous | Young Adult | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Adult | Female | Reperfusion Injury - complications | Proto-Oncogene Proteins c-akt - metabolism | Reperfusion Injury - genetics | Reperfusion Injury - metabolism | Cell Survival - drug effects | Cell Hypoxia - drug effects | Kidney Tubules, Proximal - pathology | Reperfusion Injury - pathology | Rats | Epithelial Cells - pathology | Kidney Transplantation | Gene Expression Regulation - drug effects | Animals | Signal Transduction - drug effects | Epithelial Cells - enzymology | Kidney Tubules, Proximal - metabolism | Aged | Kidney Tubular Necrosis, Acute - pathology | Kidney Tubules, Proximal - drug effects | Kidneys | Ischemia | Cell death | Analysis | Genes | Transplantation | Gene expression | Hypoxia-inducible factor 1 | Nephrology | Oxygen | Cell survival | Renal function | Transplants & implants | Interference | Tubules | Proximal tubules | Epithelium | Immunology | Reperfusion | Metabolites | Rodents | Hypoxia | Kidney diseases | Oxygen tension | Vascular endothelial growth factor | Cancer | Kidney transplantation
Journal Article
Toxicology and applied pharmacology, ISSN 0041-008X, 2013, Volume 273, Issue 2, pp. 345 - 354
Kidney ischemia–reperfusion (I/R) injury elicits cellular injury in the proximal tubule, and mitochondrial dysfunction is a pathological consequence of I/R... 
SRT1720 | Proximal tubule | Mitochondrial biogenesis | Mitochondrial dysfunction | Ischemia–reperfusion | Acute kidney injury | Ischemia-reperfusion | PGC-1-ALPHA | EPITHELIAL POLARITY | SIRT1 | ENERGY-EXPENDITURE | OXIDANT INJURY | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PROMOTES RECOVERY | HISTONE DEACETYLASE | SMALL-MOLECULE ACTIVATORS | CALORIE RESTRICTION | Kidney - pathology | Recovery of Function - drug effects | Reperfusion Injury - drug therapy | Male | Heterocyclic Compounds, 4 or More Rings - pharmacology | Kidney - metabolism | Heterocyclic Compounds, 4 or More Rings - therapeutic use | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Recovery of Function - physiology | Homeostasis - drug effects | Kidney Tubules - pathology | Kidney Tubules - metabolism | Reperfusion Injury - metabolism | Kidney - drug effects | Kidney Tubules - drug effects | Reperfusion Injury - pathology | Sirtuin 1 - biosynthesis | Rats | Transcription Factors - biosynthesis | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Rats, Sprague-Dawley | Animals | Homeostasis - physiology | Index Medicus | HOMEOSTASIS | INJURIES | EPITHELIUM | MITOCHONDRIA | CREATININE | RATS | RECEPTORS | 60 APPLIED LIFE SCIENCES | ATP | POTASSIUM IONS | SODIUM IONS | mitochondrial dysfunction | acute kidney injury | ischemia-reperfusion | proximal tubule | mitochondrial biogenesis
Journal Article