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1. Full Text Autophagy in proximal tubules protects against acute kidney injury
by Jiang, Man and Wei, Qingqing and Dong, Guie and Komatsu, Masaaki and Su, Yunchao and Dong, Zheng
Kidney international, ISSN 0085-2538, 12/2012, Volume 82, Issue 12, pp. 1271 - 1283
acute kidney injury | autophagy | Atg7 | cisplatin | ischemia–reperfusion | Ischemia-reperfusion | Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Cardiology. Vascular system | Nephrology. Urinary tract diseases | Biological and medical sciences | Kidneys | Medical sciences | Urinary system involvement in other diseases. Miscellaneous | Microtubule-Associated Proteins - genetics | Blood Urea Nitrogen | JNK Mitogen-Activated Protein Kinases - metabolism | Acute Kidney Injury - genetics | Autophagy - drug effects | Reperfusion Injury - blood | Chloroquine - pharmacology | Time Factors | Reperfusion Injury - chemically induced | Acute Kidney Injury - chemically induced | Microtubule-Associated Proteins - deficiency | Reperfusion Injury - genetics | Cytoprotection | Disease Models, Animal | Kidney Tubules, Proximal - pathology | Reperfusion Injury - pathology | Signal Transduction | Acute Kidney Injury - pathology | Acute Kidney Injury - blood | Mice, Inbred C57BL | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Biomarkers - blood | Sirolimus - pharmacology | Acute Kidney Injury - prevention & control | Cisplatin | Mice, Knockout | Autophagy-Related Protein 7 | Animals | Reperfusion Injury - prevention & control | Kidney Tubules, Proximal - metabolism | Creatinine - blood | Mice | Enzyme Activation | Apoptosis | Kidney Tubules, Proximal - drug effects | Index Medicus | ischemia-reperfusion
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2. Full Text FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2–SGK1 signaling pathway
by Andrukhova, Olena and Zeitz, Ute and Goetz, Regina and Mohammadi, Moosa and Lanske, Beate and Erben, Reinhold G
Bone (New York, N.Y.), ISSN 8756-3282, 2012, Volume 51, Issue 3, pp. 621 - 628
Orthopedics | Mice | Fibroblast growth factor-23 | Klotho | Phosphate homeostasis | Kidney | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Phosphates | Fibroblast growth factors | Index Medicus | Rapid Communication
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3. Full Text Dipeptidyl peptidase IV inhibition downregulates Na+-H+ exchanger NHE3 in rat renal proximal tubule
by Adriana Castello Costa Girardi and Lívia Emy Fukuda and Luciana Venturini Rossoni and Gerhard Malnic and Nancy Amaral Rebouças
American Journal of Physiology - Renal Physiology, ISSN 1931-857X, 02/2008, Volume 294, Issue 2, pp. 414 - 422
Serine protease | Fluid reabsorption | Sodium transport | Proton secretion | Physiology | Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Dipeptidyl Peptidase 4 - metabolism | Gene Expression - drug effects | Rats, Wistar | Male | Protein Transport - physiology | Protein Transport - drug effects | Pyrrolidines - pharmacology | Sodium-Hydrogen Exchangers - metabolism | Heart Rate - drug effects | Protease Inhibitors - pharmacology | Kidney - metabolism | Blood Pressure - drug effects | Sodium-Phosphate Cotransporter Proteins - metabolism | Lysine - analogs & derivatives | Kidney - drug effects | Urine - chemistry | Rats | gamma-Glutamyltransferase - metabolism | Down-Regulation - drug effects | Electrolytes - blood | Microvilli - drug effects | Diuresis - drug effects | Animals | Lysine - pharmacology | Microvilli - metabolism | Dipeptidyl-Peptidase IV Inhibitors | Kidney Tubules, Proximal - metabolism | Creatinine - blood | Drinking - drug effects | Hydrogen-Ion Concentration | Kidney Tubules, Proximal - drug effects | Sodium-Hydrogen Exchanger 3 | Nephrology | Kidneys | Sodium | Peptides | Proteases | Rodents | Index Medicus
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4. Full Text Protection of mitochondria prevents high-fat diet–induced glomerulopathy and proximal tubular injury
by Szeto, Hazel H and Liu, Shaoyi and Soong, Yi and Alam, Nazia and Prusky, Glen T and Seshan, Surya V
Kidney international, ISSN 0085-2538, 11/2016, Volume 90, Issue 5, pp. 997 - 1011
endothelium | fibrosis | inflammation | mitochondria | obesity | podocyte | Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Microscopy, Electron, Transmission | AMP-Activated Protein Kinases - metabolism | Endoplasmic Reticulum Stress - drug effects | Apoptosis - drug effects | Glomerulonephritis - prevention & control | Obesity - complications | Mice, Inbred C57BL | Body Weight - drug effects | Diet, High-Fat - adverse effects | Capillaries - drug effects | Endothelium, Vascular - drug effects | Mitochondria - drug effects | Mitochondria - ultrastructure | Oligopeptides - therapeutic use | Blood Glucose - drug effects | Animals | Podocytes - drug effects | Lipid Metabolism - drug effects | Glomerulonephritis - etiology | Drug Evaluation, Preclinical | Oligopeptides - pharmacology | Kidney Tubules, Proximal - drug effects | Kidney Tubules, Proximal - ultrastructure | Index Medicus
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5. Full Text Tenofovir renal toxicity targets mitochondria of renal proximal tubules
by Kohler, James J and Hosseini, Seyed H and Hoying-Brandt, Amy and Green, Elgin and Johnson, David M and Russ, Rodney and Tran, Dung and Raper, C Michael and Santoianni, Robert and Lewis, William
Laboratory investigation, ISSN 0023-6837, 05/2009, Volume 89, Issue 5, pp. 513 - 519
Tenofovir | Mitochondria | Proximal tubules | Renal toxicity | NRTI | Pathology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Fundamental and applied biological sciences. Psychology | Biotechnology | Biological and medical sciences | Investigative techniques, diagnostic techniques (general aspects) | Medical sciences | AIDS-Associated Nephropathy - chemically induced | HIV-1 | Adenine - analogs & derivatives | DNA, Mitochondrial - metabolism | Microdissection | Anti-HIV Agents - adverse effects | Didanosine - adverse effects | Mice, Inbred C57BL | Organophosphonates - adverse effects | Male | Mice, Transgenic | Mitochondria - drug effects | Mitochondria - ultrastructure | AIDS-Associated Nephropathy - pathology | Adenine - adverse effects | Animals | Kidney Tubules, Proximal - metabolism | Female | Mice | Urothelium - ultrastructure | Kidney Tubules, Proximal - drug effects | Kidney Tubules, Proximal - ultrastructure | Index Medicus
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6. Full Text ER stress contributes to renal proximal tubule injury by increasing SREBP-2-mediated lipid accumulation and apoptotic cell death
by Šárka Lhoták and Sudesh Sood and Elise Brimble and Rachel E. Carlisle and Stephen M. Colgan and Adam Mazzetti and Jeffrey G. Dickhout and Alistair J. Ingram and Richard C. Austin
American Journal of Physiology - Renal Physiology, ISSN 1931-857X, 07/2012, Volume 303, Issue 2, pp. 266 - 278
Cyclosporine A | 78-kilodalton glucose-regulated protein | Sterol regulatory element- binding protein-2 | Nephrotoxicity | Apoptosis | Endoplasmic reticulum stress | Physiology | Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Kidney Tubules, Proximal - physiopathology | Stress, Physiological - physiology | Kidney Tubules, Proximal - pathology | Apoptosis - drug effects | Cyclosporine - pharmacology | Heat-Shock Proteins - metabolism | Humans | Mice, Inbred C57BL | Cells, Cultured | Endoplasmic Reticulum - physiology | Animals | Sterol Regulatory Element Binding Protein 2 - drug effects | Biopsy | Tunicamycin - pharmacology | Endoplasmic Reticulum - drug effects | Homeostasis - physiology | Kidney Tubules, Proximal - metabolism | Lipid Metabolism - drug effects | Mice | Stress, Physiological - drug effects | Apoptosis - physiology | Sterol Regulatory Element Binding Protein 2 - metabolism | Lipid Metabolism - physiology | Physiological aspects | Genetic aspects | Research | Binding proteins | Endoplasmic reticulum | Proteins | Kidney diseases | Protease inhibitors | Gene expression | Index Medicus
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7. Full Text Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle
by Vernetti, Lawrence and Gough, Albert and Baetz, Nicholas and Blutt, Sarah and Broughman, James R and Brown, Jacquelyn A and Foulke-Abel, Jennifer and Hasan, Nesrin and In, Julie and Kelly, Edward and Kovbasnjuk, Olga and Repper, Jonathan and Senutovitch, Nina and Stabb, Janet and Yeung, Catherine and Zachos, Nick C and Donowitz, Mark and Estes, Mary and Himmelfarb, Jonathan and Truskey, George and Wikswo, John P and Taylor, D. Lansing
Scientific reports, ISSN 2045-2322, 02/2017, Volume 7, Issue 1, pp. 42296 - 42296
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Terfenadine - pharmacology | Cholecalciferol - metabolism | Humans | Blood-Brain Barrier - physiology | Liver - physiology | Metabolome | Biological Transport - drug effects | Muscle, Skeletal - physiology | Intestines - physiology | Organ Specificity | Kidney Tubules, Proximal - physiology | Methylamines - metabolism | Vitamin D3 | Excretion | Kidneys | Toxicity | Liver | Trimethylamine-N-oxide | Media | Terfenadine | Metabolism | Drug development | Skeletal muscle | Musculoskeletal system | Side effects | Trimethylamine | Jejunum | Blood-brain barrier | Metabolites | Perfusion | Intestine | Xenografts | Drug metabolism | Xenobiotics | Pharmacokinetics | Kidney transplantation | Index Medicus
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8. Full Text Bioprinting of 3D Convoluted Renal Proximal Tubules on Perfusable Chips
by Homan, Kimberly A and Kolesky, David B and Skylar-Scott, Mark A and Herrmann, Jessica and Obuobi, Humphrey and Moisan, Annie and Lewis, Jennifer A
Scientific reports, ISSN 2045-2322, 10/2016, Volume 6, Issue 1, pp. 34845 - 34845
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Kidneys | Sodium | Perfusion | Cyclosporins | Epithelial cells | Extracellular matrix | Proximal tubules | Drug screening | Kidney transplantation | Index Medicus
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9. Full Text Transgenic expression of proximal tubule peroxisome proliferator–activated receptor-α in mice confers protection during acute kidney injury
by Li, Shenyang and Nagothu, Kiran K and Desai, Varsha and Lee, Taewon and Branham, William and Moland, Carrie and Megyesi, Judit K and Crew, Mark D and Portilla, Didier
Kidney international, ISSN 0085-2538, 11/2009, Volume 76, Issue 10, pp. 1049 - 1062
acute kidney injury | cisplatin | PPARα | lipid peroxidation | ischemia–reperfusion | mitochondrial fatty acid oxidation | Ischemia-reperfusion | Lipid peroxidation | PPARa | Acute kidney injury | Cisplatin | Mitochondrial fatty acid oxidation | Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Cardiology. Vascular system | Nephrology. Urinary tract diseases | Biological and medical sciences | Kidneys | Medical sciences | Urinary system involvement in other diseases. Miscellaneous | Immunohistochemistry | Acute Disease | Oxidation-Reduction | Mice, Transgenic | PPAR alpha - genetics | Acute Kidney Injury - prevention & control | Fatty Acids, Nonesterified - metabolism | Animals | Kidney Tubules, Proximal - metabolism | Lipid Peroxidation - drug effects | Female | Mice | PPAR alpha - metabolism | Kidney - physiopathology | Index Medicus
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